The ABCs of ATP-sensitive potassium channels: More pieces of the puzzle

Current Opinion in Cell Biology

Volumn 9, Issue 4, 1997, Pages 553-559

  Bryan, Joseph ^a   Aguilar Bryan, Lydia ^a  

^a BAYLOR COLLEGE OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ABC TRANSPORTER; ADENOSINE TRIPHOSPHATASE (POTASSIUM); COMPLEMENTARY DNA; INSULIN; MEMBRANE ENZYME; MEMBRANE RECEPTOR; NUCLEOTIDE BINDING PROTEIN; POTASSIUM CHANNEL; POTASSIUM ION; SULFONYLUREA;

ENZYME STRUCTURE; ENZYME SUBUNIT; HYPERINSULINISM; INSULIN RELEASE; MEMBRANE CHANNEL; MOLECULAR CLONING; PANCREAS ISLET BETA CELL; PRIORITY JOURNAL; SHORT SURVEY; STOICHIOMETRY;

EID: 0030747393     PISSN: 09550674     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0955-0674(97)80033-6     Document Type: Article

References (44)

1. Aguilar-Bryan L, Nichols CG, Wechsler SW, Clement JP IV, Boyd AE III, Gonzalez G, Herrera-Sosa H, Nguy K, Bryan J, Nelson DA: Cloning of the beta cell high-affinity sulfonylurea receptor: a regulator of insulin secretion. Science 1995, 268:423-426.
2. Cole SP, Bhardwaj G, Gerlach JH, Mackie JE, Grant CE, Almquist KC, Stewart AJ, Kurz EU, Duncan AM, Deeley RG: Overexpression of a transporter gene in a multidrug-resistant human lung cancer cell line. Science 1992, 258:1650-1654.
3. Cole SP, Sparks KE, Fraser K, Loe DW, Grant CE, Wilson GM, Deeley RG: Pharmacological characterization of multidrug resistant MRP-transfected human tumor cells. Cancer Res 1994, 54:5902-5910.
4. Buchler M, Konig J, Brom M, Kartenbeck J, Spring H, Horie T, Keppler D: cDNA cloning of the hepatocyte canalicular isoform of the multidrug resistance protein, cMRP, reveals a novel conjugate export pump deficient in hyperbilirubinemic mutant rats. J Biol Chem 1996, 271:15091-15098.
5. Taniguchi K, Wada M, Kohno K, Nakamura T, Kawabe T, Kawakami M, Kagotani K, Okumura K, Akiyama S, Kuwano M: A human canalicular multispecific organic anion transporter (cMOAT) gene is overexpressed in cisplatin-resistant human cancer cell lines with decreased drug accumulation. Cancer Res 1996, 56:4124-4129.
6. Szczypka MS, Wemmie JA, Moye-Rowley WS, Thiele DJ: A yeast metal resistance protein similar to human cystic fibrosis transmembrane conductance regulator (CFTR) and multidrug resistance-associated protein. J Biol Chem 1994, 269:22853-22857.
7. Tusnàdy GE, Bakos E, Varadi A, Sarkadi B: Membrane topology distinguishes a subfamily of the ATP-binding cassette (ABC) transporters. FEBS Lett 1997, 402:1-3. Describes an important suggestion about ABC transporter topology that predicts a common structural motif for CRRs, MDRs and MRPs. A different suggestion about ABC transporter topology was reported in [1], which was the critical first paper describing the results of a long-term effort to purify the high-affinity sulfonylurea receptor, SUR1, using a radio-iodinated derivative of glibenclamide. The availability of SUR1 cDNAs allowed the reconstitution of KATP channel activity and the identification of mutations in SUR1 that caused PHHI [1].
8. + channels. Neuron 1996, 16:1011-1017. An important paper which extended the SUR family and showed that the SUR defines the pharmacological and nucleotide-binding properties of reconstituted KATP channels.
9. + channel. J Biol Chem 1996, 271:24321-24324. Provides the first indication that there are physiologically important splice variants of sulfonylurea receptors.
10. Thomas PM, Cote GJ, Wohlik N, Haddad B, Mathew PM, Rabl W, Aguilar-Bryan L, Gagel RF, Bryan J: Mutations in the sulfonylurea receptor gene in familial hyperinsulinemic hypoglycemia of infancy. Science 1995, 268:426-429.
11. Glaser B, Chiu KC, Anker R, Nestorowicz A, Landau H, Ben BH, Shlomai Z, Kaiser N, Thornton PS, Stanley CA et al.: Familial hyperinsulinism maps to chromosome 11p14-15.1, 30 cM centromeric to the insulin gene. Nat Genet 1994, 7:185-188.
12. Thomas PM, Cote GJ, Hallman DM, Mathew PM: Homozygosity mapping of the gene for familial persistent hyperinsulinemic hypoglycemia of infancy to chromosome 11 p. Am J Hum Genet 1995, 56:416-421.
13. Chutkow WA, Simon MC, Le Beau MM, Burant CF: Cloning, tissue expression, and chromosomal localization of SUR2, the putative drug-binding subunit of cardiac, skeletal muscle, and vascular KATP channels. Diabetes 1996, 45:1439-1445.
14. Bilginturan N, Zileli S, Karacadag S, Pirnar T: Hereditary brachydactyly associated with hypertension. J Med Genet 1973, 10:253-259.
15. Schuster H, Wienker TE, Bahring S, Bilginturan N, Toka HR, Neitzel H, Jeschke E, Toka O, Gilbert D, Lowe A et al.: Severe autosomal dominant hypertension and brachydactyly in a unique Turkish kindred maps to human chromosome 12. Nat Genet 1996, 13:98-100.
