Nuclear location and cell cycle regulation of The BRCA2 protein

Cancer Research

Volumn 57, Issue 24, 1997, Pages 5485-5488

  Bertwistle, David ^a   Swift, Sally ^a   Marston, Nicola J ^a   Jackson, Laura E ^a   Crossland, Susan ^a   Crompton, Mark R ^a   Marshall, Christopher J ^a   Ashworth, Alan ^a  

^a INSTITUTE OF CANCER RESEARCH   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

DNA;

ALLELISM; ANIMAL CELL; ARTICLE; BREAST CANCER; CELLULAR DISTRIBUTION; DNA SYNTHESIS; GENE MUTATION; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; RABBIT; SEQUENCE HOMOLOGY; TUMOR SUPPRESSOR GENE;

ANIMALS; ANTIBODIES; ANTIBODIES, MONOCLONAL; ANTIBODY SPECIFICITY; BLOTTING, WESTERN; BRCA2 PROTEIN; BREAST NEOPLASMS; CELL CYCLE; CELL NUCLEUS; FEMALE; HUMANS; NEOPLASM PROTEINS; NUCLEAR PROTEINS; RABBITS; RATS; RISK FACTORS; SUBCELLULAR FRACTIONS; TRANSCRIPTION FACTORS;

EID: 0031453970     PISSN: 00085472     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (24)

