메뉴 건너뛰기




Volumn 13, Issue 12, 1999, Pages 1524-1528

Targeting genes for self-excision in the germ line

Author keywords

Angiotensin converting enzyme; Conditional mutagenesis; Cre loxP; Gene therapy; Targeted gene modification

Indexed keywords

DIPEPTIDYL CARBOXYPEPTIDASE; RECOMBINASE;

EID: 0033564213     PISSN: 08909369     EISSN: None     Source Type: Journal    
DOI: 10.1101/gad.13.12.1524     Document Type: Article
Times cited : (213)

References (28)
  • 1
    • 0028928854 scopus 로고
    • Site-specific recombination of a transgene in fertilized eggs by transient expression of Cre-recombinase
    • Araki, K., M. Araki, J.I. Miyazaki, and P. Vassalli. 1995. Site-specific recombination of a transgene in fertilized eggs by transient expression of Cre-recombinase. Proc. Natl. Acad. Sci. 92: 160-164.
    • (1995) Proc. Natl. Acad. Sci. , vol.92 , pp. 160-164
    • Araki, K.1    Araki, M.2    Miyazaki, J.I.3    Vassalli, P.4
  • 2
    • 0018955095 scopus 로고
    • Replication and recombination functions associated with the yeast plasmid, 2 μ circle
    • Broach, J.R. and J.B. Hicks. 1980. Replication and recombination functions associated with the yeast plasmid, 2 μ circle. Cell 21: 501-508.
    • (1980) Cell , vol.21 , pp. 501-508
    • Broach, J.R.1    Hicks, J.B.2
  • 3
    • 0002745395 scopus 로고    scopus 로고
    • Human germline gene therapy: A discussion on how and why
    • (ed. G. Stock and J. Campbell), Oxford University Press, New York, NY. (In press.)
    • Capecchi, M.R. 1999. Human germline gene therapy: A discussion on how and why. In Engineering the human germline (ed. G. Stock and J. Campbell), Oxford University Press, New York, NY. (In press.)
    • (1999) Engineering the Human Germline
    • Capecchi, M.R.1
  • 5
    • 0027532257 scopus 로고
    • Location of crossovers during gene targeting with insertion and replacement vectors
    • Deng, C., K.R. Thomas, and M.R. Capecchi. 1993. Location of crossovers during gene targeting with insertion and replacement vectors. Mol. Cell. Biol. 13: 2134-2140.
    • (1993) Mol. Cell. Biol. , vol.13 , pp. 2134-2140
    • Deng, C.1    Thomas, K.R.2    Capecchi, M.R.3
  • 6
    • 84929753105 scopus 로고    scopus 로고
    • Problems of germline therapy
    • Ewbank, J. 1998. Problems of germline therapy. Nature 392: 645.
    • (1998) Nature , vol.392 , pp. 645
    • Ewbank, J.1
  • 8
    • 0027280936 scopus 로고
    • Independent control of immunoglobulin switch recombination at individual switch regions evidenced through Cre-loxP-mediated gene targeting
    • Gu, H., Y.-R. Zou, and K. Rajewsky. 1993. Independent control of immunoglobulin switch recombination at individual switch regions evidenced through Cre-loxP-mediated gene targeting. Cell 73: 1155-1164.
    • (1993) Cell , vol.73 , pp. 1155-1164
    • Gu, H.1    Zou, Y.-R.2    Rajewsky, K.3
  • 9
    • 0028059099 scopus 로고
    • Deletion of a DNA polymerase beta gene segment in T cells using cell type-specific gene targeting
    • Gu, H., J.D. Marth, P.C. Orban, H. Mossmann, and K. Rajewsky. 1994. Deletion of a DNA polymerase beta gene segment in T cells using cell type-specific gene targeting. Science 265: 103-106.
    • (1994) Science , vol.265 , pp. 103-106
    • Gu, H.1    Marth, J.D.2    Orban, P.C.3    Mossmann, H.4    Rajewsky, K.5
  • 10
    • 0026429190 scopus 로고
    • Introduction of a subtle mutation into the Hox-2.6 locus in embryonic stem cells
    • Hasty, P., R. Ramírez-Solis, R. Krumlauf, and A. Bradley. 1991. Introduction of a subtle mutation into the Hox-2.6 locus in embryonic stem cells. Nature 350: 243-246.
