5,6-Epoxyeicosatrienoic acid reduces increases in pulmonary vascular resistance in the dog

American Journal of Physiology - Heart and Circulatory Physiology

Volumn 275, Issue 1 44-1, 1998, Pages

  Stephenson, Alan H ^a   Sprague, Randy S ^a   Lonigro, Andrew J ^a  

^a SAINT LOUIS UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Cyclooxygenase; Prostacyclin; Pulmonary vasculature; Segmental resistance; Thromboxane

Indexed keywords

15 HYDROXY 11ALPHA,9ALPHA EPOXYMETHANOPROSTA 5,13 DIENOIC ACID; 5,6 EPOXY 8,11,14 ICOSATRIENOIC ACID; PROSTACYCLIN; PROSTAGLANDIN SYNTHASE; THROMBOXANE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; DOG; DRUG EFFECT; ENZYME ACTIVITY; ENZYME INHIBITION; HYPOXIA; LUNG BLOOD VESSEL; LUNG CIRCULATION; LUNG VASCULAR RESISTANCE; NONHUMAN; PRIORITY JOURNAL; PROSTAGLANDIN SYNTHESIS;

EID: 33750854854     PISSN: 03636135     EISSN: None     Source Type: Journal    
DOI: 10.1152/ajpheart.1998.275.1.h100     Document Type: Article

References (47)

