The renin-angiotensin system and experimental heart failure

Cardiovascular Research

Volumn 43, Issue 4, 1999, Pages 838-849

  Wollert, Kai C ^a   Drexler, Helmut ^a  

^a HANNOVER MEDICAL SCHOOL   (Germany)

Author keywords

Cardiac hypertrophy; Heart failure; Myocytes; Renin angiotensin system

Indexed keywords

ANGIOTENSIN; ANGIOTENSIN RECEPTOR; ENDOTHELIN 1; MESSENGER RNA;

ENDOTHELIUM CELL; HEART FAILURE; HEART MUSCLE; HEART VENTRICLE HYPERTROPHY; HUMAN; MUSCLE CELL; NONHUMAN; PATHOPHYSIOLOGY; PRIORITY JOURNAL; RENIN ANGIOTENSIN ALDOSTERONE SYSTEM; REVIEW; SIGNAL TRANSDUCTION;

ANGIOTENSIN II; ANGIOTENSIN-CONVERTING ENZYME INHIBITORS; ANIMALS; AORTIC VALVE STENOSIS; CARDIOMEGALY; CORONARY DISEASE; HEART FAILURE, CONGESTIVE; MICE; MICE, TRANSGENIC; MYOCARDIUM; RATS; RECEPTORS, ANGIOTENSIN; RENIN-ANGIOTENSIN SYSTEM; SIGNAL TRANSDUCTION;

EID: 0032853798     PISSN: 00086363     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0008-6363(99)00145-5     Document Type: Review

References (149)

1. Lorell B.H. Transition from hypertrophy to failure. Circulation. 96:1997;3824-3827.
2. Reid I.A., Morris B.J., Ganong W.F. The renin-angiotensin system. Annu Rev Physiol. 40:1978;377-410.
3. Baker K.M., Booz G.W., Dostal D.E. Cardiac actions of angiotensin II. Role of an intracardiac renin-angiotensin system. Annu Rev Physiol. 54:1992;227-241.
4. Dzau V.J., Re R. Tissue angiotensin system in cardiovascular medicine A paradigm shift? Circulation. 89:1994;493-498.
5. vonLutterotti N., Catanzaro D.F., Sealey J.E., Laragh J.H. Renin is not synthesized by cardiac and extrarenal vascular tissues. A review of experimental evidence. Circulation. 89:1994;458-470.
6. Danser A.H.J., van Kats J.P., Admiraal P.J.J., et al. Cardiac renin and angiotensins. Uptake from plasma versus in situ synthesis. Hypertension. 24:1994;37-48.
7. Danser A.H.J., van Kesteren C.A.M., Bax W.A., et al. Prorenin, renin, angiotensinogen, and angiotensin-converting enzyme in normal and failing human hearts. Evidence for renin binding. Circulation. 96:1997;220-236.
8. Campbell D.J., Valentijn A.J. Identification of vascular renin-binding proteins by chemical cross-linking. Inhibition of binding of renin by renin inhibitors. J Hypertens. 12:1994;879-890.
9. Müller D.N., Fischli W., Clozel J.P., et al. Local angiotensin II generation in the rat heart. Role of renin uptake. Circ Res. 82:1998;13-20.
10. Passier R.C.J.J., Smits J.F.M., Verluyten M.J.A., Daemen M.J.A.P. Expression and localization of renin and angiotensinogen in rat heart after myocardial infarction. Am J Physiol. 271:1996;H1040-H1048.
11. Baker K.M., Chernin M.I., Wixson S.K., Aceto J.F. Renin-angiotensin system involvement in pressure-overload cardiac hypertrophy in rats. Am J Physiol. 259:1990;H324-H332.
12. Sawa H., Tokuchi F., Mochizuki N., et al. Expression of the angiotensinogen gene and localization of its protein in the human heart. Circulation. 86:1992;138-146.
13. Lindpaintner K., Lu W., Niedermayer N., et al. Selective activation of cardiac angiotensinogen gene expression in post-infarction ventricular remodeling in the rat. J Mol Cell Cardiol. 25:1993;133-143.
