The effect of ascorbate and ubiquinone supplementation on plasma and CSF total antioxidant capacity

Free Radical Biology and Medicine

Volumn 21, Issue 2, 1996, Pages 211-217

  Lönnrot, Kimmo ^a   Metsä Ketelä, Timo ^a   Molnár, Gábor ^b   Ahonen, Jukka Pekka ^b   Latvala, Matti ^b   Peltola, Jukka ^b   Pietilä, Timo ^b   Alho, Hannu ^a  

^a TAMPERE UNIVERSITY OF TECHNOLOGY   (Finland)

^b TAMPERE UNIVERSITY HOSPITAL   (Finland)

Author keywords

Ascorbate; CSF total antioxidant capacity; Free radicals; Ubiquinone

Indexed keywords

ASCORBIC ACID; BIO C; BIO QUINON; FREE RADICAL; THIOL DERIVATIVE; TOCOPHEROL; UBIQUINONE; UNCLASSIFIED DRUG; URIC ACID;

ADULT; AEROBIC METABOLISM; ALZHEIMER DISEASE; ARTICLE; BRAIN INJURY; BRAIN ISCHEMIA; CEREBROSPINAL FLUID ANALYSIS; CLINICAL TRIAL; DOSE RESPONSE; DRUG BLOOD LEVEL; HUMAN; HUMAN EXPERIMENT; MALE; NEURONAL CEROID LIPOFUSCINOSIS; NORMAL HUMAN; ORAL DRUG ADMINISTRATION; OXIDATIVE STRESS; PARKINSON DISEASE; PRIORITY JOURNAL;

EID: 0029992521     PISSN: 08915849     EISSN: None     Source Type: Journal    
DOI: 10.1016/0891-5849(95)02207-4     Document Type: Article

References (36)

