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Volumn 51, Issue 2, 1998, Pages 55-61

Response of tumour cells to hypoxia: Role of p53 and NFkB

Author keywords

Angiogenesis; Hypoxia; NFkB; P53

Indexed keywords

IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; PROTEIN P53;

EID: 0031838786     PISSN: 13668714     EISSN: None     Source Type: Journal    
DOI: 10.1136/mp.51.2.55     Document Type: Review
Times cited : (163)

References (50)
  • 1
    • 0030744577 scopus 로고    scopus 로고
    • The influence of tumour blood flow and microenvironmental factors on the efficacy of radiation, drugs and localised hyperthermia
    • Vaupel PW. The influence of tumour blood flow and microenvironmental factors on the efficacy of radiation, drugs and localised hyperthermia. Klin Padiatr 1997;209:243-49.
    • (1997) Klin Padiatr , vol.209 , pp. 243-249
    • Vaupel, P.W.1
  • 2
    • 0015380016 scopus 로고
    • Tumour domancy in vitro by prevention of neovascularization
    • Gimbione MA Jr, Leapman SB, Cotran RS, et al. Tumour domancy in vitro by prevention of neovascularization. J Exp Med 1972;136:261-76.
    • (1972) J Exp Med , vol.136 , pp. 261-276
    • Gimbione Jr., M.A.1    Leapman, S.B.2    Cotran, R.S.3
  • 3
    • 0002481380 scopus 로고    scopus 로고
    • Vascular and interstitial physiology of tumours: Role in cancer detection and treatment
    • Lewis CE, Bicknell R, Ferrara N, eds. Oxford: Oxford University Press
    • Jain R. Vascular and interstitial physiology of tumours: role in cancer detection and treatment. In: Lewis CE, Bicknell R, Ferrara N, eds. Tumour angiogenesis. Oxford: Oxford University Press, 1997;45-60.
    • (1997) Tumour Angiogenesis , pp. 45-60
    • Jain, R.1
  • 4
    • 0028080215 scopus 로고
    • Cytokine netwoorks in solid human tumours: Regulation of angiogenesis
    • Leek RD, Harris AL, Lewis CE. Cytokine netwoorks in solid human tumours: regulation of angiogenesis. J Leuk Biol 1994;56:423-35.
    • (1994) J Leuk Biol , vol.56 , pp. 423-435
    • Leek, R.D.1    Harris, A.L.2    Lewis, C.E.3
  • 5
    • 0028861231 scopus 로고
    • Expression of vascular permeability factor (VEGF) and its receptors in breast cancer
    • Brown LF. Expression of vascular permeability factor (VEGF) and its receptors in breast cancer. Hum Pathol 1995;26:86-91.
    • (1995) Hum Pathol , vol.26 , pp. 86-91
    • Brown, L.F.1
  • 6
    • 0028954492 scopus 로고
    • Enhancement of tumour growth and vascular density by transfection of vascular endothelial growth factor into MCF7 human breast carcinoma cells
    • Zhang H-T, Craft P, Scott PAE, et al. Enhancement of tumour growth and vascular density by transfection of vascular endothelial growth factor into MCF7 human breast carcinoma cells. J Natl Cancer Inst 1995;87:213-19.
    • (1995) J Natl Cancer Inst , vol.87 , pp. 213-219
    • Zhang, H.-T.1    Craft, P.2    Scott, P.A.E.3
  • 7
    • 0030059075 scopus 로고    scopus 로고
    • Vascular endothelial growth factor promotes tumour dissemination by a mechanism distinct from its effect on primary tumour growth
    • Melnyk O, Shuman MA, Kim KJ. Vascular endothelial growth factor promotes tumour dissemination by a mechanism distinct from its effect on primary tumour growth. Cancer Res 1996;56:921-4.
    • (1996) Cancer Res , vol.56 , pp. 921-924
    • Melnyk, O.1    Shuman, M.A.2    Kim, K.J.3
  • 8
    • 0343920277 scopus 로고    scopus 로고
    • Abnormal blood vessel development and lethality in embryos lacking a single VEGF allele
    • Carmeliet P, Ferreir V, Breier G, et al. Abnormal blood vessel development and lethality in embryos lacking a single VEGF allele. Nature 1996;380:435-9.
