Neutropenia and agranulocytosis in patients receiving clozapine in the UK and Ireland

British Journal of Psychiatry

Volumn 169, Issue 4, 1996, Pages 483-488

  Atkin, Karen ^a,d   Kendall, Francis ^a   Gould, Duncan ^a   Freeman, Hugh ^b   Lieberman, Jeffrey ^c   O'Sullivan, Desmond ^a  

^a Clozaril Patient Monitoring Service

^b Sandoz Pharmaceuticals ^*  (United Kingdom)

^c ALBERT EINSTEIN COLLEGE OF MEDICINE   (United States)

^d Clozaril Patient Monitoring Service   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

CLOZAPINE;

ADOLESCENT; ADULT; AGED; AGRANULOCYTOSIS; ARTICLE; FEMALE; HUMAN; MAJOR CLINICAL STUDY; MALE; NEUTROPENIA; SCHOOL CHILD; UNITED KINGDOM;

ADULT; ADVERSE DRUG REACTION REPORTING SYSTEMS; AGED; AGRANULOCYTOSIS; ANTIPSYCHOTIC AGENTS; CLOZAPINE; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG ADMINISTRATION SCHEDULE; FEMALE; FOLLOW-UP STUDIES; GREAT BRITAIN; HUMANS; IRELAND; MALE; MIDDLE AGED; NEUTROPENIA; RISK FACTORS; SCHIZOPHRENIA;

EID: 0029775615     PISSN: 00071250     EISSN: None     Source Type: Journal    
DOI: 10.1192/bjp.169.4.483     Document Type: Article

References (13)

1. ALVIR, J. M., LIEBERMAN, J. A., SAFFERMAN, A. Z., et al (1993) Clozapine induced agranulocytosis: incidence and risk factors in the United States. New England Journal of Medicine, 329, 162-167.
2. BÖTTIGER, L. E. & BÖTTIGER, B. (1981) Incidence and cause of aplastic anaemia, hemolytic anaemia agranulocytosis and thrombocytopenia. Acta Medica Scandinavica, 210, 475-479.
3. BRUHWYLER, J., CHLEIDE, E. & MERCIER, M. (1990) Clozapine: an atypical neuroleptic. Neuroscience and Biobehavioural Reviews, 14, 357-363.
4. KANE, J., HONIGFELD, G., SINGER, J., et al (1988) Clozapine for the treatment-resistant schizophrenic a double blind comparison with chlorpromazine. Archives of General Psychiatry, 45, 789-796.
5. _, SAFFERMAN, A. Z., POLLACK, S., et al (1994) Clozapine: negative symptoms and extrapyramidal side effects. Journal of Clinical Psychiatry, 55 (suppl. B), 74-77.
6. KAUFMAN, D. W., KELLY, J. P., LEVY, M., et al (1991) The Drug Aetiology of Agranulocytosis and Aplastic Anaemia, pp. 148-158. Oxford: Oxford University Press.
7. LIEBERMAN, J. A., SALTZ, B. L., JOHNS, C. A., et al (1991) The effects of clozapine on tardive dyskinesia. British Journal of Psychiatry, 158, 503-510.
8. MANDEL, A. & GROSS, M. (1986) Agranulocytosis and phenothiazines. Diseases of the Nervous System, 29, 32-36.
9. MEDICINES CONTROL AGENCY (1993) Drug-induced neutropenia and agranulocytosis. Current Problems in Pharmacovigilance, 20, 10-11.
10. MELTZER, H. Y. (1992) Dimensions of outcome with clozapine. British Journal of Psychiatry, 160 (suppl. 17), 46-53.
11. _, BASTANI, B., KWON, K. Y., et al (1989) A prospective study of clozapine in treatment-resistant schizophrenic patients. Psychopharmacology, 99, S68-S72.
12. PISCIOTTA, V. (1978) Drug-induced agranulocytosis. Drugs, 15, 132-143.
13. REED, W. W. & DIEHL, L. F. (1991) Leukopenia, neutropenia, and reduced haemoglobin levels in healthy American blacks. Archives of Internal Medicine, 151, 501-505.