Hypoxic pulmonary vasoconstriction is modified by P-450 metabolites

American Journal of Physiology

Volumn 279, Issue 4 PART 2, 2000, Pages

  Zhu, Daling ^a   Birks, Eric K ^a   Dawson, Christopher A ^b   Patel, Monica ^a   Falck, John R ^c   Presberg, Kenneth ^b   Roman, Richard J ^a   Jacobs, Elizabeth R ^a,b  

^a Cardiovascular Research Center   (United States)

^b MEDICAL COLLEGE OF WISCONSIN   (United States)

^c UNIVERSITY OF TEXAS AT DALLAS   (United States)

Author keywords

hydroxylase inhibitor; Arachidonic acid; Cytochrome P 450 4A; Eicosanoid metabolism; Pulmonary vascular tone; Vasodilator

Indexed keywords

EID: 0033713364     PISSN: 00029513     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (33)

1. Birks EK, Bousamra M, Presberg K, Marsh JA, Effros RM, and Jacobs ER. Human pulmonary arteries dilate to 20-HETE, an endogenous eicosanoid of lung tissue. Am J Physiol Lung Cell Mol Physiol 272: L823-L829, 1997.
2. Blitzer ML, Loh E, Roddy MA, Stamler JS, and Creager MA. Endothelium-derived nitric oxide regulates systemic and pulmonary vascular resistance during acute hypoxia in humans. J Am Coll Cardiol 28: 591-596, 1996.
3. Bradford MM. A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. Anal Biochem 72: 248-254, 1976.
4. Chang SW, Dutton D, Wang HI, He LS, Stearns R, Hui A, Giacomini KM, Ortiz de Montellano P, and Voelkel NF. Intact lung cytochrome P-450 is not required for hypoxic pulmonary vasoconstriction. Am J Physiol Lung Cell Mol Physiol 263: L446-L453, 1992.
5. Chida M and Voelkel NF. Effects of acute and chronic hypoxia on rat lung cyclooxygenase. Am J Physiol Lung Cell Mol Physiol 270: L872-L878, 1996.
6. Harder DR, Gebremedhin D, Narayanan J, Jefcoate C, Falck JR, Campbell WB, and Roman RJ. Formation and action of a P-450 metabolite of arachidonic acid in cat cerebral microvessels. Am J Physiol Heart Circ Physiol 266: H2098-H2107, 1994.
7. Harder DR, Narayanan J, Birks EK, Liard JF, Imig JD, Lombard JH, Lange AR, and Roman RJ. Identification of a putative microvascular oxygen sensor. Circ Res 79: 54-61, 1996.
8. Isaacson TC, Hampl V, Weir EK, Nelson DP, Archer SL. Increased endothelium-derived NO in hypertensive pulmonary circulation of chronically hypoxic rats. J Appl Physiol 76: 933-940, 1994.
9. Jacobs ER, Effros RM, Falck JR, Reddy KM, Campbell WB, and Zhu D. Airway synthesis of 20-HETE: metabolism by cyclooxygenase to a bronchodilator. Am J Physiol Lung Cell Mol Physiol 276: L280-L288, 1999.
10. Kerkhof CJM, Bakker ENTP, and Sipkema P. Role of cytochrome P-450 in oxygen sensing and NO production in rat cremaster resistance arteries. Am J Physiol Heart Circ Physiol 277: H1546-H1552, 1999.
11. Kusunose E, Sawamura A, Kawashima H, Kubota I, and Kusunose M. Isolation of a new form of cytochrome P-450 with prostaglandin A and fatty acid ω-hydroxylase activity from rabbit kidney cortex. J Biochem 106: 194-196, 1989.
12. Ma YH, Schwartzman ML, and Roman RJ. Altered renal P-450 metabolism of arachidonic acid in Dahl Salt-sensitive rats. Am J Physiol Regulatory Integrative Comp Physiol 267: R579-R589, 1994.
13. Matsubara S, Yamamoto S, Sogawa K, Yokotani M, Fujii-Kuriyama Y, Haniu M, Shively JE, Gotoh O, Kusunose E, and Kusunose M. cDNA cloning and inducible expression during pregnancy of the mRNA for rabbit pulmonary prostaglandin ω-hydroxylase (cytochrome P450). J Biol Chem 262: 13366-13371, 1987.
14. Muerhoff AS, Williams DE, Leithauser MT, Jackson VE, Waterman MR, and Masters BSS. Regulation of the induction of a cytochrome P-450 prostaglandin ω hydroxylase by pregnancy in rabbit lung. Proc Natl Acad Sci USA 84: 7911-7914, 1987.