    • (1996) Nature , vol.380 , pp. 435-439
    • Carmeliet, P.1    Ferreir, V.2    Breier, G.3
  • 9
    • 0029868465 scopus 로고    scopus 로고
    • Assignment of the vascular endothelial growth-factor gene to human-chromosome 6P21.3
    • Vincenti V, Cassano C, Rocchi M, et al. Assignment of the vascular endothelial growth-factor gene to human-chromosome 6P21.3. Circulation 1996;93:1493-5.
    • (1996) Circulation , vol.93 , pp. 1493-1495
    • Vincenti, V.1    Cassano, C.2    Rocchi, M.3
  • 11
    • 0030922763 scopus 로고    scopus 로고
    • P53 and the hypoxia-induced apoptosis of cultured neonatal rat cardiac myocytes
    • Long X, Boluyt MO, Hipolito MdeL, et al. P53 and the hypoxia-induced apoptosis of cultured neonatal rat cardiac myocytes. J Clin Invest 1997;99:2635-43.
    • (1997) J Clin Invest , vol.99 , pp. 2635-2643
    • Long, X.1    Boluyt, M.O.2    Hipolito, M.D.L.3
  • 12
    • 0029051439 scopus 로고
    • Hypoxia-inducible factor 1 is a basic helix-loop-helix-PAS heterodimer regulated by cellular O2 tension
    • Wang GL, Jiang BH, Rue EA, et al. Hypoxia-inducible factor 1 is a basic helix-loop-helix-PAS heterodimer regulated by cellular O2 tension. Proc Natl Acad Sci USA 1995;92: 5510-14.
    • (1995) Proc Natl Acad Sci USA , vol.92 , pp. 5510-5514
    • Wang, G.L.1    Jiang, B.H.2    Rue, E.A.3
  • 13
    • 0026468180 scopus 로고
    • A nuclear factor induced by hypoxia via de novo protein synthesis binds to the human erythropoetin gene in transgenic mice
    • Semenza GL, Wang GL. A nuclear factor induced by hypoxia via de novo protein synthesis binds to the human erythropoetin gene in transgenic mice. Mol Cell Biol 1992; 12:5447-54.
    • (1992) Mol Cell Biol , vol.12 , pp. 5447-5454
    • Semenza, G.L.1    Wang, G.L.2
  • 14
    • 0031000736 scopus 로고    scopus 로고
    • A novel bHLH-PAS factor with close sequence similarity to hypoxia-inducible factor la regulates the VEGF expression and its potentially involved in lung and vascular development
    • Masatsugu E, Shinichiro T, Noboru Y, et al. A novel bHLH-PAS factor with close sequence similarity to hypoxia-inducible factor la regulates the VEGF expression and its potentially involved in lung and vascular development. Proc Natl Acad Sci USA 1997;94:4273-8.
    • (1997) Proc Natl Acad Sci USA , vol.94 , pp. 4273-4278
    • Masatsugu, E.1    Shinichiro, T.2    Noboru, Y.3
  • 15
    • 0031020884 scopus 로고    scopus 로고
    • Endothelial PAS domain protein 1 (EPAS1), atranscription factor selectively expressed in endothelial cells
    • Tian H, McKnight SL, Russell DW. Endothelial PAS domain protein 1 (EPAS1), atranscription factor selectively expressed in endothelial cells. Genes Dev 1997;11:72-82.
    • (1997) Genes Dev , vol.11 , pp. 72-82
    • Tian, H.1    McKnight, S.L.2    Russell, D.W.3
  • 16
    • 0028110809 scopus 로고
    • Hypoxia induces the accumulation of p53 protein but the activation of a G1-phase checkpoint by low oxygen conditions is independent of p53 status
    • Graeber TG, Peterson JF, Tsai M. Hypoxia induces the accumulation of p53 protein but the activation of a G1-phase checkpoint by low oxygen conditions is independent of p53 status. Mol Cell Biol 1994;14:6264-77.
