Inhibition of renal arachidonic acid ω-hydroxylase activity with ABT reduces blood pressure in the SHR

American Journal of Physiology - Regulatory Integrative and Comparative Physiology

Volumn 275, Issue 2 44-2, 1998, Pages

  Su, Ping ^a   Kaushal, K Maya ^a   Kroetz, Deanna L ^a,b,c  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

^c NONE   (United States)

Author keywords

20 hydroxyeicosatetraenoic acid; Cytochrome P 450 4A; Renal eicosanoids

Indexed keywords

CYTOCHROME P450; HYDROLASE;

ANIMAL EXPERIMENT; ARACHIDONIC ACID METABOLISM; ARTICLE; BLOOD PRESSURE REGULATION; ENZYME LOCALIZATION; KIDNEY FUNCTION; NONHUMAN; PRIORITY JOURNAL; RAT; SPONTANEOUSLY HYPERTENSIVE RAT;

EID: 0031844011     PISSN: 03636119     EISSN: None     Source Type: Journal    
DOI: 10.1152/ajpregu.1998.275.2.r426     Document Type: Article

References (13)

1. - cotransport in medullary thick ascending limb: control by PKA, PKC, and 20-HETE. Am. J. Physiol. 271 (Cell Physiol. 40): C455-C463, 1996.
2. CaJacob, C. A., W. K. Chan, E. Shephard, and P. R. Ortiz de Montellano. The catalytic site of rat hepatic lauric acid ω-hydroxylase. Protein versus prosthetic heme alkylation in the ω-hydroxylation of acetylenic fatty acids. J. Biol. Chem. 263: 18640-18649, 1988.
3. Campbell, W. B., D. Gebremedhin, P. F. Pratt, and D. R. Harder. Identification of epoxyeicosatrienoic acids as endothelium-derived hyperpolarizing factors. Circ. Res. 78: 415-423, 1996.
4. Carroll, M. A., M. Balazy, D. D. Huang, S. Rybalova, J. R. Falck, and J. C. McGiff. Cytochrome P450-derived renal HETEs: storage and release. Kidney Int. 51: 1696-1702, 1997.
5. Dierks, E. A., S. C. Davis, and P. R. Ortiz de Montellano. Glu-320 and Asp-323 are determinants of the CYP4A1 hydroxylation regiospecificity and resistance to inactivation by 1-aminobenzotriazole. Biochemistry 37: 1839-1847, 1998.
6. +-ATPase. Biochem. Biophys. Res. Commun. 152: 1269-1274, 1988.
7. Guyton, A. C. Blood pressure control-special role of the kidneys and body fluids. Science 252: 1813-1816, 1991.
8. Imig, J. D., J. R. Falck, D. Gebremedhin, D. R. Harder, and R. J. Roman. Elevated renovascular tone in young spontaneously hypertensive rats. Role of cytochrome P-450. Hypertension 22: 357-364, 1993.
9. Imig, J. D., L. G. Navar, R. J. Roman, K. K. Reddy, and J. R. Falck. Actions of epoxygenase metabolites on the preglomerular vasculature. J. Am. Soc. Nephrol. 7: 2364-2370, 1996.
10. Imig, J. D., A. P. Zou, D. E. Stec, D. R. Harder, J. R. Falck, and R. J. Roman. Formation and actions of 20-hydroxyeicosatetraenoic acid in rat renal arterioles. Am. J. Physiol. 270 (Regulatory Integrative Comp. Physiol. 39): R217-R227, 1996.
11. Kaikaus, R. M., W. K. Chan, N. Lysenko, R. Ray, P. R. Ortiz de Montellano, and N. M. Bass. Induction of peroxisomal fatty acid β-oxidation and liver fatty acid-binding protein by peroxisome proliferators. Mediation via the cytochrome P-450IVA1 ω-hydroxylase pathway. J. Biol. Chem. 268: 9593-9603, 1993.
12. Knickle, L. C., and J. R. Bend. Dose-dependent, mechanism-based inactivation of cytochrome P450 monooxygenases in vivo by 1-aminobenzotriazole in liver, lung, and kidney of untreated, phenobarbital-treated, and β-naphthoflavone-treated guinea pigs. Can. J. Physiol. Pharmacol. 70: 1610-1617, 1992.
13. Kroetz, D. L., L. M. Huse, A. Thuresson, and M. P. Grille. Developmentally regulated expression of the CYP4A genes in the spontaneously hypertensive rat kidney. Mol. Pharmacol. 52: 362-372, 1997.