T-cell-mediated cytotoxicity against keratinocytes in sulfamethoxazol- induced skin reaction

Clinical and Experimental Allergy

Volumn 28, Issue 11, 1998, Pages 1412-1417

  Schnyder, B ^a   Frutig, K ^a   Mauri Hellweg, D ^a   Limat, A ^b   Yawalkar, N ^a   Pichler, W J ^a  

^a UNIVERSITY OF BERN   (Switzerland)

^b GENEVA UNIVERSITY HOSPITALS   (Switzerland)

Author keywords

Drug eruptions; HIV; Hypersensitivity; Interferon gamma; Sulfamethoxazole; T lymphocyte

Indexed keywords

CD4 ANTIGEN; CD8 ANTIGEN; CHROMIUM 51; CONCANAMYCIN A; FAS ANTIGEN; FAS LIGAND; GAMMA INTERFERON; PERFORIN; SULFAMETHOXAZOLE;

ARTICLE; B LYMPHOBLAST; CELL KILLING; CELL MEDIATED CYTOTOXICITY; CONTROLLED STUDY; CYTOTOXIC T LYMPHOCYTE; DRUG HYPERSENSITIVITY; DRUG INDUCED DISEASE; DRUG TARGETING; ERYTHEMA MULTIFORME; HUMAN; HUMAN CELL; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; KERATINOCYTE; LYMPHOCYTE CLONE; MAJOR HISTOCOMPATIBILITY COMPLEX RESTRICTION; PRIORITY JOURNAL; RASH; SKIN MANIFESTATION;

CD4-POSITIVE T-LYMPHOCYTES; CD8-POSITIVE T-LYMPHOCYTES; CELL LINE; CLONE CELLS; CYTOTOXICITY, IMMUNOLOGIC; HLA-B ANTIGENS; HLA-DR ANTIGENS; HUMANS; IMMUNOHISTOCHEMISTRY; INTERFERON TYPE II; KERATINOCYTES; MALE; MEMBRANE GLYCOPROTEINS; PORE FORMING CYTOTOXIC PROTEINS; SKIN TESTS; SULFAMETHOXAZOLE; T-LYMPHOCYTES;

EID: 0031772156     PISSN: 09547894     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1365-2222.1998.00419.x     Document Type: Article

References (22)

1. Jick J. Adverse reactions to trimethoprim-sulfamethoxazole in hospitalized patients. Rev Infect Dis 1982; 4:426-8.
2. Smith KJ, Skelton HG, Yeager J et al. Increased drug reactions in HIV-, 1-positive patients, a possible explanation based on patterns of immune dysregulation see in HIV-1 disease. Clin Exp Dermatol 1997; 22:118-23.
3. Coopman SA, Johnson RA, Platt R, Stern RS. Cutaneous disease and drug reactions in HIV infection. N Engl J Med 1993; 328:1670-4.
4. Carr A, Garsia R. How HIV leads to hypersensitivity reactions. Med J Aust 1996; 164:227-9.
5. Carr A, Cooper DA, Penny R. Allergic manifestations of HTV infection. J Clin Immunol 1991; 11:55-64.
6. Carr A, Vasak E, Munro V, Penny R, Cooper DA. Immunohistological assesment of cutaneous drug hypersensitivity in patient with HIV infection. Clin Exp Immunol 1994; 97:260-5.
7. Carr A, Swanson C, Penny R, Cooper DA. Clinical and laboratory markers of hypersensitivity to trimethoprim-sulfamethoxazole in patients with Pneumocystis carinii pneumonia and AIDS. J Infect Dis 1993; 167:180-5.
8. Park BK, Coleman JW, Kitteringham NR. Drug disposition and drug hypersensitivity. Biochem Pharmacol 1987; 36:581-90.
9. Schnyder B, Mauri-Hellweg D, Zanni M, Bettens F, Pichler WJ. Direct, MHC dependent presentation of the drug sulfamethoxazole to human αβ T cell clones. J Clin Inves 1997; 100:136-41.
10. Mauri-Hellweg D, Bettens F, Mauri D et al. Activation of drug-specific CD4+ and CD8+ T cells in individuals allergic to sulfonamides, phenytoin, and carbamazepine. J Immunol 1995; 155:462-72.
11. 51Cr-labelled allogeneic target cells in vitro; Inhibition by isoantibody and by drugs. Immunology 1968; 14:181-96.
12. Kataoka T, Shinohara N, Takayama H et al. Concanamycin A, a powerful tool for characterization and estimation of contribution of perforin- and Fas-based lytic pathways in cell-mediated cytotoxicity. J Immunol 1996; 156:3678-86.
13. Limat A, Hunziker T, Boillat C, Bayreuther K, Noser F. Postmitotic human dermal fibroblasts efficiently support the growth of human follicular keratinocytes. J Invest Dermatol 1989; 92:758-62.
14. Schwaller J, Tobler A, Niklaus G, Hurwitz N et al. Interleukin 12 expression in human lymphomas and nonneoplastic lymphoid disorders. Blood 1995; 85:2182-8.
15. Ritter M, Huber C, Auböck J et al. Lytic susceptibility of target cells to cytotoxic T cells is determined by their constitutive major histocompatibility complex class I antigen expression and cytokine-induced activation status: Immunology 1994; 81:569-77.
16. Kägi D, Ledermann B, Bürki K, Zinkernagel RM, Hengartner H. Molecular mechanisms of lymphocyte-mediated cytotoxicity and their role in immunological protection and pathogenesis in vivo. Annu Rev Immunol 1996; 14:207-32.
17. Shafer RW, Seitzman PA, Tapper ML. Successful prophylaxis of pneumocystis carinii pneumonia with trimethoprim-sulfamethoxazole in AIDS patients with previous allergic reactions. J Acquir Immune Defic Syndr 1989; 2:389-93.
18. Howland WW, Golitz LE, Weston WL, Huff JC. Erythema multiforme: Clinical, histopathologal and immunologic study. J Am Acad Dermatol 1984; 10:428-46.
19. Mikloka Z, Kesson AM, Penfold ET, Cunningham AL. Herpés simplex protein targets for CD4 and CDS lymphocyte cytotoxicity in cultured epidermal keratinocytes treated with Interferon-γ. J Infect Dis 1996; 173:7-17.
20. Fuchs D, Hausen A, Reibegger B et al. Interferon-γ concentrations are increased in sera from individuals infected with human immunodefiency virus Type I. J Acquir Immune Defic Syndr 1989; 2:158-62.
21. Hertl M, Merk HF. Lymphocyte activation in cutaneous drug reactions. J Invest Dermatol 1995; 105:95S-98S.
22. Miyauchi H, Hosokawa H, Akaeda T, Iba H, Asada Y. T cell subsets in toxic epidermal necrolysis. Arch Dermatol 1991; 127:851-5.