    • (1994) Mol Cell Biol , vol.14 , pp. 6264-6277
    • Graeber, T.G.1    Peterson, J.F.2    Tsai, M.3
  • 17
    • 0030864485 scopus 로고    scopus 로고
    • Selection of human cervical epithelial cells that possess reduced apoptotic potential to low oxygen conditions
    • Kim CY, Tsai MH, Osmanian C, et al. Selection of human cervical epithelial cells that possess reduced apoptotic potential to low oxygen conditions. Cancer Res 1997;57: 4200-4.
    • (1997) Cancer Res , vol.57 , pp. 4200-4204
    • Kim, C.Y.1    Tsai, M.H.2    Osmanian, C.3
  • 18
    • 85038536870 scopus 로고    scopus 로고
    • A p53 mt provides a gain-of-function phenotype affecting cell cycle checkpoint control
    • Dundee
    • Titsy T. A p53 mt provides a gain-of-function phenotype affecting cell cycle checkpoint control. Proceedings of the 8th international p53 workshop, Dundee, 1996.
    • (1996) Proceedings of the 8th International P53 Workshop
    • Titsy, T.1
  • 19
    • 8544249876 scopus 로고    scopus 로고
    • Comparison of VEGF, VEGF-B, VEGF-C and Ang-1 mRNA regulation by serum, growth factors, oncoproteins and hypoxia
    • Enholm B, Paavonen K, Ristimaki A, et al. Comparison of VEGF, VEGF-B, VEGF-C and Ang-1 mRNA regulation by serum, growth factors, oncoproteins and hypoxia. Oncogene 1997;14:2475-83.
    • (1997) Oncogene , vol.14 , pp. 2475-2483
    • Enholm, B.1    Paavonen, K.2    Ristimaki, A.3
  • 20
    • 0029070920 scopus 로고
    • Hypoxiamdiated induction of acidie/basic FGF and PDGF in mononuclear phagocytes stimulates growth of hypoxic endothelial cells
    • Kuwabara K, Ogawa S, Matsumoto M, et al. Hypoxiamdiated induction of acidie/basic FGF and PDGF in mononuclear phagocytes stimulates growth of hypoxic endothelial cells. Proc Natl Acad Sci USA 1995;92:4606-10.
    • (1995) Proc Natl Acad Sci USA , vol.92 , pp. 4606-4610
    • Kuwabara, K.1    Ogawa, S.2    Matsumoto, M.3
  • 21
    • 0030806074 scopus 로고    scopus 로고
    • Upregulation of VEGF expression in a rat glioma is conferred by two distinet hypoxia-driven mechanisms
    • Damert A, Machein M, Breier G, et al. Upregulation of VEGF expression in a rat glioma is conferred by two distinet hypoxia-driven mechanisms. Cancer Res 1997;57: 3860-4.
    • (1997) Cancer Res , vol.57 , pp. 3860-3864
    • Damert, A.1    Machein, M.2    Breier, G.3
  • 22
    • 0028060380 scopus 로고
    • Control of angiogenesis in fibroblasts by p53 regulation of thromhospondin 1
    • Dameron KM, Volpert OV, Twainsky MA, et al. Control of angiogenesis in fibroblasts by p53 regulation of thromhospondin 1. Science 1944;265:1582-4.
    • (1944) Science , vol.265 , pp. 1582-1584
    • Dameron, K.M.1    Volpert, O.V.2    Twainsky, M.A.3
  • 23
    • 0028865988 scopus 로고
    • Wild-type p53 and v-src exert opposing influences on human VEGF gene expression
    • Mukhopadhyay D, Tsiokas L, Sukhatme VP. Wild-type p53 and v-src exert opposing influences on human VEGF gene expression. Cancer Res 1995;55:6161-5.
    • (1995) Cancer Res , vol.55 , pp. 6161-6165
    • Mukhopadhyay, D.1    Tsiokas, L.2    Sukhatme, V.P.3
  • 24
    • 0030767287 scopus 로고    scopus 로고
    • P53 does not repress hypoxia-induced transcription of the VEGF gene
    • Agani F, Kirsch DG, Friedman SL, et al. P53 does not repress hypoxia-induced transcription of the VEGF gene. Cancer Res 1997;57:4474-7.
