Conditional transgenic technologies

Journal of Endocrinology

Volumn 171, Issue 1, 2001, Pages 1-14

  Ryding, A D S ^a   Sharp, M G F ^a   Mullins, J J ^a  

^a UNIVERSITY OF EDINBURGH   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

CRE RECOMBINASE; CYTOCHROME P450; DOXYCYCLINE; ECDYSONE; RNA POLYMERASE; TETRACYCLINE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIBIOTIC RESISTANCE; ANTIBIOTIC SENSITIVITY; CONTROLLED STUDY; GENE DELETION; GENE DUPLICATION; GENE EXPRESSION; GENE FUNCTION; GENE INDUCTION; GENE TECHNOLOGY; GENETIC RECOMBINATION; GENETIC TRANSCRIPTION; MOUSE; MUTAGENESIS; NONHUMAN; PRIORITY JOURNAL; PROMOTER REGION; RAT; REVIEW; SOMATIC CELL; TECHNIQUE; TISSUE SPECIFICITY; TRANSGENE; TRANSGENIC ANIMAL; TRANSGENIC MOUSE;

ANIMALS; BACTERIAL PROTEINS; BRAIN; BREEDING; CYTOCHROME P-450 CYP1A1; ECDYSONE; ENDOCRINOLOGY; ENZYME INDUCTION; GENE DELETION; GENE EXPRESSION; GENE EXPRESSION REGULATION, ENZYMOLOGIC; GENE TRANSFER TECHNIQUES; HUMANS; INTEGRASES; LIVER; MICE; MICE, TRANSGENIC; MODELS, ANIMAL; MUTAGENESIS, SITE-DIRECTED; PROTEIN SYNTHESIS INHIBITORS; RECOMBINATION, GENETIC; RESEARCH; STEM CELLS; TETRACYCLINE; VIRAL PROTEINS;

EID: 0034758539     PISSN: 00220795     EISSN: None     Source Type: Journal    
DOI: 10.1677/joe.0.1710001     Document Type: Review

References (132)

