Membrane transport in the malaria-infected erythrocyte

Physiological Reviews

Volumn 81, Issue 2, 2001, Pages 495-537

  Kirk, Kiaran ^a  

^a AUSTRALIAN NATIONAL UNIVERSITY   (Australia)

Author keywords

[No Author keywords available]

Indexed keywords

ADENOSINE DIPHOSPHATE; ADENOSINE TRIPHOSPHATE; AMINO ACID; ANTIMALARIAL AGENT; CALCIUM; CHLORIDE; CHLOROQUINE; CHOLINE; CYTOTOXIC AGENT; LACTIC ACID; MAGNESIUM; MEFLOQUINE; NUCLEOSIDE; PEPTIDE; POTASSIUM; PROTON; SODIUM; SUGAR; VITAMIN;

CELL COMPOSITION; CELL INVASION; CELL MEMBRANE PERMEABILITY; CELL MEMBRANE TRANSPORT; CELL ORGANELLE; CELL VACUOLE; CYTOSOL; DRUG TRANSPORT; ELECTROCHEMISTRY; ERYTHROCYTE; ERYTHROCYTE MEMBRANE; ERYTHROCYTE METABOLISM; LIFE CYCLE; MALARIA; PLASMODIUM; PRIORITY JOURNAL; REVIEW;

EID: 0035069258     PISSN: 00319333     EISSN: None     Source Type: Journal    
DOI: 10.1152/physrev.2001.81.2.495     Document Type: Review

References (385)

1. Cytosolic free calcium in Plasmodium falciparum-infected erythrocytes and the effect of verapamil: A cytofluorimetric study
2. Artemisinin and its derivatives are transported by a vacuolar-network of Plasmodium falciparum and their anti-malarial activities are additive with toxic sphingolipid analogs that block the network
3. + uptake by plant cells
4. Increased permeability to choline in simian erythrocytes after Plasmodium knowlesi infection
5. Quaternary ammonium compounds efficiently inhibit Plasmodium falciparum growth in vitro by impairment of choline transport
6. Regulation of phosphatidylcholine biosynthesis in Plasmodium-infected erythrocytes
7. Inhibitors of choline transport into Plasmodium-infected erythrocytes are effective antiplasmodial compounds in vitro
8. Protein sorting in Plasmodium falciparum-infected red blood cells permeabilized with the pore-forming protein streptolysin O
9. Permeabilization of the erythrocyte membrane with streptolysin O allows access to the vacuolar membrane of Plasmodium falciparum and a molecular analysis of membrane topology
10. The malaria parasite supplies glutathione to its host cell: Investigation of glutathione metabolism in human erythrocytes infected with Plasmodium falciparum
11. Ultrastructural localization of erythrocyte cytoskeletal and integral membrane proteins in Plasmodium falciparum-infected erythrocytes
12. Plasmodium falciparum glutathione metabolism and growth are independent of glutathione system of host erythrocyte
13. Ion transport in parasitic protozoa
14. Plasmodium falciparum: Effect of chemical structure on efficacy specificity of antisense oligonucleotides against malaria in vitro
15. Inhibition of Plasmodium falciparum malaria using antisense oligodeoxynucleotides
16. Cloning the P. falciparum gene encoding PfEMP1, a malarial variant antigen and adherence receptor on the surface of parasitized human erythrocytes
17. Reconstitution of protein transport across the vacuolar membrane in Plasmodium falciparum-infected permeabilized cells
18. +-ATPase in the plasma membrane and intracellular vacuoles of Trypanosoma cruzi
19. Effects of low ionic strength media on passive human red cell monovalent cation transport
20. Molecular characterization of a Plasmodium falciparum gene encoding the mitochondrial phosphate carrier
21. Plasmodium falciparum: Import of a phosphate carrier protein into heterologous mitochondria
22. A guide to the use of pore-forming toxins for controlled permeabilization of cell membranes
23. Purification of Plasmodium falciparum merozoites for analysis of the processing of merozoite surface protein-1
24. The initiation of a "metabolic window" in the surface of host erytrocytes by Plasmodium berghei NYU-2
25. P-glycoprotein swelling-activated chloride channels
26. Import of host δ-aminolevulinate dehydratase into the malarial parasite: Identification of a new drug target
27. Increase in potassium and calcium transport in human red cells infected with Plasmodium falciparum in vitro
28. + antiport of Plasmodium falciparum membrane
29. The complete nucleotide sequence of chromosome 3 of Plasmodium falciparum
30. Cloning and sequence analysis of a novel member of the ATP-binding cassette (ABC) protein gene family from Plasmodium falciparum
31. The human malaria parasite Plasmodium falciparum exports the ATP-binding cassette protein PFGCN20 to membrane structures in the host red blood cell
32. Cellular uptake of chloroquine is dependent on binding to ferriprotoporphyrin IX and is independent of NHE activity in Plasmodium falciparum
