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Volumn 103, Issue 11, 1999, Pages 1509-1515

Pulmonary prostacyclin synthase overexpression in transgenic mice protects against development of hypoxic pulmonary hypertension

Author keywords

[No Author keywords available]

Indexed keywords

PROSTACYCLIN; PROSTACYCLIN SYNTHASE; PROSTAGLANDIN F1 ALPHA;

EID: 0032729325     PISSN: 00219738     EISSN: None     Source Type: Journal    
DOI: 10.1172/JCI5911     Document Type: Article
Times cited : (199)

References (31)
  • 1
    • 0017041860 scopus 로고
    • Arterial walls generate from prosraglandin endoperoxidases a substance (prostaglandin X) which relaxes strips of mesemeric and coeliac arteries and inhibits platelet aggregation
    • Bunting, S., Gryglewski, R., Moncada, S., and Vane, J.R. 1976. Arterial walls generate from prosraglandin endoperoxidases a substance (prostaglandin X) which relaxes strips of mesemeric and coeliac arteries and inhibits platelet aggregation. Prostaglandins. 12:897-913.
    • (1976) Prostaglandins , vol.12 , pp. 897-913
    • Bunting, S.1    Gryglewski, R.2    Moncada, S.3    Vane, J.R.4
  • 2
    • 0025864032 scopus 로고
    • Prostacyclin production and mediation of adenylate cyclase activity in the pulmonary artery: Alteration after prolonged hypoxia in the rat
    • Shaul, P.W., Kinanae, B., Farrar, M.A., Buja, M., and Magness, R.R. 1991. Prostacyclin production and mediation of adenylate cyclase activity in the pulmonary artery: alteration after prolonged hypoxia in the rat. J. Clin. Invest. 88:447-455.
    • (1991) J. Clin. Invest. , vol.88 , pp. 447-455
    • Shaul, P.W.1    Kinanae, B.2    Farrar, M.A.3    Buja, M.4    Magness, R.R.5
  • 4
    • 0023848599 scopus 로고
    • Interleukin 1: A mitogen for human vascular smooth muscle cells that induces the release of growth-inhibitory prosranoids
    • Libby, P., Warner, S.J.C., and Friedman, G.B. 1988. Interleukin 1: a mitogen for human vascular smooth muscle cells that induces the release of growth-inhibitory prosranoids. J. Clin. Invest. 81:487-498.
    • (1988) J. Clin. Invest. , vol.81 , pp. 487-498
    • Libby, P.1    Warner, S.J.C.2    Friedman, G.B.3
  • 5
    • 0003346535 scopus 로고
    • Prostacyclin can inhibit DNA synthesis in vascular smooth muscle cells
    • J.M. Bailey, editor. Plenum Press. New York, NY
    • Owen, N.E. 1985. Prostacyclin can inhibit DNA synthesis in vascular smooth muscle cells. In Prostaglandins, leukotrienes, and lipoxins. J.M. Bailey, editor. Plenum Press. New York, NY. 193-204.
    • (1985) Prostaglandins, Leukotrienes, and Lipoxins , pp. 193-204
    • Owen, N.E.1
  • 6
    • 0018389260 scopus 로고
    • Infarct size reduction by prostacyclin after coronary artery occlusion in conscious dogs
    • Abstr.
    • Jugdutt, B.F., Hutchins, G.M., Bulkley, B.H., and Becker, L.C. 1979. Infarct size reduction by prostacyclin after coronary artery occlusion in conscious dogs. Clin. Res. 27:177A. (Abstr.)
    • (1979) Clin. Res. , vol.27
    • Jugdutt, B.F.1    Hutchins, G.M.2    Bulkley, B.H.3    Becker, L.C.4
  • 7
    • 0019462847 scopus 로고
    • Prostacyclin in experimental myocardial ischemia: Effects on hemodynamics, regional myocardial blood flow, infarct size and mortality
