Inhibition of neurite outgrowth by familial Alzheimer's disease-linked presenilin-1 mutations

Neuroscience Letters

Volumn 267, Issue 2, 1999, Pages 141-144

  Dowjat, Wieslaw K ^a   Wisniewski, Thomas ^a,b   Efthimiopoulos, Spiros ^c   Wisniewski, Henryk M ^a  

^a NEW YORK STATE INSTITUTE FOR BASIC RESEARCH IN DEVELOPMENTAL DISABILITIES   (United States)

^b NEW YORK UNIVERSITY MEDICAL CENTER   (United States)

^c MOUNT SINAI SCHOOL OF MEDICINE   (United States)

Author keywords

Alzheimer's disease; Mutation; Neurite outgrowth; Presenilin 1; Transfection

Indexed keywords

MUTANT PROTEIN; PRESENILIN 1;

ALZHEIMER DISEASE; AMINO ACID SUBSTITUTION; ANIMAL CELL; ARTICLE; CONTROLLED STUDY; GENE EXPRESSION; GENETIC ASSOCIATION; GROWTH INHIBITION; MOUSE; NERVE FIBER GROWTH; NEUROBLASTOMA CELL; NONHUMAN; PATHOPHYSIOLOGY; PRIORITY JOURNAL; PROTEIN DETERMINATION; PROTEIN LOCALIZATION;

ALZHEIMER DISEASE; ANIMALS; BLOTTING, WESTERN; FLUORESCENT ANTIBODY TECHNIQUE, INDIRECT; GROWTH INHIBITORS; HUMANS; LINKAGE (GENETICS); MEMBRANE PROTEINS; MICE; MUTATION; NEURITES; PRESENILIN-1; TUMOR CELLS, CULTURED;

EID: 0033612153     PISSN: 03043940     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0304-3940(99)00351-1     Document Type: Article

References (14)

1. DeMattos R.B., Curtiss L.K., Williams D.L. A minimally lipidated form of cell-derived apolipoprotein E exhibits isoform-specific stimulation of neurite outgrowth in the absence of exogenous lipids or lipoproteins. J. Biol. Chem. 273:1998;4206-4212.
2. De Strooper B., Saftig P., Craessaerts K., Vanderstichele H., Guhde G., Annaert W., Von Figura K., Van Leuven F. Deficiency of presenilin-1 inhibits the normal cleavage of amyloid precursor protein. Nature. 391:1988;387-390.
3. Elder G.A., Tezapsidis N., Carter J., Shioi J., Bouras C., Li H.-C., Johnston J.M., Efthimiopoulos S., Fredrich V.L. Jr., Robakis N. Identification and neuron specific expression of the S182/presenilin-I protein in human and rodent brains. J. Neurosci. Res. 45:1966;308-320.
4. Furukawa K., Guo Q., Schellenberg G.D., Mattson M.P. Presenilin-1 mutation alters NGF-induced neurite outgrowth, calcium homeostasis, and transcription factor (AP-1) activation in PC12 cells. J. Neurosci. Res. 52:1998;618-624.
5. Guo Q., Furukawa K., Sopher B.L., Pham D.G., Xie J., Robinson N., Martin G.M., Mattson M.P. Alzheimer's PS-1 mutation perturbs calcium homeostasis and sensitizes PC12 cells to death induced by amyloid β-peptide. NeuroReport. 8:1996;379-383.
6. Mattson M.P., Guo Q., Furukawa K., Pedersen W.A. Presenilins, the endoplasmic reticulum and neuronal apoptosis in Alzheimer's disease. J. Neurochem. 70:1998;1-14.
7. Naruse S., Thinakaran G., Luo J.J., Kusiak J.W., Tomita T., Iwatsubo T., Qian X., Ginty D.D., Price D.L., Borchelt D.R., Wong P.C., Sisodia S.S. Effects of PS1 deficiency on membrane protein trafficking in neurons. Neuron. 21:1998;1213-1221.
8. Ohsawa I., Takamura C., Kohsaka S. The amino-terminal region of amyloid precursor protein is responsible for neurite outgrowth in rat neocortical explant culture. Biochem. Biophys. Res. Commun. 236:1997;59-65.
9. Price D.L., Tanzi R.E., Borchelt D.R., Sisodia S.S. Alzheimer's disease: Genetic studies and transgenic models. Annu. Rev. Genet. 32:1998;461-493.
10. Selkoe D. Alzheimer's disease: genotypes, phenotype, and treatment. Science. 275:1977;630-631.
11. Sherrington R., Rogaev E.I., Liang Y., Rogaeva I.A., Levesque G., Ikeda M., Chi H., Lin C., Li G., Holman K., Tsuda T., Mar I., Foncin J.F., Bruni A.C., Montesi M.P., Sorbi S., Rainero I., Pinessi L., Nee L., Chumakov I., Pollen D., Brookes A., Sanseau P., Polinsky R.J., Wasco W., Da Silva H.A.R., Haines J.L., Pericak-Vance M.A., Tanzi R.E., Roses A.D., Fraser P.E., Rommens J.M., St. George-Hyslop P.H. Cloning of a gene bearing missense mutations in early-onset familial Alzheimer's disease. Nature. 375:1995;754-760.
12. Thinakaran G., Borchelt D.R., Lee M.K., Slunt H.H., Spitzer L., Kim G., Ratovitsky T., Davenport F., Nordstedt C., Seeger M., Hardy J., Levey A.I., Gandy S.E., Jenkins N.A., Copeland N.G., Price D.L., Sisodia S.S. Endoproteolysis of presenilin-1 and accumulation of processed derivatives in vivo. Neuron. 17:1996;181-190.
13. Wisniewski T., Dowjat W.K., Buxbaum J.D., Khorkova O., Efthimiopoulos S., Kulczycki J., Lojkowska W., Wegiel J., Wisniewski H.M., Frangione B. A novel Polish presenilin-1 mutation (P117L) is associated with familial Alzheimer's disease and leads to death as early as age of 28 years. NeuroReport. 9:1998;217-221.
14. Wisniewski T., Dowjat W.K., Permanne B., Palha J., Kumar A., Gallo G., Frangione B. Presenilin-1 is associated with Alzheimer's disease amyloid. Am. J. Pathol. 151:1997;601-610.