33. A comparison of the phenomenology and genetics of multidrug resistance in cancer cells and quinoline resistance in Plasmodium falciparum
34. + antiporter, chloroquine uptake and drug resistance: Inconsistencies in a newly proposed model
35. Covalent modification of the permeability pathways induced in the human erythrocyte membrane by the malarial parasite Plasmodium falciparum
36. Coenzyme A requirement of malaria parasites: Enzymes of coenzyme A biosynthesis in normal duck erythrocytes and erythrocytes infected with Plasmodium lophurae
37. L-Nucleoside analogues as potential antimalarials that selectively target Plasmodium falciparum adenosine deaminase
38. Expression of human pICln and ClC-6 in Xenopus oocytes induces an identical endogenous chloride conductance
39. Altered membrane transport of malaria-infected erythrocytes: A possible pharmacologic target
40. Properties of permeation pathways induced in the human red cell membrane by malaria parasites
41. Discrete sites of permeation induced in the human red cell membrane by malaria parasites
42. Electrodiffusional ATP movement through the cystic fibrosis transmembrane conductance regulator
43. Intracellular calcium homeostasis
44. Isolation and functional characterization of the PfNT1 nucleoside transporter gene from Plasmodium falciparum
45. stevor and rif are Plasmodium falciparum multicopy gene families which potentially encode variant antigens
46. Intravacuolar proteolysis in Plasmodium falciparum digestive vacuoles is similar to intralysosomal proteolysis in mammalian cells
47. Plasmodium falciparum: ATP/ADP transport across the parasitophorous vacuolar and plasma membranes
48. Mechanism of hemolysis induced by ferriprotoporphyrin IX
49. Non-sequence-specific antimalarial activity of oligodeoxynucleotides
50. VDAC, a channel in the outer mitochondrial membrane
51. Selection for mefloquine resistance in Plasmodium falciparum is linked to amplification of the pfmdr1 gene cross-resistance to halofantrine and quinine
52. A P-glycoprotein homologue of Plasmodium falciparum is localized on the digestive vacuole
53. Targeted gene disruption shows that knobs enable malaria-infected red cells to cytoadhere under physiological shear stress
54. Plasmodium falciparum (human malaria)-induced modifications in human erythrocyte band 3 protein
55. Cytoadherence-related neoantigens on Plasmodium falciparum (human malaria)-infected human erythrocytes result from the exposure of normally cryptic regions of the band 3 protein
56. Characterization of the enhanced transport of L- and D-lactate into human red blood cells infected with Plasmodium falciparum suggests the presence of a novel saturable lactate proton cotransporter
57. Maximal calcium extrusion capacity and stoichiometry of the human red cell calcium pump
58. Current status of the Plasmodium falciparum genome project
59. Inhibition of Plasmodium falciparum hypoxanthine-guanine phosphoribo-syltransferase mRNA by antisense oligodeoxynucleotide sequence
60. Membrane modifications in erythrocytes parasitized by Plasmodium falciparum
61. Purine nucleobase transport in blood-stream forms of Trypanosoma brucei is mediated by two novel transporters
62. Hypoxanthine uptake through a purine-selective nucleobase transporter in Trypanosoma brucei brucei procyclic cells is driven by protonmotive force
63. A voltage-dependent channel involved in nutrient uptake by red blood cells infected with the malaria parasite
64. A nutrient-permeable channel on the intraerythrocytic malaria parasite
65. 2+ entry into Plasmodium falciparum-infected blood cells
66. Pore size of the malaria parasite's nutrient channel
67. 2+ entry matches active extrusion in human erythrocytes
68. A voltage-dependent anion channel on Plasmodium falciparum-infected human rbcs absent from normal rbcs
69. Discrimination of three parallel pathways of lactate transport in the human erythrocyte membrane by inhibitors and kinetic properties
70. Nutritional requirements of Plasmodium falciparum in culture. I. Exogenously supplied dialyzable components necessary for continuous growth
71. Red cell membrane protein distribution during malarial invasion
72. Origins of the parasitophorous vacuole membrane of the malaria parasite, Plasmodium falciparum, in human red blood cells
73. 2+ storage compartment in trypanosomatids and apicomplexan parasites
