-
1
-
-
0023734723
-
Progress in taxonomy of the apicomplexan protozoa
-
Levine ND: Progress in taxonomy of the apicomplexan protozoa. J Protozool 1988, 35:518-520.
-
(1988)
J Protozool
, vol.35
, pp. 518-520
-
-
Levine, N.D.1
-
2
-
-
0031554803
-
World malaria situation in 1994. Part I. Population at risk
-
World Health Organization: World malaria situation in 1994. Part I. Population at risk. Wkly Epidemiol Rec 1997, 72:269-274.
-
(1997)
Wkly Epidemiol Rec
, vol.72
, pp. 269-274
-
-
-
3
-
-
0029151285
-
Preventing toxoplasmic encephalitis in persons infected with human immunodeficiency virus
-
Richards FO Jr, Kovacs JA, Luft BJ: Preventing toxoplasmic encephalitis in persons infected with human immunodeficiency virus. Clin Infect Dis 1995, 21(suppl):49-56.
-
(1995)
Clin Infect Dis
, vol.21
, Issue.SUPPL.
, pp. 49-56
-
-
Richards F.O., Jr.1
Kovacs, J.A.2
Luft, B.J.3
-
4
-
-
0024546853
-
Stage specific actions of antimalarial drugs on Plasmodium falciparum in culture
-
Geary TG, Divo AA, Jensen JB: Stage specific actions of antimalarial drugs on Plasmodium falciparum in culture. Am J Trop Med Hygiene 1989, 40:240-244.
-
(1989)
Am J Trop Med Hygiene
, vol.40
, pp. 240-244
-
-
Geary, T.G.1
Divo, A.A.2
Jensen, J.B.3
-
5
-
-
0027955528
-
Clindamycin in combination with chloroquine or quinine is an effective therapy for uncomplicated Plasmodium falciparum malaria in children from Gabon
-
Kremsner PG, Winkler S, Brandts C, Neifer S, Bienzle U, Graninger W: Clindamycin in combination with chloroquine or quinine is an effective therapy for uncomplicated Plasmodium falciparum malaria in children from Gabon. J Infect Dis 1994, 169:467-470.
-
(1994)
J Infect Dis
, vol.169
, pp. 467-470
-
-
Kremsner, P.G.1
Winkler, S.2
Brandts, C.3
Neifer, S.4
Bienzle, U.5
Graninger, W.6
-
6
-
-
0027211078
-
Antimalarial activity of rifampin in vitro and in rodent models
-
Strath M, Scott-Finnegan T, Gardner M, Williamson D, Wilson I: Antimalarial activity of rifampin in vitro and in rodent models. Trans R Soc Trop Med Hyg 1993, 87:211-216.
-
(1993)
Trans R Soc Trop Med Hyg
, vol.87
, pp. 211-216
-
-
Strath, M.1
Scott-Finnegan, T.2
Gardner, M.3
Williamson, D.4
Wilson, I.5
-
7
-
-
0025917362
-
In vivo activity of the macrolide antibiotics azithromycin, roxithromycin, and spiramycin against Toxoplasma gondii
-
Araujo FG, Shepard RM, Remington JS: In vivo activity of the macrolide antibiotics azithromycin, roxithromycin, and spiramycin against Toxoplasma gondii. Eur J Clin Microbiol Infect Dis 1991, 10:519-524.
-
(1991)
Eur J Clin Microbiol Infect Dis
, vol.10
, pp. 519-524
-
-
Araujo, F.G.1
Shepard, R.M.2
Remington, J.S.3
-
8
-
-
0028013554
-
Comparison of mutants of Toxoplasma gondii selected for resistance to azithromycin, spiramycin, or clindamycin
-
Pfefferkorn ER, Borotz SE: Comparison of mutants of Toxoplasma gondii selected for resistance to azithromycin, spiramycin, or clindamycin. Antimicr Agents Chemother 1994, 38:31-37.
-
(1994)
Antimicr Agents Chemother
, vol.38
, pp. 31-37
-
-
Pfefferkorn, E.R.1
Borotz, S.E.2
-
9
-
-
0029044369
-
In vitro assays elucidate the peculiar mechanism of macrolide/lincosamide action against Toxoplasma gondii
-
Fichera, ME, Bhopale MK, Roos DS: In vitro assays elucidate the peculiar mechanism of macrolide/lincosamide action against Toxoplasma gondii. Antimicr Agents Chemother 1995, 39:1530-1537.
-
(1995)
Antimicr Agents Chemother
, vol.39
, pp. 1530-1537
-
-
Fichera, M.E.1
Bhopale, M.K.2
Roos, D.S.3
-
10
-
-
0030028511
-
Rifapentine is active in vitro and in vivo against Toxoplasma gondii
-
Araujo FG, Khan AA, Remington JS: Rifapentine is active in vitro and in vivo against Toxoplasma gondii. Antimicr Agents Chemother 1996, 40:1335-1337.
-
(1996)
Antimicr Agents Chemother
, vol.40
, pp. 1335-1337
-
-
Araujo, F.G.1
Khan, A.A.2
Remington, J.S.3
-
11
-
-
0030902084
-
Activity of trovafloxacin in combination with other drugs for treatment of acute murine toxoplasmosis
-
Khan AA, Slifer T, Araujo FG, Polzer RJ, Remington JS: Activity of trovafloxacin in combination with other drugs for treatment of acute murine toxoplasmosis. Antimicr Agents Chemother 1997, 41:893-897.
