Cytochrome P450, the arachidonic acid cascade, and hypertension: New vistas for an old enzyme system

FASEB Journal

Volumn 10, Issue 13, 1996, Pages 1456-1463

  Makita, Keiko ^a   Falck, John R ^b   Capdevila, Jorge H ^a,c  

^a VANDERBILT UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b UNIVERSITY OF TEXAS AT DALLAS   (United States)

^c VANDERBILT UNIVERSITY MEDICAL CENTER   (United States)

Author keywords

EETs; epoxyeicosatrienoic acid; alcohols; 1 oxygenase

Indexed keywords

CYTOCHROME P450; HYDROXYICOSATETRAENOIC ACID; OXYGENASE;

ANIMAL TISSUE; ARACHIDONIC ACID METABOLISM; CELL MEMBRANE PERMEABILITY; CELL TRANSPORT; ENZYME ACTIVITY; ENZYME REGULATION; FATTY ACID METABOLISM; HOMEOSTASIS; HORMONE SENSITIVITY; HYPERTENSION; MULTIGENE FAMILY; NONHUMAN; PRIORITY JOURNAL; RAT; REVIEW; SPONTANEOUSLY HYPERTENSIVE RAT;

ANIMALIA;

EID: 0029825327     PISSN: 08926638     EISSN: None     Source Type: Journal    
DOI: 10.1096/fasebj.10.13.8940291     Document Type: Review

References (42)