14. Iwai N., Shimoike H., Kinoshita M. Cardiac renin-angiotensin system in the hypertrophied heart. Circulation. 92:1995;2690-2696.
15. de Lannoy L.M., Danser A.H., van Kats J.P., et al. Renin-angiotensin system components in the interstitial fluid of the isolated perfused rat heart. Local production of angiotensin I. Hypertension. 29:1997;1240-1251.
16. Finckh M., Hellmann W., Ganten D., et al. Enhanced cardiac angiotensinogen gene expression and angiotensin converting enzyme activity in tachypacing-induced heart failure in rats. Basic Res Cardiol. 86:1991;303-316.
17. Falkenhahn M., Franke F., Bohle R.M., et al. Cellular distribution of angiotensin-converting enzyme after myocardial infarction. Hypertension. 25:1995;219-226.
18. Schunkert H., Dzau V.J., Tang S.S., et al. Increased rat cardiac angiotensin converting enzyme activity and mRNA expression in pressure overload left ventricular hypertrophy. Effects on coronary resistance, contractility, and relaxation. J Clin Invest. 86:1990;1913-1920.
19. Challah M., Nicoletti A., Arnal J.F., et al. Cardiac angiotensin converting enzyme overproduction indicates interstitial activation in renovascular hypertension. Cardiovasc Res. 30:1995;231-239.
20. Hirsch A.T., Talsness C.E., Schunkert H., Paul M., Dzau V.J. Tissue-specific activation of cardiac angiotensin converting enzyme in experimental heart failure. Circ Res. 69:1991;475-482.
21. Wollert K.C., Studer R., von Bülow B., Drexler H. Survival after myocardial infarction in the rat. Role of tissue angiotensin-converting enzyme inhibition. Circulation. 90:1994;2457-2467.
22. Studer R., Reinecke H., Müller B., et al. Increased angiotensin-I converting enzyme gene expression in the failing human heart. Quantification by competitive RNA polymerase chain reaction. J Clin Invest. 94:1994;301-310.
23. Sun Y., Cleutjens J.P.M., Diaz-Arias A.A., Weber K.T. Cardiac angiotensin converting enzyme and myocardial fibrosis in the rat. Cardiovasc Res. 28:1994;1423-1432.
24. Hokimoto S., Yasue H., Fujimoto K., Sakata R., Miyamoto E. Increased angiotensin converting enzyme activity in left ventricular aneurysm of patients after myocardial infarction. Cardiovasc Res. 29:1995;664-669.
25. Hokimoto S., Yasue H., Fujimoto K., et al. Expression of angiotensin-converting enzyme in remaining viable myocytes of human ventricles after myocardial infarction. Circulation. 94:1996;1513-1518.
26. Schunkert H., Jackson B., Tang S.S., et al. Distribution and functional significance of cardiac angiotensin converting enzyme in hypertrophied rat hearts. Circulation. 87:1993;1328-1339.
27. Urata H., Healy B., Stewart R.W., Bumpus F.M., Husain A. Angiotensin II-forming pathways in normal and failing human hearts. Circ Res. 66:1990;883-890.
28. Urata H., Kinoshita A., Perez D.M., et al. Cloning of the gene and cDNA for human heart chymase. J Biol Chem. 266:1991;17173-17179.
29. Wolny A., Clozel J.P., Rein J., et al. Functional and biochemical analysis of angiotensin II-forming pathways in the human heart. Circ Res. 80:1997;219-227.
30. Zisman L.S., Abraham W.T., Meixell G.E., et al. Angiotensin II formation in the intact human heart. Predominance of the angiotensin-converting enzyme pathway. J Clin Invest. 95:1995;1490-1498.
31. Kokkonen J.O., Saarinen J., Kovanen P.T. Regulation of local angiotensin II formation in the human heart in the presence of interstitial fluid. Inhibition of chymase by protease inhibitors of interstitial fluid and of angiotensin-converting enzyme by Ang-(1-9) formed by heart carboxypeptidase A-like activity. Circulation. 95:(1-9):1997;1455-1463.
