Covalent binding of sulfamethoxazole reactive metabolites to human and rat liver subcellular fractions assessed by immunochemical detection

Chemical Research in Toxicology

Volumn 9, Issue 2, 1996, Pages 500-507

  Cribb, Alastair E ^a   Nuss, Cindy E ^a   Alberts, David W ^a   Lamphere, Diane B ^a   Grant, Denis M ^b   Grossman, Scott J ^a   Spielberg, Stephen P ^a  

^a MERCK RESEARCH LABORATORIES   (United States)

^b HOSPITAL FOR SICK CHILDREN   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

ACETYL COENZYME A; DRUG METABOLITE; GLUTATHIONE; KEYHOLE LIMPET HEMOCYANIN; LIVER PROTEIN; POLYCLONAL ANTIBODY; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE; SULFAMETHOXAZOLE;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CELL FRACTIONATION; CONTROLLED STUDY; COVALENT BOND; CYTOTOXICITY; DRUG ACETYLATION; DRUG HYDROXYLATION; DRUG HYPERSENSITIVITY; DRUG METABOLISM; DRUG PROTEIN BINDING; HUMAN; HUMAN TISSUE; IMMUNE RESPONSE; INTRAPERITONEAL DRUG ADMINISTRATION; LIVER MICROSOME; LIVER SLICE; LIVER TOXICITY; MALE; NONHUMAN; PATHOGENESIS; RAT;

ANIMALS; HUMANS; IMMUNOBLOTTING; IMMUNOHISTOCHEMISTRY; LIVER; MALE; MICROSOMES, LIVER; NADP; PROTEIN BINDING; RATS; RATS, SPRAGUE-DAWLEY; SULFAMETHOXAZOLE;

EID: 0029892271     PISSN: 0893228X     EISSN: None     Source Type: Journal    
DOI: 10.1021/tx950167j     Document Type: Article

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