15. ω-nitro-L-arginine methylester on hypoxic vasoconstriction in the neonatal pig lung. Pediatr Res 34: 349-353, 1993.
16. Nguyen X, Wang MH, Reddy KM, and Falck JR. Kinetic profile of the rat CYP4A isoforms: arachidonic acid metabolism and isoform-specific inhibitors. Am J Physiol Regulatory Integrative Comp Physiol 276: R1691-R1700, 1999.
17. Ogita K, Kusunose E, Yamaoto S, Ichihara K, and Kusunose M. Multiple forms of cytochrome P-450 from kidney cortex microsomes of rabbits treated with phenobarbital. Biochem Int 6: 191-198, 1983.
18. Perrson MG, Gustafsson LE, Wiklung NP, Moncada S, and Hedqvist P. Endogenous nitric oxide as a probable modulator of pulmonary circulation and hypoxic pressor response in vivo. Acta Physiol Scand 140: 449-457, 1990.
19. Powell WS and Solomon S. Formation of 20-hydroxyprostaglandins by lungs of pregnant rabbits. J Biol Chem 253: 4609-4616, 1978.
20. Roman LJ, Palmer CNA, Clark JE, Muerhoff AS, Griffin KJ, Johnson EF, and Masters BSS. Expression of rabbit cytochromes P4504A which catalyze the ω-hydroxylation of arachidonic acid, fatty acids, and prostaglandins. Arch Biochem Biophys 307: 57-65, 1993.
21. Russell P, Wright C, Kapeller K, Barer G, and Howard P. Attenuation of chronic hypoxic pulmonary hypertension in rats by cyclooxygenase products and by nitric oxide. Eur Respir J 6: 1501-1506, 1993.
22. Sinai CJ and Bend JR. Kinetics and selectivity of mechanism-based inhibition of guinea pig hepatic and pulmonary cytochrome P450 by N-benzy-1-aminobenzotriazole and N-α-methylbenzyl-1-aminobenzotriazole. Drug Metab Dispos 24: 996-1001, 1996.
23. 2 supports blood flow to hypoxic alveoli in anesthetized dogs. J Appl Physiol 56: 1246-1251, 1984.
24. Sprague RS, Thiemermann C, and Vane JR. Endogenous endothelium-derived relaxing factor opposes hypoxic pulmonary vasoconstriction and support blood flow to hypoxic alveoli in anesthetized rabbits. Proc Natl Acad Sci USA 89: 8711-8715, 1992.
25. + channel activity and vascular tone in renal arterioles. Circ Res 83: 1069-1079, 1998.
26. Voelkel NF, Gerber JG, McMurtry IF, Nies AJ, and Reeves JT. Release of vasodilator prostaglandin PGI from isolated rat lung during vasoconstriction. Circ Res 48: 207-213, 1981.
27. Wang MH, Brand-Schieber E, Zand BA, Nguyen X, Falck JR, Blau N, and Schwartzman ML. Cytochrome P450-derived arachidonic acid metabolism in the rat kidney: characterization of selective inhibitors. J Pharmacol Exp Ther 284: 966-973, 1998.
28. Ward JPT and Aaronson PI. Mechanisms of hypoxic pulmonary vasoconstriction: can anyone be right? Respir Physiol 115: 261-271, 1999.
29. Weissmann N, Grimminger R, Walmrath D, and Seeger W. Hypoxic vasoconstriction in buffer-perfused rabbit lungs. Respir Physiol 100: 159-169, 1995.
30. Williams DE, Hale SE, Okita RT, and Masters BSS. A prostaglandin ω-hydroxylase cytochrome P-450 (P-450PGω) purified from lungs of pregnant rabbits. J Biol Chem 259: 14600-14608, 1984.
31. Zhu D, Effros RM, Harder DR, Roman RJ, and Jacobs ER. Tissue sources of cytochrome P450 4A and 20-HETE synthesis in rabbit lungs. Am J Respir Cell Mol Biol 19: 121-128, 1998.
32. Zhu D, Bousamra M, Zeldin DC, Falck JR, Townsley M, Harder DR, Roman RJ, and Jacobs ER. Epoxyeicosatrienoic acids constrict isolated pressurized rabbit pulmonary arteries. Am J Physiol Lung Cell Mol Physiol 278: L335-L343, 2000.
33. Zeldin DC, Plitman JD, Kobaytashi J, Miller RF, Snapper JR, Falck JR, Szarek JL, Philpot RM, and Capdevila JH. The rabbit pulmonary cytochrome P450 arachidonic acid metabolic pathway: characterization and significance. J Clin Invest 95: 2150-2160, 1995.