Cyp1a2(-/-) null mutant mice develop normally but show deficient drug metabolism

Proceedings of the National Academy of Sciences of the United States of America

Volumn 93, Issue 4, 1996, Pages 1671-1676

  Liang, H C Leonard ^a   Li, Hung ^b   Mckinnon, Ross A ^a   Duffy, John J ^a   Potter, S Steven ^b   Puga, Alvaro ^a   Nebert, Daniel W ^a  

^a UNIVERSITY OF CINCINNATI MEDICAL CENTER   (United States)

^b UNIVERSITY OF CINCINNATI   (United States)

Author keywords

arylamine carcinogenesis; cytochrome P450; embryonic stem cells

Indexed keywords

AFLATOXIN B1; AROMATIC AMINE; BETA NAPHTHOFLAVONE; CARCINOGEN; COMPLEMENTARY DNA; CYTOCHROME P450; MESSENGER RNA; MUSCLE RELAXANT AGENT; PARACETAMOL; ZOXAZOLAMINE;

ANIMAL CELL; ARTICLE; CHEMICAL CARCINOGENESIS; DRUG METABOLISM; EMBRYO; EMBRYO CELL; ENZYME ACTIVITY; FEMALE; GENE TARGETING; GENETIC RECOMBINATION; LIVER METABOLISM; MALE; MOLECULAR CLONING; MOUSE; MULTIGENE FAMILY; MUTANT; NEWBORN; NONHUMAN; NORTHERN BLOTTING; PRIORITY JOURNAL; STEM CELL; TOXICOKINETICS;

ANIMALS; BASE SEQUENCE; BIOTRANSFORMATION; CARCINOGENS; CYTOCHROME P-450 CYP1A2; CYTOCHROME P-450 ENZYME SYSTEM; EVOLUTION, MOLECULAR; FEMALE; FERTILITY; GENE TARGETING; GROWTH; MALE; MICE; MICE, KNOCKOUT; MOLECULAR SEQUENCE DATA; MUSCLE RELAXANTS, CENTRAL; OXIDOREDUCTASES; PARALYSIS; PHENOTYPE; PRODRUGS; XENOBIOTICS; ZOXAZOLAMINE;

EID: 0029867020     PISSN: 00278424     EISSN: None     Source Type: Journal    
DOI: 10.1073/pnas.93.4.1671     Document Type: Article

References (43)

