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Volumn 43, Issue 12, 1999, Pages 2943-2949

The pfmdr1 gene is associated with a multidrug-resistant phenotype in Plasmodium falciparum from the western border of Thailand

Author keywords

[No Author keywords available]

Indexed keywords

ANTIMALARIAL AGENT; ARTESUNATE; CHLOROQUINE; HALOFANTRINE; MEFLOQUINE; QUININE;

EID: 0032804039     PISSN: 00664804     EISSN: None     Source Type: Journal    
DOI: 10.1128/aac.43.12.2943     Document Type: Article
Times cited : (235)

References (38)
  • 1
    • 0030047034 scopus 로고    scopus 로고
    • Guinea Bissau: Association of chloroquine resistance of Plasmodium falciparum with the Tyr86 allele of the multiple drug resistance gene Pfmdr1
    • Letter
    • Adagu, I. S., F. Dias, L. Pinheiro, L. Rombo, V. do Rosario, and D. C. Warhurst. 1996. Guinea Bissau: association of chloroquine resistance of Plasmodium falciparum with the Tyr86 allele of the multiple drug resistance gene Pfmdr1. Trans. R. Soc. Trop. Med. Hyg. 90:90-91. (Letter.)
    • (1996) Trans. R. Soc. Trop. Med. Hyg. , vol.90 , pp. 90-91
    • Adagu, I.S.1    Dias, F.2    Pinheiro, L.3    Rombo, L.4    Do Rosario, V.5    Warhurst, D.C.6
  • 2
    • 0027056692 scopus 로고
    • Chloroquine-resistant Plasmodium falciparum isolates from the Sudan lack two mutations in the pfmdr1 gene thought to be associated with chloroquine resistance
    • Awad el Kariem, F. M., M. A. Miles, and D. C. Warhurst. 1992. Chloroquine-resistant Plasmodium falciparum isolates from The Sudan lack two mutations in the pfmdr1 gene thought to be associated with chloroquine resistance. Trans. R. Soc. Trop. Med. Hyg. 84:587-589.
    • (1992) Trans. R. Soc. Trop. Med. Hyg. , vol.84 , pp. 587-589
    • Awad El Kariem, F.M.1    Miles, M.A.2    Warhurst, D.C.3
  • 3
    • 0029953754 scopus 로고    scopus 로고
    • Plasmodium falciparum: Molecular characterization of multidrug-resistant Cambodian isolates
    • Basco, L. K., P. Eldin de Pecoulas, J. Le Bras, and C. M. Wilson. 1996. Plasmodium falciparum: molecular characterization of multidrug-resistant Cambodian isolates. Exp. Parasitol. 82:97-103.
    • (1996) Exp. Parasitol. , vol.82 , pp. 97-103
    • Basco, L.K.1    Eldin De Pecoulas, P.2    Le Bras, J.3    Wilson, C.M.4
  • 4
    • 0026446186 scopus 로고
    • In vitro activity of halofantrine and its relationship to other standard antimalarial drugs against African isolates and clones of Plasmodium falciparum
    • Basco, L. K., and J. Le Bras. 1992. In vitro activity of halofantrine and its relationship to other standard antimalarial drugs against African isolates and clones of Plasmodium falciparum. Am. J. Trop. Med. Hyg. 47:521-527.
    • (1992) Am. J. Trop. Med. Hyg. , vol.47 , pp. 521-527
    • Basco, L.K.1    Le Bras, J.2
  • 5
    • 0029586497 scopus 로고
    • Analysis of pfmdr1 and drug susceptibility in fresh isolates of Plasmodium falciparum from subsaharan Africa
    • Basco, L. K., J. Le Bras, Z. Rhoades, and C. M. Wilson. 1995. Analysis of pfmdr1 and drug susceptibility in fresh isolates of Plasmodium falciparum from subsaharan Africa. Mol. Biochem. Parasitol. 74:157-166.
    • (1995) Mol. Biochem. Parasitol. , vol.74 , pp. 157-166
    • Basco, L.K.1    Le Bras, J.2    Rhoades, Z.3    Wilson, C.M.4
  • 6
    • 0031724298 scopus 로고    scopus 로고
    • Molecular epidemiology of malaria in Yaounde, Cameroon. Analysis of chloroquine resistance and point mutations in the multidrug resistance (pfmdr1) gene of Plasmodium falciparum
    • Basco, L. K., and P. Ringwald. 1998. Molecular epidemiology of malaria in Yaounde, Cameroon. Analysis of chloroquine resistance and point mutations in the multidrug resistance (pfmdr1) gene of Plasmodium falciparum. Am. J. Trop. Med. Hyg. 59:577-581.
