Ileal bile acid transport regulates bile acid pool, synthesis, and plasma cholesterol levels differently in cholesterol-fed rats and rabbits

Journal of Lipid Research

Volumn 41, Issue 2, 2000, Pages 298-304

  Xu, Guorong ^a,b   Shneider, Benjamin L ^c   Shefer, Sarah ^b   Nguyen, Lien B ^b   Batta, Ashok K ^b   Tint, G Stephen ^a,b   Arrese, Marco ^f   Thevananther, Sundararajah ^d   Ma, Lin ^c   Stengelin, Siegfried ^e   Kramer, Werner ^e   Greenblatt, David ^a   Pcolinsky, Mark ^a   Salen, Gerald ^a,b  

^a VETERANS AFFAIRS MEDICAL CENTER   (United States)

^b RUTGERS NEW JERSEY MEDICAL SCHOOL   (United States)

^c MOUNT SINAI SCHOOL OF MEDICINE   (United States)

^d YALE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^e SANOFI   (France)

^f NONE

Author keywords

Absorption; Bile acids; Biosynthesis; Cholesterol 27 hydroxylase; Cholesterol 7 hydroxylase

Indexed keywords

BILE ACID; CHOLESTEROL; CHOLESTEROL 7ALPHA MONOOXYGENASE; MESSENGER RNA;

ANIMAL EXPERIMENT; ARTICLE; BILE ACID METABOLISM; BIOSYNTHESIS; CHOLESTEROL BLOOD LEVEL; CONTROLLED STUDY; ENZYME ACTIVITY; HYPERCHOLESTEROLEMIA; HYPERLIPIDEMIA; ILEUM; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; RABBIT; RAT;

ANIMALS; BILE ACIDS AND SALTS; BIOLOGICAL TRANSPORT, ACTIVE; CARRIER PROTEINS; CHOLESTEROL; CHOLESTEROL 7-ALPHA-HYDROXYLASE; CHOLESTEROL, DIETARY; HYDROXYMETHYLGLUTARYL COA REDUCTASES; HYDROXYSTEROID DEHYDROGENASES; HYPERCHOLESTEROLEMIA; ILEUM; INTESTINAL ABSORPTION; MALE; MEMBRANE GLYCOPROTEINS; MICROSOMES, LIVER; RABBITS; RATS; RATS, SPRAGUE-DAWLEY; RNA, MESSENGER; SPECIES SPECIFICITY;

EID: 0034001132     PISSN: 00222275     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (43)