74. Malarial haemozoin/beta-haematin supports haem polymerization in the absence of protein
75. Alterations of red blood cell sodium transport during malarial infection
76. The tyrosine-86 allele of the pfmdr1 gene of Plasmodium falciparum is associated with increased sensitivity to the anti-malarials mefloquine and artemisinin
77. Analysis of a cation-transporting ATPase of Plasmodium falciparum
78. Isolation and sequence analysis of a cDNA encoding an adenine nucleotide translocator from Plasmodium falciparum
79. Digestive vacuole pH of intact intraerythrocytic P. falciparum either sensitive or resistant to chloroquine
80. Quinoline anti-malarial drugs inhibit spontaneous formation of beta-haematin (malaria pigment)
81. L-Glutamine influx in malaria-infected erythrocytes: A target for antimalarials
82. Generating viable extra-erythrocytic forms of P. falciparum
83. Parasite-regulated membrane transport processes and metabolic control in malaria-infected erythrocytes
84. Selective stage-specific changes in the permeability to small hydrophilic solutes of human erythrocytes infected with Plasmodium falciparum
85. Heterogeneous substrate-specific membrane transport pathways induced in malaria-infected erythrocytes
86. Quinine inhibits cation-selective membrane transport in Plasmodium falciparum-infected human red cells
87. Freeze-fracture identification of sterol-digitonin complexes in cell and liposome membranes
88. Transport of lactate and pyruvate in the intraerythrocytic malaria parasite, Plasmodium falciparum
89. Temperature effects on red cell membrane transport processes
90. Glycine transport in human erythrocytes
91. Secretory transport in Plasmodium
92. Plasmodium falciparum exports the Golgi marker sphingomyelin synthase into a tubovesicular network in the cytoplasm of mature erythrocytes
93. Electron dense tracers fail to identify a "parasitophorous duct" in Plasmodium falciparum infected red blood cells
94. Allelic modifications of the cg2 and cg1 genes do not alter the chloroquine response of drug-resistant Plasmodium falciparum
95. Mutations in the P. falciparum digestive vacuole transmembrane protein PfCRT and evidence for their role in chloroquine resistance
96. Expression of band 3 anion exchanger induces chloride current and taurine transport: Structure-function analysis
97. Volume-sensitive taurine transport in fish erythrocytes
98. Mechanisms of magnesium transport
99. Inhibition of Plasmodium falciparum proliferation in vitro by ribozymes
100. Quinoline antimalarials: Mechanisms of action and resistance
101. Quinoline antimalarials: Mechanisms of action and resistance and prospects for new agents
102. Amplification of the multidrug resistance gene in some chloroquine-resistant isolates of P. falciparum
103. Molecular characterization and inhibition of a Plasmodium falciparum aspartic hemoglobinase
104. Heterologous expression of genes in bacterial, fungal, animal and plant cells
105. Morphological changes of clefts in Plasmodium-infected erythrocytes under adverse conditions
106. There is no ducking the duct: Reply
107. Calcium homeostasis and signaling in the blood-stage malaria parasite
108. Calcium homeostasis in intraerythrocytic malaria parasites
109. Cell volume regulation by trout erythrocytes: Characteristics of the transport systems activated by hypotonic swelling
110. Chromosome 2 sequence of the human malaria parasite Plasmodium falciparum
111. Parasite-induced processes for adenosine permeation in mouse erythrocytes infected with the malaria parasite Plasmodium yoelii
112. Pyrimidine de novo synthesis during the life cycle of the intraerythrocytic stage of Plasmodium falciparum
113. Stage-specific alteration of nucleoside membrane permeability and nitro-benzylthioinosine insensitivity in Plasmodium falciparum infected erythrocytes
114. Plasmodium falciparum: Transport of entantiomers of nucleosides into Sendai-treated trophozoites
115. Nutrient transport pathways in Plasmodium-infected erythrocytes: What and where are they?
116. Purines and pyrimidines in malarial parasites
117. Anti-malarial action of nitrobenzylthioinosine in combination with purine nucleoside antimetabolites
118. Altered membrane permeability: A new approach to malaria chemotherapy
119. Effect of diamide on nucleoside glucose and transport in Plasmodium falciparum Babesia bovis infected erythrocytes
120. Selective cytotoxicity of dermaseptin S3 toward intraerythrocytic Plasmodium falciparum and the underlying molecular basis