    • (1997) Cancer Res , vol.57 , pp. 4474-4477
    • Agani, F.1    Kirsch, D.G.2    Friedman, S.L.3
  • 25
    • 0027958348 scopus 로고
    • Mt p53 potentiates PKC induction of vascular endothelial growth factor expression
    • Keiser A, Weich HA, Brandner G, et al. Mt p53 potentiates PKC induction of vascular endothelial growth factor expression. Oncogene 1994;9:963-9.
    • (1994) Oncogene , vol.9 , pp. 963-969
    • Keiser, A.1    Weich, H.A.2    Brandner, G.3
  • 26
    • 0029125555 scopus 로고
    • Specific DNA binding by different classes of human p53 mutants
    • Rolley N, Butcher S, Milner J. Specific DNA binding by different classes of human p53 mutants. Oncogene 1995;11: 763-70.
    • (1995) Oncogene , vol.11 , pp. 763-770
    • Rolley, N.1    Butcher, S.2    Milner, J.3
  • 27
    • 85038537827 scopus 로고    scopus 로고
    • Effect of mutation and conformation on the function of the tumour suppressor gene p53 in colorectal cancer
    • In press
    • Webley KM, Royds JA. Effect of mutation and conformation on the function of the tumour suppressor gene p53 in colorectal cancer. J Pathol. [In press.]
    • J Pathol.
    • Webley, K.M.1    Royds, J.A.2
  • 29
    • 0028129836 scopus 로고
    • Release of an inhibitor of angiogenesis upon induction of wild type p53 expression in glioblastoma cells
    • Van Meier EG, Polverini PJ, Chazin VR, et al. Release of an inhibitor of angiogenesis upon induction of wild type p53 expression in glioblastoma cells. Nat Genet 1994;8:171-6.
    • (1994) Nat Genet , vol.8 , pp. 171-176
    • Van Meier, E.G.1    Polverini, P.J.2    Chazin, V.R.3
  • 30
    • 8244233169 scopus 로고    scopus 로고
    • Neoangiogenesis and p53 protein in lung cancer: Their prognostic role and their relation with vascular endothelial growth factor (VEGF) expression
    • Fontanini G, Vignati S, Mussi A, et al. Neoangiogenesis and p53 protein in lung cancer: their prognostic role and their relation with vascular endothelial growth factor (VEGF) expression. Br J Cancer 1997;75:1295-301.
    • (1997) Br J Cancer , vol.75 , pp. 1295-1301
    • Fontanini, G.1    Vignati, S.2    Mussi, A.3
  • 31
    • 7144266586 scopus 로고    scopus 로고
    • Association of p53 status with tumour angiogenesis, grade, necrosis and macrophage activity in invasive breast cancer
    • Royds JA, Lewis CE, Leek RD, et al. Association of p53 status with tumour angiogenesis, grade, necrosis and macrophage activity in invasive breast cancer [abstract]. J Pathol 1997;182:17A.
    • (1997) J Pathol , vol.182
    • Royds, J.A.1    Lewis, C.E.2    Leek, R.D.3
  • 32
    • 0028268629 scopus 로고
    • Hypoxia causes the activation of nuclear factor kappa through the phosphorylation of IKBa on tyrosine residues
    • Koong AC, Chen KY, Giaccia AJ. Hypoxia causes the activation of nuclear factor kappa through the phosphorylation of IKBa on tyrosine residues. Cancer Res 1994;54:1425-30.
    • (1994) Cancer Res , vol.54 , pp. 1425-1430
    • Koong, A.C.1    Chen, K.Y.2    Giaccia, A.J.3
  • 33
    • 0031568523 scopus 로고    scopus 로고
    • Inflammatory cytokines induce endothelial cells to produce and release bFGF and to promote Kaposi's sarcoma-like lesions in nude mice
    • Samaniego F, Markham PD, Gendelman R, et al. Inflammatory cytokines induce endothelial cells to produce and release bFGF and to promote Kaposi's sarcoma-like lesions in nude mice. J Immunol 1997;158:1887-94.