-
(1997)
Antimicr Agents Chemother
, vol.41
, pp. 893-897
-
-
Khan, A.A.1
Slifer, T.2
Araujo, F.G.3
Polzer, R.J.4
Remington, J.S.5
-
12
-
-
0015134820
-
Plasmodium: The fine structure of malarial parasites
-
Aikawa M: Plasmodium: The fine structure of malarial parasites. Exp Parasitol 1971, 30:284-320.
-
(1971)
Exp Parasitol
, vol.30
, pp. 284-320
-
-
Aikawa, M.1
-
13
-
-
0002330447
-
Ultrastructure
-
Edited by Long PL. Baltimore: University Park Press
-
Chobotar B, Scholtyseck E: Ultrastructure. In The Biology of the Coccidia. Edited by Long PL. Baltimore: University Park Press; 1982:101-165.
-
(1982)
The Biology of the Coccidia
, pp. 101-165
-
-
Chobotar, B.1
Scholtyseck, E.2
-
14
-
-
0030566712
-
Identification and localization of rab6, separation of rab6 from ERD2 and implications for an 'unstacked' Golgi in plasmodium falciparum
-
Van Wye J, Ghori N, Webster P, Mitschler RR, Elmendorf HG, Haldar K: Identification and localization of rab6, separation of rab6 from ERD2 and implications for an 'unstacked' Golgi in plasmodium falciparum. Mol Bioch Parasitol 1996, 83:107-120.
-
(1996)
Mol Bioch Parasitol
, vol.83
, pp. 107-120
-
-
Van Wye, J.1
Ghori, N.2
Webster, P.3
Mitschler, R.R.4
Elmendorf, H.G.5
Haldar, K.6
-
15
-
-
0031081556
-
Rab GTPases and the unusual secretory pathway of Plasmodium
-
Ward GE, Tilney LG, Langsley G: Rab GTPases and the unusual secretory pathway of Plasmodium. Parasitol Today 1997, 13:57-62.
-
(1997)
Parasitol Today
, vol.13
, pp. 57-62
-
-
Ward, G.E.1
Tilney, L.G.2
Langsley, G.3
-
17
-
-
12744257602
-
Chromosome 2 sequence of the human malaria parasite Plasmodium falciparum
-
Gardner MJ, Tettelin H, Carucci DJ, Cummings LM, Aravind L, Koonin EV, Shallom S, Mason T, Yu K, Fujii C et al.: Chromosome 2 sequence of the human malaria parasite Plasmodium falciparum. Science 1998, 282:1126-1132. The first complete DNA sequence of a malaria chromosome. Genes contained on this chromosome encode several proteins that are likely to be associated with endosymbiotic organelles (the mitochondrion and apicoplast), including two probable subunits of a type II fatty acyl synthase complex:acyl carrier protein and 3-ketoacyl carrier protein synthase. Import into the apicoplast has been proven for the T. gondii acyl carrier protein homolog (also identified by database analysis) [60], validating informatics-based data-mining as a productive route for the identification of nuclear-encoded apicoplast proteins.
-
(1998)
Science
, vol.282
, pp. 1126-1132
-
-
Gardner, M.J.1
Tettelin, H.2
Carucci, D.J.3
Cummings, L.M.4
Aravind, L.5
Koonin, E.V.6
Shallom, S.7
Mason, T.8
Yu, K.9
Fujii, C.10
-
18
-
-
85030361912
-
-
P. falciparum Genome Sequencing Consortium on World Wide Web URL: http://www.sanger.ac.uk/Projects/P_falciparum/who&what.shtml This Web site, along with [19-21], provides access to data from the international malaria genome project consortium, which expects sequencing of the Plasmodium falciparum genome to be substantially complete by the end of the year in 2000. Web sites from individual sequencing centers (The Sanger Center, Cambridge UK; The Institute for Genomic Research, Rockville, MD USA; Stanford University, Stanford, CA USA) and the National Institutes of Health (Bethesda, MD, USA) provide BLAST-searchable databases, graphical user interfaces, motif searches, and other useful tools for data mining.
-
-
-
-
19
-
-
85030369895
-
-
The Plasmodium falciparum Genome Database (PFDB) on World Wide Web URL: http://www.tigr.org/tdb/edb/pfdb/pfdb.html See annotation [18].
-
-
-
-
20
-
-
85030361039
-
-
Plasmodium falciparum (Pf) Genome Project Sequencing at Stanford DNA Sequence and Technology Center Chromosome 12 on World Wide Web URL: http://sequence-www.stanford.edu/ group/malaria/index.html See annotation [18].
-
-
-
-
21
-
-
85030367915
-
-
Malaria Genetic & Genomics on World Wide Web URL: http://ncbi.nlm.nih.gov/Malaria/index.html See annotation [18].