121. Separation of drug transport and chloride channel functions of the human multidrug resistance P-glycoprotein
122. Alterations caused by the intraerythrocytic malaria parasite in the permeability of its host cell membrane
123. Some reflections concerning host erythrocyte-malarial parasite interrelationships
124. Is the multidrug resistant protein of the malaria parasite involved in drug resistance?
125. How Plasmodium secures nutrients: New targets for drugs
126. Transport pathways in the malaria-infected erythrocyte. Their characterization and their use as potential targets for chemotherapy
127. The permeability properties of the parasite cell membrane
128. Inhibition of glutathione-dependent degradation of heme by chloroquine and amodiaquine as a possible basis for their antimalarial mode of action
129. Current concepts and new ideas on the mechanism of action of quinoline-containing antimalarials
130. Effects of red blood cell potassium and hypertonicity on the growth of Plasmodium falciparum in culture
131. Membrane transport in the malaria-infected erythrocyte
132. Uptake of L-tryptophan by erythrocytes infected with malaria parasites (Plasmodium falciparum)
133. Chloroquine - Some open questions on its antimalarial mode of action and resistance
134. New permeability pathways induced in membranes of Plasmodium falciparum infected erythrocytes
135. Characterization of permeation pathways appearing in the host membrane of Plasmodium falciparum infected red blood cells
136. Alkalinization of the food vacuole of malaria parasites by quinoline drugs and alkylamines is not correlated with their antimalarial activity
137. Biophysical analysis of novel transport pathways induced in red blood cell membranes
138. Kinetic modelling of chloroquine uptake by malaria-infected erythrocytes. Assessment of the factors that may determine drug resistance
139. An integrated model of chloroquine action
140. The plasma membrane electrical gradient (membrane potential) in Leishmania donovani promastigotes and amastigotes
141. Volume-activated taurine efflux from skate erythrocytes: Possible band 3 involvement
142. Taurine, betaine, and inositol share a volume-sensitive transporter in skate erythrocyte cell membrane
143. Organic osmolyte channels: Transport characteristics and regulation
144. Efflux of 6-deoxy-D-glucose from Plasmodium falciparum-infected erythrocytes via two saturable carriers
145. Characterization of macromolecular transport pathways in malaria-infected erythrocytes
146. Lipid traffic between high density lipoproteins and Plasmodium falciparum-infected red blood cells
147. Cln: A chloride channel paramount for cell volume regulation
148. Transport of fluorescent phospholipid analogues from the erythrocyte membrane to the parasite in Plasmodium falciparum-infected cells
149. In vitro secretory assays with erythrocyte-free malaria parasites
150. The movement of fluorescent endocytotic tracers in Plasmodium falciparum infected erythrocytes
151. The proton-linked monocarboxylate transporter (MCT) family: Structure, function and regulation
152. Evidence for the presence of volume-sensitive KCl transport in "young" human red cells
153. Plasmodium falciparum: Transport of entantiomers of nucleosides into Sendai-treated trophozoites
154. Characterization of volume sensitive organic osmolyte efflux and anion current in Xenopus oocytes
155. Protein kinase C-mediated phosphorylation of the human multidrug resistance P-glycoprotein regulates cell volume-activated chloride channels
156. Single or multiple localization of ADP/ATP transporter in human malarial Plasmodium falciparum
157. Molecular characterisation of the ADP/ATP-transporter cDNA from the human malaria parasite Plasmodium falciparum
158. +-ATPase localized in plasma membranes of malaria parasite cells, Plasmodium falciparum, is involved in regional acidification of parasitized erythrocytes