16. Doupnik CA, Davidson N, Lester HA: The inward rectifier potassium channel family. Curr Opin Neurobiol 1995, 5:268-277.
17. Inagaki N, Tsuura Y, Namba N, Masuda K, Gonoi T, Horie M, Seino Y, Mizuta M, Seino S: Cloning and functional characterization of a novel ATP-sensitive potassium channel ubiquitously expressed in rat tissues, including pancreatic islets, pituitary, skeletal muscle, and heart. J Biol Chem 1995, 270:5691-5694.
18. ATP channels.
19. + currents expressed in Xenopus oocytes. J Physiol 1997, 498:87-98.
20. Inagaki N, Inazawa J, Seino S: cDNA sequence, gene structure, and chromosomal localization of the human ATP sensitive potassium channel, uKATP-1, gene (KCNJ8). Genomics 1995, 30:102-104.
21. Aguilar-Bryan L, Bryan J: ATP-sensitive potassium channels, sulfonylurea receptors and persistent hyperinsulinemic hypoglycemia of infancy. Diabetes Rev 1996, 4:336-346.
22. Inagaki N, Gonoi T, Clement JP IV, Namba N, Inazawa J, Gonzalez G, Aguilar-Bryan L, Seino S, Bryan J: Reconstitution of IKATP: an inward rectifier subunit plus the sulfonylurea receptor. Science 1995, 270:1166-1170.
23. Sakura H, Ämmälä C, Smith PA, Gribble FM, Ashcroft FM: Cloning and functional expression of the cDNA encoding a novel ATP-sensitive potassium channel subunit expressed in pancreatic beta-cells, brain, heart and skeletal muscle. FEBS Lett 1995, 377:338-344.
24. Schwanstecher M, Loser S, Chudziak F, Bachmann C, Panten U: Photoaffinity labeling of the cerebral sulfonylurea receptor using a novel radioiodinated azidoglibenclamide analogue. J Neurochem 1994, 63:698-708.
25. Schwanstecher M, Loser S, Chudziak F, Panten U: Identification of a 38-kDa high affinity sulfonylurea-binding peptide in insulin-secreting cells and cerebral cortex. J Biol Chem 1994, 269:17768-17771.
26. Ozanne SE, Guest PC, Hutton JC, Hales CN: Intracellular localization and molecular heterogeneity of the sulphonylurea receptor in insulin-secreting cells. Diabetologia 1995, 38:277-282.
27. + channels is caused by intracellular spermine. Cell 1995, 80:149-154.
28. 2+ of the inward rectifier, IRK1. J Physiol 1994, 478:1-6.
29. + channel IRK1. EMBO J 1995, 14:5532-5541.
30. + channel. Neuron 1995, 14:1047-1054.
31. IR6.2. Biophys J 1997, 72:A252.
32. Permutt MA, Nestorowicz A, Glaser B: Familial hyperinsulinism: an inherited disorder of spontaneous hypoglycemia in neonates and infants. Diabetes Rev 1996, 4:347-355.
33. Nestorowicz A, Wilson BA, Schoor KP, lnoue H, Glaser B, Landau H, Stanley CA, Thornton PS, Clement JP IV, Bryan J et al.: Mutations in the sulfonylurea receptor gene are associated with familial hyperinsulinism in Ashkenazi Jews. Hum Mol Genet 1996, 5:1813-1822. This paper is important because it confirms the observation, reported in a key paper [10], that mutations in the high-affinity sulfonylurea receptor segregate with PHHI.
34. Inoue H, Ferrer J, Welling CM, Elbein SC, Hoffman M, Mayorga R, Warren-Perry M, Zhang Y, Millns H, Turner R et al.: Sequence variants in the sulfonylurea receptor (SUR) gene are associated with NIDDM in Caucasians. Diabetes 1996, 45:825-831.
35. + channel and linkage studies with NIDDM in Japanese. Diabetes 1996, 45:267-269.
36. Stirling B, Cox NJ, Bell GI, Hanis CL, Spielman RS, Concannon P: Linkage studies in NIDDM with markers near the sulphonylurea receptor gene. Diabetologia 1995, 38:1479-1481.
37. IR6.2, the inward rectifier, cause PHHI. This observation was confirmed in [38].
38. Thomas P, Ye Y, Lightner E: Mutations of the pancreatic islet inward rectifier also lead to familial persistent hyperinsulinemic hypoglycemia of infancy. Hum Mol Genet 1996, 5:1809-1812.
39. Kane C, Shepherd RM, Squires PE, Johnson PR, James RF, Milla PJ, Aynsley-Green A, Lindley KJ, Dunne MJ: Loss of functional KATP channels in pancreatic beta-cells causes persistent hyperinsulinemic hypoglycemia of infancy. Nat Med 1996, 2:1344-1347. Provides the first demonstration that KATP channels are missing in ßcells from individuals diagnosed with PHHI.
40. ATP channel activity.
41. ATP channel activity in vivo. Describes the analysis of a point mutation that generates channels that are silent in intact cells, but active in excised cell patches. The defect was shown to be due to an inability to respond to Mg·ADP.
42. 2+ as evidences in single pancreatic islets. J Biol Chem 1993, 268:22265-22268.
43. + channels in clonal pancreatic alpha cells. Evidence for two high affinity sulfonylurea receptors. J Biol Chem 1993, 268:15221-15228.
44. Dunne MJ, Kane C, Squires PE, Lindley KJ, Johnson PRV, James RFL: Persistent neonatal hyperinsulinaemic hypoglycaemia in humans involves a defect in pancreatic β-cell K-channels. J Physiol 1995, 489:7-8.