-
-
-
-
22
-
-
0031887672
-
Gene discovery by EST sequencing in Toxoplasma gondii reveals sequences restricted to the apicomplexa
-
Ajioka J, Boothroyd JC, Brunk BP, Hehl A, Hillier L, Manger ID, Overton GC, Marra M, Roos DS, Wan KL et al.: Gene discovery by EST sequencing in Toxoplasma gondii reveals sequences restricted to the apicomplexa. Genome Research 1998, 8:18-28. An international consortium produced >10,000 ESTs from the tachyzoite and bradyzoite stages of T. gondii, defining several thousand genes, including many putative nuclear-encoded plastid genes [60].
-
(1998)
Genome Research
, vol.8
, pp. 18-28
-
-
Ajioka, J.1
Boothroyd, J.C.2
Brunk, B.P.3
Hehl, A.4
Hillier, L.5
Manger, I.D.6
Overton, G.C.7
Marra, M.8
Roos, D.S.9
Wan, K.L.10
-
23
-
-
85030363520
-
-
Mining data from dbEST - querying the Toxoplasma gondii expressed sequence tag (EST) database on World Wide Web URL: http://www.cbil.upenn.edu/ParaDBs/Toxoplasma/index.html A Web site designed to facilitate data-mining from T. gondii EST sequences. More than 10,000 ESTs are grouped into ≃4600 clusters in a BLAST-searchable database that permits identification of stage- and strain-specific transcripts and polymorphisms, identification of gene families and differentially spliced transcripts, analysis of sequence motifs, and text queries of the results from BLAST searches of GenBank. The success of this Web site has led to the establishment of several similar databases for other parasite ESTs (http://www.cbil.upenn.edu/ParaDBs/).
-
-
-
-
24
-
-
0028709114
-
Molecular tools for genetic dissection of the protozoan parasite Toxoplasma gondii
-
Roos DS, Donald RGK, Morrissette NS, Moulton ALC: Molecular tools for genetic dissection of the protozoan parasite Toxoplasma gondii. Methods Cell Biol 1994, 45:27-63.
-
(1994)
Methods Cell Biol
, vol.45
, pp. 27-63
-
-
Roos, D.S.1
Donald, R.G.K.2
Morrissette, N.S.3
Moulton, A.L.C.4
-
25
-
-
0002445757
-
Forward and reverse genetics in the study of the obligate intracellular parasite Toxoplasma gondii
-
Boothroyd JC, Kim K, Pfefferkorn ER, Sibley LD, Soldati D: Forward and reverse genetics in the study of the obligate intracellular parasite Toxoplasma gondii. Methods Mol Genet 1994, 3:1-29.
-
(1994)
Methods Mol Genet
, vol.3
, pp. 1-29
-
-
Boothroyd, J.C.1
Kim, K.2
Pfefferkorn, E.R.3
Sibley, L.D.4
Soldati, D.5
-
26
-
-
0030035041
-
Transformation of Plasmodium falciparum malaria parasites by homologous integration of plasmids that confer resistance to pyrimethamine
-
Wu Y, Kirkman LA, Wellems TE: Transformation of Plasmodium falciparum malaria parasites by homologous integration of plasmids that confer resistance to pyrimethamine. Proc Natl Acad Sci USA 1996, 93:1130-1134.
-
(1996)
Proc Natl Acad Sci USA
, vol.93
, pp. 1130-1134
-
-
Wu, Y.1
Kirkman, L.A.2
Wellems, T.E.3
-
27
-
-
0001110354
-
Transfection of malaria parasites
-
Waters AP, Thomas AW, van Dijk MR, Janse CJ: Transfection of malaria parasites. Methods 1997, 13:134-147.
-
(1997)
Methods
, vol.13
, pp. 134-147
-
-
Waters, A.P.1
Thomas, A.W.2
Van Dijk, M.R.3
Janse, C.J.4
-
28
-
-
0031452191
-
Stable transgene expression in Plasmodium falciparum
-
Crabb BS, Triglia T, Waterkeyn JG, Cowman AF: Stable transgene expression in Plasmodium falciparum. Mol Bioch Parasitol 1997, 90:131-144.
-
(1997)
Mol Bioch Parasitol
, vol.90
, pp. 131-144
-
-
Crabb, B.S.1
Triglia, T.2
Waterkeyn, J.G.3
Cowman, A.F.4
-
29
-
-
0031255827
-
Tagging genes and trapping promoters in Toxoplasma gondii by insertional mutagenesis
-
Roos DS, Sullivan WJ, Striepen B, Bohne W, Donald RGK: Tagging genes and trapping promoters in Toxoplasma gondii by insertional mutagenesis. Methods 1997, 13:112-122.
-
(1997)
Methods
, vol.13
, pp. 112-122
-
-
Roos, D.S.1
Sullivan, W.J.2
Striepen, B.3
Bohne, W.4
Donald, R.G.K.5
-
30
-
-
0028090066
-
The extrachromosomal DNAs of apicomplexan parasites
-
Feagin JE: The extrachromosomal DNAs of apicomplexan parasites. Annu Rev Microbiol 1994, 48:81-104.
-
(1994)
Annu Rev Microbiol
, vol.48
, pp. 81-104
-
-
Feagin, J.E.1
-
32
-
-
15844369205
-
Plastid in human parasites
-
McFadden GI, Reith ME, Mulholland J, Lang-Unnasch N. Plastid in human parasites. Nature 1996, 381:482.