    • (1991) Nature , vol.350 , pp. 243-246
    • Hasty, P.1    Ramírez-Solis, R.2    Krumlauf, R.3    Bradley, A.4
  • 11
    • 0031770816 scopus 로고    scopus 로고
    • Engineering chromosomes in mice through targeted meiotic recombination (TAMERE)
    • Hérault, Y., M. Rassoulzadegan, F. Cuzin, and D. Duboule. 1998. Engineering chromosomes in mice through targeted meiotic recombination (TAMERE). Nat. Genet. 20: 381-384.
    • (1998) Nat. Genet. , vol.20 , pp. 381-384
    • Hérault, Y.1    Rassoulzadegan, M.2    Cuzin, F.3    Duboule, D.4
  • 13
    • 0021751751 scopus 로고
    • Molecular cloning and chromosome mapping of a mouse DNA sequence homologous to homeotic genes of Drosophila
    • McGinnis, W., C.P. Hart, W.J. Gehring, and F.H. Ruddle. 1984. Molecular cloning and chromosome mapping of a mouse DNA sequence homologous to homeotic genes of Drosophila. Cell 38: 675-680.
    • (1984) Cell , vol.38 , pp. 675-680
    • McGinnis, W.1    Hart, C.P.2    Gehring, W.J.3    Ruddle, F.H.4
  • 14
    • 84929753105 scopus 로고    scopus 로고
    • Problems of germline therapy
    • McLaren, A. 1998. Problems of germline therapy. Nature 392: 645.
    • (1998) Nature , vol.392 , pp. 645
    • McLaren, A.1
  • 15
    • 0031916557 scopus 로고    scopus 로고
    • An Fgf8 mutant allelic series generated by Cre- and Flp-mediated recombination
    • Meyers, E.N., M. Lewandoski, and G.R. Martin. 1998. An Fgf8 mutant allelic series generated by Cre-and Flp-mediated recombination. Nat. Genet. 18: 136-141.
    • (1998) Nat. Genet. , vol.18 , pp. 136-141
    • Meyers, E.N.1    Lewandoski, M.2    Martin, G.R.3
  • 16
    • 0027321548 scopus 로고
    • Derivation of completely cell culture-derived mice from early-passage embryonic stem cells
    • Nagy, A., J. Rossant, R. Nagy, W. Abramow-Newerly, and J.C. Roder. 1993. Derivation of completely cell culture-derived mice from early-passage embryonic stem cells. Proc. Natl. Acad. Sci. 90: 8424-8428.
    • (1993) Proc. Natl. Acad. Sci. , vol.90 , pp. 8424-8428
    • Nagy, A.1    Rossant, J.2    Nagy, R.3    Abramow-Newerly, W.4    Roder, J.C.5
  • 17
    • 0031443874 scopus 로고    scopus 로고
    • Protamine-Cre recombinase transgenes efficiently recombine target sequences in the male germ line of mice, but not in embryonic stem cells
    • O'Gorman, S., N.A. Dagenais, M. Qian, and Y. Marchuk. 1997. Protamine-Cre recombinase transgenes efficiently recombine target sequences in the male germ line of mice, but not in embryonic stem cells. Proc. Natl. Acad. Sci. 94: 14602-14607.
    • (1997) Proc. Natl. Acad. Sci. , vol.94 , pp. 14602-14607
    • O'Gorman, S.1    Dagenais, N.A.2    Qian, M.3    Marchuk, Y.4
  • 18
    • 0029993449 scopus 로고    scopus 로고
    • Know your neighbors: Three phenotypes in null mutants of the myogenic bHLH gene MRF4
    • Olson, E.N., H.-H. Arnold, P.W.J. Rigby, and B.J. Wold. 1996. Know your neighbors: Three phenotypes in null mutants of the myogenic bHLH gene MRF4. Cell 85: 1-4.
    • (1996) Cell , vol.85 , pp. 1-4
    • Olson, E.N.1    Arnold, H.-H.2    Rigby, P.W.J.3    Wold, B.J.4
  • 19
    • 0032530174 scopus 로고    scopus 로고
    • Loss of transcriptional activity of a transgene is accompanied by DNA methylation and histone deacetylation and is prevented by insulators
    • Pikaart, M.J., F. Recillas-Targa, and G. Felsenfeld. 1998. Loss of transcriptional activity of a transgene is accompanied by DNA methylation and histone deacetylation and is prevented by insulators. Genes & Dev. 12: 2852-2862.