159. Volume-regulatory amino acid transport in erythrocytes of the little skate, Raja erinacea
160. Rosetting Plasmodium falciparum-infected erythrocytes express unique strain-specific antigens on their surface
161. Macromolecular transport in malaria - Does the duct exist?
162. The ABC of channel regulation
163. Regulation of metabolite flux through voltage-gating of VDAC channels
164. Lipids and the malarial parasite
165. Plasmodium falciparum: Isolation of intact and erythrocyte-free trophozoites from sorbitol lysates
166. Calcium-dependent modulation by melatonin of the circadian rhythm in malarial parasites
167. Modification of host cell membrane lipid composition by the intra-erythrocytic human malaria parasite Plasmodium falciparum
168. Volume-activated taurine permeability in cells of the human erythroleukemic cell line K562
169. Transport processes of 2-deoxy-D-glucose in erythrocytes infected with Plasmodium yoelii, a rodent malaria parasite
170. + anti-porter confers sodium and lithium tolerance in fission yeast
171. +-ATPase from Leishmania donovani
172. Two pathways for choline transport in eel erythrocytes: A saturable carrier and a volume-activated channel
173. Identification of hemoglobin degradation products in Plasmodium falciparum
174. Compartment analysis of ATP in malaria-infected erythrocytes
175. Metabolic interconnection between the human malarial parasite Plasmodium falciparum and its host erythrocyte. Regulation of ATP levels by means of an adenylate translocator and adenylate kinase
176. Transport of lactate in Plasmodium falciparum-infected human erythrocytes
177. Inhibitory monoclonal antibody against a (myristylated) small-molecular-weight antigen from Plasmodium falciparum associated with the parasitophorous vacuole membrane
178. Cloning and characterization of a vacuolar ATPase A subunit homologue from Plasmodium falciparum
179. Cloning and characterization of the vacuolar ATPase B subunit from Plasmodium falciparum
180. Cloning of a Ca(2+)-ATPase gene of Plasmodium falciparum and comparison with vertebrate Ca(2+)-ATPases
181. Proton NMR spectroscopic studies of dipeptidase in human erythrocytes
182. Swelling-activated organic osmolyte channels
183. + transport in human erythrocytes infected with Plasmodium falciparum
184. Transport of organic substrates via a volume-activated channel
185. In search of a selective inhibitor of the induced transport of small solutes in Plasmodium falciparum-infected erythrocytes: Effects of arylaminobenzoates
186. Novel anion dependence of induced cation transport in malaria-infected erythrocytes
187. Transport of diverse substrates into malaria-infected erythrocytes via a pathway showing functional characteristics of a chloride channel
188. Glucose uptake in Plasmodium falciparum-infected erythrocytes is an equilibrative not an active process
189. Glibenclamide and meglitinide block the transport of low molecular weight solutes into malaria-infected erythrocytes
190. Effect of cell age on erythrocyte choline transport: Implications for the increased choline permeability of malaria-infected erythrocytes
191. Transport properties of the host cell membrane
192. + transport in human erythrocytes infected with the malaria parasite Plasmodium falciparum
193. A plastid of probable green algal origin in Apicomplexan parasites
194. Generation of hemoglobin peptides in the acidic digestive vacuole of Plasmodium falciparum implicates peptide transport in amino acid production
195. Calcium transport and compartment analysis of free and exchangeable calcium in Plasmodium falciparum-infected red blood cells
196. A family of cation ATPase-like molecules from Plasmodium falciparum
197. Plasmodium falciparum: Further characterization of putative cation ATPases
198. Expression of parasite transporters in Xenopus oocytes
199. Hexose transport in asexual stages of Plasmodium falciparum and Kinetoplastidae
200. 2+-ATPase (PfATP4) belonging to a sub-class unique to apicomplexan organisms
201. P-type ATPase of malaria parasites
202. Efflux of chloroquine from Plasmodium falciparum: Mechanism of chloroquine resistance
203. Antimalarials increase vesicle pH in Plasmodium falciparum
204. Characterization of permeation pathways in the plasma membrane of human erythrocytes infected with early stages of Plasmodium falciparum: Association with parasite development
205. On the mode of action of phlorizin as an antimalarial agent in in vitro cultures of Plasmodium falciparum
206. Permselectivity changes in malaria (Plasmodium falciparum) infected human red blood cell membranes
207. Rifins: A second family of clonally variant proteins expressed on the surface of red cells infected with Plasmodium falciparum
208. 15N saturation transfer NMR spectroscopy
209. Synchronization of Plasmodium falciparum erythrocytic stages in culture
210. A membrane network for nutrient import in red cells infected with the malaria parasite
211. Vacuolar uptake of host components, and a role for cholesterol sphingomyelin in malarial infection
212. X-ray microanalysis of Plasmodium falciparum and infected red blood cells: Effects of qinghaosu and chloroquine on potassium, sodium, and phosphorus composition
213. Intraerythrocytic plasmodial calcium metabolism
214. i level and pump-leak turnover in intact red cells measured using an incorporated Ca chelator
215. Anion-selectivity of the swelling-activated osmolyte channel in eel erythrocytes
216. The parasitophorous vacuole membrane surrounding Plasmodium and Toxoplasma: An unusual compartment in infected cells
217. Adenosine triphosphate-dependent asymmetry of anion permeation in the cystic fibrosis transmembrane conductance regulator chloride channel
218. Glutathione permeability of CFTR
219. Permeability of wild-type and mutant cystic fibrosis transmembrane conductance regulator chloride channels to polyatomic anions
220. Antimalarial action of hydrophilic drugs: Involvement of aqueous access routes to intracellular parasites
221. The antimalarial action of desferal involves a direct access route to erythrocytic (Plasmodium falciparum) parasites
222. A plant-like vacuolar H(+)-pyrophosphatase in Plasmodium falciparum
223. Alterations in erythrocyte membrane phospholipid organization due to the intracellular growth of the human malaria parasite, Plasmodium falciparum
