Cellular uptake of chloroquine is dependent on binding to ferriprotoporphyrin IX and is independent of NHE activity in Plasmodium falciparum

Journal of Cell Biology

Volumn 145, Issue 2, 2000, Pages 363-376

  Bray, Patrick G ^a   Janneh, Omar ^a   Raynes, Kaylene J ^a   Mungthin, Mathirut ^a   Ginsburg, Hagai ^b   Ward, Stephen A ^a  

^a UNIVERSITY OF LIVERPOOL   (United Kingdom)

^b HEBREW UNIVERSITY OF JERUSALEM   (Israel)

Author keywords

Chloroquine; Drug resistance; Heme binding; Na+ H+ exchanger; Plasmodium falciparum

Indexed keywords

AMILORIDE DERIVATIVE; CHLOROQUINE; HEMATIN; LEUPEPTIN; N [N (3 CARBOXYOXIRANE 2 CARBONYL)LEUCYL]AGMATINE; PROTEINASE INHIBITOR; VERAPAMIL;

ANTIMALARIAL ACTIVITY; ARTICLE; BINDING AFFINITY; CELL PH; CONTROLLED STUDY; DRUG INHIBITION; DRUG PROTEIN BINDING; DRUG UPTAKE; ENDOSOME; ENZYME INHIBITION; ENZYME SUBSTRATE; LYSOSOME; NONHUMAN; PLASMODIUM FALCIPARUM; PRIORITY JOURNAL; PROTON SODIUM EXCHANGE;

AMILORIDE; ANIMALS; ANTIMALARIALS; BICARBONATES; BIOLOGICAL TRANSPORT; CHLOROQUINE; ERYTHROCYTE MEMBRANE; ERYTHROCYTES; HEMIN; HEMOGLOBINS; HUMANS; HYDROGEN-ION CONCENTRATION; KINETICS; LEUPEPTINS; PLASMODIUM FALCIPARUM; SODIUM-HYDROGEN ANTIPORTER; VERAPAMIL;

PLASMODIUM FALCIPARUM; PROTOZOA;

EID: 0344867895     PISSN: 00219525     EISSN: None     Source Type: Journal    
DOI: 10.1083/jcb.145.2.363     Document Type: Article

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