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Volumn 25, Issue 10, 1998, Pages 783-787

Cytochrome P450 knockout mice: New toxicological models

Author keywords

Cyp1a2; Cyp2e1; Cytochrome P450; Gene targeting; Toxicological models

Indexed keywords

CYTOCHROME P450; XENOBIOTIC AGENT;

EID: 0031712338     PISSN: 03051870     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1440-1681.1998.tb02153.x     Document Type: Review
Times cited : (14)

References (38)
  • 1
    • 9044254525 scopus 로고    scopus 로고
    • P450 superfamily: Update on new sequences, gene mapping, accession numbers and nomenclature
    • Nelson DR, Koymans LO, Kamataki T et al. P450 superfamily: Update on new sequences, gene mapping, accession numbers and nomenclature. Pharmacogenetics 1996; 6: 1-42.
    • (1996) Pharmacogenetics , vol.6 , pp. 1-42
    • Nelson, D.R.1    Koymans, L.O.2    Kamataki, T.3
  • 2
    • 0028040226 scopus 로고
    • Drug-metabolizing enzymes in ligand-modulated transcription
    • Nebert DW. Drug-metabolizing enzymes in ligand-modulated transcription. Biochem. Pharmacol. 1994; 47: 25-37.
    • (1994) Biochem. Pharmacol. , vol.47 , pp. 25-37
    • Nebert, D.W.1
  • 4
    • 0029867020 scopus 로고    scopus 로고
    • Cyp1a2 (-/-) null mutant mice develop normally, but show deficient drug metabolism
    • Liang H-C, Li H, McKinnon RA et al. Cyp1a2 (-/-) null mutant mice develop normally, but show deficient drug metabolism. Proc. Natl Acad. Sci. USA 1996; 93: 1671-6.
    • (1996) Proc. Natl Acad. Sci. USA , vol.93 , pp. 1671-1676
    • Liang, H.-C.1    Li, H.2    McKinnon, R.A.3
  • 6
    • 0024564718 scopus 로고
    • The new mouse genetics: Altering the genome by gene targeting
    • Capecchi MR. The new mouse genetics: Altering the genome by gene targeting. Trends Genet. 1989; 5: 70-6.
    • (1989) Trends Genet. , vol.5 , pp. 70-76
    • Capecchi, M.R.1
  • 7
    • 0028135079 scopus 로고
    • Altering mice by homologous recombination using embryonic stem cells
    • Bronson SK, Smithies O. Altering mice by homologous recombination using embryonic stem cells. J. Biol. Chem. 1994; 269: 27 155-8.
    • (1994) J. Biol. Chem. , vol.269 , pp. 27155-27158
    • Bronson, S.K.1    Smithies, O.2
  • 8
    • 0027446505 scopus 로고
    • The P450 superfamily: Update on new sequences, gene mapping, accession numbers, early trivial names, and nomenclature
    • Nelson DR, Kamataki T, Waxman DJ et al. The P450 superfamily: Update on new sequences, gene mapping, accession numbers, early trivial names, and nomenclature. DNA Cell Biol. 1993; 12: 1-51.
    • (1993) DNA Cell Biol. , vol.12 , pp. 1-51
    • Nelson, D.R.1    Kamataki, T.2    Waxman, D.J.3
  • 10
    • 0023061373 scopus 로고
    • P450 genes: Structure, evolution and regulation
    • Nebert DW, Gonzalez FJ. P450 genes: Structure, evolution and regulation. Annu. Rev. Biochem. 1987; 56: 945-93.
    • (1987) Annu. Rev. Biochem. , vol.56 , pp. 945-993
    • Nebert, D.W.1    Gonzalez, F.J.2
  • 11
    • 0023518502 scopus 로고
    • The murine Ah locus: A new allele and mapping to chromosome 12
    • Poland AP, Glover E, Taylor BA. The murine Ah locus: A new allele and mapping to chromosome 12. Mol. Pharmacol. 1988; 32: 471-8.
    • (1988) Mol. Pharmacol. , vol.32 , pp. 471-478