    • (1998) Genes & Dev. , vol.12 , pp. 2852-2862
    • Pikaart, M.J.1    Recillas-Targa, F.2    Felsenfeld, G.3
  • 20
    • 0029562967 scopus 로고
    • Chromosome engineering in mice
    • Ramírez-Solis, R., P. Liu, and A. Bradley. 1995. Chromosome engineering in mice. Nature 378: 720-724.
    • (1995) Nature , vol.378 , pp. 720-724
    • Ramírez-Solis, R.1    Liu, P.2    Bradley, A.3
  • 21
    • 0033555655 scopus 로고    scopus 로고
    • 'Cre'-ating mouse mutants - A meeting review on conditional mouse genetics
    • Rossant, J. and A. McMahon. 1999. 'Cre'-ating mouse mutants - A meeting review on conditional mouse genetics. Genes & Dev. 13: 142-145.
    • (1999) Genes & Dev. , vol.13 , pp. 142-145
    • Rossant, J.1    McMahon, A.2
  • 22
    • 0029566108 scopus 로고
    • A cre-transgenic mouse strain for the ubiquitous deletion of loxP-flanked gene segments including deletion in germ cells
    • Schwenk, F., U. Baron, and K. Rajewsky. 1995. A cre-transgenic mouse strain for the ubiquitous deletion of loxP-flanked gene segments including deletion in germ cells. Nucleic Acids Res. 23: 5080-5081.
    • (1995) Nucleic Acids Res. , vol.23 , pp. 5080-5081
    • Schwenk, F.1    Baron, U.2    Rajewsky, K.3
  • 23
    • 0000721466 scopus 로고    scopus 로고
    • Seed-sterilizing 'terminator technology' sows discord
    • Service, R.F. 1998. Seed-sterilizing 'terminator technology' sows discord. Science 282: 850-851.
    • (1998) Science , vol.282 , pp. 850-851
    • Service, R.F.1
  • 24
    • 0028950996 scopus 로고
    • A site-directed chromosomal translocation induced in embryonic stem cells by Cre-loxP recombination
    • Smith, A.J.H., M.A.D. Sousa, B. Kwabi-Addo, A. Heppell-Parton, H. Impey, and P. Rabbitts. 1995. A site-directed chromosomal translocation induced in embryonic stem cells by Cre-loxP recombination. Nat. Genet. 9: 376-385.
    • (1995) Nat. Genet. , vol.9 , pp. 376-385
    • Smith, A.J.H.1    Sousa, M.A.D.2    Kwabi-Addo, B.3    Heppell-Parton, A.4    Impey, H.5    Rabbitts, P.6
  • 25
    • 0028085960 scopus 로고
    • Targeted disruption of the even-skipped gene, evx1, causes early postimplantation lethality of the mouse conceptus
    • Spyropoulos, D.D. and M.R. Capecchi. 1994. Targeted disruption of the even-skipped gene, evx1, causes early postimplantation lethality of the mouse conceptus. Genes & Dev. 8: 1949-1961.
    • (1994) Genes & Dev. , vol.8 , pp. 1949-1961
    • Spyropoulos, D.D.1    Capecchi, M.R.2
  • 26
    • 0019888362 scopus 로고
    • Bacteriophage P1 site-specific recombination. I. Recombination between loxP sites
    • Sternberg, N. and D. Hamilton. 1981. Bacteriophage P1 site-specific recombination. I. Recombination between loxP sites. J. Mol. Biol. 150: 467-486.
    • (1981) J. Mol. Biol. , vol.150 , pp. 467-486
    • Sternberg, N.1    Hamilton, D.2
  • 27
    • 0023646810 scopus 로고
    • Site-directed mutagenesis by gene targeting in mouse embryo-derived stem cells
    • Thomas, K.R. and M.R. Capecchi. 1987. Site-directed mutagenesis by gene targeting in mouse embryo-derived stem cells. Cell 51: 503-512.
    • (1987) Cell , vol.51 , pp. 503-512
    • Thomas, K.R.1    Capecchi, M.R.2
  • 28
    • 0032563868 scopus 로고    scopus 로고
    • US gene-therapy proposals come under fire
    • Wadman, M. 1998. US gene-therapy proposals come under fire. Nature 395: 309.
    • (1998) Nature , vol.395 , pp. 309
    • Wadman, M.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.