    • Ribeiro, L.G.T., et al. 1981. Prostacyclin in experimental myocardial ischemia: effects on hemodynamics, regional myocardial blood flow, infarct size and mortality. Am. J. Cardiol. 47:835-840.
    • (1981) Am. J. Cardiol. , vol.47 , pp. 835-840
    • Ribeiro, L.G.T.1
  • 8
    • 0027745733 scopus 로고
    • Bovine prostacyclin synthase: Purification and isolation of partial cDNA
    • Pereira, B., Wu, K.K., and Wang, L.H. 1993. Bovine prostacyclin synthase: purification and isolation of partial cDNA. Biochem. Biophys. Res. Commun. 197:1041-1048.
    • (1993) Biochem. Biophys. Res. Commun. , vol.197 , pp. 1041-1048
    • Pereira, B.1    Wu, K.K.2    Wang, L.H.3
  • 9
    • 0028037572 scopus 로고
    • Isolation and molecular cloning of prostacyclin synthase from bovine endothelial cells
    • Hara, S., et al. 1994. Isolation and molecular cloning of prostacyclin synthase from bovine endothelial cells. J. Biol. Chem. 269:19897-19903.
    • (1994) J. Biol. Chem. , vol.269 , pp. 19897-19903
    • Hara, S.1
  • 10
    • 0027964217 scopus 로고
    • Molecular cloning and characterization of bovine prostacyclin synthase
    • Pereira, B., Wu, K.K., and Wang, L.H. 1994. Molecular cloning and characterization of bovine prostacyclin synthase. Biochem. Biophys. Res. Commun. 203:59-66.
    • (1994) Biochem. Biophys. Res. Commun. , vol.203 , pp. 59-66
    • Pereira, B.1    Wu, K.K.2    Wang, L.H.3
  • 11
    • 0028332262 scopus 로고
    • Molecular cloning and expression of human prosracyclin synthase
    • Miyata, A., et al. 1994. Molecular cloning and expression of human prosracyclin synthase. Biochem. Biophys. Res. Commun. 200:1728-1734.
    • (1994) Biochem. Biophys. Res. Commun. , vol.200 , pp. 1728-1734
    • Miyata, A.1
  • 12
    • 0028785786 scopus 로고
    • Overexpression of prostacyclin synthase inhibits growth of vascular smooth muscle cells
    • Hara, S., et al. 1995 Overexpression of prostacyclin synthase inhibits growth of vascular smooth muscle cells. Biochem. Biophys. Res. Commun. 216:862-867.
    • (1995) Biochem. Biophys. Res. Commun. , vol.216 , pp. 862-867
    • Hara, S.1
  • 13
    • 0028898442 scopus 로고
    • Pathology and pathophysiology of primary pulmonary hypertension
    • Rubin, L.J. 1995. Pathology and pathophysiology of primary pulmonary hypertension. Am. J. Cardiol. 75:51A-54A.
    • (1995) Am. J. Cardiol. , vol.75
    • Rubin, L.J.1
  • 14
    • 0026628265 scopus 로고
    • An imbalance between excretion of thromboxane and prostacyclin metabolites in pulmonary hypertension
    • Christman, B.W., et al. 1992. An imbalance between excretion of thromboxane and prostacyclin metabolites in pulmonary hypertension. N. Engl. J. Med. 327:70-75.
    • (1992) N. Engl. J. Med. , vol.327 , pp. 70-75
    • Christman, B.W.1
  • 15
    • 0024794487 scopus 로고
    • Decreased arterial wall prostaglandin production in neonatal calves with severe chronic pulmonary hypertension
    • Badesch, D.B., et al. 1989. Decreased arterial wall prostaglandin production in neonatal calves with severe chronic pulmonary hypertension. Am. J. Respir. Cell Mol. Biol. 1:489-498.
    • (1989) Am. J. Respir. Cell Mol. Biol. , vol.1 , pp. 489-498
    • Badesch, D.B.1
  • 16
    • 0023941301 scopus 로고