    • Poland, A.P.1    Glover, E.2    Taylor, B.A.3
  • 12
    • 0027458138 scopus 로고
    • The AH receptor: Genetics, structure and function
    • Swanson HI, Bradfield CA. The AH receptor: Genetics, structure and function. Pharmacogenetics 1993; 3: 213-30.
    • (1993) Pharmacogenetics , vol.3 , pp. 213-230
    • Swanson, H.I.1    Bradfield, C.A.2
  • 13
    • 0025790577 scopus 로고
    • Localization of CYP1A1 and CYP1A2 messenger RNA in normal human liver and in hepatocellular carcinoma by in situ hybridization
    • McKinnon RA, Hall P de la M. Quattrochi LC, Tukey RH, McManus ME. Localization of CYP1A1 and CYP1A2 messenger RNA in normal human liver and in hepatocellular carcinoma by in situ hybridization. Hepatology 1991; 14: 848-56.
    • (1991) Hepatology , vol.14 , pp. 848-856
    • McKinnon, R.A.1    Hall, P.D.L.M.2    Quattrochi, L.C.3    Tukey, R.H.4    McManus, M.E.5
  • 14
    • 0027057963 scopus 로고
    • Elucidation of catalytic specificities of human cytochrome P450 and glutathione S-transferase enzymes and relevance to molecular epidemiology
    • Guengerich FP, Shimada T, Raney KD et al. Elucidation of catalytic specificities of human cytochrome P450 and glutathione S-transferase enzymes and relevance to molecular epidemiology. Environ. Health Perspect. 1992; 98: 75-80.
    • (1992) Environ. Health Perspect. , vol.98 , pp. 75-80
    • Guengerich, F.P.1    Shimada, T.2    Raney, K.D.3
  • 16
    • 0028820801 scopus 로고
    • Role of cytochrome P4501A2 in chemical carcinogenesis: Implications for human variability in expression and enzyme activity
    • Eaton DL, Gallagher EP, Bammler TK, Kunze KL. Role of cytochrome P4501A2 in chemical carcinogenesis: Implications for human variability in expression and enzyme activity. Pharmacogenetics 1995; 5: 259-74.
    • (1995) Pharmacogenetics , vol.5 , pp. 259-274
    • Eaton, D.L.1    Gallagher, E.P.2    Bammler, T.K.3    Kunze, K.L.4
  • 18
    • 0032520017 scopus 로고    scopus 로고
    • Uroporphyria produced in mice by iron and 5-aminolevulinic acid does not occur in Cyp1a2(-/-) null mutant mice
    • Sinclair PR, Gorman N, Dalton T et al. Uroporphyria produced in mice by iron and 5-aminolevulinic acid does not occur in Cyp1a2(-/-) null mutant mice. Biochem. J. 1998; 330: 149-53.
    • (1998) Biochem. J. , vol.330 , pp. 149-153
    • Sinclair, P.R.1    Gorman, N.2    Dalton, T.3
  • 19
    • 0031054440 scopus 로고    scopus 로고
    • How knockout mouse lines will be used to study the role of drug-metabolizing enzymes and their receptors during reproduction, development, and environmental toxicity, cancer and oxidative stress
    • Nebert DW, Duffy JJ. How knockout mouse lines will be used to study the role of drug-metabolizing enzymes and their receptors during reproduction, development, and environmental toxicity, cancer and oxidative stress. Biochem. Pharmacol. 1997; 53: 249-54.
    • (1997) Biochem. Pharmacol. , vol.53 , pp. 249-254
    • Nebert, D.W.1    Duffy, J.J.2
  • 20
    • 0029045856 scopus 로고
    • Strain-dependent epithelial defects in mice lacking the EGF receptor
    • Siblia M, Wagner EF. Strain-dependent epithelial defects in mice lacking the EGF receptor. Science 1995; 269: 234-8.
    • (1995) Science , vol.269 , pp. 234-238
    • Siblia, M.1    Wagner, E.F.2