1. Smith, W. L. (1992) Prostanoid biosynthesis and mechanism of action. Am. J. Physiol. 263, 383-417
2. McGiff, J.C. (1991) Cytochrome P450 metabolism of arachidonic acid. Annu. Rev. Pharmacol. Toxicol. 31 339-369
3. Capdevila, J. H., Falck, J. R., and Estabrook, R.W. (1992) Cytochrome P450 and the arachidonate cascade. FASEB J. 6 731-736
4. Oliw, E. H. (1994) Oxygenation of polyunsaturated fatty acids by Cytochrome P450 monooxygenases. Proc. Lipid Res. 33, 329-354
5. Harder, D. R., Campbell, W. B., and Roman, R. J. (1995) Role of cylochrome P450 enzymes and metabolites of arachidonic acid in the control of vascular tone. J. Vasc. Res. 32, 79-92
6. Capdevila, J. H., Zeldin, D., Makita, K., Karara, A., and Falck, J. R. (1995) Cytochrome P450 and the metabolism of arachidonic acid and oxygenated eicosanoids. In Cytochrome P450: Structure, Mechanism and Biochemistry (Ortiz de Montellano, P., ed) Second Ed, pp. 443-471, Plenum Press, New York
7. Capdevila, J., Parkhill, L., Chacos, N., Okila, R., Masters, B. S., and Estabrook, R. W. (1981) The oxidative metabolism of arachidonic acid by purified cytochromes P450. Biochem. Biophys. Res. Commun. 101, 1357-1363
8. Capdevila, J., Chacos, N., Weningloer, J., Prough, R. A., and Estabrook, R. W. (1981) Liver microsomal cytochrome P450 and the oxidative metabolism of arachidonic acid. Proc. Natl. Acad. Sci. USA 78, 5362-5366
9. Oliw, E. H., and Oates, J. A. (1981) Oxygenation of arachidonic acid by hepatic microsomes of the rabbit. Mechanism of synthesis of two vicinal diols. Biochim. Biophys. Acta 666, 327-340
10. Morrison, A. R., and Pascoe, N. (1981) Metabolism of arachidonic acid through NADPH-dependent oxygenase of renal cortex. Proc. Natl. Acad. Sci. USA 78, 7375-7378
11. Sacerdoti, D., Escalante, B., Abraham, N. G., McGiff, J. C., Levere, R. D., and Schwartzman, M. L. (1989) Treatment with tin prevents the development of hypertension in spontaneously hypertensive rats. Science 243, 388-390
12. Nelson, D. R., Kamataki, T., Waxman, D. J., Guengerich, F. P., Estabrook, R. W., Feyereisen, R., Gonzalez, F. J., Coon, M. J., Gunsalus, I. C., Gotoh, O., Okuda, K., and Neben, D. W. (1993) The P450 superfamily: Update on new sequences, gene mapping, accession numbers, early trivial names of enzymes and nomenclature. DNA & Cell Biol. 12, 1-51
13. Imaoka, S., Tanaka, S., and Funae, Y. (1989) CD and (ω-1)-hydroxylation of lauric acid and arachidonic acid by rat renal cytochrome P-450. Biochem. Int. 18, 731-740
14. Roman, L. J., Palmer, C. N. A., Clark, J. E., Muerhoff, S. A., Griffin, K. L., Johnson, E. F., and Masters, B. S. S. (1993) Expression of rabbit cytochrome P4504A which catalyzes the ω-hydroxylalion of arachidonic acid, fatty acids, and prostaglandins. Arch. Biochem. Biophys. 307, 57-65
15. 2-terminal amino acid sequences of human and rat kidney fatty acid ωw-hydroxylases. Biochem. Biophys. Acta 1123, 156-162
16. Hardwick J. P. (1991) Cyp 4A subfamily: functional analysis by immunocy-tochemistry and in situ hybridization. Methods Enzymol. 206, 273-283
17. Omata, K., Abraham, N. G., and Laniado-Schwartzman, M. (1992) Arachidonic acid ω/ω-l hydroxylase along the nephron of the spontaneously hypertensive rat. Am. J. Physiol. 262, F592-599
18. Jacobson, H. R., Corona, S., Capdevila, J. H., Chacos, N., Manna, S., Womack, A., and Falck, J. R. (1984) Prostaglandins and Membrane Ion Transport (Braquet, P., Frolich, J. C., Nicosia, S., Garay, R., eds) 311 pp., Raven Press, New York
19. Capdevila, J. H., Wei, S., Yan, Y., Karara, A., Jacobson, H. R., Falck, J. R., Guengerich, F. P., and DuBois, R. N. (1992) Cytochrome P-450 arachidonic acid epoxygenase. Regulatory control of the renal epoxygenase by dietary salt loading. J. Biol. Chem. 267, 21720-21726
20. Karara, A., Makita, K., Jacobson, J. R., Falck, J. R., Guengerich, F. P., DuBois, R. N., and Capdevila, J. H. (1993) Molecular cloning, expression, and enzymatic characterization of the rat kidney cytochrome P-450 arachidonic acid epoxygenase. J. Biol. Chem. 268, 13565-13570
21. Schwartzman, M. L., Falck, J. R., Yadagiri, P., and Escalante, B. (1989) Metabolism of 20-hydroxyeicosatetraenoic acidby cyclooxygenase: Formation and identification of novel endothelium-dependent vasoconstrictor metabolites. J. Biol. Chem. 264, 11658-11662
22. Ma Y.-H, Gebremedhim, D., Schwartzman, M. L., Falek, J. R., Clark, J. E., Masters, B. S. M., Harder, D. R., and Roman, R. J. (1993) 20-Hydroxyei-cosatetraenoic acid is an endogenous vasoconstrictor of canine renal arcuate arteries. Circ. Res. 72, 126-136
23. Escalanle, B., Erlij, D., Falck, J. R., and McGiff, J. C. (1994) Cytochrome P450 arachidonate metabolites affect ion fluxes in rabbit medullary thick ascending limb. Am. J. Physiol. 266, C1775-1782
24. Katoh, T., Takahashi, K., Capdevila, J., Karara, A., Falck, J. R., Jacobson, H. R., and Badr, K. F. (1991) Glomerular stereospecific synthesis and hemodynamic actions of 8,9-epoxyeicosatrienoic acid in rat kidney. Am. J. Physiol. 30, F578-F586
25. Carrol, M. A., Garcia, M. P., Falck, J. R., and McCiff, J. C. (1992) Cyclooxygenase dependency of the renovascular actions of cytochrome P450 derived arachidonate metabolites. J. Pharmacol. Exp. Ther. 260, 104-109
26. 2+ binding, uptake and release. Prostaglandins 26, 13-21
27. 2+ in anterior pituitary cells. Biochem. Biophys. Res. Commun. 139, 1188-1194
28. Romero, M. F., Hopfer, U., Madhun, Z. T., Zhou, W., and Douglas, J. G. (1991) Angiotensin II actions in the rabbit proximal tubule. Angiutensin II mediated signaling mechanisms and electrolyte transport in the rabbit proximal tubule. Renal Physiol. Biochem. 14, 199-207
29. Burns, K. D., Capdevila, J. H., Wei, S., Breyer, M. D., Homma.T., and Harris, R. C. (1995) Role of cytochrome P450 epoxygenase in EGF signaling in renal proximal tubule. Am. J.Physiol. 269, C831-C840
30. Sakairi, Y., Jacobson, H. R., Noland, T. D., Capdevila, J. H., Falck, J. R., and Breyer, M. D. (1995) 5,6-EET inhibits ion transport in collecting duct by stimulating endogenous prostaglundin synthesis. Am. J. Physiol. 268, F931-F939
31. 2+ entry in human and bovine endothelial cells. J. Physiol. 482, 259-274
32. + channel in vascular smooth muscles by cytochrome P450 metabolites of arachidonic acid. Eur. J. Pharmacol. 230, 215-221
33. 86Rb uptake in renal epithelial cells. J. Cell. Physiol. 160, 69-74
34. Vainionpaa, V., Heikkinen, E. R., and Vapaatalo, H., (1974) Drug metabolism in spontaneously hypertensive rats. Pharmacol. Res. Commun. 6, 343-346
35. Merrick, A. B., Davies, M. H., Cook, D. E., Holeslaw, T. L., and Schnell, R. C. (1985) Alterations in hepatic drug metabolism and cytochrome P450 proteins in spontaneously hypertensive rats. Pharmacology 30, 129-135
36. Schwartzman, M. L., and McGiff, J. C. (1995) Renal cytochrome P450. J. Lipid Mediators Cell Signaling 12, 229-242
37. Makita, K., Takahashi, K., Karara, A., Jacobson, H. R., Falck, J. R., and Capdevila, J. H. (1994) Experimental and/or genetically controlled alterations of the renal microsomal cytochrome P450 epoxygenase induce hypertension in rats fed a high salt diet. J. Clin. Invest. 94, 2414-2420
38. 11β-mediated reactions by imidazole derivatives and mineralocorticoid analogs. J. Steroid Biochem. 31, 803-308
39. Rapp, J. P. (1982) Dahl salt-susceptible and Dahl salt-resistant rats. A review. Hypertension 4, 753-763
40. Capdevila, J. H., Dishman, E., Karara, A., and Falck, J. R. (1991) Cytochrome P450 arachidonic acid epoxygenase: Stereochemical characterization of epoxyeicosatrienoic acids. Methods Enzymol. 206, 441-453
41. 11β, but the salt-sensitive hypertensive rat does not. J. Biol. Chem. 268, 9117-9121
42. Stec., D. E., Deng, A. Y., Rapp, J. P., and Roman, R. J. (1996) Cylochrome P4504A genotype cosegregates with hypertension in Dahl S rats. Hypertension 27, 564-568