Allelic knockout of novel splice variants of human recombination repair gene RAD51B in t(12;14) uterine leiomyomas

Cancer Research

Volumn 59, Issue 1, 1999, Pages 19-23

  Schoenmakers, Eric F P M ^a,b   Huysmans, Christel ^b   Van De Ven, Wim J M ^b  

^a DEPARTMENT OF PLANT SYSTEMS BIOLOGY   (Belgium)

^b UNIVERSITY OF LEUVEN   (Belgium)

Author keywords

[No Author keywords available]

Indexed keywords

CONTIG;

ALLELE; ANIMAL CELL; ARTICLE; CANCER CELL CULTURE; CHROMOSOME TRANSLOCATION 12; EXON; FLUORESCENCE IN SITU HYBRIDIZATION; GENE EXPRESSION; GENE ISOLATION; GENE SEQUENCE; HUMAN; HUMAN CELL; KNOCKOUT GENE; NONHUMAN; NUCLEOTIDE SEQUENCE; PLEIOTROPY; PRIORITY JOURNAL; PROTEIN DOMAIN; RECOMBINANT GENE; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; RNA SPLICING; UTERUS MYOMA;

CHROMOSOMES, HUMAN, PAIR 12; CHROMOSOMES, HUMAN, PAIR 14; DNA REPAIR; DNA-BINDING PROTEINS; FEMALE; HUMANS; LEIOMYOMA; LOSS OF HETEROZYGOSITY; RAD51 RECOMBINASE; RECOMBINATION, GENETIC; RNA SPLICING; TRANSLOCATION, GENETIC; TUMOR CELLS, CULTURED; UTERINE NEOPLASMS;

EID: 0032893998     PISSN: 00085472     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (20)

1. Cramer, S. F., and Patel, A. The frequency of uterine leiomyomas. Am. J. Clin. Pathol., 94: 435-438, 1990.
2. Carlson, K. J., Nichols, D. H., and Schiff, I. Indications for hysterectomy N. Engl. J. Med., 28: 856-860, 1993.
3. Mitelman, F. Catalog of Chromosome Aberrations in Cancer, Ed. 4. New York: Wiley-Liss, 1991.
4. Schoenmakers, E. F. P. M., Wanschura, S., Mols, R., Bullerdiek, J., Van den Berghe, H., and Van de Ven, W. J. Recurrent rearrangements in the high mobility group protein gene, HMGI-C, in benign mesenchymal rumours. Nat. Genet., 10: 436-444, 1995.
5. Ashar, H. R., Schoenberg-Fejzo, M., Tkachenko, A., Zhou, X., Fletcher, J. A., Weremowicz, S., Morton, C. C., and Chada K. Disruption of the architectural factor HMGI-C: DNA-binding AT hook motifs fused in lipomas to distinct transcriptional regulatory domains. Cell, 82: 57-65, 1995.
6. Doney, M. K., Gerken, S. C., Lynch, R., Bhugra, B., Hug, K., White, R., Weissenbach, J., and Menon, A. G. Precise mapping of t(12;14) leiomyoma breakpoint on chromosome 14 between D14S298 and D14S540. Cancer Lett., 96: 245-252, 1995.
7. Bhugra, B., Smolarek, T. A., Lynch, R. A., Meloni, A. M., Sandberg, A. A., Deaven, L., and Menon, A. G. Cloning of a breakpoint cluster region on chromosome 14 in uterine leiomyoma. Cancer Lett., 126: 119-126, 1998.
8. Albala, J. S., Thelen, M. P., Prange, C., Fan, W., Christensen, M., Thompson, L., and Lennon, G. G. Identification of a novel human RAD51 homolog, RAD51B. Genomics, 46: 476-479, 1997.
9. Cartwright, R., Dunn, A. M., Simpson, P. J., Tambini, C. E., and Thacker, J. Isolation of novel human and mouse genes of the recA/RAD51 recombination-repair gene family. Nucleic Acids Res., 26: 1653-1659, 1998.
10. Rice, M. C., Smith, S. T., Bullrich, F., Havre, P., and Kmiec, E. B. Isolation of human and mouse genes based on homology to REC2, a recombinational repair gene from the fungus Ustilago maydis. Proc. Natl. Acad. Sci. USA, 94: 7417-7422, 1997.
11. Shinohara, A., Ogawa H. and Ogawa T. Rad51 protein involved in repair and recombination in S. cerevisiae is a RecA-like protein. Cell, 69: 457-470, 1992.
12. Schoenmakers, E. F. P. M., Mols, R., Wanschura, S., Kools, P. F. G., Geurts, G. M. W., Bartnitzke, S., Bullerdiek, J., Van Den Berghe, H., and Van de Ven, W. J. M. Identification, molecular cloning and characterization of the chromosome 12 breakpoint cluster region of uterine leiomyomas. Genes Chromosomes Cancer, 11: 106-118, 1994.
13. Schoenmakers, E. F. P. M. The molecular basis of benign solid tumors: discovery of a common genetic denominator on the long arm of human chromosome 12, Ph.D. Thesis. Leuven, Belgium: University of Leuven, 1997.
14. Schoenberg-Fejzo, M., Ashar, H. R., Krauter, K. S., Powell, W. L., Rein, M. S., Weremowicz, S., Yoon, S. J., Kucherlapati, R. S., Chada, K., and Morton, C. C. Translocation breakpoints upstream of the HMGIC gene in uterine leiomyomata suggest dysregulation of this gene by a mechanism different from that in lipomas. Genes Chromosomes Cancer, 17: 1-6, 1996.
15. Bauman, P., Benson, F. E., and West, S. C. Human Rad51 protein promotes ATP-dependent homologous pairing and strand transfer reactions in vitro. Cell, 87: 757-766, 1996.
16. Lim, D. S., and Hasty, P. A mutation in mouse rad51 results in an early embryonic lethal that is suppressed by a mutation in p53. Mol. Cell. Biol., 16: 7133-7143, 1996.
17. Tsuzuki, T., Fujii, Y., Sakumi, K., Tominaga, Y., Nakao, K., Sekiguchi, M., Matsushiro, A., Yoshimura, Y., and Morita, T. Targeted disruption of the Rad51 gene leads to lethality in embryonic mice. Proc. Natl. Acad. Sci. USA, 93: 6236-6240, 1996.
18. Stürzbecher, H. W., Donzelmann, B., Henning, W., Knippschild, U., and Buchhop, S. p53 is linked directly to homologous recombination processes via RAD51/RecA protein interaction. EMBO J., 15: 1992-2002, 1996.
19. Scully, R., Chen, J., Plug, A., Xiao, Y., Weaver, D., Feunteun, J., Ashley, T., and Livingston, D. M. Association of BRCA1 with Rad51 in mitotic and meiotic cells. Cell, 88: 265-275, 1997.
20. Sharan, S. K., Morimatsu, M., Albrecht, U., Lim, D. S., Regel, E., Dinh, C., Sands, A., Eichele, G., Hasty, P., and Bradley, A. Embryonic lethality and radiation hypersensitivity mediated by Rad51 in mice lacking Brca2. Nature (Lond.), 386: 804-810, 1997.