1. Adipose-selective targeting of the GLUT4 gene impairs insulin action in muscle and liver
2. Cre-mediated somatic site-specific recombination in mice
3. A novel tetracycline-dependent transactivator with E2F4 transcriptional activation domain
4. Sustained mammary gland-directed, ponasterone A-inducible expression in transgenic mice
5. Delay in resumption of the activity of tetracycline-regulatable promoter following removal of tetracycline analogues
6. Co-regulation of two gene activities by tetracycline via a bidirectional promoter
7. Tetracycline-controlled transcription in eukaryotes: Novel transactivators with graded transactivation potential
8. Generation of conditional mutants in higher eukaryotes by switching between the expression of two genes
9. Kit/stem cell factor receptor-induced activation of phosphatidyl 3′-kinase is essential for male fertility
10. + channel subunit, SK3
11. Multifunctional aspects of the action of indole-3-carbinole as an antitumour agent
12. Spatio-temporally controlled site-specific somatic mutagensis in the mouse
13. A chimeric Cre recombinase inducible by synthetic, but not natural ligands of the glucocorticoid receptor
14. Altering mice by homologous recombination using embryonic stem cells
15. A muscle-specific insulin receptor knockout exhibits features of the metabolic syndrome of NIDDM without altering glucose tolerance
16. Improved properties of FLP recombinase evolved by cycling mutagenesis
17. Inducible chromosomal translocation of AML1 and ETO genes through Cre/loxP-mediated recombination in the mouse
18. Targeting genes for self-excision in the germline
19. Regulation of the CYP1A1 promoter in transgenic mice: An exquisitely sensitive on-off system for cell specific gene regulation
20. Role of the region 3′ to Xist exon 6 in the counting process of X-chromosome inactivation
21. Inter-chromosomal recombination of Mll and Af9 genes mediated by cre-loxP in mouse development
22. Modification of gene activity in mouse embryos in utero by a tamoxifen-inducible form of Cre recombinase
23. Cloning and expression of a human Ah receptor cDNA
24. Inhibition of Acyl-CoA:cholesterol acyltransferase activity and reduction of serum LDL/VLDL cholesterol levels by glucobrassin derivatives
25. Flp recombinase promotes site-specific DNA recombination in embryonic stem cells and transgenic mice
26. Using Flp-recombinase to characterise expansion of Wnt1-expressing neural progenitors in the mouse
27. Conditional transformation of a pancreatic β-cell line derived from transgenic mice expressing a tetracycline-regulated oncogene
28. 2,3,7,8-Tetrachlorodibenzo-p-dioxin-inducible, Ah receptor-mediated bending of enhancer DNA
29. Dietary indole-3-carbinol alters immune function in rats
30. Ligand-activated site-specific recombination in mice
31. Targeted deletion of 5′HS2 of the murine β-globin LCR reveals that it is not essential for proper regulation of the β-globin locus
32. Use of the Cre/lox recombination system to develop a non-lethal knock-in murine model for osteogenesis imperfecta with an α 1 (I) G349C substitution
33. The 4S benzo(a)pyrene-binding protein is not a transcriptional activator of Cyp 1 a 1 gene in Ah receptor-deficient (AHR-/-) transgenic mice
34. A tetracycline controlled activation/repression system with increased potential for gene transfer into mammalian cells
35. Polymorphic forms of the Ah receptor and induction of the CYP1A1 gene
36. Temporal control of gene expression in transgenic mice by a tetracycline-responsive promoter
37. Evolution of the P450 gene superfamily: Animal-plant 'warfare', molecular drive and human genetic differences in drug oxidation
38. Tight control of gene expression in mammalian cells by tetracycline-responsive promoters
39. Anhydrotetracycline, a novel effector of the tetracycline controlled gene expression systems in eukaryotic cells
40. Control of gene activity in higher eukaryotic cells by prokaryotic regulatory elements
41. Transcriptional activation by tetracyclines in mammalian cells
42. Tissue-specific targeting of the pthrp gene: The generation of mice with floxed alleles
43. Engineering chromosomes in mice through targeted meiotic recombination (TAMERE)
44. The herpes simplex virus VP16-induced complex: Mechanisms of combinatorial transcriptional regulation
45. Adult insulin- and glucagon-producing cells differentiate from two independent cell lineages
46. Cre-mediated germline mosaicism: A method allowing rapid generation of several alleles of a target gene
47. A targeted partial invalidation of the insulin-like growth factor receptor gene in mice causes a postnatal growth deficit
48. Adenovirus-mediated inducible gene expression in vivo by a hybrid ecdysone receptor
49. Molecular dissection of cardiac repolarization by in vivo Kv4.3 gene transfer
50. Reversibility of acute B-cell leukaemia induced by BCR-ABL1
51. T2) in adipocytes
52. A regulatory network for the efficient control of transgene expression
53. Temporally-controlled site-specific mutagenesis in the basal layer of the epidermis: Comparison of the recombinase activity of the tamoxifen-inducible Cre-ER(T) and Cre-ER(T2) recombinases
54. Induction of the Cyp 1a1 dioxin-responsive enhancer in transgenic mice
55. Overexpression of a kinase-deficient transforming growth factor-β type II receptor in mouse mammary stroma results in increased epithelial branching
56. Genetic mapping of modifier loci affecting malignant hypertension in TGRmRen2 rats
57. Controlled hypertension: A transgenic toggle switch reveals differential mechanisms underlying vascular disease
58. Concurrent flavin-containing monooxygenase down-regulation and cytochrome P-450 induction by dietary indoles in rat: Implications for drug-drug interaction
59. A novel reporter mouse strain that expresses enhanced green fluorescent protein upon Cre-mediated recombination
60. Regulation of Cre recombinase activity by the synthetic steroid RU 486
61. Inducible site-specific recombination in the brain
62. Tetracycline-controlled expression but not toxicity of an attenuated diphtheria toxin mutant
63. Site-specific recombinases: Tools for genome engineering
64. Doxycycline-mediated quantitative and tissue-specific control of gene expression in transgenic mice
65. Targeted inversion of a polar silencer within the HoxD complex re-allocates domains of enhancer sharing