  • 21
    • 0029064203 scopus 로고
    • Targeted disruption of mouse EGF receptor: Effect of genetic background on mutant phenotype
    • Threadgill DW, Glugosz AA, Hansen LA et al. Targeted disruption of mouse EGF receptor: Effect of genetic background on mutant phenotype. Science 1995; 269: 230-4.
    • (1995) Science , vol.269 , pp. 230-234
    • Threadgill, D.W.1    Glugosz, A.A.2    Hansen, L.A.3
  • 23
    • 0029670543 scopus 로고    scopus 로고
    • Position effects and genetic disease
    • Milot E, Fraser P, Grosveld F. Position effects and genetic disease. Trends Genet. 1996; 12: 123-6.
    • (1996) Trends Genet. , vol.12 , pp. 123-126
    • Milot, E.1    Fraser, P.2    Grosveld, F.3
  • 24
    • 0029993449 scopus 로고    scopus 로고
    • Know your neighbours. Three phenotypes in null mutants of the myogenic bHLH gene MRF4
    • Olson EN, Arnold H-H, Rigby PWJ, Wold BJ. Know your neighbours. Three phenotypes in null mutants of the myogenic bHLH gene MRF4. Cell 1996; 85: 1-4.
    • (1996) Cell , vol.85 , pp. 1-4
    • Olson, E.N.1    Arnold, H.-H.2    Rigby, P.W.J.3    Wold, B.J.4
  • 25
    • 0031039041 scopus 로고    scopus 로고
    • Mapping of a major genetic modifier of embryonic lethality in TGFβ1 knockout mice
    • Bonyadi M, Rusholme SAB, Cousins FM et al. Mapping of a major genetic modifier of embryonic lethality in TGFβ1 knockout mice. Nature Genet. 1997; 15: 207-11.
    • (1997) Nature Genet. , vol.15 , pp. 207-211
    • Bonyadi, M.1    Rusholme, S.A.B.2    Cousins, F.M.3
  • 27
    • 0030709320 scopus 로고    scopus 로고
    • Sensitivity of CYP1A1 mRNA inducibility is the same in Cyp1a2(+/+) wild-type and Cyp1a2(-/-) null mutant mice
    • Liang HC, McKinnon RA, Nebert DW. Sensitivity of CYP1A1 mRNA inducibility is the same in Cyp1a2(+/+) wild-type and Cyp1a2(-/-) null mutant mice. Biochem. Pharmacol. 1997; 54: 1127-31.
    • (1997) Biochem. Pharmacol. , vol.54 , pp. 1127-1131
    • Liang, H.C.1    McKinnon, R.A.2    Nebert, D.W.3
  • 29
    • 0026035519 scopus 로고
    • Role of human cytochrome P-450 IIE1 in the oxidation of many low molecular weight cancer suspects
    • Guengerich FP, Kim DH, Iwasaki M. Role of human cytochrome P-450 IIE1 in the oxidation of many low molecular weight cancer suspects. Chem. Res. Toxicol. 1991; 4: 168-79.
    • (1991) Chem. Res. Toxicol. , vol.4 , pp. 168-179
    • Guengerich, F.P.1    Kim, D.H.2    Iwasaki, M.3
  • 30
    • 0030296583 scopus 로고    scopus 로고
    • Reduction of benzene metabolism and toxicity in mice that lack CYP2E1 expression
    • Valentine JL, Lee SST, Seaton MJ et al. Reduction of benzene metabolism and toxicity in mice that lack CYP2E1 expression. Toxicol. Appl. Pharmacol. 1996; 141: 205-13.
    • (1996) Toxicol. Appl. Pharmacol. , vol.141 , pp. 205-213
    • Valentine, J.L.1    Lee, S.S.T.2    Seaton, M.J.3
  • 31
    • 0012473279 scopus 로고
    • The nuclear receptor superfamily: The second decade
    • Mangelsdorf DJ, Thummel C, Beato M et al. The nuclear receptor superfamily: The second decade. Cell 1995; 83: 835-9.
    • (1995) Cell , vol.83 , pp. 835-839
    • Mangelsdorf, D.J.1    Thummel, C.2    Beato, M.3
  • 32
    • 0029000839 scopus 로고
    • Immune system impairment and hepatic fibrosis in mice lacking the aryl-hydrocarbon receptor
