Heterogeneity of tumor oxygenation: Relationship to tumor necrosis, tumor size, and metastasis

International Journal of Radiation Oncology Biology Physics

Volumn 42, Issue 4, 1998, Pages 717-721

  De Jaeger, Katrien ^a,b   Merlo, Fernando Moreno ^a,b   Kavanagh, Mary Claire ^a,b   Fyles, Anthony W ^a,b   Hedley, David ^a,b   Hill, Richard P ^a,b  

^a PRINCESS MARGARET HOSPITAL   (Canada)

^b UNIVERSITY OF TORONTO   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; CONFERENCE PAPER; GENETIC VARIABILITY; HYPOXIA; METASTASIS; NONHUMAN; PRIORITY JOURNAL; RAT; SOLID TUMOR; TISSUE OXYGENATION; TUMOR GROWTH; TUMOR NECROSIS; TUMOR VOLUME; UTERINE CERVIX CARCINOMA;

ANIMALS; CELL HYPOXIA; CELL SURVIVAL; HUMANS; MICE; MICE, INBRED C3H; NECROSIS; NEOPLASM METASTASIS; NEOPLASMS; OXYGEN CONSUMPTION; PARTIAL PRESSURE;

EID: 0031774283     PISSN: 03603016     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0360-3016(98)00323-X     Document Type: Conference Paper

References (23)

1. Gatenby R.A., Kessler H.B., Rosenblum J.S., Coia L.R., Moldofsky P.J., Hartz W.H., Broder G.J. Oxygen distribution in squamous cell carcinoma metastases and its relationship to outcome of radiation therapy. Int J Radiat Oncol Biol Phys. 14:1988;831-838.
2. 2 tension measurements . Cancer Res. 51:1991;3316-3322.
3. Nordsmark M., Overgaard M., Overgaard J. Pretreatment oxygenation predicts radiation response in advanced squamous cell carcinoma of the head and neck. Radiother Oncol. 41:1996;31-39.
4. Brizel D.M., Sibley G.S., Prosnitz L.R., Scher R.L., Dewhirst M.W. Tumor hypoxia adversely affects the prognosis of carcinoma of the head and neck. Int J Radiat Oncol Biol Phys. 38:1997;285-289.
5. Brizel D.M., Scully S.P., Harrelson J.M., Layfield L.J., Bean J.M., Prosnitz L.R., Dewhirst M.W. Tumor oxygenation predicts for the likelihood of distant metastases in human soft tissue sarcoma. Cancer Res. 56:1996;941-943.
6. Hockel M., Schlenger K., Aral B., Mitze M., Schaffer U., Vaupel P. Association between tumor hypoxia and malignant progression in advanced carcinoma of the uterine cervix. Cancer Res. 56:1996;4509-4515.
7. 2 in cervix carcinoma. Gynecol Oncol. 64:1997;230-236.
8. Fyles AW, Milosevic M, Wong R, Kavanagh M-C, Pintilie M, Sun A, Chapman W, Levin W, Manchul L, Keane T, Hill RP. Oxygenation predicts radiation response and survival in patients with cervix cancer. Radiother Oncol. 1998;48:149-156.
9. Graeber T.G., Osmanian C., Jacks T., Housman D.E., Koch C.J., Lowe S.W., Giaccia A.J. Hypoxia-mediated selection of cells with diminished apoptotic potential in solid tumours. Nature. 379:1996;88-91.
10. Reynolds T.Y., Rockwell S., Glazer P.M. Genetic instability induced by the tumor microenvironment. Cancer Res. 56:1996;5754-5757.
11. Horsman M.R., Khalil A.A., Siemann D.W., Grau C., Hill S.A., Lynch E.M., Chaplin D.J., Overgaard J. Relationship between radiobiological hypoxia in tumors and electrode measurements of tumor oxygenation. Int J Radiat Oncol Biol Phys. 29:1994;439-442.
12. 3H-misonidazole binding, and paired survival curve assay . Radiat Res. 145:(4):1996;491-500.
13. Yeh K.A., Biade S., Lanciano R.M., Brown D.Q., Fenning M.C., Babb J.S., Hanks G.E., Chapman J.D. Polarographic needle electrode measurements of oxygen in rat prostate carcinomas Accuracy and reproducibility . Int J Radiat Oncol Biol Phys. 33:1995;111-118.
14. 2. Acta Oncol. 36:1997;183-189.
15. Bristow R.G., Hardy P.A., Hill R.P. Comparison between in vitro radiosensitivity and in vivo radioresponse of murine tumor cell lines I: Parameters of in vitro radiosensitivity and endogenous cellular glutathione levels . Int J Radiat Oncol Biol Phys. 18:1990;133-145.
16. Khalil A.A., Horsman M.R., Overgaard J. The importance of determining necrotic fraction when studying the effect of tumor volume on tissue oxygenation. Acta Oncol. 34:1995;297-300.
17. Lyng H., Sundfor K., Rofstad E.K. Oxygen tension in human tumours measured with polarographic needle electrodes and its relationship to vascular density, necrosis and hypoxia. Radiother Oncol. 44:1997;163-169.
18. Hill R.P., Young S.D., Ling V. Metastatic cell phenotypes Quantitative studies using the experimental metastasis assay . Cancer Rev. 5:1986;118-151.
19. Young S.D., Marshall R.S., Hill R.P. Hypoxia induces DNA overreplication and enhances the metastatic potential of murine tumor cells. Proc Natl Acad Sci USA. 85:1988;9533-9537.
20. Young S.D., Hill R.P. Effects of reoxygenation on cells from hypoxic regions of solid tumors Anticancer drug sensitivity and metastatic potential . J Natl Cancer Inst. 82:1990;371-380.
21. Cuvier C., Jang A., Hill R.P. Exposure to hypoxia and glucose starvation; effect on invasive capacity of murine tumour cells . Clin Exp Metast. 15:1997;19-25.
22. Jang A., Hill R.P. An examination of the effects of hypoxia, acidosis, and glucose starvation on the expression of metastasis-associated genes in murine tumor cells. Clin Exp Metast. 15:1997;469-483.
23. Chiarotto JA, Hill RP. Unpublished data, 1998.