    • (1997) J Immunol , vol.158 , pp. 1887-1894
    • Samaniego, F.1    Markham, P.D.2    Gendelman, R.3
  • 34
    • 0031034814 scopus 로고    scopus 로고
    • Hypoxia induces cyclooxygenase-2 via the NFkB p65 transcription factor in human vascular endothelial cells
    • Schmedtje JF, Ji YS, Liu W, et al. Hypoxia induces cyclooxygenase-2 via the NFkB p65 transcription factor in human vascular endothelial cells. J Biol Chem 1997;272: 601-8.
    • (1997) J Biol Chem , vol.272 , pp. 601-608
    • Schmedtje, J.F.1    Ji, Y.S.2    Liu, W.3
  • 35
    • 0029670083 scopus 로고    scopus 로고
    • Mapping of the inducible I-k-B phosphorylation sites that signal its ubiquination and degradation
    • DiDonato J, Mercurio F, Rosette C, et al. Mapping of the inducible I-k-B phosphorylation sites that signal its ubiquination and degradation. Mol Cell Biol 1996;16:1295-54.
    • (1996) Mol Cell Biol , vol.16 , pp. 1295-1354
    • DiDonato, J.1    Mercurio, F.2    Rosette, C.3
  • 36
    • 16044365828 scopus 로고    scopus 로고
    • Tyrosine phosphorylation of IkB activates NFkB without proteolytic degradation of IkB
    • Imbert V, Rupee RA, Livolsi A, et al. Tyrosine phosphorylation of IkB activates NFkB without proteolytic degradation of IkB. Cell 1996;86:787-98.
    • (1996) Cell , vol.86 , pp. 787-798
    • Imbert, V.1    Rupee, R.A.2    Livolsi, A.3
  • 37
    • 0029956644 scopus 로고    scopus 로고
    • Site-specific tyrosine phosphorylation of IkB negatively regulates its inducible phosphorylation and degradation
    • Singh S, Darnay BG, Aggarwal BB, et al. Site-specific tyrosine phosphorylation of IkB negatively regulates its inducible phosphorylation and degradation. J Biol Client 1996;271:31049-54.
    • (1996) J Biol Client , vol.271 , pp. 31049-31054
    • Singh, S.1    Darnay, B.G.2    Aggarwal, B.B.3
  • 38
    • 0031558258 scopus 로고    scopus 로고
    • IkB all zipped up
    • Isreal A. IkB all zipped up. Nature 1997;388:519-21.
    • (1997) Nature , vol.388 , pp. 519-521
    • Isreal, A.1
  • 39
    • 0028172914 scopus 로고
    • Disruption of I-Kappa-B-alpha regulation by antisense RNA expression leads to malignant transformation
    • Beauparlant P, Kwan I, Bitar R, et al. Disruption of I-Kappa-B-alpha regulation by antisense RNA expression leads to malignant transformation. Oncogene 1994;9:3189-97.
    • (1994) Oncogene , vol.9 , pp. 3189-3197
    • Beauparlant, P.1    Kwan, I.2    Bitar, R.3
  • 40
    • 0028992611 scopus 로고
    • Macrophages derived from C3H/HEJ (LPS(D)) mice respond to bacterial lipopolysaccharide by activating NF-Kappa-B
    • Hwang S, Ding A. Macrophages derived from C3H/HEJ (LPS(D)) mice respond to bacterial lipopolysaccharide by activating NF-Kappa-B Cancer Biochem Biophys 1995;14: 265-72.
    • (1995) Cancer Biochem Biophys , vol.14 , pp. 265-272
    • Hwang, S.1    Ding, A.2
  • 41
    • 0028167599 scopus 로고
    • NFkB activation of p53
    • Wu H, Lozano G. NFkB activation of p53. J Biol Chem 1994;269:20067-74.
    • (1994) J Biol Chem , vol.269 , pp. 20067-20074
    • Wu, H.1    Lozano, G.2
  • 42
    • 0029007316 scopus 로고
    • Identification of a novel p53 promoter element involved in genotoxic stressinducible p53 gene expression
    • Sun X, Shimizu H, Yamamoto K-I. Identification of a novel p53 promoter element involved in genotoxic stressinducible p53 gene expression. Mol Cell Biol 1995;15: 4489-96.