66. Temporally controlled somatic mutagenesis in smooth muscle
67. Inducible gene targeting in mice
68. Tissue-specific knockout of the insulin receptor in pancreatic β cells creates an insulin secretory defect similar to that in type 2 diabetes
69. Targeted oncogene activation by site specific recombination in transgenic mice
70. Conditional lineage ablation to model human disease
71. Disruption of the c/ebpa gene in adult mouse liver
72. Cre-mediated chromosome loss in mice
73. Transcriptional activation function of the mouse Ah receptor nuclear translocator
74. Z/AP, a double reporter for cre-mediated recombination
75. Ligand-regulated site-specific recombination
76. Positive and negative discrimination of estrogen receptor agonists and antagonists using site-specific DNA recombinase fusion proteins
77. A 'knockdown' mutation created by cis-element gene targeting reveals the dependence of erythroid cell maturation on the level of transcription factor GATA-1
78. Improved reporter strain for monitoring Cre recombinase-mediated DNA excisions in mice
79. Activation of EGFP expression by cre-mediated excision in a new ROSA26 reporter mouse strain
80. Conditional site-specific recombination in mammalian cells using a ligand-dependent chimeric Cre recombinase
81. An Fgf8 mutant allelic series generated by Cre- and Flp-mediated recombination
82. Fgf8 is required for outgrowth and patterning of the limbs
83. Modifier genes in mice and humans
84. Dissecting the role of N-myc in development using a single targeting vector to generate a series of alleles
85. Ecdysone-inducible gene expression in mammalian cells and transgenic mice
86. Z/EG, a double reporter mouse line that expresses enhanced green fluorescent protein upon cre-mediated excision
87. Protamine-Cre recombinase transgenes efficiently recombine target sequences in the male germ line of mice, but not in embryonic stem cells
88. Dioxin induces localised, graded changes in chromatin structure: Implications for Cyp 1a1 gene transcription
89. Know your neighbors: Three phenotypes in null mutants of the myogenic bHLH gene MRF41
90. Metallothionein-human GH fusion genes stimulate growth of mice
91. Induction of cytochrome P4501A1 by 2,3,7,8-tetrachlorodibenzo-p-dioxin or indolo (3,2-b)carbazole is associated with oxidative DNA damage
92. Dual roles for glucokinase in glucose homeostasis as determined by liver and pancreatic β-cell-specific gene knock-outs using Cre recombinase
93. i-coupled receptor in transgenic mice
94. 1-coupled receptor causes ventricular conduction delay and a lethal cardiomyopathy
95. Origin of the precerebellar system
96. High-efficiency deleter mice show that FLPe is an alternative to Cre-loxP
97. Inducible inactivation of hepatic LRP gene by Cre-mediated recombination confirms a role of LRP in clearance of chylomicron remnants
98. 'Cre'-ating mouse mutants - A meeting review on conditional mouse genetics
99. Tetracycline-regulatable factors with distinct dimerization domains allow reversible growth inhibition by p16
100. Piperonyl butoxide and acenaphthylene induce cytochrome P450 1A2 and 1B1 mRNA in aromatic hydrocarbon-responsive receptor knock-out mouse liver
101. Inducible gene knockouts in the small intestinal and colonic epithelium
102. Identification of ligands and coligands for the ecdysone-regulated gene switch
103. Gene transfer into individual muscle fibers and conditional gene expression in living animals
104. Illegitimate Cre-dependent chromosome rearrangements in transgenic mouse spermatids
105. Efficient control of gene expression by single step integration of the tetracycline system in transgenic mice
106. Temporally and spatially regulated somatic mutagenesis in mice
107. Efficient BLG-Cre mediated gene deletion in the mammary gland
108. Overexpression of apolipoprotein CII causes hypertriglyceridemia in transgenic mice
109. The temporal requirement for endothelin receptor-B signalling during neural crest development
110. Cytochrome P450 1A1 promoter as a genetic switch for the regulatable and physiological expression of a plasma protein in transgenic mice
111. A site-directed chromosomal translocation induced in embyonic stem cells by Cre-loxP recombination
112. Generalised lacZ expression with the ROSA26 Cre reporter strain
113. Mechanisms of tumour modulation by indole-3-carbinol. Disposition and excretion in male Fischer 344 rats
114. Nested chromosomal deletions induced with retroviral vectors in mice
115. Mammalian genomes contain active recombinase recognition sites
116. Conditional disruption of the aryl hydrocarbon receptor nuclear translocator (Arnt) gene leads to loss of target gene induction by the aryl hydrocarbon receptor and hypoxia-inducible factor 1 alpha
117. Disruption of the glucocorticoid receptor gene in the nervous system results in reduced anxiety
118. Exploring the sequence space for tetracycline-dependent transcriptional activators: Novel mutations yield expanded range and sensitivity
119. The p65 domain of NF-kB is an efficient human activator in the tetracycline-regulatable gene expression system
120. Temporal, spatial, and cell-type specific control of Cre-mediated DNA recombination in transgenic mice
121. Flp-mediated tissue-specific inactivation of the retinoblastoma tumor suppressor geme in the mouse
122. Targeted DNA recombination in vitro using an adenovirus carrying the Cre recombinase gene
123. New variants of inducible Cre recombinase: A novel mutant of Cre-PR fusion protein exhibits enhanced sensitivity and an expanded range of inducibility
124. Conditional mutation of Brca 1 in mammary epithelial cells results in blunted ductal morphogenesis and tumour formation
125. Normal growth and development in the absence of hepatic insulin-like growth factor I
126. Liver-specific igf-1 gene deletion leads to muscle insulin insensitivity
127. Reversal of neuropathology and motor dysfunction in a conditional model of Huntington's disease
128. Role of Ahch in gonadal development and gametogenesis
129. Effect of phenobarbital on hepatic CYP1A1 and CYP1A2 in the Ahr- null mouse
130. Steroidogenic factor 1 (SF1) is essential for pituitary gonadotrope function
131. Engineering mouse chromosomes with Cre-loxP: Range, efficiency, and somatic applications
132. Use of the tetracycline controlled transcriptional silencer (tTS) to eliminate transgene leak in inducible overexpression transgenic mice