Genetic variation in cholesterol absorption efficiency among inbred strains of mice

Journal of Nutrition

Volumn 127, Issue 7, 1997, Pages 1344-1348

  Carter, Christopher P ^a   Howles, Philip N ^a   Hui, David Y ^a  

^a UNIVERSITY OF CINCINNATI COLLEGE OF MEDICINE   (United States)

Author keywords

Absorption; Cholesterol; Diet; Genetics; Mice

Indexed keywords

ANIMAL EXPERIMENT; ARTICLE; CHOLESTEROL BLOOD LEVEL; CHOLESTEROL METABOLISM; CONTROLLED STUDY; FAT INTAKE; FECES; GENE CONTROL; GENETIC VARIABILITY; LIPID ABSORPTION; LOW FAT DIET; MOUSE; NONHUMAN;

ANIMALIA;

EID: 0030829268     PISSN: 00223166     EISSN: None     Source Type: Journal    
DOI: 10.1093/jn/127.7.1344     Document Type: Article

References (41)

1. Aubert, R., Perdereau, D., Roubiscoul, M., Herzog, J. & Lemonnier, D. (1988) Genetic variations in serum lipid levels of inbred mice and response to hypercholesterolemic diet. Lipids 23: 48-54.
2. Beynen, A. C., Katan, M. B. & Van Zutphen, L.F.M. (1987) Hypo- and hyperresponders: individual differences in the response of serum cholesterol concentration to changes in diet. Adv. Lipid Res. 22: 115-171.
3. Bhattacharyya, A. K., Baker, H. N., Eggen, D. A., Malcom, G. T., Roheim, P. S. & Strong, J. P. (1989) Effect of cholesterol feeding on lipolytic activities in high and low responding rhesus monkeys. Arteriosclerosis 9: 380-389.
4. Bhattacharyya, A. K. & Eggen, D. A. (1988) Studies on the mechanisms of high intestinal absorption of cholesterol and campesterol in high responding rhesus monkeys. Atherosclerosis 72: 109-114.
5. Brodt-Eppley, J. & Hui, D. Y. (1994) Dietary regulation of cholesterol esterase mRNA level in rat pancreas. J. Lipid Res. 35: 27-35.
6. Chan, L. & Dresel, H. A. (1990) Genetic factors influencing lipoprotein structure: implications for atherosclerosis. Lab. Invest. 62: 522-537.
7. Clark, S. B. & Tercyak, A. M. (1984) Reduced cholesterol transmucosal transport in rats with inhibited mucosal acyl CoA:cholesterol acyltransferase and normal pancreatic function. J. Lipid Res. 25: 148-159.
8. Clarke, C. F., Edwards, P. A., Lan, S. F., Tanaka, R. D. & Fogelman, A. M. (1983) Regulation of 3-hydroxy-3-methyl-glutaryl-coenzyme A reductase mRNA levels in rat liver. Proc. Natl. Acad. Sci. U.S.A. 79: 7704-7708.
9. Dietschy, J. M. & Wilson, J. D. (1970) Regulation of cholesterol metabolism. N. Engl. J. Med. 282: 1179-1183.
10. Dueland, S., Drisko, J., Graf, L., Machleder, D., Lusis, A. J. & Davis, R. A. (1993) Effect of dietary cholesterol and taurocholate on cholesterol 7alpha-hydroxylase and hepatic LDL receptors in inbred mice. J. Lipid Res. 34: 923-931.
11. Fernandez, E. & Borgstrom, B. (1989) Effects of tetrahydrolipstatin, a lipase inhibitor, on absorption of fat from the intestine of the rat. Biochim. Biophys. Acta 1001: 249-255.
12. Gallo, L. L., Clark, S. B., Myers, S. & Vahouny, G. V. (1984) Cholesterol absorption in rat intestine: role of cholesterol esterase and acyl coenzyme A:cholesterol acyltransferase. J. Lipid Res. 25: 604-612.
13. Gallo, L. L., Newbill, T., Hyun, J., Vahouny, G. V. & Treadwell, C. R. (1977) Role of pancreatic cholesterol esterase in the uptake and esterification of cholesterol by isolated intestinal cells. Proc. Soc. Exp. Biol. Med. 156: 277-281.
14. Grundy, S. M., Ahrens, E. H. & Salen, G. (1968) Dietary β-sitosterol as an internal standard to correct for cholesterol losses in sterol balance studies. J. Lipid Res. 9: 374-387.
15. Grundy, S. M. & Denke, M. A. (1990) Dietary influences on serum lipids and lipoproteins. J. Lipid Res. 31: 1149-1172.
16. Howles, P. N., Carter, C. P. & Hui, D. Y. (1996) Dietary free and esterified cholesterol absorption in cholesterol esterase (bile salt-stimulated lipase) gene-targeted mice. J. Biol. Chem. 271: 7196-7202.
17. Hwa, J. J., Zollman, S., Warden, C. H., Taylor, B. A., Edwards, P. A., Fogelman, A. M. & Lusis, A. J. (1992) Genetic and dietary interactions in the regulation of HMG-CoA reductase gene regulation. J. Lipid Res. 33: 711-725.
18. Ishida, B. Y. & Paigen, B. (1989) Atherosclerosis in the mouse. In: Monographs in Human Genetics (Sparkes, R. S., ed.), Vol. 12, pp. 189-222. Karger, Basel, Switzerland.
19. Jiang, X. C., Agellon, L. B., Walsh, A., Breslow, J. L. & Tall, A. (1992) Dietary cholesterol increases transcription of the human cholesteryl ester transfer protein gene in transgenic mice. Dependence on natural flanking sequences. J. Clin. Invest. 90: 1290-1295.
