Dietary indole-3-carbinol alters immune functions in rats

Journal of Toxicology and Environmental Health - Part A

Volumn 59, Issue 4, 2000, Pages 271-279

  Exon, Jerry H ^a   South, E H ^a  

^a UNIVERSITY OF IDAHO   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

3 INDOLEMETHANOL; KEYHOLE LIMPET HEMOCYANIN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIBODY PRODUCTION; ARTICLE; B LYMPHOCYTE; CARCINOGENESIS; CELL ACTIVITY; CELLULAR IMMUNITY; CONTROLLED STUDY; DIETARY INTAKE; HUMORAL IMMUNITY; IMMUNE RESPONSE; MALE; NATURAL KILLER CELL; NONHUMAN; PRIORITY JOURNAL; RAT;

ANIMALS; ANTIBODY FORMATION; ANTICARCINOGENIC AGENTS; DIET; DISEASE MODELS, ANIMAL; HYPERSENSITIVITY, DELAYED; IMMUNE SYSTEM; IMMUNITY, CELLULAR; INDOLES; KILLER CELLS, NATURAL; MALE; RATS; RATS, SPRAGUE-DAWLEY; T-LYMPHOCYTES;

EID: 0034712063     PISSN: 15287394     EISSN: 10872620     Source Type: Journal    
DOI: 10.1080/009841000156934     Document Type: Article

References (38)

