Alzheimer's amyloid-β as a preventive antioxidant for brain lipoproteins

Cellular and Molecular Neurobiology

Volumn 21, Issue 4, 2001, Pages 299-315

  Kontush, Anatol ^a  

^a UNIVERSITY MEDICAL CENTER HAMBURG EPPENDORF   (Germany)

Author keywords

Alzheimer's disease; Amyloid ; Antioxidant; Lipoproteins; Oxidation; Transition metals

Indexed keywords

AMYLOID BETA PROTEIN; COPPER; LIPOPROTEIN; REACTIVE OXYGEN METABOLITE;

AGING; ALZHEIMER DISEASE; ANTIOXIDANT ACTIVITY; ARTICLE; CHELATION; HUMAN; NEUROTOXICITY; NONHUMAN; OXIDATION; OXIDATION REDUCTION REACTION; OXIDATIVE STRESS; PRIORITY JOURNAL;

ALZHEIMER DISEASE; AMYLOID BETA-PROTEIN; ANIMALS; ANTIOXIDANTS; BRAIN; HUMANS; LIPOPROTEINS;

EID: 0035661661     PISSN: 02724340     EISSN: None     Source Type: Journal    
DOI: 10.1023/A:1012629603390     Document Type: Article

References (113)

1. Evaluation of CSF-tau and CSF-Abeta42 as diagnostic markers for Alzheimer disease in clinical practice
2. Time-course of oxidation of lipids in human cerebrospinal fluid in vitro
3. Dramatic aggregation of Alzheimer Abeta by Cu(II) is induced by conditions representing physiological acidosis
4. Characterization of copper interactions with Alzheimer amyloid beta peptides: Identification of an attomolar-affinity copper binding site on amyloid beta 1-42
5. Hydrogen peroxide mediates amyloid beta protein toxicity
6. Neuronal cell cultures protect low density lipoprotein from oxidation
7. Is copper pro- or anti-inflammatory? A reconciling view and a novel approach for the use of copper in the control of inflammation
8. Does human betaA4 exert a protective function against oxidative stress in Alzheimer's disease?
9. Promotion of transition metal-induced reactive oxygen species formation by beta-amyloid
10. Mitochondrial involvement in Alzheimer's disease
11. Peptides in membranes: Tipping the balance of membrane stability
12. Regulated intramembrane proteolysis: A control mechanism conserved from bacteria to humans
13. Generation of beta-amyloid in the secretory pathway in neuronal and nonneuronal cells
14. Metals and neuroscience
15. In vivo inhibition of A-beta amyloid formation in a transgenic mouse model for Alzheimer's disease following oral treatment with a copper/zinc chelator
16. Rapid induction of Alzheimer A beta amyloid formation by zinc
17. Beta-Amyloid peptide free radical fragments initiate synaptosomal lipoperoxidation in a sequence-specific fashion: Implications to Alzheimer's disease
18. Mitochondrial free radical generation, oxidative stress, and aging
19. Differential expression of cytochrome oxidase (COX) genes in different regions of monkey brain
20. Platelets are the primary source of amyloid beta-peptide in human blood
21. Aqueous dissolution of Alzheimer's disease Abeta amyloid deposits by biometal depletion
22. The oxidation of lipoproteins by monocytes-macrophages. Biochemical and biological mechanisms
23. Evidence that the beta-amyloid plaques of Alzheimer's disease represent the redox-silencing and entombment of Abeta by zinc
24. The role of cholesterol in the biosynthesis of beta-amyloid
25. Oxidative stress increases production of beta-amyloid precursor protein and beta-amyloid (Abeta) in mammalian lenses, and Abeta has toxic effects on lens epithelial cells
26. Inhibition of energy metabolism alters the processing of amyloid precursor protein and induces a potentially amyloidogenic derivative
27. A beta 42 is the predominant form of amyloid beta-protein in the brains of short-term survivors of head injury
28. The cerebrospinal-fluid soluble form of Alzheimer's amyloid beta is complexed to SP-40,40 (apolipoprotein J), an inhibitor of the complement membrane-attack complex
29. Amyloid beta-peptide is produced by cultured cells during normal metabolism
30. Apolipoprotein E is present in hippocampal neurons without neurofibrillary tangles in Alzheimer's disease and in age-matched controls
31. Amyloid, the presenilins and Alzheimer's disease
32. The Abeta peptide of Alzheimer's disease directly produces hydrogen peroxide through metal ion reduction
