A comparison of the oxidation of clozapine and olanzapine to reactive metabolites and the toxicity of these metabolites to human leukocytes

Molecular Pharmacology

Volumn 53, Issue 6, 1998, Pages 991-998

  Gardner, Iain ^a   Zahid, Nasir ^a   MacCrimmon, Duncan ^c   Uetrecht, Jack P ^a,b  

^a UNIVERSITY OF TORONTO   (Canada)

^b UNIVERSITY OF TORONTO   (Canada)

^c MCMASTER UNIVERSITY   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

CLOZAPINE; DRUG METABOLITE; GLUTATHIONE; OLANZAPINE;

AGRANULOCYTOSIS; ARTICLE; CELL STRAIN HL 60; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG CYTOTOXICITY; DRUG OXIDATION; DRUG STRUCTURE; HUMAN; HUMAN CELL; MONONUCLEAR CELL; NEUTROPHIL; NORMAL HUMAN; PRIORITY JOURNAL;

AGRANULOCYTOSIS; ANTIPSYCHOTIC AGENTS; BENZODIAZEPINES; CLOZAPINE; HL-60 CELLS; HUMANS; HYPOCHLOROUS ACID; NEUTROPHILS; OXIDATION-REDUCTION; PIRENZEPINE;

EID: 0031842867     PISSN: 0026895X     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

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