1. 1. Halliwell, B.; Gutteridge, J. M. C., eds. Free radicals in biology and medicine. 2nd ed. Oxford: Clarendon Press; 1989.
2. 2. Sies, H., ed. Oxidative stress: Oxidants and antioxidants. London: Academic Press; 1991.
3. 3. Ames, B. N. Dietary carcinogens and anticarcinogens. Oxygen radicals and degenerative diseases. Science 221(4617):1256-1264; 1983
4. 4. Troll, W.; Wiesner, R. The role of oxygen radicals as a possible mechanism of tumor promotion. Annu. Rev. Pharmacol. Toxicol. 25:509-528; 1985
5. 5. Cheeseman, K. H.; Collins, M.; Proudfoot, K.; Slater, T. F.; Burton, G. W.; Webb, A. C.; Ingold, K. U. Studies on lipid peroxidation in normal and tumour tissue. The Novikoff rat liver tumour. Biochem. J. 235(2):507-514; 1986
6. 6. Halliwell, B.; Gutteridge, J. M. C. Oxygen radicals and the nervous system. Trends. Neurosci. 8:22-32; 1985.
7. 7. Hunter, M. I. S.; Nlemadim, B. C.; Davidson, D. L. W. Lipid peroxidation products and antioxidant proteins in human plasma and cerebrospinal fluid from multiple sclerosis patients. Neurochem. Res. 10:1645-1652; 1985.
8. 8. Krinsky, N. I. Mechanism of action of biological antioxidants. Proc. Soc. Exp. Biol. Med. 200(2):248-254, 1992.
9. 9. Stocks, J.; Gutteridge, J. M. C.; Sharp, R. J.; Dormandy, T. L. The inhibition of lipid autoxidation by human serum and its relation to serum proteins and alpha-tocopherol. Clin. Sci. Mol. Med. 47(3):223-233; 1974
10. 10. Gutteridge, J. M. C. Ceruloplasmin: A plasma protein, enzyme, and antioxidant. Ann. Clin. Biochem. 15(6):293-296; 1978
11. 11. Halliwell, B.; Gutteridge, J. M. C. Oxygen free radicals and iron in relation to biology and medicine: Some problems and concepts. Arch. Biochem. Biophys. 246(2):501-514; 1986
12. 12. Esterbauer, H.; Gebinski, J.; Puhl, H.; Jürgen, G. The role of lipid peroxidation and antioxidants in oxidative modification of LDL. Free Radic. Biol. Med. 13:341-390; 1992
13. 13. Wayner, D.; Burton, G.; Ingold, K.; Locke, S. The relative contributions of vitamin E, urate, ascorbate and proteins to the total peroxyl radical-trapping antioxidant activity of human blood plasma. Biochim. Biophys. Acta 924:408-419; 1987.
14. 14. Spector, R.; Eells, J. Deoxynucleoside and vitamin transport into the central nervous system. Fed. Proc. 43:196-200; 1984.
15. 15. Grünewald, R. A. Ascorbic acid in the brain. Brain Res. Rew. 18:123-133; 1993.
16. 16. Metsä-Ketelä T. Luminescent assay for total peroxyl radical-trapping capability of plasma. In: Stanley, P.; Kricka, L., eds. Bioluminescence and chemiluminescence current status. Chichester: John Wiley & Sons; 1991:389-392.
17. 17. Uotila, J.; Kirkkola, A.-L.; Rorarius, M.; Tuimala, R.; Metsä-Ketelä, T. The total peroxyl radical-trapping ability of plasma and cerebrospinal fluid in normal and preeclaptic parturients. Free Radic. Biol. Med. 16:581-590; 1994.
18. 18. Lindeman, J.; van Zoeren-Grobben, D.; Schrijver, J.; Speek, A.; Poorthuis, B.; Berger. H. The total free radical-trapping ability of cord blood plasma in preterm and term babies. Pediatr. Res. 26:20-24; 1989.
19. 19. Lang, J.; Gohil, K.; Packer, L. Simultaneous determination of tocopherols, ubiquinols and ubiquinones in blood, plasma, tissue homogenates and subcellular fractions. Anal. Biochem. 157:106-116; 1986.
20. 20. Frei, B.; England, L.; Ames, B. Ascorbate is an outstanding antioxidant in human blood plasma. Proc. Natl. Acad. Sci. USA 86:6377-6381; 1989.
21. 21. Ellman, G. Tissue sulfhydryl groups. Arch. Biochem. Biophys. 82:70-77; 1959.
22. 22. Wayner, D. D. M.; Burton, G. W.; Ingold, K. U. The antioxidant efficiency of vitamin-C is concentration dependent. Biochim. Biophys. Acta 884:119-123; 1986.
23. 23. Tappel, A. L. Will antioxidant nutrients slow aging processes? Geriatrics 23:97-105; 1968.
24. 24. Frei, B.; England, L.; Ames, B. N. Ascorbate is an outstanding antioxidant in human blood plasma. Proc. Natl. Acad. Sci. USA 86:6377-6381; 1989
25. 25. Ewing, A. G.; Wightman, R. M.; Dayton, M. A. In vivo voltammetry with electrodes which distinguish between dopamine and ascorbate. Brain Res. 249:361-370; 1982.
26. 26. Majewska, M. D.; Bell, J. A.; London, E. D. Regulation of the NDMA receptor by redox phenomena: Inhibitory role of ascorbate. Brain Res. 537:328-332; 1990.
27. 27. Sutor, B.; Ten Bruggencate, G. Ascorbic acid: A useful reductant to avoid oxidation of catecholamines in electrophysiological experiments in vitro? Neurosci. Lett. 116:287-292; 1990.
28. 28. Tolbert, L. C.; Thomas, N. T.; Middaugh, L. D.; Zemp, J. W. Ascorbate blocks amphetamine-induced turning behaviour in rats with unilateral nigrostriatal lesions. Brain Res. Bull. 4:43-48; 1979.
29. 29. White, L. K.; Maurer, M.; Kraft, M. E.; Oh, C.; Rebec, G. V. Intrastriatal infusions of ascorbate antagonize the behavioral response to amphetamine. Pharmacol. Biochem. Behav. 36:485-489; 1990.
30. 30. Hisanaga, K.; Sagar, S. M.; Sharp, F. R. Ascorbate neurotoxicity in cortical cell culture. Ann. Neural. 31(5):562-565; 1992.
31. 31. Sevanian, A.; Davies, K. J. A.; Hochstein, P. Serum urate as an antioxidant for ascorbic acid. Am. J. Clin. Nutr. 54:1129S-1134S; 1991.
32. 32. Miller, N. J.; Rice-Evans, C.; Davies, M. J.; Gopinathan, V.; Milner, A. A novel method for measuring antioxidant capacity and its application to monitoring the antioxidant status in premature neonates. Clin. Sci. 84:407-412; 1993.
33. 33. Ghiselli, A.; Serafini, M.; Maiani, G.; Azzini, E.; Ferro-Luzzi, A. A fluorecence-based method for measuring total plasma antioxidant capability. Free Radic. Biol. Med. 18:29-36; 1995.
34. 34. Lindeman, J.; Van Zoeren-Grobben, D.; Schrijver, J.; Speek, A.; Poorthuis, B.; Berger, H. The total free radical trapping ability of cord blood plasma in preterm and term babies. Pediatr. Res. 26:20-24; 1989.
35. 35. Judy, W. V.; Folkers, K. Management of chronic fatigue syndrome patients with CoQ-10. Abstract of the 8th international symposium on the biomedical and clinical aspects of coenzyme Q. Sweden: Stockholm; 1993.
36. 36. Elkashef, A. M.; Gold, J.; Isikawa, A.; Folkers, K.; Wyatt, R. J. The effect of coenzyme-Q10 on the cognitive functions in patients with Schizophrenia. Abstract of the 8th international symposium on the biomedical and clinical aspects of coenzyme Q. Sweden: Stockholm; 1993.