Disruption of cholesterol 7α-hydroxylase gene in mice. II. Bile acid deficiency is overcome by induction of oxysterol 7α-hydroxylase

Journal of Biological Chemistry

Volumn 271, Issue 30, 1996, Pages 18024-18031

  Schwarz, Margrit ^a   Lund, Erik G ^a   Setchell, Kenneth D R ^b   Kayden, Herbert J ^c   Zerwekh, Joseph E ^a   Björkhem, Ingemar ^d   Herz, Joachim ^a   Russell, David W ^a  

^a UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER   (United States)

^b CINCINNATI CHILDREN'S HOSPITAL MEDICAL CENTER   (United States)

^c NEW YORK UNIVERSITY MEDICAL CENTER   (United States)

^d KAROLINSKA UNIVERSITY HOSPITAL   (Sweden)

Author keywords

[No Author keywords available]

Indexed keywords

CHOLESTEROL 7ALPHA MONOOXYGENASE; ALPHA TOCOPHEROL; BILE ACID; CHOLESTEROL; COLECALCIFEROL; CYTOCHROME P450; LIPOPROTEIN; OXYSTEROL 7 ALPHA HYDROXYLASE; OXYSTEROL 7-ALPHA-HYDROXYLASE; STEROID MONOOXYGENASE; TRIACYLGLYCEROL;

ANIMAL MODEL; ARTICLE; BILE ACID SYNTHESIS; CHOLESTEROL METABOLISM; DYSLIPIDEMIA; ENZYME INDUCTION; LIPID METABOLISM; MOUSE; NONHUMAN; PRIORITY JOURNAL; AGE; ANIMAL; BILE; BIOSYNTHESIS; BLOOD; CHEMISTRY; DRUG ANTAGONISM; ENZYMOLOGY; FECES; FEMALE; GENETICS; METABOLISM; MICROSOME; MITOCHONDRION; MOUSE MUTANT; PHENOTYPE;

AGE FACTORS; ANIMALS; BILE; BILE ACIDS AND SALTS; CHOLECALCIFEROL; CHOLESTEROL; CHOLESTEROL 7-ALPHA-HYDROXYLASE; CYTOCHROME P-450 ENZYME SYSTEM; ENZYME INDUCTION; FECES; FEMALE; LIPOPROTEINS; MICE; MICE, KNOCKOUT; MICROSOMES; MITOCHONDRIA; PHENOTYPE; STEROID HYDROXYLASES; TRIGLYCERIDES; VITAMIN E;

EID: 0029666290     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.271.30.18024     Document Type: Article

References (26)

1. Russell, D. W., andSetchell, K. D. R. (1992) Biochemistry 31, 4737-4749
2. Axelson, M., andSjövall, J. (1990) J. Steroid Biochem. 36, 631-640
3. Björkhem, I. (1992) J. Lipid Res. 33, 455-471
4. Toll, A., Wikvall, K., Sudjana-Sugiaman, E., Kondo, K., andBjörkhem, I. (1994) Eur. J. Biochem. 224, 309-316
5. Axelson, M., Shoda, J., Sjövall, J., Toll, A., andWikvall, K. (1992) J. Biol. Chem. 267, 1701-1704
6. Payne, D. W., Shackleton, C., Toms, H., Ben-Shlomo, I., Kol, S., deMoura, M., Strauss, J. F., andAdashi, E. Y. (1995) J. Biol. Chem. 270, 18888-18896
7. Zhang, J., Larsson, O., andSjövall, J. (1995) Biochim. Biophys. Acta 1256, 353-359
8. Danielsson, H., Einarsson, K., andJohansaon, G. (1967) Eur. J. Biochem. 2, 44-49
9. Spady, D. K., Cuthbert, J. A., Willard, M. N., andMeidell, R. S. (1995) J. Clin. Invest. 96, 700-709
10. Ishibashi, S., Schwarz, M., Frykman, P. K., Herz, J., andRussell, D. W. (1996) J. Biol. Chem. 261, 18017-18023
11. Ishibashi, S., Brown, M. S., Goldstein, J. L., Gerard, R. D., Hammer, R. E., andHerz, J. (1993) J. Clin. Invest. 92, 883-893
12. Traber, M. G., andKayden, H. J. (1987) Am. J. Clin. Nutr. 46, 488-495
13. Popoff, S. N., Osier, L. K., Zerwekh, J. E., andMarks, S. C. (1994) Bone (Elmsford) 15, 515-522
14. Sakhaee, K., Baker, S., Zerwekh, J. E., Poindexter, J., Garcia-Hernandez, P. A., andPak, C. Y. C. (1994) J. Urol. (Paris) 152, 324-327
15. Setchell, K. D. R., Yamashita, H., Rodrigues, C. M. P., O'Connell, N. C., Kren, B. T., andSteer, C. J. (1995) Biochemistry 34, 4169-4178
16. Schenck, G. O., Golinick, K., andNeumüller, O. A. (1957) Ann. Chem. (Justus Liebigs) 603, 46-59
17. Schenck, G. O., Neumüller, O. A., andEisfeld, W. (1958) Angew. Chem. Int. Ed. Engl. 19, 595
18. Dzeletovic, S., Breuer, O., Lund, E., andDiczfalusy, U. (1995) Anal. Biochem. 225, 73-80
19. Lund, E., Boberg, K. M., Byström, S., Ölund, J., Carlström, K., andBjörkhem, I. (1991) J. Biol. Chem. 266, 4929-4937
20. Nicolaides, N., Fu, H. C., andAnsari, M. N. A. (1970) Lipids 5, 299-307
21. Grigor, M. R. (1977) in Lipid Metabolism in Mammals (Snyder, F., ed) pp. 209-235, Plenum Press, New York
22. Uchida, K., Takase, H., Nomura, Y., Takeda, K., Takeuchi, N., andIshikawa, Y. (1984) J. Lipid Res. 25, 236-245
23. Stewart, M. E., andDowning, D. T. (1991) Adv. Lipid Res. 24, 263-301
24. Bergström, S., Danielsson, H., andGöransson, A. (1959) Acta Chem. Scand. 13, 776-784
25. Suchy, F. J., andBalistreri, W. F. (1982) Pediatr. Res. 16, 282-285
26. Shneider, B. L., Dawson, P. A., Christie, D.-M., Hardikar, W., Wong, M. H., andSuchy, F. J. (1995) J. Clin. Invest. 95, 745-754