224. +-pyrophosphatase in malaria parasites
225. Reversal of chloroquine resistance in Plasmodium falciparum by verapamil
226. Verapamil reversal of chloroquine resistance in the malaria parasite Plasmodium falciparum is specific for resistant parasites and independent of the weak base effect
227. Chloroquine uptake, altered partitioning and the basis of drug resistance: Evidence for chloride-dependent ionic regulation
228. Effect of dietary magnesium on the susceptibility of nuce to infection by protozoan parasites of the Apicomplexa Mastigophora phyla
229. Protective effect of severe magnesium deficiency on Plasmodium chabaudi infection
230. 2+ kill Plasmodium falciparum in vitro
231. Plastid in human parasites
232. Plastids in parasites of humans
233. + pumping vacuolar pyrophosphatase of plants
234. Passive permeability of human red blood cells to calcium
235. The antimalarial drug, chloroquine, interacts with lactate dehydrogenase from Plasmodium falciparum
236. Membrane potential of Plasmodium-infected erythrocytes
237. Membrane potential of erythrocytic stages of Plasmodium chabaudi free of the host cell membrane
238. Preferential invasion of malaria merozoites into young red blood cells
239. +-ATPase regulates cytoplasmic pH in Toxoplasma gondii tachyzoites
240. Association of the band 3 protein with a volume-activated, anion and amino acid channel: A molecular approach
241. Red cell volume regulation: The pivotal role of ionic strength in controlling swelling-dependent transport systems
242. The cell as an extreme environment
243. Band 3 modulation and hypotonic-stimulated taurine efflux in skate erythrocytes
244. Selective and ATP-dependent translocation of peptides by the MHC-encoded transporter
245. Vacuolar and plasma membrane proton-adenosinetriphosphatases
246. An additional mechanism of ribosome-inactivating protein cytotoxicity: Degradation of extra-chromosomal DNA
247. Properties of volume-regulated anion channels in mammalian cells
248. Extracellular development of Plasmodium knowlesi erythrocytic stages in an artificial intracellular medium
249. Characterisation of peptide fluxes into human erythrocytes: A proton NMR study
250. - channel: Fresh start to the molecular identity and volume sensor
251. Hemin lyses malaria parasites
252. Reversible cellular permeability alterations in disease. In vivo studies on sodium, potassium and chloride concentrations in erythrocytes of the malarious monkey
253. The structure of malaria pigment β-haematin
254. Identification of a nucleoside/nucleobase transporter from Plasmodium falciparum, a novel target for antimalarial chemotherapy
255. 2+ transport activity associated with a non-mitochondrial calcium pool in the rodent malaria parasite P. chabaudi
256. 2+ release from chloroquine-sensitive and -insensitive intracellular stores in the intraerythrocytic stage of the malaria parasite P. chabaudi
257. Separation of viable schizont-infected red cells of Plasmodium falciparum from human blood
258. Foreign anion substitution for chloride in human red blood cells: Effect on ionic and osmotic equilibria
259. Derivation of highly mefloquine-resistant lines from Plasmodium falciparum in vitro
260. Expression of substrate-specific transporters encoded by Plasmodium falciparum in Xenopus laevis oocytes
261. Plasmodium falciparum: Stage-specific lactate production in synchronized cultures
262. A high-conductance solute channel in the chloroplastic outer envelope from pea
263. Transport of lactate and other mono-carboxylates across mammalian plasma membranes
264. Characterization of trafficking pathways and membrane genesis in malaria-infected erythrocytes
265. Presence of the parasitophorous duct in Plasmodium falciparum and P. vivax parasitized Saimiri monkey red blood cells
266. Direct access to serum macromolecules by intraerythrocytic malaria parasites
267. Cellular ATP release by the cystic fibrosis transmembrane conductance regulator
268. The pfmdr1 gene is associated with a multidrug-resistant phenotype in Plasmodium falciparum from the western border of Thailand
269. Anti-sense oligodeoxynucleoside phosphorothioates nonspecifically inhibit invasion of red blood cells by malaria parasites
270. Antimalarial activities of oligodeoxynucleotide phosphorothioates in chloroquine-resistant Plasmodium falciparum
271. 2+ is required for reinfection of red cells by Plasmodium falciparum
272. Novel bisquinoline antimalarials: Synthesis, antimalarial activity and inhibition of haem polymerisation
273. Localisation and role of ADP-ATP transporter in cytoplasmic membrane of Plasmodium falciparum
274. Pgh1 modulates sensitivity and resistance to multiple antimalarials in Plasmodium falciparum
275. The cystic fibrosis transmembrane conductance regulator is a dual ATP and chloride channel
276. Haematin (haem) polymerization and its inhibition by quinoline antimalarials
277. Rapid switching to multiple antigenic and adhesive phenotypes in malaria
278. Origin, targeting, and function of the apicomplexan plastid
279. Hemoglobin processing and the metabolism of amino acids, heme and iron
280. Plasmodium falciparum carbohydrate metabolism: A connection between host cell and parasite
281. P. falciparum rosetting mediated by a parasite-variant erythrocyte membrane protein and complement-receptor 1
282. Plasmodium falciparum: The pfmdr2 protein is not overexpressed in chloroquine-resistant isolates of the malaria parasite
283. The ATP-binding cassette (ABC) gene family of Plasmodium falciparum
284. The pfmdr1 gene of Plasmodium falciparum confers cellular resistance to antimalarial drugs in yeast cells
285. Role for the Plasmodium falciparum digestive vacuole in chloroquine resistance
286. Transport and metabolism of the essential vitamin pantothenic acid in human erythrocytes infected with the malaria parasite Plasmodium falciparum
287. Uptake of an antiplasmodial protease inhibitor into Plasmodium falciparum-infected human erythrocytes via a parasite-induced pathway
288. +-ATPase
289. A novel "anion channel" in the malaria-infected erythrocyte: Opportunities for antimalarial chemotherapy
290. Malaria parasite exit from the host erythrocyte: A two-step process requiring extraerythrocytic proteolysis
291. + exchanger of Plasmodium falciparum?