33. Cu(II) potentiation of Alzheimer Abeta neurotoxicity. Correlation with cell-free hydrogen peroxide production and metal reduction
34. Abeta deposition is associated with neuropil changes, but not with overt neuronal loss in the human amyloid precursor protein V717F (PDAPP) transgenic mouse
35. The toxicity in vitro of beta-amyloid protein
36. Identification of the major Abetal-42-degrading catabolic pathway in brain parenchyma: Suppression leads to biochemical and pathological deposition
37. A beta peptide immunization reduces behavioural impairment and plaques in a model of Alzheimer's disease
38. Seeding "one-dimensional crystallization" of amyloid: A pathogenic mechanism in Alzheimer's disease and scrapie?
39. Ischemic stress induces deposition of amyloid beta immunoreactivity in human brain
40. Statins and the risk of dementia
41. Nerve endings from rat brain tissue release copper upon depolarization. A possible role in regulating neuronal excitability
42. Targeting small Abeta oligomers: The solution to an Alzheimer's disease conundrum?
43. Lipoproteins in the brain: A new frontier?
44. Amyloid-beta is an antioxidant for lipoproteins in cerebrospinal fluid and plasma
45. Resistance of human cerebrospinal fluid to in vitro oxidation is directly related to its amyloid-beta content
46. The soluble form of Alzheimer's amyloid beta protein is complexed to high density lipoprotein 3 and very high density lipoprotein in normal human plasma
47. Alzheimer's soluble amyloid beta protein is secreted by HepG2 cells as an apolipoprotein
48. Biochemical characterization of Alzheimer's soluble amyloid beta protein in human cerebrospinal fluid: Association with high density lipoproteins
49. Brain alpha-ketoglutarate dehydrogenase complex: Kinetic properties, regional distribution, and effects of inhibitors
50. Increased production of 4 kDa amyloid beta peptide in serum deprived human primary neuron cultures: Possible involvement of apoptosis
51. Histidine-13 is a crucial residue in the zinc ion-induced aggregation of the A beta peptide of Alzheimer's disease
52. Increased regional brain concentrations of ceruloplasmin in neurodegenerative disorders
53. The effect of ascorbate and ubiquinone supplementation on plasma and CSF total antioxidant capacity
54. Copper, iron and zinc in Alzheimer's disease senile plaques
55. Copper catalyzed oxidation of ascorbate (vitamin C). Inhibitory effect of catalase, superoxide dismutase, serum proteins (ceruloplasmin, albumin, apotransferrin) and amino acids
56. Physiological thiol compounds exert pro- and anti-oxidant effects, respectively, on iron- and copper-dependent oxidation of human low-density lipoprotein
57. The pattern of acquisition of plaques and tangles in the brains of patients under 50 years of age with Down's syndrome
58. Aluminum, iron, and zinc ions promote aggregation of physiological concentrations of beta-amyloid peptide
59. Amyloid beta-peptide and oxidative cellular injury in Alzheimer's disease
60. A role for 4-hydroxynonenal, an aldehydic product of lipid peroxidation, in disruption of ion homeostasis and neuronal death induced by amyloid beta-peptide
61. Amyloid beta-peptide impairs glucose transport in hippocampal and cortical neurons: Involvement of membrane lipid peroxidation
62. Oxidative stress hypothesis in Alzheimer's disease
63. Distribution and fluidizing action of soluble and aggregated amyloid beta-peptide in rat synaptic plasma membranes
64. Ambivalent effect of protein binding on computed distributions of metal ions complexed by ligands in blood plasma
65. Intramuscular desferrioxamine in patients with Alzheimer's disease
66. Microglial in neurodegenerative disorders: Emphasis on Alzheimer's disease
67. Normal and pathological aging: Findings of positron-emission-tomography
68. Oxidative stress induces intracellular accumulation of amyloid beta-protein (Abeta) in human neuroblastoma cells
69. Metal binding modes of Alzheimer's amyloid beta-peptide in insoluble aggregates and soluble complexes