1. Nebert, D. W. & Gonzalez, F. J. (1987) Annu. Rev. Biochem. 56, 945-993.
2. Nebert, D. W. (1990) Nature (London) 347, 709-710.
3. Nebert, D. W. (1991) Mol. Endocrinol. 5, 1203-1214.
4. Nebert, D. W. (1994) Biochem. Pharmacol. 47, 25-37.
5. Nelson, D. R., Koymans, L., Kamataki, T., Stegeman, J. J., Feyereisen, R., Waxman, D. J., Waterman, M. R., Gotoh, O., Coon, M. J., Estabrook, R. W., Gunsalus, I. C. & Nebert, D. W. (1996) Pharmacogenetics 6, in press.
6. Nebert, D. W. & McKinnon, R. A. (1994) Prog. Liver Dis. 14, 63-97.
7. Hildebrand, C. E., Gonzalez, F. J., Kozak, C. A. & Nebert, D. W. (1985) Biochem. Biophys. Res. Commun. 130, 396-406.
8. Cobb, R. R., Stoming, T. A. & Whitney, J. B., III (1987) Biochem. Genet. 25, 401-412.
9. Poland, A. P., Glover, E. & Taylor, B. A. (1988) Mol. Pharmacol. 32, 471-478.
10. Burbach, K. M., Poland, A. & Bradfield, C. A. (1992) Proc. Natl. Acad. Sci. USA 89, 8185-8189.
11. Ema, M., Sogawa, K., Watanabe, N., Chujoh, Y., Matsushita, N., Gotoh, O., Funae, Y. & Fujii-Kuriyama, Y. (1992) Biochem. Biophys. Res. Commun. 184, 246-253.
12. Fernandez-Salguero, P., Pineau, T., Hilbert, D. M., McPhail, T., Lee, S. S. T., Kimura, S., Nebert, D. W., Rudikoff, S., Ward, J. M. & Gonzalez, F. J. (1995) Science 268, 722-726.
13. Schweikl, H., Taylor, J. A., Kitareewan, S., Linko, P., Nagorney, D. & Goldstein, J. A. (1993) Pharmacogenetics 3, 239-249.
14. Guengerich, F. P., Shimada, T., Raney, K. D., Yun, C.-H., Meyer, D. J., Ketterer, B., Harris, T. M., Groopman, J. D. & Kadlubar, F. F. (1992) Environ. Health Perspect. 98, 75-80.
15. Butler, M. A., Lang, N. P., Young, J. F., Caporaso, N. E., Vineis, P., Hayes, R. B., Teitel, C. H., Massengill, J. P., Lawsen, M. F. & Kadlubar, F. F. (1992) Pharmacogenetics 2, 116-127.
16. Tang, B. K., Zhou, Y. & Kalow, W. (1994) Pharmacogenetics 4, 117-124.
17. Kimura, S., Gonzalez, F. J. & Nebert, D. W. (1984) J. Biol. Chem. 259, 10705-10713.
18. Ausubel, F. M., Brent, R., Kingston, R. E., Moore, D. D., Smith, J. A., Seidman, J. G. & Struhl, K. (1991) Current Protocols in Molecular Biology (Greene/Wiley-Interscience, New York).
19. Li, H., Zeitler, P. S., Valerius, M. T., Small, K. & Potter, S. S. (1996) EMBO J., in press.
20. Small, K. M. & Potter, S. S. (1993) Genes Dev. 7, 2318-2328.
21. Doetschman, T., Eistetter, H., Katz, M., Schmidt, W. & Kemler, R. (1985) J. Embryol. Exp. Morphol. 87, 27-45.
22. Hooper, M., Handy, K., Handyside, A., Hunter, S. & Monk, M. (1987) Nature (London) 326, 292-295.
23. Doetschman, T. (1994) in Transgenic Animal Technology: A Laboratory Handbook, ed. Pinkert, C. (Academic, New York), pp. 115-146.
24. Li, H., Witte, D. P., Brandford, W. W., Aronow, B. J., Weinstein, M., Kaur, S., Wert, S., Singh, G., Schreiner, C. M., Whitsett, J. A., Scott, W. J. & Potter, S. S. (1994) EMBO J. 13, 2876-2885.
25. Chomczynski, O. & Sacchi, N. (1987) Anal. Biochem. 162, 156-159.
26. Robinson, J. R. & Nebert, D. W. (1974) Mol. Pharmacol. 10, 484-493.
27. Ozols, J., Heinemann, F. S. & Johnson, E. F. (1981) J. Biol. Chem. 256, 11405-11408.
28. Ono, S., Hatanaka, T., Hotta, H., Tsutsui, M., Satoh, T. & Gonzalez, F. J. (1995) Pharmacogenetics 5, 143-150.
29. Nebert, D. W. (1980) J. Natl. Cancer Inst. 64, 1279-1290.
30. Tuteja, N., Gonzalez, F. J. & Nebert, D. W. (1985) Dev. Biol. 112, 177-184.
31. Kimura, S., Donovan, J. C. & Nebert, D. W. (1987) J. Exp. Pathol. 3, 61-74.
32. Dey, A., Westphal, H. & Nebert, D. W. (1989) Proc. Natl. Acad. Sci. USA 86, 7446-7450.
33. Pasco, D. S., Boyum, K. W., Merchant, S. N., Chalberg, S. C. & Fagan, J. B. (1988) J. Biol. Chem. 263, 8671-8676.
34. Silver, G. J. & Krauter, K. S. (1988) J. Biol. Chem. 263, 11802-11807.
35. Gonzalez, F. J. & Nebert, D. W. (1990) Trends Genet. 6, 182-186.
36. Heilmann, L. J., Sheen, Y. Y., Bigelow, S. W. & Nebert, D. W. (1988) DNA 7, 379-387.
37. Pineau, T., Fernandez-Salguero, P., Lee, S. T. T., McPhail, T., Ward, J. M. & Gonzalez, F. J. (1995) Proc. Natl. Acad. Sci. USA 92, 5134-5138.
38. Liu, J. P., Baker, J., Perkins, A. S., Robertson, E. J. & Efstratiadis, A. (1993) Cell 75, 59-72.
39. Ratcliff, R., Evans, M. J., Cuthbert, A. W., MacVinish, L. J., Foster, D., Anderson, J. R. & Colledge, W. H. (1993) Nat. Genet. 4, 35-41.
40. O'Neal, W. K., Hasty, P., McCray, Jr., J. B., Casey, B., Rivera-Perez, J., Welsh, P. J., Beaudet, A. L. & Bradley, A. (1993) Hum. Mol. Genet. 2, 1561-1569.
41. Hyde, S. C., Gill, D. R., Higgins, C. F., Trezise, A. E., MacVinish, L. J., Cuthbert, A. W., Ratcliff, R., Evans, M. J. & Colledge, W. H. (1993) Nature (London) 362, 250-255.
42. Dorin, J. R., Dickinson, P., Alton, E. W., Smith, S. N., Geddes, D. M., Stevenson, B. J., Kimber, W. L., Fleming, S., Clark, A. R., Hooper, M. L., Anderson, L., Beddington, R. S. P. & Porteous, D. J. (1993) Nature (London) 359, 211-215.
43. Liang, H. C., Li, H., Potter, S. S., Duffy, J. J., Puga, A., McKinnon, R. A. & Nebert, D. W. (1995) Toxicologist 15, 59 (abstr.).