1. Stratton, M. R. Recent advances in understanding of genetic susceptibility to breast cancer. Hum. Mol. Genet., 5: 1515-1519, 1996.
2. Miki, Y., Swensen, J., Shattuck-Eidens, D., Futreal, P. A., Harshman, K., Tavtigian, S., Liu, Q., Cochran, C., Bennett, L. M., Ding, W., Bell, R., Rosenthal, J., Hussey, C., Tran, T., McClure, M., Frye, C., Hattier, T., Phelps, R., Haugen-Strano, A., Katcher, H., Yakumo, K., Gholami, Z., Shaffer, D., Stone, S., Bayer, S., Wray, C., Bogden, R., Dayananth, P., Ward, J., Tonin, P., Narod, S., Bristow, P. K., Noms, F. J., Helvering, L., Morrison, P., Rosteck, P., Lai, M., Barrett, J. C., Lewis, C., Neuhausen, S., Cannon-Albright, L., Goldgar, D., Wiseman, R., Kamb, A., and Skolnick, M. H. A strong candidate for the breast and ovarian cancer susceptibility gene BRCA1. Science (Washington DC), 266: 66-71, 1994.
3. Wooster, R., Bignell, G., Lancaster, J., Swift, S., Seal, S., Mangion, J., Collins, N., Gregory, S., Gumbs, C., Micklem, G., Barfoot, R., Hamoudi, R., Patel, S., Rice, C., Biggs, P., Hashim, Y., Smith, A., Connor, F., Arason, A., Gudmundsson, J., Ficenec, D., Kelsell, D., Ford, D., Tonin, P., Bishop, T., Spurr, N. K., Ponder, B. A. J., Eeles, R., Peto, J., Devilee, P., Cornelisse, C., Lynch, H., Narod, S., Lenoir, G., Egilsson, V., Barkadottir, R. B., Easton, D. G., Bentley, D. R., Futreal, P. A., Ashworth, A., and Stratton, M. R. Identification of the breast cancer gene BRCA2. Nature (Lond.), 378: 789-791, 1995.
4. Easton, D. Breast cancer genes - what are the real risks? Nat. Genet., 16: 210-211, 1997.
5. Tavtigian, S. V., Simard, J., Rommens, J., Couch, F., Shattuck-Eidens, D., Neuhausen, S., Merajver, S., Thorlacius, S., Offit, K., Stoppa-Lyonnet, D., Belanger, C., Bell, R., Berry, S., Bogden, R., Chen, Q., Davis, T., Dumont, M., Frye, C., Hattier, T., Jammulapati, S., Janecki, T., Jiang, P., Kehrer, R., Leblanc, J. F., Mitchell, J. T., McArthur-Morrison, J., Nguyen, K., Peng, Y., Samson, C., Schroeder, M., Snyder, S. C., Steele, L., Stringfellow, M., Stroup, C., Swedlund, B., Swensen, J., Teng, D., Thomas, A., Tran, T., Tran, T., Tranchant, M., Weaver-Feldhaus, J., Wong, A. K. C., Shizuya, H., Eyfjord, J. E., Cannon-Albright, L., Labrie, F., Skolnick, M. H., Weber, B., Kamb, A., and Goldgar, D. E. The complete BRCA2 gene and mutations in chromosome 13q-linked kindreds. Nat. Genet., 12: 333-337, 1996.
6. Bork, P., Blomberg, N., and Nilges, M. Internal repeats in the BRCA2 protein sequence. Nat Genet., 13: 22-23, 1996.
7. Bignell, G., Micklem, G., Stratton, M. R., Ashworth, A., and Wooster, R. The BRC repeats are conserved in mammalian BRCA2 proteins. Hum. Mol. Genet., 6: 53-58, 1997.
8. Gayther, S. A., Mangion, J., Russell, P., Seal, S., Barfoot, R., Ponder, B. A., Stratton, M. R., and Easton, D. Variation of risks of breast and ovarian cancer associated with different germline mutations of the BRCA2 gene. Nat. Genet., 15: 103-105, 1997.
9. Milner, J., Ponder, B., Hughes-Davies, L., Seltmann, M., and Kouzarides, T. Transcriptional activation functions in BRCA2. Nature (Lond.), 386: 772-773, 1997.
10. Chapman, M. S. and Verma, I. M. Transcriptional activation by BRCA1. Nature (Lond.), 382: 678-679, 1996.
11. Sharan, S. K., Morimatsu, M., Albrecht, U., Lim, D-S., Regel, E., Dinh, C, Sands, A., Eichele, G., Hasty, P., and Bradley, A. Embryonic lethality and radiation hypersensitivity mediated by Rad51 in mice lacking Brca2. Nature (Lond.), 386: 804-810, 1997.
12. Lachmann, P. J., Strangeways, L., Vyakarnam, A., and Evans, G. Raising antibodies by coupling peptides to PPD and immunizing BCG-sensitized animals. CIBA Foundation Symposium, 119: 25-27, 1986.
13. Zarkowska, T., U. S., Harlow, E., and Mittnacht, S. Monoclonal antibodies specific for underphosphorylated retinoblastoma protein identify a cell cycle-regulated phosphorylation site targeted by CDKs. Oncogene, 14: 249-254, 1997.
14. Mosca, P. J., Dijkwel, P. A., and Hamlin, J. Z. The plant amino acid mimosine may inhibit initiation of origins of replication in CHO cells. Mol. Cell. Biol., 12: 4375-4383, 1992.
15. Lee, W. H., Shaw, J. Y., Hong, F. D., Sery, T. W., Donoso, L. A., Young, L. J., Bookstein, R., and Lee, E. Y. H. P. The retinoblastoma susceptibility gene encodes a nuclear phosphoprotein associated with DNA-binding activity. Nature (Lond.), 329: 642-645, 1987.
16. Goggins, M., Schutte, M., Lu, J., Moskaluk, C. A., Weinstein, C. L., Peterson, G. M., Yeo, C. J., Jackson, C. E., Lynch, H. T., Hruban, R. H., and Kern, S. E. Germline BKCA2 gene mutations in patients with apparently sporadic pancreatic carcinomas. Cancer Res., 56: 5360-5364, 1996.
17. Chen, Y., Chen, C-F., Riley, D. J., Allred, D. C., Chen, P-L., von Hoff, D., Osborne, C. K., and Lee, W-H. Aberrant subcellular localization of BRCA1 in breast cancer. Science (Washington DC), 270: 789-791, 1995.
18. Scully, R., Ganesan, S., Brown, M., DeCaprio, J. A., Cannistra, S. A., Feunteun, J., Schnitt, S., and Livingston, D. M. Location of BRCA1 in human breast and ovarian cancer cells. Science (Washington DC), 272: 123-125, 1996.
19. Chen, Y., Chen, P-L., Riley, D. J., Lee, W-H., Allred, D. C., and Osborne, C. K. Location of BRCA1 in human breast and ovarian cancer cells. Science (Washington DC), 272: 125-126, 1996.
20. Wilson, C. A., Payton, M. N., Pekar, S. K., Zhang, K., Pacifici, R. E., Gudas, J. L., Thukral, S., Calzone, F. J., Reese, D. M., and Slamon, D. I. BRCA1 protein products: antibody specificity. Nat Genet., 13: 264-265, 1996.
21. Jensen, R. A., Thompson, M. E., Jetton, T. L., van der Meer, R., Helou, B., Arteaga, C. L., Page, D. L., Holt, J. T., Tronick, S. R., Gown, A. M., Skelly, M., Ostermeyer, B., Schieltz, D., Szabo, C. I., and King, M-C. BRCA1 protein products: antibody specificity. Nat. Genet., 13: 269-272, 1996.
22. Vaughn, J. P., Cirisano, F. D., Huper, G., Berchuck, A., Futreal, P. A., Marks, J. R., and Iglehart, J. D. Cell cycle control of BRCA2. Cancer Res., 56: 4590-4594, 1996.
23. Chen, Y., Farmer, A. A., Chen, C-F., Jones, D. C., Chen, P-L., and Lee, W-H. BRCA1 is a 220-kDa nuclear phosphoprotein that is expressed and phosphorylated in a cell cycle-dependent manner. Cancer Res., 56: 3168-3172, 1996.
24. Scully, R., Chen, J., Plug, A., Xiao, Y., Weaver, D., Feunteun, J., Ashley, T., and Livingstone, D. M. Association of BRCA1 with RAD51 in mitotic and meiotic cells. Cell, 88: 265-275, 1997.