1. Barnes, P. J., and S. F. Liu. Regulation of pulmonary vascular tone. Pharmacol. Rev. 47: 87-131, 1995.
2. Bradley, J. D., P. B. Zanaboni, and T. E. Dahms. Species differences in pulmonary vasoactive responses to histamine, 5-hydroxytryptamine and KCl. J. Appl. Physiol. 74: 139-146, 1993.
3. Capdevila, J. H., J. R. Falck, and R. W. Estabrook. Cytochrome P-450 and the arachidonate cascade. FASEB J. 6: 731-736, 1992.
4. Carroll, M. A., M. Balazy, P. Margiotta, J. R. Falck, and J. C. McGiff. Renal vasodilator activity of 5,6-epoxyeicosatrienoic acid depends upon conversion by cyclooxygenase and release of prostaglandins. J. Biol. Chem. 268: 12260-12266, 1993.
5. Carroll, M. A., M. P. Garcia, J. R. Falck, and J. C. McGiff. 5,6-Epoxyeicosatrienoic acid, a novel arachidonate metabolite: mechanism of vasoactivity in the rat. Circ. Res. 67: 1082-1088, 1990.
6. Carroll, M. A., M. P. Garcia, J. R. Falck, and J. C. McGiff. Cyclooxygenase dependency of the renovascular actions of cytochrome P-450-derived arachidonate metabolites. J. Pharmacol. Exp. Ther. 260: 104-109, 1992.
7. Carroll, M. A., M. P. Garcia, J. R. Falck, and J. C. McGiff. Cyclooxygenase dependency of the renovascular actions of cytochrome P-450-derived arachidonate metabolites. J. Pharmacol. Exp. Ther. 260: 104-109, 1992.
8. 2+-dependent translocation domain with homology to PKC and GAP. Cell 65: 1043-1051, 1991.
9. Corey, E. J., H. Niwa, and J. R. Falck. Selective epoxidation of eicosa-cis-5,8,11,14-tetraenoic (arachidonic) and eicosa-cis-8,11,14-trienoic acid. J. Am. Chem. Soc. 101: 1586-1587, 1979.
10. Dawson, C. A., J. H. Linehan, and D. A. Rickaby. Pulmonary microcirculatory hemodynamics. Ann. NY Acad. Sci. 384: 90-106, 1982.
11. Ellis, E. F., R. J. Police, L. Yancey, J. D. McKinney, and S. C. Amruthesh. Dilation of cerebral arterioles by cytochrome P-450 metabolites of arachidonic acid. Am. J. Physiol. 259 (Heart Circ. Physiol. 28): H1171-H1177, 1990.
12. Fitzpatrick, F. A., and R. C. Murphy. Cytochrome P-450 metabolism of arachidonic acid: formation and biological actions of "epoxygenase"-derived eicosanoids. Pharmacol. Rev. 40: 229-242, 1988.
13. Fulton, D., M. Balazy, J. C. McGiff, and J. Quilley. Possible contribution of platelet cyclooxygenase to the renal vascular action of 5,6-epoxyeicosatrienoic acid. J. Pharmacol. Exp. Ther. 277: 1195-1199, 1996.
14. Gao, Y., H. Zhou, and J. U. Raj. Endothelium-derived nitric oxide plays a larger role in pulmonary veins than in arteries of newborn lambs. Circ. Res. 76: 559-565, 1995.
15. Harder, D. R., W. B. Campbell, and R. J. Roman. Role of cytochrome P-450 enzymes and metabolites of arachidonic acid in the control of vascular tone. J. Vasc. Res. 32: 79-92, 1995.
16. Hecker, M., A. T. Bara, J. Bauersachs, and R. Busse. Characterization of endothelium-derived hyperpolarizing factor as a cytochrome P-450-derived arachidonic acid metabolite in mammals. J. Physiol. (Lond.) 481: 407-414, 1994.
17. Kadowitz, P. J., C. A. Gruetter, E. W. Spannhake, and A. L. Hyman. Pulmonary vascular responses to prostaglandins. Federation Proc. 40: 1991-1996, 1981.
18. Kaye, A. D., B. D. Nossaman, I. N. Ibrahim, and P. J. Kadowitz. Influence of PLC and MLCK inhibitors and the role of L-calcium channels in the cat pulmonary vascular bed. Am. J. Physiol. 269 (Lung Mol. Cell. Physiol. 13): L507-L513, 1995.
19. Knickle, L. C., and J. R. Bend. Bioactivation of arachidonic acid by the cytochrome P-450 monooxgenases of guinea pig lung: the orthologue of cytochrome P-450 2B4 is solely responsible for formation of epoxyeicosatrienoic acids. Mol. Pharmacol. 45: 1273-1280, 1994.
20. Lands, W. E. M. Biological consequences of fatty acid oxygenase reactions. Prostaglandins Leukot. Med. 13: 35-46, 1984.
21. Leeman, M., M. Delcroix, J.-L. Vachiéry, C. Mélot, and R. Naeije. Blunted hypoxic vasoconstriction in oleic acid lung injury: effect of cyclooxygenase inhibitors. J. Appl. Physiol. 72: 251-258, 1992.
22. Leeper-Woodford, S. K., P. D. Carey, K. Byrne, B. J. Fisher, C. Blocher, H. J. Sugerman, and A. A. Fowler. Ibuprofen attenuates plasma tumor necrosis factor activity during sepsis-induced acute lung injury. J. Appl. Physiol. 71: 915-923, 1991.
23. Makita, K., J. R. Falck, and J. H. Capdevila. Cytochrome P-450, the arachidonic acid cascade, and hypertension: new vistas for an old enzyme system. FASEB J. 10: 1456-1463, 1996.