1. Bailey, G. S., Hendricks, J. D., Shelton, D. W., Nixon, J. E., and Pawlowski, N.W. 1987. Enhancement of carcinogenesis by the natural anticarcinogen indole-3-carbinol. JNCI 78:931-934.
2. Bjeldanes, L. F., Kim, J. Y., Grose, K. R., Bartholomew, J. C., and Bradfield, C. A. 1991. Aromatic hydrocarbon responsiveness-receptor agonists generated from indole-3-carbinol in vitro and in vivo-comparisons with 2,3,7,8-tetrach lorodibenzo-p-dioxin. Proc. Natl. Acad. Sci. USA 88: 9543-9547.
3. Bradlow, H. L., Michnovicz, J. J., Telang, N. T., and Osborne, M. P. 1991. Effects of dietary indole-3-carbinol on estradiol metabolism and spontaneous mammary tumors in mice. Carcinogenesis 12:1571-1574.
4. Chang, Y.-C., Riby, J., Chang, G. H.-F., Peng, B.-C., Firestone, G., and Bjeldanes, L. F. 1999. Cytostatic and antiestrogenic effects of 2-(indol-3-ylmethyl)-3,3-diindolylmethane, a major in vivo product of dietary indole-3-carbinol. Biochem. Pharmacol. 58:825-834.
5. Chen, I., Safe, S., and Bjeldanes, L. 1996. Indole-3-carbinol and diindolylmethane as aryl hydrocarbon (Ah) receptor agonists in T47D human breast cancer cells. Biochem. Pharmacol. 51:1069-1076.
6. Chen, I., McDougal, A., Wang, F., and Safe, S. 1998. Aryl hydrocarbon receptor-mediated antiestrogenic and antitumorigenic activity of diindolylmethane. Carcinogenesis 19:1631-1639.
7. Chen, Y.-H., Riby, J., Srivastiava, P., Bartholomew, J., Denison, M., and Bjeldanes, L. 1995. Regulation of CYP1A1by indolo[3,2-6]carbazole in murine hepatoma cells. J. Biol. Chem. 270:22548-22555.
8. d'Argy, R., Bergman, J., and Dencker, L. 1989. Effects of immunosuppressive chemicals on lymphoid development in foetal thymus organ cultures. Pharmacol. Toxicol. 64:33-38.
9. Dashwood, R. H. 1999. Early detection and prevention of colorectal cancer (Review). Oncol. Rep. 6:277-281.
10. Dashwood, R. H., Abogast, D. N., Fong, A. T., Pereira, C., Hendricks, J. D., and Bailey, G. S. 1989. Quantitative inter-relationships between aflatoxin B1carcinogen dose, indole-3-carbinol anticarcinogen dose, target organ DNA adduction and final tumor response. Carcinogenesis 10:175-181.
11. Dashwood, R. H., Fong, A. T., Williams, D. E., Hendricks, J. D., and Bailey, G. S. 1991. Promotion of aflatoxin B1carcinogenesis by the natural tumor modulator indole-3-carbinol: Influence of dose, duration, and intermittent exposure on indole-3-carbinol promotional potency. Cancer Res. 51:2362-2365.
12. Exon, J. H., Koller, L. D., Talcott, P. A., O'Reilly, C. A., and Henningsen, G. M. 1986. Immunotoxicity testing: An economical multiple-assay approach. Fundam. Appl. Toxicol. 7:387-397.
13. Exon, J. H., Bussiere, J. L., and Mather, G. G. 1990. Immunotoxicity testi ng in the rat: An improved multiple assay model. Int. J. Immunopharmacol. 12:699-701.
14. Ge, X., Yannai, S., Rennert, G., Gruener, N., and Fares, F. 1996. 3,3'-Diindolylmethane induces apoptosis in human cancer cells. Biochem. Biophys. Res. Commun. 228:153-158.
15. Grubbs, C. J., Steele, V. E., Casebolt, T., Juliana, M. M., Eto, I., Whitaker, L. M., Dragnev, K. H., Kelloff, G. J., and Lubet, R. L. 1995. Chemoprevention of chemically-induced mammary carcinogenesis by indole-3-carbinol. Anticancer Res. 15:709-716.
16. Guo, D., Schut, H. A. J., Davis, C. D., Snyderwine, E. G., Bailey, G. S., and Dashwood, R. H. 1995. Protection by chlorophyllin and indole-3-carbinol against 2-amino-1-methyl-6-phenylimidazo[4,5-b] pyridine (PhIP)-induced DNA adducts and colonic aberrant crypts in the F344 rat. Carcinogenesis 15:2931-2937.
17. Katdare, M., Osborne, M. P., and Telang, N. T. 1998. Inhibition of aberrant proliferation and induction of apoptosis in pre-neoplastic human mammary epithelial cells by natural phytochemicals. Oncol. Rep. 5:311-315.
18. Kim, D. J., Lee, K. K., Bae, J. H., Jang, J. J., Tatematsu, M., and Furihata, C. 1994a. The inhibitory effects of allyl sulfide and indole-3-carbinol on N-methyl-N'-nitro-N-nitrosoguanidine-induced glandular stomach carcinogenesis in rats. J. Korean Cancer Assoc. 26:392-398.
19. Kim, D. J., Lee, K. K., Han, B. S., Ahn, B., Bae, J. H., and Jang, J. J. 1994b. Biphasic modifying effect of indole-3-carbinol on diethylnitrosamine-induced preneoplastic glutathione 5-transferase placental form-positive liver cell foci in Sprague-Dawley rats. Jpn. J. Cancer Res. 85:578-583.