32. Urata H., Boehm K.D., Philip A., et al. Cellular localization and regional distribution of an angiotensin II-forming chymase in the heart. J Clin Invest. 91:1993;1269-1281.
33. Frangogiannis N.G., Lindsey M.L., Michael L.H., et al. Resident cardiac mast cells degranulate and release preformed TNF-α, initiating the cytokine cascade in experimental canine myocardial ischemia/reperfusion. Circulation. 98:1998;699-710.
34. van Kats J.P., Danser A.H.J., van Meegen J.R., et al. Angiotensin production by the heart. A quantitative study in pigs with the use of radiolabeled angiotensin infusions. Circulation. 98:1998;73-81.
35. Dell'Italia L.J., Meng Q.C., Balcells E., et al. Compartmentalization of angiotensin II generation in the dog heart. Evidence for independent mechanisms in intravascular and interstitial spaces. J Clin Invest. 100:1997;253-258.
36. deLannoy L.M., Danser A.H.J., Bouhuizen A.M.B., et al. Localization and production of angiotensin II in the isolated perfused rat heart. Hypertension. 31:1998;1111-1117.
37. Mukoyama M., Nakajima M., Horiuchi M., et al. Expression cloning of type 2 angiotensin II receptor reveals a unique class of seven-transmembrane receptors. J Biol Chem. 268:1993;24539-24542.
38. Kambayashi Y., Bardhan S., Takahashi K., et al. Molecular cloning of a novel angiotensin II receptor isoform involved in phosphotyrosine phosphate inhibition. J Biol Chem. 268:1993;24543-24546.
39. Iwai N., Inagami T. Identification of two subtypes in the rat type I angiotensin II receptor. FEBS Lett. 298:1992;257-260.
40. Burson J.M., Aguilera G., Gross K.W., Sigmund C.D. Differential expression of angiotensin receptor 1A and 1B in mouse. Am J Physiol. 267:1994;E260-E267.
41. Nio Y., Matsubara H., Murasawa S., Kanasaki M., Inada M. Regulation of gene transcription of angiotensin II receptor subtypes in myocardial infarction. J Clin Invest. 95:1995;46-54.
42. Sechi L.A., Griffin C.A., Grady E.F., Kalinyak J.E., Schambelan M. Characterization of angiotensin II receptor subtypes in rat heart. Circ Res. 71:1992;1482-1489.
43. Suzuki J., Matsubara H., Urakami M., Inada M. Rat angiotensin II (type 1A) receptor mRNA regulation and subtype expression in myocardial growth and hypertrophy. Circ Res. 73:1993;439-447.
44. 2-receptor subtypes in hypertrophied rat hearts. Am J Physiol. 267:1994;H844-H852.
45. Meggs L.G., Coupet J., Huang H., et al. Regulation of angiotensin II receptors on ventricular myocytes after myocardial infarction in rats. Circ Res. 72:1993;1149-1162.
46. Crabos M., Roth M., Hahn A.W., Erne P. Characterization of angiotensin II receptors in cultured adult rat cardiac fibroblasts. Coupling to signaling systems and gene expression. J Clin Invest. 93:1994;2372-2378.
47. 2+ modulation. Circ Res. 78:1996;302-311.
48. 2+ transients in neonatal and adult rat cardiomyocytes by angiotensin II and endothelin-1. Am J Physiol. 270:1996;H857-H868.
49. 2) receptor protein in rat heart. Hypertension. 32:1998;78-83.
50. Ohkubo N., Matsubara H., Nozawa Y., et al. Angiotensin type 2 receptors are reexpressed by cardiac fibroblasts from failing myopathic hamster hearts and inhibit cell growth and fibrillar collagen metabolism. Circulation. 96:1997;3954-3962.
51. Tsutsumi Y., Matsubara H., Ohkubo N., et al. Angiotensin II type 2 receptor is upregulated in human heart with interstitial fibrosis, and cardiac fibroblasts are the major cell type for its expression. Circ Res. 83:1998;1035-1046.
52. Shanmugam S., Corvol P., Gasc J.M. Angiotensin II type 2 receptor mRNA expression in the developing cardiopulmonary system of the rat. Hypertension. 28:1996;91-97.