20. Jiang, X. C. & Bruce, C. (1995) Regulation of murine plasma phospholipid transfer protein activity and mRNA levels by lipopolysaccharide and high cholesterol diet. J. Biol. Chem. 270: 17133-17138.
21. Kirk, E. A., Moe, G. L., Caldwell, M. T., Lernmark, J. A., Wilson, D. L. & LeBoeuf, R. C. (1995) Hyper- and hypo-responsiveness to dietary fat and cholesterol among inbred mice: searching for level and variability genes. J. Lipid Res. 36: 1522-1532.
22. Krause, B. R., Anderson, M., Bisgaier, C. L., Bocan, T., Bousley, R., HeHart, P., Essenburg, A., Hamelehle, K., Homan, R., Kieft, K., McNally, W. & Stanfield, R. (1993) In vivo evidence that the lipid regulating activity of the ACAT inhibitor Cl-976 In rats is due to inhibition of both intestinal and liver ACAT. J. Lipid Res. 34: 279-294.
23. Lipka, G., Schulthess, G., Thurnhofer, H., Wacker, H., Wehrli, E., Zeman, K., Weber, F. E. & Hauser, H. (1995) Characterization of lipid exchange proteins isolated from small intestinal brush border membrane. J. Biol. Chem. 270: 5917-5925.
24. Lopez-Candales, A., Bosner, M. S., Spilburg, C. A. & Lange, L. G. (1993) Cholesterol transport function of pancreatic cholesterol esterase: directed sterol uptake and esterification In enterocytes. Biochemistry 32: 12085-12089.
25. Lusis, A. J. (1988) Genetic factors affecting blood lipoproteins: the candidate gene approach. J. Lipid Res. 29: 397-429.
26. Lusis, A. J., Taylor, B. A., Quon, D., Zollman, S. & LeBoeuf, R. C. (1987) Genetic factors controlling structure and expression of apolipoprotein B and E in mice. J. Biol. Chem. 262: 7594-7604.
27. Mahley, R. W., Weisgraber, K. H. & Innerarity, T. L. (1974) Canine lipoproteins and atherosclerosis. II. Characterization of the plasma lipoproteins associated with atherogenic and nonatherogenic hyperlipidemia. Circ. Res. 35: 722-733.
28. McNamara, D. J., Kolb, R., Parker, T. S., Batwin, H., Simon, P., Brown, C. D. & Ahrens, E. H. (1987) Heterogeneity of cholesterol responsiveness in man. J. Clin. Invest. 79: 1729-1739.
29. National Research Council (1985) Guide for the Care and Use of Laboratory Animals. Publication no. 85-23 (rev.), National Institutes of Health, Bethesda, MD.
30. Overturf, M. L., Smith, S. A., Gotto, A. M., Morrisett, J. D., Tewson, T., Poorman, J. & Loose-Mitchell, D. S. (1990) Dietary cholesterol absorption and sterol and bile acid excretion in hypercholesterolemic resistant white rabbits. J. Lipid Res. 31: 2019-2027.
31. Paigen, B. (1995) Genetics of responsiveness to high fat and high cholesterol diets in the mouse. Am. J. Clin. Nutr. 62: 458S-462S.
32. Paigen, B., Morrow, A., Brandon, C., Mitchell, D. & Holmes, P. A. (1985) Variation in susceptibility to atherosclerosis among inbred strains of mice. Atherosclerosis 57: 65-73.
33. Roberts, A. & Thompson, J. (1976) Inbred mice and their hybrids as an animal model for atherosclerosis research. Adv. Exp. Med. Biol. 67: 313-327.
34. Rose, H. G. & Juliano, J. (1979) Regulation of plasma lecithin:cholesterol acyltransferase in man. III. Role of high density lipoprotein cholesteryl esters in the activating effect of a high fat test meal. J. Lipid Res. 20: 399-407.
35. Safonova, I. G., Sviridov, D. D., Roytman, A., Rytikov, F. M., Dolgov, V. V., Nano, J. L., Rampal, P. & Repin, V. S. (1993) Cholesterol uptake in the human intestine. Hypo- and hyperresponsiveness. Biochim. Biophys, Acta 1166: 313-316.
36. Schroeder, F., Jefferson, J. R., Powell, D., Incerpi, S., Woodford, J. K., Colles, S. M., Myers-Payne, S., Emge, T., Hubbell, T. & Moncecchi, D., Prows, D. R., & Heyliger, C. E. (1993) Expression of rat L-FABP in mouse fibroblasts: role In fat absorption. Mol. Cell. Biochem. 123: 73-83.
37. Sing, C. F. & Davignon, J. (1985) Role of apolipoprotein E polymorphism in determining normal plasma lipid and lipoprotein variation. Am. J. Human Genet. 37: 268-285.
38. Spady, D. K. & Cuthbert, J. A. (1992) Parallel regulation of activity and mRNA for 7-alpha-hydroxylase but not 3-hydroxy-3-methylglutaryl-coenzyme A reductase or low density lipoprotein receptor. J. Biol. Chem. 267: 5584-5591.
39. Spady, D. K., Woollett, L. A. & Dietschy, J. M. (1993) Regulation of plasma LDL-cholesterol levels by dietary cholesterol and fatty acids. Annu. Rev. Nutr. 13: 355-381.
40. Thompson, J. S. (1969) Atheromata in an inbred strain of mice. J. Atheroscler. Res. 10: 113-122.
41. Thurnhofer, H., Schnabel, J., Betz, M., Lipka, G., Pidgeon, C. & Hauser, H. (1991) Cholesterol-transfer protein located in the intestinal brush-border membrane. Partial purification and characterization. Biochim. Biophys. Acta 1064: 275-286.