    • Fernandez-Salguero P, Pineau T, Hubert DM et al. Immune system impairment and hepatic fibrosis in mice lacking the aryl-hydrocarbon receptor. Science 1995; 268: 722-6.
    • (1995) Science , vol.268 , pp. 722-726
    • Fernandez-Salguero, P.1    Pineau, T.2    Hubert, D.M.3
  • 33
    • 0028997684 scopus 로고
    • Targeted disruption of the α isoform of the peroxisome proliferator-activated receptor gene in mice results in abolishment of the pleiotropic effects of peroxisome proliferators
    • Lee SST, Pineau T, Drago J et al. Targeted disruption of the α isoform of the peroxisome proliferator-activated receptor gene in mice results in abolishment of the pleiotropic effects of peroxisome proliferators. Mol. Cell Biol. 1995; 15: 3012-22.
    • (1995) Mol. Cell Biol. , vol.15 , pp. 3012-3022
    • Lee, S.S.T.1    Pineau, T.2    Drago, J.3
  • 34
    • 0030015421 scopus 로고    scopus 로고
    • Characterisation of murine Ahr null allele: Involvement of the receptor in hepatic growth and development
    • Schmidt JV, Su GH-T, Reddy JK, Simon MC, Bradfield CA. Characterisation of murine Ahr null allele: Involvement of the receptor in hepatic growth and development. Proc. Natl Acad. Sci. USA 1996; 93: 6731-6.
    • (1996) Proc. Natl Acad. Sci. USA , vol.93 , pp. 6731-6736
    • Schmidt, J.V.1    Su, G.H.-T.2    Reddy, J.K.3    Simon, M.C.4    Bradfield, C.A.5
  • 35
    • 0027922810 scopus 로고
    • Role of the Ah receptor and the dioxin-inducible (Ah) gene battery in toxicity, cancer, and signal transduction
    • Nebert DW, Puga A, Vasiliou V. Role of the Ah receptor and the dioxin-inducible (Ah) gene battery in toxicity, cancer, and signal transduction. Ann. N.Y. Acad. Sci. 1993; 685: 624-40.
    • (1993) Ann. N.Y. Acad. Sci. , vol.685 , pp. 624-640
    • Nebert, D.W.1    Puga, A.2    Vasiliou, V.3
  • 36
    • 26844480867 scopus 로고
    • Cytochrome P450: Evolution and functional variability
    • Nebert DW, McKinnon RA. Cytochrome P450: Evolution and functional variability. Prog. Liver Dis. 1994; 14: 1-31.
    • (1994) Prog. Liver Dis. , vol.14 , pp. 1-31
    • Nebert, D.W.1    McKinnon, R.A.2
  • 37
    • 0030942553 scopus 로고    scopus 로고
    • Identification of three different truncating mutations in cytochrome P450 1B1 CYP1B1] as the principal cause of primary congenital glaucoma (buphthalmos) in families linked to the GLC3A locus on chromosome 2p21
    • Stoilov I, Akarsu AN, Sarfarazi M. Identification of three different truncating mutations in cytochrome P450 1B1 (CYP1B1] as the principal cause of primary congenital glaucoma (buphthalmos) in families linked to the GLC3A locus on chromosome 2p21. Hum. Mol. Genet. 1997; 6: 641-7.
    • (1997) Hum. Mol. Genet. , vol.6 , pp. 641-647
    • Stoilov, I.1    Akarsu, A.N.2    Sarfarazi, M.3
  • 38
    • 0028059099 scopus 로고
    • Deletion of a DNA polymerase β gene segment in T cells using cell type-specific gene targeting
    • Gu H, Marth JD, Orban PC, Mossmann H, Rajewsky K. Deletion of a DNA polymerase β gene segment in T cells using cell type-specific gene targeting. Science 1994; 265: 103-6.
    • (1994) Science , vol.265 , pp. 103-106
    • Gu, H.1    Marth, J.D.2    Orban, P.C.3    Mossmann, H.4    Rajewsky, K.5


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.