53. 1a receptor gene expression in the heart. AP-1 and GATA-4 participate in the response to pressure overload. Proc Natl Acad Sci USA. 94:1997;7543-7548.
54. Regitz-Zagrosek V., Friedel N., Heymann A., et al. Regulation, chamber localization, and subtype distribution of angiotensin II receptors in human hearts. Circulation. 91:1995;1461-1471.
55. 1-receptor subtype in failing human ventricular myocardium. Circulation. 95:1997;1193-1200.
56. 2 angiotensin receptor gene expression in human heart failure. Circulation. 95:1997;1201-1206.
57. Kurabayashi M., Yazaki Y. Downregulation of angiotensin II receptor type I in heart failure. A process of adaptation or deterioration? Circulation. 95:1997;1104-1107.
58. Silvestre J.S., Robert V., Heymes C., et al. Myocardial production of aldosterone and corticosterone in the rat. Physiological regulation. J Biol Chem. 273:1998;4883-4891.
59. Zhou G., Kandala J.C., Tyagi S.C., Katwa L.C., Weber K.T. Effects of angiotensin II and aldosterone on collagen gene expression and protein turnover in cardiac fibroblasts. Mol Cell Biochem. 154:1996;171-178.
60. Sato A., Funder J.W. High glucose stimulates aldosterone-induced hypertrophy via type I mineralocorticoid receptors in neonatal rat cardiomyocytes. Endocrinology. 137:1996;4145-4153.
61. Pitt B. Effectiveness of spironolactone added to an angiotensin-converting enzyme inhibitor and a loop diuretic for severe chronic congestive heart failure (the Randomized Aldactone Evaluation Study [RALES]), American Heart Association, Dallas, TX, 1998, Presented at the 71st Scientific Sessions.
62. Matsubara H., Kanasaki M., Murasawa S., et al. Differential gene expression and regulation of angiotensin II receptor subtypes in rat cardiac fibroblasts and cardiomyocytes in culture. J Clin Invest. 93:1994;1592-1601.
63. Kijima K., Matsubara H., Murasawa S., et al. Mechanical stretch induces enhanced expression of angiotensin II receptor subtypes in neonatal rat cardiac myocytes. Circ Res. 79:1996;887-897.
64. 1 receptor subtype. Circ Res. 73:1993;413-423.
65. Ju H., ScammelLaFleur T., Dixon I.M. Altered mRNA abundance of calcium transport genes in cardiac myocytes induced by angiotensin II. J Mol Cell Cardiol. 28:1996;1119-1128.
66. Booz G.W., Baker K.M. Role of type 1 and type 2 angiotensin receptors in angiotensin II-induced cardiomyocyte hypertrophy. Hypertension. 28:1996;635-640.
67. van Kesteren C.A.M., van Heugten H.A.A., Lamers J.M.J., et al. Angiotensin II-mediated growth and antigrowth effects in cultured neonatal rat cardiac myocytes and fibroblasts. J Mol Cell Cardiol. 29:1997;2147-2157.
68. Sadoshima J. Versatility of the angiotensin II type 1 receptor. Circ Res. 82:1998;1352-1355.
69. Sadoshima J., Izumo S. Signal transduction pathways of angiotensin II-induced c-fos gene expression in cardiac myocytes in vitro. Roles of phospholipid-derived second messengers. Circ Res. 73:1993;424-438.
70. 2+-dependent signaling. Circ Res. 76:1995;1-15.
71. Zou Y., Komuro I., Yamazaki T., et al. Protein kinase C., but not tyrosine kinases or Ras, plays a critical role in angiotensin II-induced activation of Raf-1 kinase and extracellular signal-regulated protein kinases in cardiac myocytes. J Biol Chem. 271:1996;33592-33597.
72. q protein-coupled angiotensin II receptor activates p21ras via the tyrosine kinase-Shc-Grb2-Sos pathway in cardiac myocytes. EMBO J. 15:1996;775-787.
73. 2-terminal kinase in cultured cardiac myocytes of neonatal rats. Circ Res. 80:1997;139-146.