24. McGiff, J. C. Cytochrome P-450 metabolism of arachidonic acid. Annu. Rev. Pharmacol. Toxicol. 31: 339-369, 1991.
25. McGoon, M. D., and P. M. Vanhoutte. Aggregating platelets contract isolated canine pulmonary arteries by releasing 5-hydroxytryptamine. J. Clin. Invest. 74: 828-833, 1984.
26. Mitzner, W. Resistance of the pulmonary circulation. Clin. Chest Med. 4: 127-137, 1983.
27. 1 metabolites. Biochim. Biophys. Acta 793: 408-415, 1984.
28. 1. FEBS Lett. 172: 279-283, 1984.
29. Oliw, E. H. Metabolism of 5(6)-oxidoeicosatrienoic acid by ram seminal vesicles. J. Biol. Chem. 259: 2716-2721, 1984.
30. Pinto, A., N. G. Abraham, and K. M. Mullane. Cytochrome P-450-dependent monooxygenase activity and endothelial-dependent relaxations induced by arachidonic acid. J. Pharmacol. Exp. Ther. 236: 445-451, 1986.
31. Pradelles, P., J. Grassi, and J. Maclouf. Enzyme immunoassays of eicosanoids using acetylcholine esterase as label: an alternative to radioimmunoassay. Anal. Chem. 57: 1170-1173, 1985.
32. Proctor, K. G., J. R. Falck, and J. Capdevila. Intestinal vasodilation by epoxyeicosatrienoic acids: arachidonic acid metabolites produced by a cytochrome P-450 monooxygenase. Circ. Res. 60: 50-59, 1987.
33. Raj, J. U., R. Hillyard, P. Kaapa, M. Cropper, and J. Aderson. Pulmonary arterial and venous constriction during hypoxia in 3- to 5-wk-old and adult ferrets. J. Appl. Physiol. 69: 2183-2189, 1990.
34. Rippe, B., J. C. Parker, M. I. Townsley, N. A. Mortillaro, and A. E. Taylor. Segmental vascular resistances and compliances in dog lung. J. Appl. Physiol. 62: 1206-1215, 1987.
35. 2 and epoxyeicosatrienoic acids in relaxation of bovine coronary arteries to arachidonic acid. Am. J. Physiol. 264 (Heart Circ. Physiol. 33): H327-H335, 1993.
36. Rosolowsky, M., J. R. Falck, J. T. Willerson, and W. B. Campbell. Synthesis of lipoxygenase and epoxygenase products of arachidonic acid by normal and stenosed canine coronary arteries. Circ. Res. 66: 608-621, 1990.
37. 2 analogue on vascular resistance distribution and permeability in isolated blood-perfused dog lungs. Lung 173: 209-221, 1995.
38. Sprague, R. S., A. H. Stephenson, T. E. Dahms, and A. J. Lonigro. Effect of cyclooxygenase inhibition on ethchlorvynol-induced acute lung injury in dogs. J. Appl. Physiol. 61: 1058-1064, 1986.
39. Stephenson, A. H., R. S. Sprague, T. E. Dahms, and A. J. Lonigro. Thromboxane does not mediate pulmonary hypertension in phorbol ester-induced acute lung injury in dogs. J. Appl. Physiol. 69: 345-352, 1990.
40. Stephenson, A. H., R. S. Sprague, N. L. Weintraub, L. McMurdo, and A. J. Lonigro. Inhibition of cytochrome P-450 attenuates hypoxemia of acute lung injury in dogs. Am. J. Physiol. 270 (Heart Circ. Physiol. 39): H1355-H1362, 1996.
41. Takahashi, K., J. Capdevila, A. Karara, J. R. Falck, H. R. Jacobson, and K. F. Badr. Cytochrome P-450 arachidonate metabolites in rat kidney: characterization and hemodynamic responses. Am. J. Physiol. 258 (Renal Fluid Electrolyte Physiol. 27): F781-F789, 1990.
42. Walker, B. R. Evidence for uneven distribution of L-type calcium channels in rat pulmonary circulation. Am. J. Physiol. 269 (Heart Circ. Physiol. 38): H2051-H2056, 1995.
43. 4 in rat lung: comparison of GC/MS, RIA and EIA. Prostaglandins 32: 857-873, 1986.
44. Wu, W., P. H. Halebian, R. J. Hariri, S. X. Cabrales, G. T. Shires, and P. S. Barie. Differential effects of cyclo-oxygenase and thromboxane synthase inhibition on ventilation-perfusion relationships in acid aspiration-induced acute lung injury. J. Trauma 33: 561-567, 1992.
45. Wurtz, M. M., A. H. Stephenson, R. S. Sprague, and A. J. Lonigro. Enhanced microvascular permeability of PMA-induced acute lung injury is not mediated by cyclooxygenase products. J. Appl. Physiol. 73: 2135-2141, 1992.
46. Zeldin, D. C., J. Foley, J. Ma, J. E. Boyle, J. M. S. Pascual, C. R. Moomaw, K. B. Tomer, C. Steenbergen, and S. Wu. CYP2J subfamily P-450s in the lung: expression, localization and potential functional significance. Mol. Pharmacol. 50: 1111-1117, 1996.
47. Zeldin, D. C., J. D. Plitman, J. Kobayashi, R. F. Miller, J. R. Snapper, J. R. Falck, J. L. Szarek, R. M. Philpot, and J. H. Capdevila. The rabbit pulmonary cytochrome P-450 arachidonic acid metabolic pathway: characterization and significance. J. Clin. Invest. 95: 2150-2160, 1995.