    • Angiotensin II prevents hypoxic pulmonary hypertension and vascular changes in rat
    • Rabinovitch, M., et al. 1988. Angiotensin II prevents hypoxic pulmonary hypertension and vascular changes in rat. Am. J. Phvsiol. 254:H500-H508.
    • (1988) Am. J. Phvsiol. , vol.254
    • Rabinovitch, M.1
  • 17
    • 0033032949 scopus 로고    scopus 로고
    • Prostacyclin synthase expression is decreased in lungs from patients with severe pulmonary hypertension
    • Tuder, R.M., et al. 1999. Prostacyclin synthase expression is decreased in lungs from patients with severe pulmonary hypertension. Am. J. Respir. Crit. Care Med. 159:1925-1932.
    • (1999) Am. J. Respir. Crit. Care Med. , vol.159 , pp. 1925-1932
    • Tuder, R.M.1
  • 18
    • 0028597038 scopus 로고
    • Survival in primary pulmonary hypertension with long-term continuous intravenous prostacyclin
    • Barst, R.J., et al. 1994. Survival in primary pulmonary hypertension with long-term continuous intravenous prostacyclin. Ann. Intern. Med. 121:409-415.
    • (1994) Ann. Intern. Med. , vol.121 , pp. 409-415
    • Barst, R.J.1
  • 19
    • 0030031888 scopus 로고    scopus 로고
    • A comparison of continuous intravenous epoprosrenol (prostacyclin) with conventional therapy for primary pulmonary hypertension
    • Barst, R.J., et al. 1996. A comparison of continuous intravenous epoprosrenol (prostacyclin) with conventional therapy for primary pulmonary hypertension. N. Engl. J. Med. 334:296-301.
    • (1996) N. Engl. J. Med. , vol.334 , pp. 296-301
    • Barst, R.J.1
  • 20
    • 0028913446 scopus 로고
    • Effects of aerosolized prostacyclin in severe pneumonia: Impact of fibrosis
    • Walmrath, D., et al. 1995. Effects of aerosolized prostacyclin in severe pneumonia: impact of fibrosis. Am. J. Respir. Crit. Care Med. 151:724-730.
    • (1995) Am. J. Respir. Crit. Care Med. , vol.151 , pp. 724-730
    • Walmrath, D.1
  • 21
    • 0029880173 scopus 로고    scopus 로고
    • Direct comparison of inhaled nitric oxide and aerosolized prostacyclin in acute respiratory distress syndrome
    • Walmrath, D., et al. 1996. Direct comparison of inhaled nitric oxide and aerosolized prostacyclin in acute respiratory distress syndrome. Am. J. Respir. Crit. Care Med. 153:991-996.
    • (1996) Am. J. Respir. Crit. Care Med. , vol.153 , pp. 991-996
    • Walmrath, D.1
  • 22
    • 0029114068 scopus 로고
    • Inhaled nitric oxide versus inhaled prosracyclin and intravenous versus inhaled prostacyclin in acute respiratory failure with pulmonary hypertension in piglets
    • Zobel, G., Dacar, D., Rodl, S., and Friehs, I. 1995. Inhaled nitric oxide versus inhaled prosracyclin and intravenous versus inhaled prostacyclin in acute respiratory failure with pulmonary hypertension in piglets. Pediatr. Res. 38:198-204.
    • (1995) Pediatr. Res. , vol.38 , pp. 198-204
    • Zobel, G.1    Dacar, D.2    Rodl, S.3    Friehs, I.4
  • 23
    • 0023735395 scopus 로고
    • Two SP-C genes encoding human pulmonary surfactant proteolipid
    • Glasser, S.W., et al. 1988. Two SP-C genes encoding human pulmonary surfactant proteolipid. J. Biol. Chem. 263:10326-10331.
    • (1988) J. Biol. Chem. , vol.263 , pp. 10326-10331
    • Glasser, S.W.1
  • 24
    • 0025078491 scopus 로고