74. Kodama H., Fukuda K., Pan J., et al. Biphasic activation of the JAK/STAT pathway by angiotensin II in rat cardiomyocytes. Circ Res. 82:1998;244-250.
75. McWhinney C.D., Dostal D., Baker K. Angiotensin II activates Stat5 through Jak2 kinase in cardiac myocytes. J Mol Cell Cardiol. 30:1998;751-761.
76. Sadoshima J., Izumo S. Rapamycin selectively inhibits angiotensin II-induced increase in protein synthesis in cardiac myocytes in vitro. Potential role of 70-kD S6 kinase in angiotensin II-induced cardiac hypertrophy. Circ Res. 77:1995;1040-1052.
77. Aoki H., Izumo S., Sadoshima J. Angiotensin II activates RhoA in cardiac myocytes. A critical role of RhoA in angiotensin II-induced premyofibril formation. Circ Res. 82:1998;666-676.
78. Nakamura K., Fushimi K., Kouchi H., et al. Inhibitory effects of antioxidants on neonatal rat cardiac myocyte hypertrophy induced by tumor necrosis factor-α and angiotensin II. Circulation. 98:1998;794-799.
79. Kim N.N., Villarreal F.J., Printz M.P., Lee A.A., Dillmann W.H. Trophic effects of angiotensin II on neonatal rat cardiac myocytes are mediated by cardiac fibroblasts. Am J Physiol. 269:1995;E426-E437.
80. Harada M., Itoh H., Nakagawa O., et al. Significance of ventricular myocytes and nonmyocytes interaction during cardiocyte hypertrophy. Evidence for endothelin-1 as a paracrine hypertrophic factor from cardiac nonmyocytes. Circulation. 96:1997;3737-3744.
81. Sadoshima J., Izumo S. The cellular and molecular response of cardiac myocytes to mechanical stress. Annu Rev Physiol. 59:1997;551-571.
82. Komuro I., Kaida T., Shibazaki Y., et al. Stretching cardiac myocytes stimulates protooncogene expression. J Biol Chem. 265:1990;3595-3598.
83. Sadoshima J., Jahn L., Takahashi T., Kulik T.J., Izumo S. Molecular characterization of the stretch-induced adaptation of cultured cardiac cells. An in vitro model of load-induced cardiac hypertrophy. J Biol Chem. 267:1992;10551-10560.
84. Sadoshima J., Izumo S. Mechanical stretch rapidly activates multiple signal transduction pathways in cardiac myocytes. Potential involvement of an autocrine/paracrine mechanism. EMBO J. 12:1993;1681-1692.
85. Yamazaki T., Tobe K., Hoh E., et al. Mechanical loading activates mitogen-activated protein kinase and S6 peptide kinase in cultured rat cardiac myocytes. J Biol Chem. 268:1993;12069-12076.
86. Yamazaki T., Komuro I., Kudoh S., et al. Mechanical stress activates protein kinase cascade of phosphorylation in neonatal rat cardiac myocytes. J Clin Invest. 96:1995;438-446.
87. Komuro I., Kudo S., Yamazaki T., et al. Mechanical stretch activates the stress-activated protein kinases in cardiac myocytes. FASEB J. 10:1996;631-636.
88. Tamura K., Umemura S., Nyui N., et al. Activation of angiotensinogen gene in cardiac myocytes by angiotensin II and mechanical stretch. Am J Physiol. 275:1998;R1-R9.
89. Sadoshima J., Xu Y., Slayter H.S., Izumo S. Autocrine release of angiotensin II mediates stretch-induced hypertrophy of cardiac myocytes in vitro. Cell. 75:1993;977-984.
90. Kojima M., Shiojima I., Yamazaki T., et al. Angiotensin II receptor antagonist TCV-116 induces regression of hypertensive left ventricular hypertrophy in vivo and inhibits the intracellular signaling pathway of stretch-mediated cardiomyocyte hypertrophy in vitro. Circulation. 89:1994;2204-2211.
91. Yamazaki T., Komuro I., Kudoh S., et al. Angiotensin II partly mediates mechanical stress-induced cardiac hypertrophy. Circ Res. 77:1995;258-265.
