Advances in molecular toxicology - Towards understanding idiosyncratic drug toxicity

Toxicology

Volumn 153, Issue 1-3, 2000, Pages 39-60

  Park, B Kevin ^a   Kitteringham, Neil R ^a   Powell, Helen ^a   Pirmohamed, Munir ^a  

^a UNIVERSITY OF LIVERPOOL   (United Kingdom)

Author keywords

Cell signalling; Drug; Hypersensitivity; Idiosyncratic; Toxicity

Indexed keywords

ALCOHOL; AMODIAQUINE; ANTICONVULSIVE AGENT; CARBAMAZEPINE; DICLOFENAC; DIHYDRALAZINE; HALOTHANE; PENICILLIN G; SULFAMETHOXAZOLE; TACRINE;

ANAPHYLAXIS; ANIMAL MODEL; ARTICLE; BLOOD DYSCRASIA; DRUG HYPERSENSITIVITY; DRUG SAFETY; IMMUNE RESPONSE; LIVER TOXICITY; NONHUMAN; PRIORITY JOURNAL; SIGNAL TRANSDUCTION; SKIN MANIFESTATION; T LYMPHOCYTE; TISSUE INJURY;

ANIMALS; DRUG HYPERSENSITIVITY; HUMANS; MOLECULAR BIOLOGY; PHARMACEUTICAL PREPARATIONS; TOXICOLOGY;

ANIMALIA;

EID: 0034676475     PISSN: 0300483X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0300-483X(00)00303-6     Document Type: Article

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105. Reactive metabolites from the bioactivation of toxic methylfurans
106. 2+ in the nucleus during acetaminophen-induced liver injury
107. Protection of acetaminophen-induced hepatocellular apoptosis and necrosis by cholesteryl hemisuccinate pretreatment
108. Paracetamol hepatotoxicity in metallothionein-null mice
109. Severe adverse cutaneous reactions to drugs
110. Medication use and the risk of Stevens-Johnson syndrome or toxic epidermal necrolysis
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113. Lamotrigine-associated anticonvulsant hypersensitivity syndrome
114. Direct MHC-dependent presentation of the drug sulfamethoxazole to human alpha beta T cell clones
115. T-cell-mediated cytotoxicity against keratinocytes in sulfamethoxazole-induced skin reaction
116. Anticonvulsant hypersensitivity syndrome: In vitro risk assessment
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118. Metabolic polymorphisms and cancer susceptibility
119. Acyl glucuronides revisited: Is the glucuronidation process a toxification as well as detoxification mechanism
120. Studies on cytochrome-P450-mediated bioactivation of diclofenac in rats and in human hepatotocytes: Identification of glutathione conjugated metabolites
121. Advances in our understanding of the mechanisms of the neurotoxicity of MPTP and related compounds
122. 4
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124. The role of leukocyte-generated reactive metabolites in the pathogenesis of idiosyncratic drug reactions
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126. Drug intolerance in HIV disease
127. CYP4B1 activates 4-ipomeanol in rat lung
128. Immunopathology of toxic epidermal necrolysis
129. Lamotrigine and toxic epidermal necrolysis
130. Theta-class glutathione-S-transferase GSTT1 genotypes and susceptibility to cervical neoplasia-interactions with GSTM1, CYP2D6 and smoking
131. Neutrophil cytotoxicity of the chemically reactive metabolite(s) of clozapine: Possible role in agranulocytosis
132. Chronic physical-activity alters hepatobiliary excretory function in rats
133. Chloramphenicol toxicity: 25 years of research
134. Protection against acetaminophen toxicity in CYP1A2 and CYP2E1 double-null mice
135. In vitro lymphocyte proliferation by carbamazepine, carbamazepine-10,11-epoxide, and oxcarbazepine in the diagnosis of drug-induced hypersensitivity
136. HLA-restricted, processing- and metabolism-independent pathway of drug recognition by human αβ T lymphocytes
137. Cyclosporin A increases hypoxia and free radical production in rat kidneys: Prevention by dietary glycine