    • (1998) Am. J. Trop. Med. Hyg. , vol.59 , pp. 577-581
    • Basco, L.K.1    Ringwald, P.2
  • 7
    • 0030818265 scopus 로고    scopus 로고
    • Alleles of the Plasmodium falciparum Pfmdr1 gene appear not to be associated with chloroquine resistance in India
    • Bhattacharya, P. R., S. Biswas, and L. Kabilan. 1997. Alleles of the Plasmodium falciparum Pfmdr1 gene appear not to be associated with chloroquine resistance in India. Trans. R. Soc. Trop. Med. Hyg. 91:454-455.
    • (1997) Trans. R. Soc. Trop. Med. Hyg. , vol.91 , pp. 454-455
    • Bhattacharya, P.R.1    Biswas, S.2    Kabilan, L.3
  • 8
    • 84908219488 scopus 로고
    • Statistical methods for assessing agreement between two methods of clinical measurement
    • Bland, M., and D. Altman. 1986. Statistical methods for assessing agreement between two methods of clinical measurement. Lancet i:307-310.
    • (1986) Lancet , vol.1 , pp. 307-310
    • Bland, M.1    Altman, D.2
  • 9
    • 0344784465 scopus 로고    scopus 로고
    • Unpublished data
    • Brockman, A. Unpublished data.
    • Brockman, A.1
  • 10
    • 0032922705 scopus 로고    scopus 로고
    • Application of genetic markers to the identification of recrudescent Plasmodium falciparum infections on the northwestern border of Thailand
    • Brockman, A., R. E. L. Paul, T. J. C. Anderson, I. Hackford, L. Phaipun, S. Looareesuwan, F. Nosten, and K. P. Day. 1999. Application of genetic markers to the identification of recrudescent Plasmodium falciparum infections on the northwestern border of Thailand. Am. J. Trop. Med. Hyg. 60: 14-21.
    • (1999) Am. J. Trop. Med. Hyg. , vol.60 , pp. 14-21
    • Brockman, A.1    Paul, R.E.L.2    Anderson, T.J.C.3    Hackford, I.4    Phaipun, L.5    Looareesuwan, S.6    Nosten, F.7    Day, K.P.8
  • 11
    • 0028014644 scopus 로고
    • Selection for mefloquine resistance in Plasmodium falciparum is linked to amplification of the pfmdr1 gene and cross-resistance to halofantrine and quinine
    • Cowman, A. F., D. Galatis, and J. K. Thompson. 1994. Selection for mefloquine resistance in Plasmodium falciparum is linked to amplification of the pfmdr1 gene and cross-resistance to halofantrine and quinine. Proc. Natl. Acad. Sci. USA 91:1143-1147.
    • (1994) Proc. Natl. Acad. Sci. USA , vol.91 , pp. 1143-1147
    • Cowman, A.F.1    Galatis, D.2    Thompson, J.K.3
  • 12
    • 0029165911 scopus 로고
    • Assessment of the association between three pfmdr1 point mutations and chloroquine resistance in vitro of Malaysian Plasmodium falciparum isolates
    • Cox Singh, J., B. Singh, A. Alias, and M. S. Abdullah. 1995. Assessment of the association between three pfmdr1 point mutations and chloroquine resistance in vitro of Malaysian Plasmodium falciparum isolates. Trans. R. Soc. Trop. Med. Hyg. 89:436-437.
    • (1995) Trans. R. Soc. Trop. Med. Hyg. , vol.89 , pp. 436-437
    • Cox Singh, J.1    Singh, B.2    Alias, A.3    Abdullah, M.S.4
  • 13
    • 0032079104 scopus 로고    scopus 로고
    • Plasmodium falciparum: Detection of polymorphisms in the dihydrofolate reductase and dihydropteroate synthetase genes by PCR and restriction digestion
    • Duraisingh, M. T., J. Curtis, and D. C. Warhurst. 1998. Plasmodium falciparum: detection of polymorphisms in the dihydrofolate reductase and dihydropteroate synthetase genes by PCR and restriction digestion. Exp. Parasitol. 89:1-8.
    • (1998) Exp. Parasitol. , vol.89 , pp. 1-8
    • Duraisingh, M.T.1    Curtis, J.2    Warhurst, D.C.3
  • 15
    • 0025269612 scopus 로고
    • Several alleles of the multidrug resistance gene are closely linked to chloroquine resistance in Plasmodium falciparum