92. Kudoh S., Komuro I., Harada K., et al. Angiotensin II is not necessary for mechanical stretch-induced activation of mitogen-activated protein kinase in cardiac myocytes of AT1 knockout mice. Circulation. 94:(Suppl.I):1996;I-284.
93. Nyui N., Tamura K., Mizuno K., et al. Stretch-induced MAP kinase activation in cardiomyocytes of angiotensinogen-deficient mice. Biochem Biophys Res Commun. 235:1997;36-41.
94. Yamazaki T., Komuro I., Kudoh S., et al. Endothelin-1 is involved in mechanical stress-induced cardiomyocyte hypertrophy. J Biol Chem. 271:1996;3221-3228.
95. Nyui N., Tamura K., Mizuno K., et al. gp130 is involved in stretch-induced MAP kinase activation in cardiac myocytes. Biochem Biophys Res Commun. 245:1998;928-932.
96. Yamazaki T., Komuro I., Kudoh S., et al. Role of ion channels and exchangers in mechanical stretch-induced cardiomyocyte hypertrophy. Circ Res. 82:1998;430-437.
97. + exchanger and cardiac hypertrophy. Circ Res. 83:1998;870-873.
98. Matsui H., Barry W.H., Livsey C., Spitzer K.W. Angiotensin II stimulates sodium-hydrogen exchange in adult rabbit ventricular myocytes. Cardiovasc Res. 29:1995;215-221.
99. + exchange is impaired in cardiac hypertrophy. J Clin Invest. 99:1997;125-135.
100. Lefroy D.C., Crake T., DelMonte F., et al. Angiotensin II and contraction of isolated myocytes from human, guinea pig, and infarcted rat hearts. Am J Physiol. 270:1996;H2060-H2069.
101. Holubarsch C., Hasenfuss G., Schmidt-Schweda S., et al. Angiotensin I and II exert inotropic effects in atrial but not in ventricular human myocardium. An in vitro study under physiological experimental conditions. Circulation. 88:1993;1228-1237.
102. Mann D.L., Kent R.L., Cooper G. Load regulation of the properties of adult feline cardiocytes. Growth induction by cellular deformation. Circ Res. 64:1989;1079-1090.
103. Kent R.L., McDermott P.J. Passive load and angiotensin II evoke differential responses of gene expression and protein synthesis in cardiac myocytes. Circ Res. 78:1996;829-838.
104. Wada H., Zile M.R., Ivester C.T., Cooper G., McDermott P.J. Comparative effects of contraction and angiotensin II on growth of adult feline cardiocytes in primary culture. Am J Physiol. 271:1996;H29-H37.
105. Liu Y., Leri A., Li B., et al. Angiotensin II stimulation in vitro induces hypertrophy of normal and postinfarcted ventricular myocytes. Circ Res. 82:1998;1145-1159.
106. 2 receptors in regulation of MAPKs and MKP-1 by ANG II in adult cardiac myocytes. Am J Physiol. 275:1998;H906-H916.
107. Schunkert H., Weinberg E.O., Bruckschlegel G., Riegger A.J.G., Lorell B.H. Alteration of growth responses in established cardiac pressure overload hypertrophy in rats with aortic banding. J Clin Invest. 96:1995;2768-2774.
108. Schunkert H., Sadoshima J., Cornelius T., et al. Angiotensin II-induced growth responses in isolated adult rat hearts. Evidence for load-independent induction of cardiac protein synthesis by angiotensin II. Circ Res. 76:1995;489-497.
109. 1 receptor. Circulation. 95:1997;2677-2683.
110. Bartunek J., Weinberg E.O., Tajima M., Rohrbach S., Lorell B.H. Angiotensin II type 2 receptor blockade amplifies the early signals of cardiac growth response to angiotensin II in hypertrophied hearts. Circulation. 99:1999;22-25.
111. Leri A., Claudio P.P., Li Q., et al. Stretch-mediated release of angiotensin II induces myocyte apoptosis by activating p53 that enhances the local renin-angiotensin system and decreases the Bcl-2-to-Bax protein in the cell. J Clin Invest. 101:1998;1326-1342.