1. Katan, M. B., and A. C. Beynen. 1987. Characteristics of human hypo-and hyperresponders to dietary cholesterol. Am. J. Epidemiol. 125: 387-399.
2. McNamara, D. J., R. Kolb, T. S. Parker, H. Batwin, P. Samuel, C. D. Brown, and E. H. Ahrens. 1987. Heterogeneity of cholesterol homeostasis in man. J. Clin. Invest. 79: 1729-1739.
3. Spady, D. K., and J. A. Guthbert. 1992. Regulation of hepatic sterol metabolism in the rat. J. Biol. Chem. 267: 5584-5591.
4. Kovanen, P. T., M. S. Brown, S. K. Basu, D. W. Bilheimer, and J. L. Goldstein. 1981. Saturation and suppression of hepatic lipoprotein receptor: a mechanism for the hypercholesterolemia of cholesterol-fed rabbits. Proc. Natl. Acad. Sci. USA. 78: 1396-1400.
5. Shefer, S., L. B. Nguyen, G. Salen, G. C. Ness, I. R. Chowdhary, S. Lerner, A. K. Batta, and G. S. Tint. 1992. Differing effects of cholesterol and taurocholate on steady state hepatic HMG-CoA reductase and cholesterol 7α-hydroxylase activities and mRNA levels in the rat. J. Lipid Res. 33: 1193-1200.
6. Pandak, W. M., Y. C. Li, Y. L. Chiang, E. J. Studer, E. C. Gurley, D. M. Heuman, Z. R. Vlahcevic, and P. B. Hylemon. 1991. Regulation of cholesterol 7α-hydroxylase mRNA and transcriptional activity by taurocholate and cholesterol in the chronic biliary diverted rat. J. Biol. Chem. 266: 3416-3421.
7. Jelinek, D. F., S. Andersson, C. A. Slaughter, and D. W. Russell. 1990. Cloning and regulalion of cholesterol 7α-hydroxylase, the rate-limiting enzyme in bile acid biosynthesis. J. Biol. Chem. 265: 8190-8197.
8. Xu, G., G. Salen, S. Shefer, G. C. Ness, T. S. Chen, Z. Zhao, and G. S. Tint. 1995. Unexpected inhibition of cholesterol 7α-hydroxylase by cholesterol in New Zealand white and Watanabe heritable hyperlipidemic rabbits. J. Clin. Invest. 95: 1497-1504.
9. Overturf, M. L., S. A. Smith, D. Hewett-Emmett, D. S. Lose-Mitchell, M. R. Soma, A. M. Gotto, Jr., and J. D. Morrisett. 1989. Development and partial metabolic characterization of a dietary cholesterol-resistant colony of rabbits. J. Lipids Res. 30: 263-273.
10. Poorman, J. A., R. A. Buck, S. A. Smith, M. L. Overturf, and D. S. Loose-Mitchell, 1993. Bile acid excretion and cholesterol 7α-hydroxylase expression in hypercholesterolemia-resistant rabbits. J. Lipid Res. 34: 1675-1685.
11. Rudel, L., C. Decheiman, M. Wilson, M. Scobey and R. Anderson. 1994. Dietary cholesterol and downregulation of cholesterol 7α-hydroxylase and cholesterol absorption in African green monkeys. J. Clin. Invest. 93: 2463-2472.
12. Horton, J. D., J. A. Cuthbert, and D. K. Spady. 1995. Regulation of hepatic 7α-hydroxylase expression and response to dietary cholesterol in the rat and hamster. J. Biol. Chem. 270: 5381-5387.
13. Pandak, W. M., M. Doerner, D. M. Heuman, P. B. Hylemon, J. Y. L. Chiang and Z. R. Vlahcevic. 1995. Expression of cholesterol 7α-hydroxylase in response to cholesterol and bile and feeding in the hamster and rat. Gastroenterology. 108: A1141.
14. Xu, G., G. Salen, S. Shefer, G. S. Tint, B. T. Kren, L. B. Nguyen, C. J. Steer, T. S. Chen, L. Salen, and D. Greenblatt. 1997. Increased bile acid pool inhibits cholesterol 7α-hydroxylase in cholesterol-fed rabbits. Gastroenterology. 113: 1958-1965.
15. Xu, G., G. Salen, S. Shefer, G. S. Tint, L. B. Nguyen, T. S. Chen, and D. Greenblatt. 1999. Increasing dietary cholesterol induces different regulation of classic and alternative bile acid synthesis. J. Clin. Invest. 103: 89-95.
16. Hofmann, A.F. 1991. Intestinal absorption of bile acids and biliary constituents: the intestinal component of the enterohepatic circulation and the integrated system. In Physiology of the Gastrointestinal Tract. L. R. Johnson, editor. Raven Press, New York. 1845-1865.
17. +-dependent bile acid transport system in brush border membrane vesicles from rabbit ileum. Biochem. Biophys. Acta. 1111: 93-102.
18. Shneider, B. L., P. A. Dawson, D. M. Christie, W. Hardikar, W. H. Wong, and F. J. Sucky. 1995. Cloning and molecular characterization of the ontogeny of a rat ileal sodium-dependent bile acid transporter. J. Clin. Invest. 95: 745-754.
19. Björkhem, I., G. Eggertson, and U. Andersson. 1996. On the mechanism of stimulation of cholesterol 7α-hydroxylase by dietary cholesterol. Biochim. Biophys. Acta. 1085: 329-335.
20. Torchia, E. C., S. K. Cheema, and L. B. Agellon. 1996. Coordinate regulation of bile acid biosynthetic and recovery pathways. Biochem. Biophys. Res. Commun. 225: 128-133.
21. +-dependent bile acid transport activity in rabbit small intestine correlates with the coexpression of an integral 93 kDa and a peripheral 14 kDa bile acid-binding membrane protein along the duodenum-ileum axis. J. Biol. Chem. 268: 18035-18046.
22. Crossman, M. W., S. H. Hauft, and J. I. Gordon. 1994. The mouse ileal lipid-binding protein gene: A model for studying axial patterning during gut morphogenesis. J. Cell Biol. 126: 1547-1564.