    • Foote, S. J., D. E. Kyle, R. K. Martin, A. M. Oduola, K. P. Forsyth, D. J. Kemp, and A. F. Cowman. 1990. Several alleles of the multidrug resistance gene are closely linked to chloroquine resistance in Plasmodium falciparum. Nature 345:255-258.
    • (1990) Nature , vol.345 , pp. 255-258
    • Foote, S.J.1    Kyle, D.E.2    Martin, R.K.3    Oduola, A.M.4    Forsyth, K.P.5    Kemp, D.J.6    Cowman, A.F.7
  • 16
    • 0024338609 scopus 로고
    • Amplification of the multidrug resistance gene in some chloroquine-resistant isolates of P. falciparum
    • Foote, S. J., J. K. Thompson, A. F. Cowman, and D. J. Kemp. 1989. Amplification of the multidrug resistance gene in some chloroquine-resistant isolates of P. falciparum. Cell 57:921-930.
    • (1989) Cell , vol.57 , pp. 921-930
    • Foote, S.J.1    Thompson, J.K.2    Cowman, A.F.3    Kemp, D.J.4
  • 17
    • 0030219812 scopus 로고    scopus 로고
    • Plasmodium falciparum: Amplification and overexpression of pfmdr1 is not necessary for increased mefloquine resistance
    • Lim, A. S., D. Galatis, and A. F. Cowman. 1996. Plasmodium falciparum: amplification and overexpression of pfmdr1 is not necessary for increased mefloquine resistance. Exp. Parasitol. 83:295-303.
    • (1996) Exp. Parasitol. , vol.83 , pp. 295-303
    • Lim, A.S.1    Galatis, D.2    Cowman, A.F.3
  • 19
    • 0028135205 scopus 로고
    • A strong association between mefloquine and halofantrine resistance and amplification, overexpression, and mutation in the P-glycoprotein gene homolog (pfmdr) of Plasmodium falciparum in vitro
    • Peel, S. A., P. Bright, B. Yount, J. Handy, and R. S. Baric. 1994. A strong association between mefloquine and halofantrine resistance and amplification, overexpression, and mutation in the P-glycoprotein gene homolog (pfmdr) of Plasmodium falciparum in vitro. Am. J. Trop. Med. Hyg. 51:648-658.
    • (1994) Am. J. Trop. Med. Hyg. , vol.51 , pp. 648-658
    • Peel, S.A.1    Bright, P.2    Yount, B.3    Handy, J.4    Baric, R.S.5
  • 20
    • 0031900723 scopus 로고    scopus 로고
    • In vitro activity of artemether against African isolates (Senegal) of Plasmodium falciparum in comparison with standard antimalarial drugs
    • Pradines, B., C. Rogier, T. Fusai, A. Tall, J. F. Trape, and J. C. Doury. 1998. In vitro activity of artemether against African isolates (Senegal) of Plasmodium falciparum in comparison with standard antimalarial drugs. Am. J. Trop. Med. Hyg. 58:354-357.
    • (1998) Am. J. Trop. Med. Hyg. , vol.58 , pp. 354-357
    • Pradines, B.1    Rogier, C.2    Fusai, T.3    Tall, A.4    Trape, J.F.5    Doury, J.C.6
  • 22
    • 0030615279 scopus 로고    scopus 로고
    • Assessment of pfmdr1 gene copy number by tendem competitive polymerase chain reaction
    • Price, R., G. Robinson, A. Brockman, A. Cowman, and S. Krishna. 1997. Assessment of pfmdr1 gene copy number by tendem competitive polymerase chain reaction. Mol. Biochem. Parasitol. 85:161-169.
    • (1997) Mol. Biochem. Parasitol. , vol.85 , pp. 161-169
    • Price, R.1    Robinson, G.2    Brockman, A.3    Cowman, A.4    Krishna, S.5
  • 25
    • 0019420730 scopus 로고
    • Drug therapy for Plasmodium falciparum malaria resistant to pyrimethamine and sulfadoxine
    • Reacher, M. 1981. Drug therapy for Plasmodium falciparum malaria resistant to pyrimethamine and sulfadoxine. Lancet ii:1066-1068.
    • (1981) Lancet , vol.2 , pp. 1066-1068
    • Reacher, M.1
  • 26
    • 0029762423 scopus 로고    scopus 로고
    • In vitro activity of antimalarials against clinical isolates of Plasmodium falciparum in yaounde, Cameroon
    • Ringwald, P., J. Bickii, and L. K. Basco. 1996. In vitro activity of antimalarials against clinical isolates of Plasmodium falciparum in Yaounde, Cameroon. Am. J. Trop. Med. Hyg. 55:254-258.