112. Kajstura J., Cigola E., Malhotra A., et al. Angiotensin II induces apoptosis of adult ventricular myocytes in vitro. J Mol Cell Cardiol. 29:1997;859-870.
113. Colucci W.S. Apoptosis in the heart. N Engl J Med. 335:1996;1224-1226.
114. Brown N.J., Vaughan D.E. Angiotensin-converting enzyme inhibitors. Circulation. 97:1998;1411-1420.
115. Pitt B., Segal R., Martinez F.A., et al. Randomized trial of losartan versus captopril in patients over 65 with heart failure. Evaluation of losartan in the elderly study, ELITE. Lancet. 349:1997;747-752.
116. Campbell D.J., Kladis A., Duncan A.M. Bradykinin peptides in kidney, blood, and other tissues of the rat. Hypertension. 21:1993;155-165.
117. Baumgarten C.R., Linz W., Kunkel G., Schölkens B.A., Wiemer G. Ramiprilat increases bradykinin outflow from isolated hearts of rat. Br J Pharmacol. 108:1993;293-295.
118. Campbell D.J., Kladis A., Duncan A.M. Effects of converting enzyme inhibitors on angiotensin and bradykinin peptides. Hypertension. 23:1994;439-449.
119. Goldberg M.R., Tanaka W., Barchowsky A., et al. Effects of losartan on blood pressure, plasma renin activity, and angiotensin II in volunteers. Hypertension. 21:1993;704-713.
120. 2 receptor stimulation increases aortic cyclic GMP in SHRSP by a kinin-dependent mechanism. Hypertension. 31:1998;349-355.
121. Pfeffer M.A., Pfeffer J.M., Fishbein M.C., et al. Myocardial infarct size and ventricular function in rats. Circ Res. 44:1979;503-512.
122. Pfeffer J.M., Pfeffer M.A., Fletcher P.J., Braunwald E. Progressive ventricular remodeling in rat with myocardial infarction. Am J Physiol. 260:1991;H1406-H1414.
123. Pfeffer J.M., Pfeffer M.A., Braunwald E. Influence of chronic captopril therapy on the infarcted left ventricle of the rat. Circ Res. 57:1985;84-95.
124. Pfeffer M.A., Pfeffer J.M., Steinberg C., Finn P. Survival after an experimental myocardial infarction. Beneficial effects of long-term therapy with captopril. Circulation. 72:1985;406-412.
125. Wollert K.C., Studer R., Doerfer K., et al. Differential effects of kinins on cardiomyocyte hypertrophy and interstitial collagen matrix in the surviving myocardium after myocardial infarction in the rat. Circulation. 95:1997;1910-1917.
126. Liu Y.H., Yang X.P., Sharov V.G., et al. Effects of angiotensin-converting enzyme inhibitors and angiotensin II type 1 receptor antagonists in rats with heart failure. Role of kinins and angiotensin II type 2 receptors. J Clin Invest. 99:1997;1926-1935.
127. Duncan A.M., Burrell L.M., Kladis A., Campbell D.J. Effects of angiotensin-converting enzyme inhibition on angiotensin and bradykinin peptides in rats with myocardial infarction. J Cardiovasc Pharmacol. 28:1996;746-754.
128. Michel J.B., Lattion A.L., Salzmann J.L., et al. Hormonal and cardiac effects of converting enzyme inhibition in rat myocardial infarction. Circ Res. 62:1988;641-650.
129. Santos R.A.S., Brosnihan K.B., Jacobsen D.W., DiCorleto P.E., Ferrario C.M. Production of angiotensin-(1-7) by human vascular endothelium. Hypertension. 19:(suppl II):1992;56-61.
130. Chappel M.C., Tallant E.A., Brosnihan K.B., Ferrario C.M. Conversion of angiotensin I to angiotensin-(1-7) by thimet oligopeptidase (EC 3.4.24.15) in vascular smooth muscle cells. J Vasc Med Biol. 5:1994;129-137.
