The tyrosine-86 allele of the pfmdr1 gene of Plasmodium falciparum is associated with increased sensitivity to the anti-malarials mefloquine and artemisinin

Molecular and Biochemical Parasitology

Volumn 108, Issue 1, 2000, Pages 13-23

  Duraisingh, Manoj T ^a,b   Jones, Peter ^b   Sambou, Idrissa ^b   Von Seidlein, Lorenz ^b   Pinder, Margaret ^b   Warhurst, David C ^a  

^a LONDON SCHOOL OF HYGIENE AND TROPICAL MEDICINE   (United Kingdom)

^b MEDICAL RESEARCH COUNCIL LABORATORIES   (Gambia)

Author keywords

Artemisinin; Chloroquine; Drug resistance; Mefloquine; pfmdr1; Plasmodium falciparum

Indexed keywords

ARTEMISININ; CHLOROQUINE; DIHYDROARTEMISININ; HALOFANTRINE; MEFLOQUINE; QUININE; TYROSINE;

ALLELE; ARTICLE; BACTERIUM ISOLATION; DISEASE ASSOCIATION; DNA POLYMORPHISM; DRUG SENSITIVITY; GAMBIA; GENE MUTATION; MALARIA; PLASMODIUM FALCIPARUM; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL;

ALLELES; ANIMALS; ANTIMALARIALS; ARTEMISININS; ATP-BINDING CASSETTE TRANSPORTERS; HUMANS; MALARIA, FALCIPARUM; MEFLOQUINE; PLASMODIUM FALCIPARUM; POLYMERASE CHAIN REACTION; POLYMORPHISM, GENETIC; POLYMORPHISM, RESTRICTION FRAGMENT LENGTH; PROTOZOAN PROTEINS; SESQUITERPENES; TETRAHYDROFOLATE DEHYDROGENASE; TYROSINE;

BACTERIA (MICROORGANISMS); CINCHONA PUBESCENS; PLASMODIUM FALCIPARUM; PROTOZOA;

EID: 0034732666     PISSN: 01666851     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0166-6851(00)00201-2     Document Type: Article

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