-
(1996)
Nature
, vol.381
, pp. 482
-
-
McFadden, G.I.1
Reith, M.E.2
Mulholland, J.3
Lang-Unnasch, N.4
-
33
-
-
0040982083
-
A plastid of probable green algal origin in apicomplexan parasites
-
Köhler S, Delwiche CF, Denny PW, Tilney LG, Webster P, Wilson RJM, Palmer JD, Roos DS: A plastid of probable green algal origin in apicomplexan parasites. Science 1997, 275:1485-1488.
-
(1997)
Science
, vol.275
, pp. 1485-1488
-
-
Köhler, S.1
Delwiche, C.F.2
Denny, P.W.3
Tilney, L.G.4
Webster, P.5
Wilson, R.J.M.6
Palmer, J.D.7
Roos, D.S.8
-
35
-
-
0032815207
-
Apicomplexan plastids as drug targets
-
McFadden GI, Roos DS: Apicomplexan plastids as drug targets. Trends Microbiol 1999; 7:328-333. A recent review of possible apicoplast functions, focusing on the potential of this organelle as a drug target for parasiticidal chemotherapy. Also considers the number of membranes surrounding the apicoplast, concluding that the T. gondii organelle is enclosed by four membranes.
-
(1999)
Trends Microbiol
, vol.7
, pp. 328-333
-
-
McFadden, G.I.1
Roos, D.S.2
-
36
-
-
0030590259
-
Complete gene map of the plastid-like DNA of the malaria parasite Plasmodium falciparum
-
Wilson RJM, Denny PW, Preiser PR, Roberts K, Roy A, Whyte A, Strath M, Moore DJ, Williamson DH: Complete gene map of the plastid-like DNA of the malaria parasite Plasmodium falciparum. J Mol Biol 1997, 261:155-172. This paper presents the first complete map of an apicomplexan plastid genome, and a thorough discussion of apicoplast genome organization, gene identification and gene expression. See [31] for a comprehensive and well-written review on the mitochondrial and apicoplast DNAs of Plasmodium, Toxoplasma, and other apicomplexa (including a discussion of the evolution and possible functions of these organelles). Also see [33,39 for in situ localization and phylogenetic analysis.
-
(1997)
J Mol Biol
, vol.261
, pp. 155-172
-
-
Wilson, R.J.M.1
Denny, P.W.2
Preiser, P.R.3
Roberts, K.4
Roy, A.5
Whyte, A.6
Strath, M.7
Moore, D.J.8
Williamson, D.H.9
-
37
-
-
85030369771
-
-
Toxoplasma gondii 35kb plastid DNA annotation on World Wide Web URL: http://www.sas.upenn.edu/~jkissing/toxomap.html Web site providing a complete map of the 35 kb apicoplast genome from T. gondii, updated annotation, and comparisons with the P. falciparum apicoplast genome.
-
-
-
-
38
-
-
0031850991
-
Evidence for a single origin on the 35 kb plastid DNA in apicomplexans
-
Denny P, Preiser P, Williamson D, Wilson I: Evidence for a single origin on the 35 kb plastid DNA in apicomplexans. Protist 1998, 149:51-59.
-
(1998)
Protist
, vol.149
, pp. 51-59
-
-
Denny, P.1
Preiser, P.2
Williamson, D.3
Wilson, I.4
-
39
-
-
0000115839
-
Plastids in apicomplexan parasites
-
Edited by Bhattacharya D. New York: Springer-Verlag
-
McFadden GI, Waller RF, Reith ME, Lang-Unnasch N: Plastids in apicomplexan parasites. In Origins of Algae and their Plastids. Edited by Bhattacharya D. New York: Springer-Verlag; 1997:261-287. A helpful review of apicoplast distribution among the apicomplexa, including a useful discussion of genome structure, arguing for red-algal affinity based on the organization of ribosomal protein genes. Also see [33] for molecular phylogenetic analysis of the elongation factor Tu gene, which provides support for a green algal origin of the apicoplast.
-
(1997)
Origins of Algae and their Plastids
, pp. 261-287
-
-
McFadden, G.I.1
Waller, R.F.2
Reith, M.E.3
Lang-Unnasch, N.4
-
40
-
-
0026017244
-
Ribosomal RNA sequences of Sarcocystis muris, Theileria annulata and Crypthecodinium cohnii reveal evolutionary relationships among apicomplexans, dinoflagellates, and ciliates
-
Gajadhar AA, Marquadt WC, Hall R, Gunderson J, Ariztia-Carmona EV, Sogin ML: Ribosomal RNA sequences of Sarcocystis muris, Theileria annulata and Crypthecodinium cohnii reveal evolutionary relationships among apicomplexans, dinoflagellates, and ciliates. Mol Bioch Parasitol 1991, 45:147-154.
-
(1991)
Mol Bioch Parasitol
, vol.45
, pp. 147-154
-
-
Gajadhar, A.A.1
Marquadt, W.C.2
Hall, R.3
Gunderson, J.4
Ariztia-Carmona, E.V.5
Sogin, M.L.6
-
41
-
-
0028998727
-
Evolutionary origins of Plasmodium and other apicomplexa based on rRNA genes
-
Escalante AA, Ayala FJ: Evolutionary origins of Plasmodium and other apicomplexa based on rRNA genes. Proc Natl Acad Sci USA 1995, 92:5793-5797.