131. Chappel M.C., Pirro N.T., Sykes A., Ferrario C.M. Metabolism of angiotensin-(1-7) by angiotensin-converting enzyme. Hypertension. 31:1998;362-367.
132. Seyedi N., Xu X., Nasjletti A., Hintze T.H. Coronary kinin generation mediates nitric oxide release after angiotensin receptor stimulation. Hypertension. 26:1995;164-170.
133. Brosnihan K.B., Li P., Ferrario C.M. Angiotensin-(1-7) dilates canine coronary arteries through kinins and nitric oxide. Hypertension. 27:1996;523-528.
134. Ferrario C.M., Chappell M.C., Tallant E.A., Brosnihan K.B., Diz D.I. Counterregulatory actions of angiotensin-(1-7). Hypertension. 30:1997;535-541.
135. Schieffer B., Wirger A., Meybrunn M., et al. Comparative effects of chronic angiotensin-converting enzyme inhibition and angiotensin II type 1 receptor blockade on cardiac remodeling after myocardial infarction in the rat. Circulation. 89:1994;2273-2282.
136. Milavetz J.J., Raya T.E., Johnson C.S., Morkin E., Goldman S. Survival after myocardial infarction in rats. Captopril versus losartan. J Am Coll Cardiol. 27:1996;714-719.
137. Litwin S.E., Katz S.E., Weinberg E.O., et al. Serial echocardiographic-doppler assessment of left ventricular geometry and function in rats with pressure-overload hypertrophy. Chronic angiotensin-converting enzyme inhibition attenuates the transition to heart failure. Circulation. 91:1995;2642-2654.
138. Weinberg E.O., Schoen F.J., George D., et al. Angiotensin-converting enzyme inhibition prolongs survival and modifies the transition to heart failure in rats with pressure overload hypertrophy due to ascending aortic stenosis. Circulation. 90:1994;1410-1422.
139. 1 receptor inhibition. Effects on hypertrophic remodeling and ACE expression in rats with pressure-overload hypertrophy due to ascending aortic stenosis. Circulation. 95:1997;1592-1600.
140. Christensen G., Wang Y., Chien K.R. Physiological assessment of complex cardiac phenotypes in genetically engineered mice. Am J Physiol. 272:1997;H2513-H2524.
141. Hein L., Stevens M.E., Barsh G.S., et al. Overexpression of angiotensin AT1 receptor transgene in the mouse myocardium produces a lethal phenotype associated with myocyte hyperplasia and heart block. Proc Natl Acad Sci USA. 94:1997;6391-6396.
142. Masaki H., Kurihara T., Yamaki A., et al. Cardiac-specific overexpression of angiotensin II AT2 receptor causes attenuated response to AT1 receptor-mediated pressor and chronotropic effects. J Clin Invest. 101:1998;527-535.
143. Ito M., Oliverio M.I., Mannon P.J., et al. Regulation of blood pressure by the type 1A angiotensin II receptor gene. Proc Natl Acad Sci USA. 92:1995;3521-3525.
144. Sugaya T., Nishimatsu S., Tanimoto K., et al. Angiotensin II type 1a receptor-deficient mice with hypotension and hyperreninemia. J Biol Chem. 270:1995;18719-18722.
145. Hein L., Barsh G.S., Pratt R.E., Dzau V.J., Kobilka B.K. Behavioural and cardiovascular effects of disrupting the angiotensin II type-2 receptor gene in mice. Nature. 377:1995;744-747.
146. Ichiki T., Labosky P.A., Shiota C., et al. Effects on blood pressure and exploratory behaviour of mice lacking angiotenin II type-2 receptor. Nature. 377:1995;748-750.
147. Harada K., Komuro I., Shiojima I., et al. Pressure overload induces cardiac hypertrophy in angiotensin II type 1A receptor knockout mice. Circulation. 97:1998;1952-1959.
148. Harada K., Komuro I., Zou Y., et al. Acute pressure overload could induce hypertrophic responses in the heart of angiotensin II type 1a knockout mice. Circ Res. 82:1998;779-785.
149. Homcy C.J. Signaling hypertrophy. How many switches, how many wires. Circulation. 97:1998;1890-1892.