    • (1996) Am. J. Trop. Med. Hyg. , vol.55 , pp. 254-258
    • Ringwald, P.1    Bickii, J.2    Basco, L.K.3
  • 27
    • 0029840467 scopus 로고    scopus 로고
    • The pfmdr1 gene of Plasmodium falciparum confers cellular resistance to antimalarial drugs in yeast cells
    • Ruetz, S., U. Delling, M. Brault, E. Schurr, and P. Gros. 1996. The pfmdr1 gene of Plasmodium falciparum confers cellular resistance to antimalarial drugs in yeast cells. Proc. Natl. Acad. Sci. USA 93:9942-9947.
    • (1996) Proc. Natl. Acad. Sci. USA , vol.93 , pp. 9942-9947
    • Ruetz, S.1    Delling, U.2    Brault, M.3    Schurr, E.4    Gros, P.5
  • 28
    • 0031589733 scopus 로고    scopus 로고
    • Complex polymorphisms in an ∼330 kDa protein are linked to chloroquine-resistant P. falciparum in Southeast Asia and Africa
    • Su, X. Z., L. A. Kirkman, H. Fujioka, and T. E. Wellems. 1997. Complex polymorphisms in an ∼330 kDa protein are linked to chloroquine-resistant P. falciparum in Southeast Asia and Africa. Cell 91:593-603.
    • (1997) Cell , vol.91 , pp. 593-603
    • Su, X.Z.1    Kirkman, L.A.2    Fujioka, H.3    Wellems, T.E.4
  • 33
    • 0021848032 scopus 로고
    • Antimalarial drug susceptibility testing of Plasmodium falciparum in Thailand using a microdilution radioisotope method
    • Webster, H. K., E. F. Boudreau, K. Pavanand, K. Yongvanitchit, and L. W. Pang. 1985. Antimalarial drug susceptibility testing of Plasmodium falciparum in Thailand using a microdilution radioisotope method. Am. J. Trop. Med. Hyg. 34:228-235.
    • (1985) Am. J. Trop. Med. Hyg. , vol.34 , pp. 228-235
    • Webster, H.K.1    Boudreau, E.F.2    Pavanand, K.3    Yongvanitchit, K.4    Pang, L.W.5
  • 35
    • 0027074439 scopus 로고
    • Antimalarial drug resistance: The pace quickens
    • Review
    • White, N. J. 1992. Antimalarial drug resistance: the pace quickens. J. Antimicrob. Chemother. 30:571-585. (Review.)
    • (1992) J. Antimicrob. Chemother. , vol.30 , pp. 571-585
    • White, N.J.1
  • 36
    • 0024356582 scopus 로고
    • Amplification of a gene related to mammalian mdr genes in drug-resistant Plasmodium falciparum
    • Wilson, C. M., A. E. Serrano, A. Wasley, M. P. Bogenschutz, A. H. Shankar, and D. F. Wirth. 1989. Amplification of a gene related to mammalian mdr genes in drug-resistant Plasmodium falciparum. Science 244:1184-1186.
    • (1989) Science , vol.244 , pp. 1184-1186
    • Wilson, C.M.1    Serrano, A.E.2    Wasley, A.3    Bogenschutz, M.P.4    Shankar, A.H.5    Wirth, D.F.6
  • 37
    • 0027339057 scopus 로고
    • Amplification of pfmdr1 associated with mefloquine and halofantrine resistance in Plasmodium falciparum from Thailand
    • Wilson, C. M., S. K. Volkman, S. Thaithong, R. K. Martin, D. E. Kyle, W. K. Milhous, and D. F. Wirth. 1993. Amplification of pfmdr1 associated with mefloquine and halofantrine resistance in Plasmodium falciparum from Thailand. Mol. Biol. Parasitol. 57:151-160.
    • (1993) Mol. Biol. Parasitol. , vol.57 , pp. 151-160
    • Wilson, C.M.1    Volkman, S.K.2    Thaithong, S.3    Martin, R.K.4    Kyle, D.E.5    Milhous, W.K.6    Wirth, D.F.7
  • 38
    • 0031836529 scopus 로고    scopus 로고
    • Characterization of Plasmodium falciparum isolated from the Amazon region of Brazil: Evidence for quinine resistance
    • Zalis, M. G., L. Pang, M. S. Silveira, W. K. Milhous, and D. F. Wirth. 1998. Characterization of Plasmodium falciparum isolated from the Amazon region of Brazil: evidence for quinine resistance. Am. J. Trop. Med. Hyg. 58: 630-637.
    • (1998) Am. J. Trop. Med. Hyg. , vol.58 , pp. 630-637
    • Zalis, M.G.1    Pang, L.2    Silveira, M.S.3    Milhous, W.K.4    Wirth, D.F.5


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