20. Kim, D. J., Han, B., Ahn, B., Hasegawa, R., Shirai, T., Ito, N., and Tsuda, H. 1997. Enhancement by indole-3-carbinol of liver and thyroid gland neoplastic development in a rat medium-term multiorgan carcinogenesis model. Carcinogenesis 18:377-381.
21. Kojima, T., Tanaka, T., and Mori, H. 1994. Chemoprevention of spontaneous endometrial cancer in female Donryu rats by dietary indole-3-carbinol. Cancer Res. 54:144 6-1449.
22. Kwon, C.-S., Grose, K. R., Riby, J., Chen, Y.-H., and Bjeldanes, L. F. 1994. In vivo production and enzyme-inducing activity of indolo[3,2-6]carbazole. J. Agric. Food Chem. 42:2536-2540.
23. Lawrence, B. P., Leid, M., and Kerkvliet, N. I. 1996. Distribution and behavior of the Ah receptor in murine T lymphocytes. Toxicol. Applied Pharmacol. 138:275-284.
24. Liu, H., Wormke, M., Safe, S. H., and Bjeldanes, L. F. 1994. Indolo[3,2-6]carbazole: A dietary-derived factor that exhibits both antiestrogenic and estrogenic activity. JNCI 86:1758-1765.
25. Manson, M. M., Ball, H. W. L., Barrett, M. C., Clark, H. L., Judah, D. J., Williamson, G., and Neal, G. E. 1997. Mechanism of action of dietary chemoprotective agents in rat liver: Induction of phase I and II drug metabolizing enzymes and aflatoxin Bi metabolism. Carcinogenesis 18:1729-1738.
26. Manson, M. M., Hudson, E. A., Ball, H. W. I., Barrett, M. C., Clark, H. L., Judah, D. J., Verschoyle, R. D., and Neal, G. E. 1998. Chemoprevention of aflatoxin B1-induced carcinogenesis by indole-3-carbinol in rat liver-Predicting the outcome using early biomarkers. Carcinogenesis 19: 1829-1836.
27. Michnovicz, J. J. 1998. Increased estrogen 2-hydroxylation in obese women using oral indole-3-carbinol. Int. J. Obesity 22:227-229.
28. Michnovicz, J. J., and Bradlow, H. L. 1990. Induction of estradiol metabolism by dietary indole-3-carbinol in humans. JNCI 82:947-949.
29. Pence, B. C., Buddingh, F., and Yang, S. P. 1986. Multiple dietary factors in the enhancement of dimethylhydrazine carcinogenesis: Main effect of indole-3-carbinol. JNCI 77:269-276.
30. Stresser, D. M., Bailey, G. S., and Williams, D. E. 1994a. Indole-3-carbinol and p-naphthoflavone induction of aflatoxin B1metabolism and cytochromes P-450 associated with bioactivation and detoxication of aflatoxin B1in the rat. Drug Metab. Dispos. 22:383-391.
31. Stresser, D. M., Williams, D. E., McLellan, L. I., Harris, T. M., and Bailey, G. S. 1994b. Indole-3-carbinol induces a rat liver glutathione transferase subunit (Yc2) with high activity toward aflatoxin B1exo-epoxide. Drug Metab. Dispos. 22:392-399.
32. Stresser, D. M., Bjeldanes, L. F., Bailey, G. S., and Williams, D. E. 1996a. Anticarcinogen 3,3'-diin-dolymethane is an inhibitor of cytochrome P-450. J. Biochem. Toxicol. 10:191-201.
33. Stresser, D. M., Williams, D. E., Griffin, D. A., and Bailey, G. S. 1995b. Mechanisms of tumor modulation by indole-3-carbinol disposition and excretion in male Fischer 344 rats. Drug Metab. Dispos. 23:965-975.
34. Sulentic, C. E. W., Holsapple, M. P., and Kaminske, N. E. 1998. Aryl hydrocarbon receptor-dependent suppression by 2,3,7,8-tetrachlorodibenzo-p-dioxin of IgM secretion in activated B cells. Mol. Pharmacol. 53:623-629.
35. Takahashi, N., Williams, D. E., and Bailey, G. S. 1995. Induction of hepatic CYP1A by indole-3-carbinol in protection against aflatoxin B1hepatocarcinogenesis in rainbow trout. Food Chem. Toxicol. 33:841-850.
36. Tanaka, T., Kojima, T., Morishita, Y., and Mori, H. 1992. Inhibitory effects of the natural products indole-3-carbinol and sinigrin during initiation and promotion phases of 4-nitroquinoline 1-oxide-induced rat tongue carcinogenesis. Jpn. J. Cancer Res. 83:835-842.
37. Wattenberg, L. W., and Loub, W. D. 1978. Inhibition of polycyclic aromatic hydrocarbon-induced neoplasia by naturally occurring indoles. Cancer Res. 38:1410-1413.
38. Xu, M., Bailey, A. C., Hernaez, J. F., Taoka, C. R., Schut, H. A. J., and Dashwood, R. H. 1996. Protection by green tea, black tea, and indole-3-carbinol against 2-amino-3-methylimidazo[4,5-/J quinoline-induced DNA adducts and colonic aberrant crypts in the F344 rat. Carcinogenesis 17:1429-1434.