292. Changing ideas on chloroquine in Plasmodium falciparum
293. Identification of a chloroquine importer in Plasmodium falciparum. Differences in import kinetics are genetically linked with the chloroquine-resistant phenotype
294. Calcium and calmodulin antagonists inhibit human malaria parasites (Plasmodium falciparum): Implications for drug design
295. The parasitophorous vacuole membrane surrounding intracellular Toxoplasma gondii functions as a molecular sieve
296. Altered plasma membrane phospholipid organization in Plasmodium falciparum-infected human erythrocytes
297. ABC transporter-facilitated ATP conductive transport
298. Parasite uptake of desferroxamine: A prerequisite for antimalarial activity
299. Transient holes in the erythrocyte membrane during hypotonic hemolysis and stable holes in the membrane after lysis by saponin and lysolecithin
300. Structure of membrane holes in osmotic and saponin lysis
301. + channel regulators on cystic fibrosis transmembrane conductance regulator chloride currents
302. Transport of amino acids and nucleic acid precursors in malarial parasites
303. Mechanisms of molecular trafficking in malaria
304. Glucose transport in the malarial (Plasmodium lophurae) infected erythrocyte
305. Antigens on the Plasmodium falciparum infected erythrocyte surface are not parasite derived
306. A parasitophorous duct in Plasmodium-infected red blood cells
307. Viral and cellular small integral membrane proteins can modify ion channels endogenous to Xenopus oocytes
308. Bioflavonoid effects on in vitro cultures of Plasmodium falciparum. Inhibition of permeation pathways induced in the host cell membrane by the intraerythrocytic parasite
309. Plasmodium knowlesi induces alterations in phosphatidylcholine and phosphatidylethanolamine molecular species composition of parasitized monkey erythrocytes
310. Characterization of simian malarial parasite (Plasmodium knowlesi)-induced putrescine transport in rhesus monkey erythrocytes. A novel putrescine conjugate arrests in vitro growth of simian malarial parasite (Plasmodium knowlesi) and cures multi-drug resistant murine malaria (Plasmodium yoelii) infection in vivo
311. Inhibition by chloroquine of a novel haem polymerase enzyme activity in malaria trophozoites
312. Elasticity of the red cell membrane and its relation to hemolytic disorders: An optical tweezers study
313. Switches in expression of Plasmodium falciparum var genes correlate with changes in antigenic and cytoadherent phenotypes of infected erythrocytes
314. Deformation-induced ATP release from red blood cells requires CFTR activity
315. + transport in Plasmodium falciparum-infected red cells
316. + pump-leak balance in malaria-infected erythrocytes
317. Increased choline transport in erythrocytes from mice infected with the malaria parasite Plasmodium vinckei vinckei
318. Increased permeability of the malaria-infected erythrocyte to organic cations
319. Cellular and molecular physiology of volume-sensitive anion channels
320. Complex polymorphisms in an approximately 330 kDa protein are linked to chloroquine-resistant P. falciparum in Southeast Asia and Africa
321. Genome discovery and malaria research: Current status and promise
322. The large diverse gene family var encodes proteins involved in cytoadherence and antigenic variation of Plasmodium falciparum-infected erythrocytes
323. Glucose transport in malaria-infected erythrocytes
324. 2+ and calmodulin modulators
325. Calcium transport of Plasmodium chabaudi-infected erythrocytes
326. A subfamily of P-type ATPases with aminophospholipid transporting activity
327. Macromolecular transport in malaria-infected erythrocytes
328. There is no ducking the duct
329. There is no ducking the duct: Reply
330. Irreversible ATP depletion caused by low concentrations of formaldehyde and of calcium-chelator esters in intact human red cells
331. 2+ pump in Plasmodium falciparum-infected human red blood cells
332. Rotational dynamics of the integral membrane protein, band 3, as a probe of the membrane events associated with Plasmodium falciparum infections of human erythrocytes
333. Regulation of cell volume by active cation transport in high and low potassium sheep red cells
334. Parasitophorous duct? Still more questions than answers
