Antigenicity and immunogenicity of sulphamethoxazole: Demonstration of metabolism-dependent haptenation and T-cell proliferation in vivo

British Journal of Pharmacology

Volumn 133, Issue 2, 2001, Pages 295-305

  Naisbitt, Dean J ^a   Gordon, S Fraser ^a   Pirmohamed, Munir ^a   Burkhart, Christoph ^b   Cribb, Alistair E ^c   Pichler, Werner J ^b   Park, B Kevin ^a  

^a UNIVERSITY OF LIVERPOOL   (United Kingdom)

^b UNIVERSITY OF BERN   (Switzerland)

^c UNIVERSITY OF PRINCE EDWARD ISLAND   (Canada)

Author keywords

Antigen presentation; Delayed type hypersensitivity; in vivo animal model; Skin; Sulphamethoxazole; T lymphocytes

Indexed keywords

CD4 ANTIGEN; CD8 ANTIGEN; GAMMA INTERFERON; GLUTATHIONE; HAPTEN; INTERLEUKIN 4; NITROSO DERIVATIVE; SULFAMETHOXAZOLE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIGEN PRESENTATION; ANTIGENICITY; ARTICLE; CELL PROLIFERATION; CELL SURFACE; CONTROLLED STUDY; CYTOKINE PRODUCTION; DELAYED HYPERSENSITIVITY; DRUG METABOLISM; HYPERSENSITIVITY; IMMUNE RESPONSE; IMMUNOGENICITY; MALE; NONHUMAN; PRIORITY JOURNAL; RAT; SIGNAL TRANSDUCTION; SPLEEN CELL; T LYMPHOCYTE ACTIVATION; T LYMPHOCYTE SUBPOPULATION;

EID: 0034980953     PISSN: 00071188     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.bjp.0704074     Document Type: Article

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