70. Apolipoprotein E allele-specific antioxidant activity and effects on cytotoxicity by oxidative insults and beta-amyloid peptides
71. Differential effects of apolipoprotein E isoforms on metal-induced aggregation of A beta using physiological concentrations
72. Reduction of beta-amyloid peptide42 in the cerebrospinal fluid of patients with Alzheimer's disease
73. Neuronal oxidative stress precedes amyloid-beta deposition in Down syndrome
74. RNA oxidation in Alzheimer and Parkinson diseases
75. N-acetyl-L-cysteine protects SHSY5Y neuroblastoma cells from oxidative stress and cell cytotoxicity: Effects on beta-amyloid secretion and tau phosphorylation
76. Mercury induces cell cytotoxicity and oxidative stress and increases beta-amyloid secretion and tau phosphorylation in SHSY5Y neuroblastoma cells
77. Reactive oxygen species mediate cellular damage in Alzheimer's disease
78. Is oxidative damage the common mechanism of neurodegenerative diseases?
79. Soluble amyloid beta-protein in the cerebrospinal fluid from patients with Alzheimer's disease, vascular dementia and controls
80. Lipoproteins and their receptors in the central nervous system
81. Traumatic brain injury increases beta-amyloid peptide 1-42 in cerebrospinal fluid
82. Undetectable intracellular free copper: The requirement of a copper chaperone for superoxide dismutase
83. Hypercholesterolemia accelerates the Alzheimer's amyloid pathology in a transgenic mouse model
84. Redox-active iron mediates amyloid-beta toxicity
85. In situ oxidative catalysis by neurofibrillary tangles and senile plaques in Alzheimer's disease: A central role for bound transition metals
86. Increased lipoprotein oxidation in Alzheimer's disease
87. The role of iron in beta amyloid toxicity
88. Alzheimer's disease: Genes, proteins, and therapy
89. Oxidative damage and mitochondrial decay in aging
90. Cholesterol depletion inhibits the generation of beta-amyloid in hippocampal neurons
91. Apolipoprotein E4: An allele associated with many diseases
92. Arson: Tracking the culprit in Alzheimer's disease
93. Metabolic, metallic, and mitotic sources of oxidative stress in Alzheimer disease
94. What are the facts and artifacts of the pathogenesis and etiology of Alzheimer disease?
95. Molecular and cellular aspects of oxidative damage in Alzheimer's disease
96. Oxidative stress in Alzheimer's disease
97. Antioxidant potential of anaerobic human plasma: Role of serum albumin and thiols as scavengers of carbon radicals
98. Induction of Alzheimer-like beta-amyloid immunoreactivity in the brains of rabbits with dietary cholesterol
99. Lipoprotein oxidation: Mechanistic aspects, methodological approaches and clinical relevance
100. Intracellular and secreted Alzheimer beta-amyloid species are generated by distinct mechanisms in cultured hippocampal neurons
101. Lipidation of apolipoprotein E influences its isoform-specific interaction with Alzheimer's amyloid beta peptides
102. Amyloids beta40 and beta42 are generated intracellularly in cultured human neurons and their secretion increases with maturation
103. Review: Alzheimer's amyloid beta-peptide-associated free radical oxidative stress and neurotoxicity
104. Alzheimer's disease amyloid beta peptide 25-35 inhibits lipid peroxidation as a result of its membrane interactions
105. Amyloid beta protein enhances the survival of hippocampal neurons in vitro
106. Apolipoprotein E: A pathological chaperone protein in patients with cerebral and systemic amyloid
107. Aluminium and Alzheimer's disease
108. Decreased prevalence of Alzheimer disease associated with 3-hydroxy-3-methyglutaryl coenzyme A reductase inhibitors
109. Amyloid-beta peptides are cytotoxic to oligodendrocytes
110. Non-enzymatically glycated tau in Alzheimer's disease induces neuronal oxidant stress resulting in cytokine gene expression and release of amyloid beta-peptide
111. Mechanisms of neuronal degeneration in Alzheimer's disease
112. 2-induced apoptosis in human neuronal cells