Natural proteolytic processing of hemofiltrate CC chemokine 1 generates a potent CC chemokine receptor (CCR)1 and CCR5 agonist with anti-HIV properties

Journal of Experimental Medicine

Volumn 192, Issue 10, 2000, Pages 1501-1508

  Detheux, Michel ^a   Ständker, Ludger ^b   Vakili, Jalal ^c   Münch, Jan ^d   Forssmann, Ulf ^b,e   Adermann, Knut ^b   Pöhlmann, Stefan ^d   Vassart, Gilbert ^c   Kirchhoff, Frank ^d   Parmentier, Marc ^c   Forssmann, Wolf Georg ^b  

^a Euroscreen SA   (Belgium)

^b IPF PHARMACEUTICALS GMBH   (Germany)

^c UNIVERSITÉ LIBRE DE BRUXELLES   (Belgium)

^d UNIVERSITY OF ERLANGEN NUREMBERG   (Germany)

^e JOHANNES GUTENBERG UNIVERSITY   (Germany)

Author keywords

Biological assay; CC; CCR5; Chemokines; Endopeptidase; HIV; Receptors

Indexed keywords

BETA CHEMOKINE; CHEMOKINE RECEPTOR CCR1; CHEMOKINE RECEPTOR CCR5; HEMOFILTRATE CC CHEMOKINE 1; UNCLASSIFIED DRUG;

ACQUIRED IMMUNE DEFICIENCY SYNDROME; ARTICLE; BIOASSAY; CALCIUM TRANSPORT; CHEMOTAXIS; DRUG ISOLATION; EOSINOPHIL; HEMOFILTRATION; HUMAN; HUMAN CELL; HUMAN IMMUNODEFICIENCY VIRUS 1; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; MONOCYTE; PATHOGENESIS; PRIORITY JOURNAL; PROTEIN DEGRADATION; T LYMPHOBLAST;

ADULT; AMINO ACID SEQUENCE; ANTI-HIV AGENTS; BIOLOGICAL ASSAY; BLOOD PROTEINS; CALCIUM SIGNALING; CHEMOKINES, CC; CHEMOTACTIC FACTORS; CHEMOTAXIS, LEUKOCYTE; CULTURE MEDIA, CONDITIONED; ENDOPEPTIDASES; HUMANS; MOLECULAR SEQUENCE DATA; PEPTIDE FRAGMENTS; PROTEIN PROCESSING, POST-TRANSLATIONAL; RECEPTORS, CCR5; RECEPTORS, CHEMOKINE;

EID: 0034694019     PISSN: 00221007     EISSN: None     Source Type: Journal    
DOI: 10.1084/jem.192.10.1501     Document Type: Article

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