-
(1995)
Proc Natl Acad Sci USA
, vol.92
, pp. 5793-5797
-
-
Escalante, A.A.1
Ayala, F.J.2
-
42
-
-
0027145102
-
Kingdom protozoa and its 18 phyla
-
Cavalier-Smith T: Kingdom protozoa and its 18 phyla. Microbiol Rev 1993, 57:953-994.
-
(1993)
Microbiol Rev
, vol.57
, pp. 953-994
-
-
Cavalier-Smith, T.1
-
43
-
-
0002097030
-
The evolution of algal chloroplasts
-
Edited by Lewin RA. London: Chapman & Hall
-
Gibbs SP: The evolution of algal chloroplasts. In Origins of Plastids. Edited by Lewin RA. London: Chapman & Hall; 1993:107-121.
-
(1993)
Origins of Plastids
, pp. 107-121
-
-
Gibbs, S.P.1
-
44
-
-
0030598645
-
Second-hand chloroplasts and the case of the disappearing nucleus
-
Palmer JD, Delwiche CF: Second-hand chloroplasts and the case of the disappearing nucleus. Proc Natl Acad Sci USA 1996, 93:7432-7435.
-
(1996)
Proc Natl Acad Sci USA
, vol.93
, pp. 7432-7435
-
-
Palmer, J.D.1
Delwiche, C.F.2
-
45
-
-
0002962230
-
The origin of plastids and their spread via secondary endosymbiosis
-
Edited by Bhattacharya D. Vienna: Springer-Verlag
-
Delwiche CF, Palmer JD: The origin of plastids and their spread via secondary endosymbiosis. In Origins of Algae and their Plastids. Edited by Bhattacharya D. Vienna: Springer-Verlag; 1997:53-86. This comprehensive review examines the molecular, biochemical and ultrastructural data available for plastids, and discusses how processes such as gene transfer and gene loss have played an important role in plastid evolution. Special emphasis is given to the role of molecular phylogenetics and the analysis of entire genomes (in addition to individual genes).
-
(1997)
Origins of Algae and their Plastids
, pp. 53-86
-
-
Delwiche, C.F.1
Palmer, J.D.2
-
46
-
-
0031738436
-
Plastid evolution: Origins, diversity, trends
-
Douglas SE: Plastid evolution: Origins, diversity, trends. Curr Opin Genet Dev 1998, 8:655-661. A review of the molecular evidence for plastid origins, providing possible scenarios for primary, secondary and tertiary endosymbioses. Incorporates recent data based on the analysis of complete plastid genome sequences.
-
(1998)
Curr Opin Genet Dev
, vol.8
, pp. 655-661
-
-
Douglas, S.E.1
-
47
-
-
0030985044
-
Peculiarities of the symbiotic systems of protists with diverse patterns of cellular organization
-
Ossipov DV, Karpov SA, Smirnov AV, Rautian MS: Peculiarities of the symbiotic systems of protists with diverse patterns of cellular organization. Acta Protozoologica 1997, 36:3-21. An extensive review of the literature on symbiotic associations in the protozoa (focusing on ciliates), including associations that may represent early stages of endosymbiosis. Particularly strong in its review of Russian literature that is not easily accessible elsewhere.
-
(1997)
Acta Protozoologica
, vol.36
, pp. 3-21
-
-
Ossipov, D.V.1
Karpov, S.A.2
Smirnov, A.V.3
Rautian, M.S.4
-
48
-
-
0031026931
-
Phylogenetic affinity of mitochondria of euglena gracilis and kinetoplastids using cytochrome oxidase I and hsp60
-
Yasuhira S, Simpson L: Phylogenetic affinity of mitochondria of euglena gracilis and kinetoplastids using cytochrome oxidase I and hsp60. J Mol Evol 1997, 44:341-347.
-
(1997)
J Mol Evol
, vol.44
, pp. 341-347
-
-
Yasuhira, S.1
Simpson, L.2
-
49
-
-
0001030798
-
The chloroplasts of Euglena may have evolved from symbiotic green algae
-
Gibbs SP: The chloroplasts of Euglena may have evolved from symbiotic green algae. Can J Bot 1978, 56:2883-2889.
-
(1978)
Can J Bot
, vol.56
, pp. 2883-2889
-
-
Gibbs, S.P.1
-
50
-
-
0028832133
-
Inhibition of cytoplasmic and organellar protein synthesis in Toxoplasma gondii: Implications for the target of macrolide antibiotics
-
Beckers CJM, Roos DS, Donald RGK, Luft BJ, Schwab JC, Cao Y, Joiner KA: Inhibition of cytoplasmic and organellar protein synthesis in Toxoplasma gondii: Implications for the target of macrolide antibiotics. J Clin Invest 1995, 95:367-376.
-
(1995)
J Clin Invest
, vol.95
, pp. 367-376
-
-
Beckers, C.J.M.1
Roos, D.S.2
Donald, R.G.K.3
Luft, B.J.4
Schwab, J.C.5
Cao, Y.6
Joiner, K.A.7
-
51
-
-
0031030313
-
Inhibition of Plasmodium falciparum protein synthesis. Targeting the plastid-like organelle with thiostrepton
-
McConkey GA, Rogers MJ, McCutchan TF: Inhibition of Plasmodium falciparum protein synthesis. Targeting the plastid-like organelle with thiostrepton. J Biol Chem 1997, 272:2046-2049. This paper presents evidence that the large subunit rRNA encoded in the apicoplast genome is a probable target of thiopeptide antibiotics, which are highly effective against P. falciparum in vitro. In addition, rifampicin is shown to specifically inhibit transcription of the 35 kb apicoplast genome, suggesting that this drug targets the plastid-encoded RNA polymerase.
