Thrombotic thrombocytopenic purpura associated with clopidogrel

New England Journal of Medicine

Volumn 342, Issue 24, 2000, Pages 1773-1777

  Bennett, Charles L ^d   Connors, Jean M ^e   Carwile, John M ^e   Moake, Joel L ^a   Bell, William R ^e   Tarantolo, Stefano R ^e   McCarthy, Leo J ^e   Sarode, Ravindra ^e   Hatfield, Amy J ^b   Feldman, Marc D ^e   Davidson, Charles J ^e   Tsai, Han Mou ^c   Michalets, Elizabeth L ^e  

^a INDIANA UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b Mission St Joseph's Health System   (United States)

^c ALBERT EINSTEIN COLLEGE OF MEDICINE   (United States)

^d JESSE BROWN VA MEDICAL CENTER   (United States)

^e NONE

Author keywords

[No Author keywords available]

Indexed keywords

ATENOLOL; ATORVASTATIN; CLOPIDOGREL; CYCLOSPORIN; SIMVASTATIN; THIENO[2,3 B]PYRIDINE DERIVATIVE; TICLOPIDINE;

ADULT; AGED; ARTICLE; BLOOD BANK; CLINICAL ARTICLE; CLINICAL TRIAL; COHORT ANALYSIS; DRUG MECHANISM; FEMALE; HEALTH SURVEY; HUMAN; LABORATORY DIAGNOSIS; MALE; PHASE 3 CLINICAL TRIAL; PLASMAPHERESIS; PRIORITY JOURNAL; THROMBOTIC THROMBOCYTOPENIC PURPURA;

ADULT; AGED; FATAL OUTCOME; FEMALE; HUMANS; MALE; MIDDLE AGED; PLASMA EXCHANGE; PLATELET AGGREGATION INHIBITORS; PURPURA, THROMBOTIC THROMBOCYTOPENIC; RECURRENCE; TICLOPIDINE;

EID: 0034660472     PISSN: 00284793     EISSN: None     Source Type: Journal    
DOI: 10.1056/NEJM200006153422402     Document Type: Article

References (25)

1. Amorosi E, Ultmann J. Thrombotic thrombocytopenic purpura: report of 16 cases and review of the literature. Medicine (Baltimore) 1966;45:139-59.
2. Rock GA, Shumak KH, Buskard NA, et al. Comparison of plasma exchange with plasma infusion in the treatment of thrombotic thrombocytopenic purpura. N Engl J Med 1991;325:393-7.
3. Torok TJ, Holman RC, Chorba TL. Increasing mortality from thrombotic thrombocytopenic purpura in the United States: analysis of national mortality data, 1968-1991. Am J Hematol 1995;50:84-90.
4. Bell WR, Braine HG, Ness PM, Kickler TS. Improved survival in thrombotic thrombocytopenic purpura-hemolytic uremic syndrome: clinical experience in 108 patients. N Engl J Med 1991;325:398-403.
5. Sarode R, Gottschall JL, Aster RH, McFarland JG. Thrombotic thrombocytopenic purpura: early and late responders. Am J Hematol 1997;54: 102-7.
6. Gordon LI, Kwaan HC. Cancer-and drug-associated thrombotic thrombocytopenic purpura and hemolytic uremic syndrome. Semin Hematol 1997;34:140-7.
7. Tsai H-M, Lian EC-Y. Antibodies to von Willebrand factor-cleaving protease in acute thrombotic thrombocytopenic purpura. N Engl J Med 1998;339:1585-94.
8. Furlan M, Robles R, Galbusera M, et al. Von Willebrand factor-cleaving protease in thrombotic thrombocytopenic purpura and the hemolytic-uremic syndrome. N Engl J Med 1998;339:1578-84.
9. Moake JL. Moschcowitz, multimers, and metalloprotease. N Engl J Med 1998;339:1629-31.
10. Bennett CL, Weinberg PD, Rozenberg-Ben-Dror K, Yarnold PR, Kwaan HC, Green D. Thrombotic thrombocytopenic purpura associated with ticlopidine: a review of 60 cases. Ann Intern Med 1998;128:541-4.
11. Steinhubl SR, Tan WA, Foody JM, Topol EJ. Incidence and clinical course of thrombotic thrombocytopenic purpura due to ticlopidine following coronary stenting. JAMA 1999;281:806-10.
12. Bennett CL, Kiss JE, Weinberg PD, et al. Thrombotic thrombocytopenic purpura after stenting and ticlopidine. Lancet 1998;352:1036-7.
13. Bennett CL, Davidson CJ, Raisch DW, Weinberg PD, Bennett RH, Feldman MD. Thrombotic thrombocytopenic purpura associated with ticlopidine in the setting of coronary artery stents and stroke prevention. Arch Intern Med 1999;159:2524-8.
14. CAPRIE Steering Committee. A randomised, blinded, trial of clopidogrel versus aspirin in patients at risk of ischaemic events (CAPRIE). Lancet 1996;348:1329-39.
15. Sharis PJ, Cannon CP, Loscalzo J. The antiplatelet effects of ticlopidine and clopidogrel. Ann Intern Med 1998;129:394-405.
16. Klein LW, Calvin JE. Use of clopidogrel in coronary stenting: what was the question? J Am Coll Cardiol 1999;34:1895-8.
17. Moussa I, Oetgen M, Roubin G, et al. Effectiveness of clopidogrel and aspirin versus ticlopidine and aspirin in preventing stent thrombosis after coronary stent implantation. Circulation 1999;99:2364-6.
18. Connors JM, Gopfert C, Robson S, Churchill WH, Benjamin RJ. Clopidogrel associated TTP. Transfusion 1999;39:Suppl:56S. abstract.
19. Carwile JM, Laber DA, Soltero ER, et al. Thrombotic thrombocytopenic purpura occurring after exposure to clopidogrel. Blood 1999;94: Suppl 1:78b. abstract.
20. Rose M, Eldor A. High incidence of relapses in thrombotic thrombocytopenic purpura: clinical study of 38 patients. Am J Med 1987;83:437-44.
21. Page Y, Tardy B, Zeni F, Comtet C, Terrana R, Bertrand JC. Thrombotic thrombocytopenic purpura related to ticlopidine. Lancet 1991;337: 774-6.
22. Wysowski DK, Bacsanyi J. Blood dyscrasias and hematologic reactions in ticlopidine users. JAMA 1996;276:952.
23. McCarthy LJ, Porcu P, Fausel CA, Sweeney CJ, Danielson CFM. Thrombotic thrombocytopenic purpura and simvastatin. Lancet 1999; 352:1284.
24. Tsai H-M, Rice L, Sarode R, Chow TW, Moake JL. Antibody inhibitors to von Willebrand factor metalloproteinase and increased von Willebrand factor-platelet binding in ticlopidine-associated thrombotic thrombocytopenic purpura. Ann Intern Med 2000;132:794-9.
25. Mauro M, Dang C, Raife T, Laurence J. Ticlopidine-linked thrombotic thrombocytopenic purpura: association with endothelial cell apoptosis and disruption of extracellular matrix in vitro and in vivo, Blood 1999;94: Suppl 1:646a. abstract.