Engineering chromosomes in mice through targeted meiotic recombination (TAMERE)

Nature Genetics

Volumn 20, Issue 4, 1998, Pages 381-384

  Hérault, Yann ^a   Rassoulzadegan, Minoo ^b   Cuzin, François ^b   Duboule, Denis ^a  

^a UNIVERSITY OF GENEVA   (Switzerland)

^b INSERM   (France)

Author keywords

[No Author keywords available]

Indexed keywords

ALLELE; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CHROMATID; CHROMOSOMAL LOCALIZATION; CHROMOSOME ANALYSIS; CHROMOSOME PAIRING; CONTROLLED STUDY; GENE CLUSTER; GENE DUPLICATION; GENE REARRANGEMENT; GENE TARGETING; GENETIC ENGINEERING; GENETIC RECOMBINATION; GENETIC REGULATION; MEIOSIS; MOUSE; NONHUMAN; PRIORITY JOURNAL;

ANIMALS; BASE SEQUENCE; CHROMOSOMES; CROSSES, GENETIC; DNA; FEMALE; GENE DELETION; GENE DUPLICATION; GENES, HOMEOBOX; GENETIC ENGINEERING; MALE; MEIOSIS; MICE; MOLECULAR SEQUENCE DATA; RECOMBINATION, GENETIC;

EID: 0031770816     PISSN: 10614036     EISSN: None     Source Type: Journal    
DOI: 10.1038/3861     Document Type: Article

References (18)

1. Mann, R.S. Why are Hox genes clustered? Bioessays 19, 661-664 (1997).
2. Hérault, Y. et al. Genetic analysis of a Hoxd12 regulatory element reveals global versus local modes of controls in the HoxD complex. Development 125, 1669-1677 (1998).
3. Sharpe, J., Nonchev, S., Gould, A., Whiting, J. & Krumlauf, R. Selectivity, sharing and competitive interactions in the regulation of Hoxb genes. EMBO J. 17, 1788-1798 (1998).
4. Zákány, J., Gérard, M. & Duboule, D. Deletion of a shared HoxD enhancer induces transcriptional heterochrony leading to a transposition of the sacrum. EMBO J. 16, 4393-4402 (1997).
5. Gérard, M. et al. In vivo targeted mutagenesis of a regulatory element required for positioning the Hoxd11 and Hoxd10 expression boundaries. Genes Dev. 10, 2326-2334 (1996).
6. Kondo, T., Zákány, J. & Duboule, D. Control of colinearity in AbdB genes of the mouse HoxD complex. Mol. Cell 1, 289-300 (1998).
7. van der Hoeven, F., Zákány, J. & Duboule, D. Gene transpositions in the HoxD complex reveal a hierarchy of regulatory controls. Cell 85, 1025-1035 (1996).
8. Sauer, B. & Henderson, N. Cre-stimulated recombination at loxP-containing DNA sequences placed into the mammalian genome. Nucleic Acids Res. 17, 147-161 (1989).
9. Gu, H., Zou, Y.R. & Rajewsky, K. Independent control of immunoglobulin switch recombination at individual switch regions evidenced through Cre-loxP-mediated gene targeting. Cell 73, 1155-1164 (1993).
10. Ramirez-Solis, R., Liu, P. & Bradley, A. Chromosome engineering in mice. Nature 378, 720-724 (1995).
11. Zákány, J. & Duboule, D. Synpolydactyly in mice with a targeted deficiency in the HoxD complex. Nature 384, 69-71 (1996).
12. Smith, A.J. et al. A site-directed chromosomal translocation induced in ES cells by Cre-loxP recombination. Nature Genet. 9, 376-385. (1995).
13. Dupé, V. et al. In vivo functional analysis of the Hoxa-1 3′ retinoic acid response element (3′RARE). Development 124, 399-410 (1997).
14. Meuwissen, R.L.J. et al. A coiled-coiled protein specific for synapsed regions of meiotic prophase chromosomes. EMBO J. 11, 5091-5100 (1992).
15. Vidal, F., Sage, J., Cuzin, F. & Rassoulzadegan, M. Cre expression in primary spermatocytes: a tool for genetic engineering of the germ line. Mol. Reprod. Dev. (in press).
16. Beckers, J. & Duboule, D. Genetic analysis of a conserved sequence in the HoxD complex: regulatory redundancy or limitations of the transgenic approaches? Dev. Dyn. 213, 1-11 (1998).
17. Kondo, T. et al. Function of posterior HoxD genes in the morphogenesis of the anal sphincter. Development 122, 2651-2659 (1996).
18. Davis, A.P. & Capecchi, M.R. A mutational analysis of the 5′ HoxD genes: dissection of genetic interactions during limb development in the mouse. Development 122, 1175-1185 (1996).