335. Human malaria parasites in continuous culture
336. Continuous culture of Plasmodium falciparum: Its impact on malaria research
337. Initial extracellular development in vitro of erythrocytic stages of malaria parasites (Plasmodium falciparum)
338. The current global malaria situation
339. Molecular cloning and sequence of two novel P-type adenosinetriphosphatases from Plasmodium falciparum
340. Cloning of a new cation ATPase from Plasmodium falciparum: Conservation of critical amino acids involved in calcium binding in mammalian organellar Ca(2+)-ATPases
341. Induction of endogenous channels by high levels of heterologous membrane proteins in Xenopus oocytes
342. Parasite-induced permeation of nucleosides in Plasmodium falciparum malaria
343. Oxidative phosphorylation, Ca(2+) transport, and fatty acid-induced uncoupling in malaria parasites mitochondria
344. Mitochondrial physiology as a target for atovaquone and other antimalarials
345. Volume-regulated chloride channels associated with the human multidrug-resistance P-glycoprotein
346. The role of a H(+)-ATPase in the regulation of cytoplasmic pH in Trypanosoma cruzi epimastigotes
347. Characterization of a hemoglobin-degrading, low molecular weight protease from Plasmodium falciparum
348. D-Lactate production in erythrocytes infected with Plasmodium falciparum
349. Stable transfection of malaria parasite blood stages
350. Enhanced lysosomal acidification leads to increased chloroquine accumulation in CHO cells expressing the pfmdr1 gene
351. Malaria lipids
352. Transport of phospholipid synthesis precursors and lipid trafficking into malaria-infected erythrocytes
353. + pumping by Leishmania major promastigotes
354. The chloride current induced by expression of the protein pICln in Xenopus oocytes differs from the endogenous volume-sensitive chloride current
355. Functional complementation of the ste6 gene of Saccharomyces cerevisiae with the pfmdr1 gene of Plasmodium falciparum
356. Nuclear-encoded proteins target to the plastid in Toxoplasma gondii and Plasmodium falciparum
357. The origin of parasitophorous vacuole membrane lipids in malaria-infected erythrocytes
358. 2+ depletion on the asexual cell cycle of Plasmodium falciparum
359. Transfection of malaria parasites
360. + exchangers
361. + antiport in an animal plasma membrane
362. Amplification of a gene related to mammalian mdr genes in drug-resistant Plasmodium falciparum
363. Amplification of pfmdr1 associated with mefloquine and halofantrine resistance in Plasmodium falciparum from Thailand
364. Measurement of transport versus metabolism in cultured cells
365. Hexose permeation pathways in Plasmodium falciparum-infected erythrocytes
366. Intraerythrocytic Plasmodium falciparum expresses a high affinity facilitative hexose transporter
367. Anion selectivity in biological systems
368. Transfection of Plasmodium falciparum within human red blood cells
369. Distinct lipid compositions of parasite and host cell plasma membranes from Plasmodium chabaudi-infected erythrocytes
370. Single-cell in vivo measurements of ion concentrations within the intracellular parasite Plasmodium falciparum
371. A method to measure the cytoplasmic pH of single, living Plasmodium falciparum parasites
372. + exchanger determines chloroquine uptake in Plasmodium falciparum
373. Identification of the acidic compartment of Plasmodium falciparum-infected human erythrocytes as the target of the antimalarial drug chloroquine
374. Susceptibility of human malaria parasites to chloroquine is pH dependent
375. Effects of chloroquine on the feeding mechanism of the intraerythrocytic human malarial parasite Plasmodium falciparum
376. Conflicting evidence regarding the transport of alpha-glutamyl-dipeptides by human erythrocytes
377. Characterization of the pfmdr2 gene for Plasmodium falciparum
378. Water and urea transport in human erythrocytes infected with the malaria parasite Plasmodium falciparum
379. Digestion of the host erythrocyte by malaria parasites is the primary target for quinoline-containing antimalarials
380. p-Aminobenzoic acid transport by normal and Plasmodium falciparum-infected erythrocytes
381. Identification of a surface membrane proton-translocating ATPase in promastigotes of the parasitic protozoan Leishmania donovani