-
(1997)
J Biol Chem
, vol.272
, pp. 2046-2049
-
-
McConkey, G.A.1
Rogers, M.J.2
McCutchan, T.F.3
-
52
-
-
0031407768
-
DNA gyrase, topoisomerase IV, and the 4-quinolones
-
Drlica K, Zhao X: DNA gyrase, topoisomerase IV, and the 4-quinolones. Microbiol Mol Biol Rev 1997, 61:377-392.
-
(1997)
Microbiol Mol Biol Rev
, vol.61
, pp. 377-392
-
-
Drlica, K.1
Zhao, X.2
-
53
-
-
0031444101
-
A plastid organelle as a drug target in apicomplexan parasites
-
Fichera ME, Roos DS: A plastid organelle as a drug target in apicomplexan parasites. Nature 1997, 389:407-409.
-
(1997)
Nature
, vol.389
, pp. 407-409
-
-
Fichera, M.E.1
Roos, D.S.2
-
54
-
-
0031431683
-
Topoisomerase II inhibitors induce cleavage of nuclear and 35 kb plastid DNAs in the malaria parasite Plasmodium falciparum
-
Weissig V, Vetro-Widenhouse TS, Rowe TC: Topoisomerase II inhibitors induce cleavage of nuclear and 35 kb plastid DNAs in the malaria parasite Plasmodium falciparum. DNA Cell Biol 1997, 16:1483-1492. Along with [53], this paper provides evidence that the fluoroquinolone antibiotic ciprofloxacin specifically reduces copy number of the apicoplast genome, presumably via inhibition of a prokaryotic-type DNA gyrase.
-
(1997)
DNA Cell Biol
, vol.16
, pp. 1483-1492
-
-
Weissig, V.1
Vetro-Widenhouse, T.S.2
Rowe, T.C.3
-
56
-
-
0029731659
-
Import and routing of nucleus-encoded chloroplast proteins
-
Cline K, Henry R: Import and routing of nucleus-encoded chloroplast proteins. Annu Rev Cell Devel Biol 1996, 12:1-26.
-
(1996)
Annu Rev Cell Devel Biol
, vol.12
, pp. 1-26
-
-
Cline, K.1
Henry, R.2
-
57
-
-
0030969942
-
Protein import into mitochondria
-
Neupert W: Protein import into mitochondria. Annu Rev Bioch 1997, 66:863-917.
-
(1997)
Annu Rev Bioch
, vol.66
, pp. 863-917
-
-
Neupert, W.1
-
58
-
-
0031106617
-
Import of proteins into mitochondria and chloroplasts
-
Haucke V, Schatz G: Import of proteins into mitochondria and chloroplasts. Trends Cell Biol 1997, 7:103-106.
-
(1997)
Trends Cell Biol
, vol.7
, pp. 103-106
-
-
Haucke, V.1
Schatz, G.2
-
59
-
-
0028815455
-
Parasitic apicomplexans harbor a chlorophyll a-D1 complex, the potential target for therapeutic triazines
-
Hackstein JHP, Mackenstedt U, Mehlhorn H, Meijerink JPP, Schubert H, Leunissen JAM: Parasitic apicomplexans harbor a chlorophyll a-D1 complex, the potential target for therapeutic triazines. Parasitol Res 1995, 81:207-216.
-
(1995)
Parasitol Res
, vol.81
, pp. 207-216
-
-
Hackstein, J.H.P.1
Mackenstedt, U.2
Mehlhorn, H.3
Meijerink, J.P.P.4
Schubert, H.5
Leunissen, J.A.M.6
-
60
-
-
0344549379
-
Nuclear-encoded proteins target to the plastid in Toxoplasma gondii and Plasmodium falciparum
-
Waller RF, Keeling PJ, Donald RGK, Striepen B, Handman E, Lang-Unnasch N, Cowman AF, Besra GS, Roos DS, McFadden GI: Nuclear-encoded proteins target to the plastid in Toxoplasma gondii and Plasmodium falciparum. Proc Natl Acad Sci USA 1998, 95:12352-12357. The first proof of nuclear-encoded apicoplast genes. Sequences obtained from the T. gondii EST and P. falciparum genome databases [17,18-21,22,23] exhibit phylogenetic and/or structural features of nuclear-encoded plastid genes. These proteins were shown to localize to the apicoplast by immuno-electron microscopy (using antibody to recombinant protein), and by virtue of their ability to target recombinant fusion proteins to the apicoplast in transgenic parasites.
-
(1998)
Proc Natl Acad Sci USA
, vol.95
, pp. 12352-12357
-
-
Waller, R.F.1
Keeling, P.J.2
Donald, R.G.K.3
Striepen, B.4
Handman, E.5
Lang-Unnasch, N.6
Cowman, A.F.7
Besra, G.S.8
Roos, D.S.9
McFadden, G.I.10
-
61
-
-
0032565968
-
Evidence for the shikimate pathway in apicomplexan parasites
-
Roberts F, Roberts CW, Johnson JJ, Kyle DE, Krell T, Coggins JR, Coombs GH, Milhous WK, Tzipori S, Ferguson DJ, Chakrabarti D, McLeod R: Evidence for the shikimate pathway in apicomplexan parasites. Nature 1998, 393:801-805.