    • (1995) Mol Cell Biol , vol.15 , pp. 4489-4496
    • Sun, X.1    Shimizu, H.2    Yamamoto, K.-I.3
  • 43
    • 0029061587 scopus 로고
    • Correction of radiation senstivity in ataxia telangiectasia cells by a truncated IkB-α
    • Jung M, Zhang Y, Lee S, et al. Correction of radiation senstivity in ataxia telangiectasia cells by a truncated IkB-α. Science 1995;268:1619-21.
    • (1995) Science , vol.268 , pp. 1619-1621
    • Jung, M.1    Zhang, Y.2    Lee, S.3
  • 44
    • 0024573893 scopus 로고
    • Characterisation of the human p53 gene promoter
    • Tuck SP, Crawford L. Characterisation of the human p53 gene promoter. Mol Cell Biol 1989;9:2163-72.
    • (1989) Mol Cell Biol , vol.9 , pp. 2163-2172
    • Tuck, S.P.1    Crawford, L.2
  • 45
    • 0029874138 scopus 로고    scopus 로고
    • The NFkB and IkB proteins: New discoveries and insights
    • Baldwin AS. The NFkB and IkB proteins: new discoveries and insights. Ann Rev Immunol 1996;14:649-83.
    • (1996) Ann Rev Immunol , vol.14 , pp. 649-683
    • Baldwin, A.S.1
  • 46
    • 0028032360 scopus 로고
    • Hypoxic activation of nuclear factor K B is mediated by a ras and raf signalling pathway and does not involve MAP kinase (ERK1 or ERK2)
    • Koong AC, Chen KY, Mivechi NF, et al. Hypoxic activation of nuclear factor K B is mediated by a ras and raf signalling pathway and does not involve MAP kinase (ERK1 or ERK2). Cancer Res 1994;54:5273-9.
    • (1994) Cancer Res , vol.54 , pp. 5273-5279
    • Koong, A.C.1    Chen, K.Y.2    Mivechi, N.F.3
  • 47
    • 0029681850 scopus 로고    scopus 로고
    • Oncogenic transformation and hypoxia synergistically act to modulate VEGF expression
    • Mazure NM, Chen KY, Yeh P, et al. Oncogenic transformation and hypoxia synergistically act to modulate VEGF expression. Cancer Res 1996;56:3436-40.
    • (1996) Cancer Res , vol.56 , pp. 3436-3440
    • Mazure, N.M.1    Chen, K.Y.2    Yeh, P.3
  • 48
    • 0030994587 scopus 로고    scopus 로고
    • Protease inhibitor TPCK represses Ha-ras (Val-12) transformation and nuclear factor-kappa B activation
    • Denko NC, Chen KY, Laderoute KR, et al. Protease inhibitor TPCK represses Ha-ras (Val-12) transformation and nuclear factor-kappa B activation. Int J Oncol 1997;10: 895-900.
    • (1997) Int J Oncol , vol.10 , pp. 895-900
    • Denko, N.C.1    Chen, K.Y.2    Laderoute, K.R.3
  • 49
    • 0030298294 scopus 로고    scopus 로고
    • Dissection of TNF receptor 1 effector functions: JNK activation is not linked to apoptosis while NFkB activation prevents cell death
    • Liu Z, Hsu H, Goeddel DV, et al. Dissection of TNF receptor 1 effector functions: JNK activation is not linked to apoptosis while NFkB activation prevents cell death. Cell 1996;87:565-76.
    • (1996) Cell , vol.87 , pp. 565-576
    • Liu, Z.1    Hsu, H.2    Goeddel, D.V.3
  • 50
    • 0029814063 scopus 로고    scopus 로고
    • Inhibition of NFkB/Rel induces apoptosis in murine B cells
    • Wu GH, Havyuong L, Bellas RE, et al. Inhibition of NFkB/Rel induces apoptosis in murine B cells. EMBO J 1996;15: 4682-90.
    • (1996) EMBO J , vol.15 , pp. 4682-4690
    • Wu, G.H.1    Havyuong, L.2    Bellas, R.E.3


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