23. Tserng, K. Y., D. L. Hackey, and P. D. Klein. 1977. An improved procedure for the synthesis of glycine and taurine conjugates of bile acids. J. Lipid Res. 18: 404-407.
24. Xu, G., G. Saden, A. K. Batta, S. Shefer, L. B. Nguyen, W. Niemann, T. S. Chen, R. Arora-Mirchandani, G. C. Ness, and G. S. Tint. 1992. Glycocholic acid and glycodeoxycholic acid but not glycoursocholic acid inhibit bile acid synthesis in the rabbit. Gastroenterology. 102: 1717-1723.
25. Mok, H. Y. I., P. M. Perry, and R. H. Dowling. 1974. The control of bile acid pool size: effect of jejunal resection and phenobarbitone on bile acid metabolism in the rat. Gut. 15: 247-253.
26. Nguyen, L. B., S. Shefer, G. Salen, I. Horak, G. S. Tint, and D. J. McNamara. 1988. The effect of abnormal plasma and cellular sterol content and composition on low density lipoprotein uptake and degradation by monocytes and lymphocytes in sitosterolemia with xanthomatosis. Metabolism. 37: 346-351.
27. Sun, A-Q., M. Ananthanaryanan, C. J. Soroka, S. Thevananther, B. L. Shneider, and F. J. Suchy. 1998. Sorting of rat liver and ileal sodium-dependent bile acid transporters in polarized epithelial cells. Am. J. Physiol. 275: G1045-1055.
28. Shneider, B., K. D. R. Setchell, and M. Crossman. 1997. Fetal and perinatal expression of ileal and renal sodium-dependent bile acid transport in the rat. Pediatr. Res. 42: 189-194.
29. Arrese, M., M. Trauner, R. J. Sacchiero, M. W. Crossman, and B. L. Shneider. 1998. Neither intestinal sequestration of bile acids nor common bile duel ligation modulate the expression and function of the rat ileal bile acid transporter. Hepatology. 28: 1081-1987.
30. Bradford, M. M. 1976. A rapid and sensitive method for the quantitation of microgram quantities of proteins utilizing the principle of protein-dye binding. Anal. Biochem. 72: 248-254.
31. Laemmli, U. K. 1970. Cleavage of structural proteins during the assembly of the head of bacteriophage T4. Nature. 227: 680-685.
32. Shefer, S., G. Salen, and A. K. Batta. 1986. Methods of assay. In Cholesterol 7α-hydroxylase (7α-Monooxygenase). R. Fears and J. R. Sabine, editors. CRC Press, Boca Raton, FL. 43-49.
33. Lowry, O. H., N. J. Rosebrough, A. L. Farr, and R. J. Randall. 1951. Protein measurement with the Folin phenol reagent. J. Biol. Chem. 193: 265-275.
34. George, R., P. J. Davis, L. Luong, and N. J. Poznansky. 1990. Cholesterol-mediated regulation of HMG-CoA reductase in microsomes from human skin fibroblasts and rat liver. Biochem. Cell Biol. 68: 674-679.
35. Shefer, S., B. T. Kren, G. Salen, C. J. Steer, L. B. Nguyen, T. S. Chen, G. S. Tint, and A. K. Batta. 1995. Regulation of bile acid synthesis by deoxycholic acid in the rat: different effects on cholesterol 7α-hydroxylase and sterol 27-hydroxylase. Hepatology. 22: 1215-1221.
36. Ness, G. C., R. K. Keller, and L. C. Pendelton. 1991. Feedback regulation of hepatic 3-hydroxy-3-methyl glutaryl coenzyme A reductase activity by dietary cholesterol is not clue to altered mRNA levels. J. Biol. Chem. 266: 14854-14857.
37. Stalenhoef, A. F. H., J. L. M. van Niekerk, P. N. M. Demacker, and A. van't Laar. 1984. Partial ileal bypass reduces the production rate of low density lipoproteins in Watanabe heritable hyper-lipidemic rabbits. J. Lipid Res. 25: 1350-1357.
38. Xu, G., G. Salen, S. Shefer, G. C. Ness, L. B. Nguyen, G. S. Tint, T. S. Paker, J. Roberts, A. K. Batta, T. S. Chen, Z. Zhao, and X. Kong. 1996. Increasing hepatic cholesterol 7α-hydroxylase reduces plasma cholesterol concentrations in normo-and hypercholesterolemic rabbits. Hepatology. 24: 882-887.
39. Xu, G., G. Salen, S. Shefer, G. C. Ness, T. S. Chen, Z. Zhao, L. Salen, and G. S. Tint. 1995. Treatment of the cholesterol biosynthetic defect in Smith-Lemli-Opitz syndrome reproduced in rat by BM 15.766. Gastroenterology. 109: 1301-1307.
40. Wang J., D. J. Freeman, S. M. Grundy, D. M. Levine, R. Guerra, and J. C. Cohen. 1998. Linkage between cholesterol 7α-hydroxylase and high plasma low-density lipoprotein cholesterol concentrations. J. Clin. Invest. 101: 1283-1291.
41. Lillienau, J., D. L. Crombie, J. Munoz, S. J. Longmire-Cook, L. R. Hagey, and A. F. Hofmann. 1993. Negative feedback regulation of the ileal bile acid transport system in rodents. Gastroenterology. 104: 38-46.
42. Stravitz, R. T., A. J. Sanyal, W. M. Pandak, Z. R. Vlahcevic, J. W. Beets, and P. A. Dawson. 1997. Induction of sodium-dependent bile acid transporter messenger RNA, protein, and activity in rat ileum by cholic acid. Gastroenterology. 113: 1599-1608.
43. Arrese, M., M. Trauner, R. J. Sacchiero, M. W. Crossman, and B. L. Shneider. 1998. Neither intestinal sequestration of bile acids nor common bile duct ligation modulate the expression and function of the rat ileal bile acid transporter. Hepatology. 28: 1081-1087.