-
(1998)
Nature
, vol.393
, pp. 801-805
-
-
Roberts, F.1
Roberts, C.W.2
Johnson, J.J.3
Kyle, D.E.4
Krell, T.5
Coggins, J.R.6
Coombs, G.H.7
Milhous, W.K.8
Tzipori, S.9
Ferguson, D.J.10
Chakrabarti, D.11
McLeod, R.12
-
62
-
-
0033590505
-
Shikimate in apicomplexa ... But not in the plastid
-
Keeling PJ, Palmer JD, Donald RGK, Roos DS, Waller RF, McFadden GI: Shikimate in apicomplexa ... but not in the plastid. Nature 1999, 397:219-220.
-
(1999)
Nature
, vol.397
, pp. 219-220
-
-
Keeling, P.J.1
Palmer, J.D.2
Donald, R.G.K.3
Roos, D.S.4
Waller, R.F.5
McFadden, G.I.6
-
63
-
-
0032078205
-
Expression, selection, and organellar targeting of the green fluorescent protein in Toxoplasma gondii
-
Striepen, B, He CY, Matrajt M, Soldati D, Roos DS: Expression, selection, and organellar targeting of the green fluorescent protein in Toxoplasma gondii. Mol Bioch Parasitol 1998, 92:328-338. Development of the green fluorescent protein as a recombinant reporter for organellar targeting (and other) studies in Toxoplasma.
-
(1998)
Mol Bioch Parasitol
, vol.92
, pp. 328-338
-
-
Striepen, B.1
He, C.Y.2
Matrajt, M.3
Soldati, D.4
Roos, D.S.5
-
64
-
-
85030369666
-
-
T. gondii parasite expressing green fluorescent protein fusions on World Wide Web URL: http://www.sas.upenn.edu/~striepen/gfp.html A gallery of intracellular organelle labelling in transgenic T. gondii parasites expressing various green fluorescent protein (GFP) fusion proteins. This Web site includes images of apicoplast labelling in living parasites, and time-lapse video-microscopy of organellar replication during mitosis (endodyogeny).
-
-
-
-
65
-
-
0030733819
-
Mechanism of protein targeting to the chlorarachniophyte plastids and the evolution of complex plastids with four membranes: A hypothesis
-
Bodyl A: Mechanism of protein targeting to the chlorarachniophyte plastids and the evolution of complex plastids with four membranes: A hypothesis. Boten Acta 1997, 110:395-400.
-
(1997)
Boten Acta
, vol.110
, pp. 395-400
-
-
Bodyl, A.1
-
66
-
-
0032169539
-
Protein import into cyanelles and complex chloroplasts
-
Schwartzbach SD, Osafune T, Löffelhardt W: Protein import into cyanelles and complex chloroplasts. Plant Mol Biol 1998, 38:247-263. A survey of literature on protein import into secondary endosymbiotic plastids. Highlights fundamental differences in the mechanism of import into classic chloroplasts and cyanelles (primary endosymbionts) versus various types of secondary endosymbiotic plastids with distinct evolutionary histories.
-
(1998)
Plant Mol Biol
, vol.38
, pp. 247-263
-
-
Schwartzbach, S.D.1
Osafune, T.2
Löffelhardt, W.3
-
67
-
-
0032955849
-
Topology of Euglena chloroplast protein precursors within endoplasmic reticulum to Golgi to chloroplast transport vesicles
-
Sulli C, Fang Z, Muchhal U, Schwartzbach SD: Topology of Euglena chloroplast protein precursors within endoplasmic reticulum to Golgi to chloroplast transport vesicles. J Biol Chem 1999, 274:457-463.
-
(1999)
J Biol Chem
, vol.274
, pp. 457-463
-
-
Sulli, C.1
Fang, Z.2
Muchhal, U.3
Schwartzbach, S.D.4
-
68
-
-
0028928697
-
The gene family encoding the fucoxanthin chlorophyll proteins from the brown alga Macrocystis pyrifera
-
Apt KE, Clendennen SK, Powers DA, Grossman AR: The gene family encoding the fucoxanthin chlorophyll proteins from the brown alga Macrocystis pyrifera. Molec Gen Genet 1995, 246:455-464.
-
(1995)
Molec Gen Genet
, vol.246
, pp. 455-464
-
-
Apt, K.E.1
Clendennen, S.K.2
Powers, D.A.3
Grossman, A.R.4
-
69
-
-
0032553297
-
Protein transport into 'complex' diatom plastids utilizes two different targeting signals
-
Lang M, Apt KE, Kroth PG: Protein transport into 'complex' diatom plastids utilizes two different targeting signals. J Biol Chem 1998, 273:30973-30978.