    • Cis-acting sequences from a human surfactant protein gene confer pulmonary-specific gene expression in transgenic mice
    • Korfhagen, T.R., et al. 1990. Cis-acting sequences from a human surfactant protein gene confer pulmonary-specific gene expression in transgenic mice. Proc. Natl. Acad. Sci. USA. 87:6122-6126.
    • (1990) Proc. Natl. Acad. Sci. USA , vol.87 , pp. 6122-6126
    • Korfhagen, T.R.1
  • 25
    • 0024567081 scopus 로고
    • Targeted ablation of alpha-crystallin-synthesizing cells produces lens-deficient eyes in transgenic mice
    • Kaur, S., et al. 1989. Targeted ablation of alpha-crystallin-synthesizing cells produces lens-deficient eyes in transgenic mice. Development. 105:613-619.
    • (1989) Development , vol.105 , pp. 613-619
    • Kaur, S.1
  • 26
    • 0028106745 scopus 로고
    • Agarose infiltration improves morphology of cryostat sections of lung
    • Halbower, A.C., Mason, R.J., Abman, S.H., and Tuder, R.M. 1994. Agarose infiltration improves morphology of cryostat sections of lung. Lab. Invest. 71:149-153.
    • (1994) Lab. Invest. , vol.71 , pp. 149-153
    • Halbower, A.C.1    Mason, R.J.2    Abman, S.H.3    Tuder, R.M.4
  • 27
    • 0029936155 scopus 로고    scopus 로고
    • Inhibition of 5-lipoxygenase-activating protein (FLAP) reduces pulmonary vascular reactivity and pulmonary hypertension in hypoxic rats
    • Voelkel, N.F., et al. 1996. Inhibition of 5-lipoxygenase-activating protein (FLAP) reduces pulmonary vascular reactivity and pulmonary hypertension in hypoxic rats. J. Clin. Invest. 97:2491-2498.
    • (1996) J. Clin. Invest. , vol.97 , pp. 2491-2498
    • Voelkel, N.F.1
  • 28
    • 0022992735 scopus 로고
    • Analysis of 6-keto PGF 1α. 5-HETE and LTC4 in rat lung: Comparison of GC/MS, RIA, and EIA
    • Wesrcott, J.Y., et al. 1986. Analysis of 6-keto PGF 1α. 5-HETE and LTC4 in rat lung: comparison of GC/MS, RIA, and EIA. Prostaglandins. 32:857-873.
    • (1986) Prostaglandins , vol.32 , pp. 857-873
    • Wesrcott, J.Y.1
  • 29
    • 0344304192 scopus 로고    scopus 로고
    • The pulmonary circulation of mice with either homozygous or heterozygous disruption of endothelial nitric oxide synthase is hyperresponsive to chronic mild hypoxia
    • In press
    • Fagan, K.A., et al. 1999. The pulmonary circulation of mice with either homozygous or heterozygous disruption of endothelial nitric oxide synthase is hyperresponsive to chronic mild hypoxia. J. Clin. Invest. In press.
    • (1999) J. Clin. Invest.
    • Fagan, K.A.1
  • 30
    • 0030894717 scopus 로고    scopus 로고
    • Prolonged endothelin a receptor blockade attenuates chronic pulmonary hypertension in the ovine fetus
    • Ivy, D.D., et al. 1997. Prolonged endothelin A receptor blockade attenuates chronic pulmonary hypertension in the ovine fetus. J. Clin. Invest. 99:1179-1186.
    • (1997) J. Clin. Invest. , vol.99 , pp. 1179-1186
    • Ivy, D.D.1
  • 31
    • 0029939736 scopus 로고    scopus 로고
    • Effects of acute and chronic hypoxia on rat lung cyclooxygenase
    • Chida, M., and Voelkel, N.F. 1996. Effects of acute and chronic hypoxia on rat lung cyclooxygenase. Am. J. Physiol. 270:L872-L878.
    • (1996) Am. J. Physiol. , vol.270
    • Chida, M.1    Voelkel, N.F.2


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