-
(1998)
J Biol Chem
, vol.273
, pp. 30973-30978
-
-
Lang, M.1
Apt, K.E.2
Kroth, P.G.3
-
70
-
-
0030614959
-
Identification of prokaryotic and eukaryotic signal peptides and prediction of their cleavage sites
-
Nielsen H, Engelbrecht J, Brunak S, von Heijne G: Identification of prokaryotic and eukaryotic signal peptides and prediction of their cleavage sites. Prof Engineering 1997, 10:1-6.
-
(1997)
Prof Engineering
, vol.10
, pp. 1-6
-
-
Nielsen, H.1
Engelbrecht, J.2
Brunak, S.3
Von Heijne, G.4
-
71
-
-
0028170807
-
Signal sequence recognition and protein targeting to the endoplasmic reticulum membrane
-
Walter P, Johnson AE: Signal sequence recognition and protein targeting to the endoplasmic reticulum membrane. Annu Rev Cell Biol 1994, 10:87-119.
-
(1994)
Annu Rev Cell Biol
, vol.10
, pp. 87-119
-
-
Walter, P.1
Johnson, A.E.2
-
72
-
-
0029897169
-
Rampant horizontal transfer and duplication of rubisco genes in eubacteria and plastids
-
Delwiche CF, Palmer JD: Rampant horizontal transfer and duplication of rubisco genes in eubacteria and plastids. Mol Biol Evol 1996, 13:873-882.
-
(1996)
Mol Biol Evol
, vol.13
, pp. 873-882
-
-
Delwiche, C.F.1
Palmer, J.D.2
-
73
-
-
0032516147
-
Gene transfer to the nucleus and the evolution of chloroplasts
-
Martin W, Stoebe B, Goremykin V, Hansmann S, Hasegawa M, Kowallik KV: Gene transfer to the nucleus and the evolution of chloroplasts. Nature 1998, 393:162-165. This paper exploits the availability of organellar sequence data to track the loss of genes from the plastid to the host cell nucleus (and nucleomorph), and generates a comprehensive tree for the evolution of plastids as primary and secondary endosymbionts.
-
(1998)
Nature
, vol.393
, pp. 162-165
-
-
Martin, W.1
Stoebe, B.2
Goremykin, V.3
Hansmann, S.4
Hasegawa, M.5
Kowallik, K.V.6
-
74
-
-
0033082247
-
Mosaic bacterial chromosomes: A challenge en route to a tree of genomes
-
Martin W: Mosaic bacterial chromosomes: A challenge en route to a tree of genomes. Bioessays 1999, 21:99-104. A review of new evidence on the prominence of lateral genetic transfer in bacterial evolution, amplifying the need to revise classic views of the evolutionary 'tree of life'.
-
(1999)
Bioessays
, vol.21
, pp. 99-104
-
-
Martin, W.1
-
75
-
-
0032512051
-
The genome sequence of Rickettsia prowazekii and the origin of mitochondria
-
Andersson SG, Zomorodipuor A, Andersson JO, Sicheritz-Ponten T, Alsmark UC, Podowski RM, Naslund AK, Eriksson AS, Winkler HH, Kurland CG: The genome sequence of Rickettsia prowazekii and the origin of mitochondria. Nature 1998, 396:133-140. The first complete genomic sequence of an α-proteobacterium supports an endosymbiotic origin for mitochondria.
-
(1998)
Nature
, vol.396
, pp. 133-140
-
-
Andersson, S.G.1
Zomorodipuor, A.2
Andersson, J.O.3
Sicheritz-Ponten, T.4
Alsmark, U.C.5
Podowski, R.M.6
Naslund, A.K.7
Eriksson, A.S.8
Winkler, H.H.9
Kurland, C.G.10
-
77
-
-
0031586003
-
Prediction of complete gene structures in human genomic DNA
-
Burge C, Karlin S: Prediction of complete gene structures in human genomic DNA. J Mol Biol 1997, 268:78-94. Pioneering work on the use of Hidden Markov Models for the identification of DNA and protein motifs.
-
(1997)
J Mol Biol
, vol.268
, pp. 78-94
-
-
Burge, C.1
Karlin, S.2
-
78
-
-
0031678064
-
A homology identification method that combines protein sequence and structure information
-
Yu L, White JV, Smith TF: A homology identification method that combines protein sequence and structure information. Prot Sci 1998, 7:2499-2510. A Hidden Markov Model-based approach to the identification of signal sequences.
-
(1998)
Prot Sci
, vol.7
, pp. 2499-2510
-
-
Yu, L.1
White, J.V.2
Smith, T.F.3
-
79
-
-
0031603460
-
Prediction of signal peptides and signal anchors by a hidden Markov model
-
Nielsen H, Krogh A: Prediction of signal peptides and signal anchors by a hidden Markov model. ISMB, 1998 6:122-130.
-
(1998)
ISMB
, vol.6
, pp. 122-130
-
-
Nielsen, H.1
Krogh, A.2
-
80
-
-
0032845689
-
The nuclear envelope serves as an intermediary between the ER and Golgi complex in the intracellular parasite Toxoplasma gondii
-
Harger KM, Striepen B, Tilney LG, Roos DS: The nuclear envelope serves as an intermediary between the ER and Golgi complex in the intracellular parasite Toxoplasma gondii. J Cell Sci 1999, 112: in press.
-
(1999)
J Cell Sci
, vol.112
-
-
Harger, K.M.1
Striepen, B.2
Tilney, L.G.3
Roos, D.S.4
|