Synthetic muscle promoters: Activities exceeding naturally occurring regulatory sequences

Nature Biotechnology

Volumn 17, Issue 3, 1999, Pages 241-245

  Li, Xuyang ^a   Eastman, Eric M ^b   Schwartz, Robert J ^a   Draghia Akli, Ruxandra ^a  

^a BAYLOR COLLEGE OF MEDICINE   (United States)

^b Genemedicine   (United States)

Author keywords

Gene therapy; Human growth hormone releasing hormone; Myogenic regulatory elements

Indexed keywords

ALPHA ACTIN; GENE PRODUCT; MYOGENIC FACTOR; SERUM RESPONSE FACTOR;

ARTICLE; GENE ACTIVITY; GENE CONSTRUCT; GENE EXPRESSION; GENE LIBRARY; GENE SEQUENCE; GENE THERAPY; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN ANALYSIS; REGULATOR GENE; REGULATORY MECHANISM; REPORTER GENE; SERUM RESPONSIVE ELEMENT; SKELETAL MUSCLE;

NASA DISCIPLINE MUSCULOSKELETAL; NON-NASA CENTER;

ACTINS; ANIMALS; BETA-GALACTOSIDASE; BLOTTING, NORTHERN; CELLS, CULTURED; CHICKENS; DNA-BINDING PROTEINS; GENE EXPRESSION; GENE LIBRARY; GENE THERAPY; GROWTH HORMONE-RELEASING HORMONE; HELA CELLS; HUMANS; LUCIFERASES; MALE; MICE; MICE, INBRED ICR; MICE, TRANSGENIC; MODELS, BIOLOGICAL; MUSCLE, SKELETAL; MYOGENIC REGULATORY FACTORS; MYOSIN LIGHT CHAINS; NUCLEAR PROTEINS; PROMOTER REGIONS (GENETICS); RADIOIMMUNOASSAY; SERUM RESPONSE FACTOR; TIME FACTORS; TISSUE DISTRIBUTION; TRANSCRIPTION FACTORS;

MAMMALIA;

EID: 0033066691     PISSN: 10870156     EISSN: None     Source Type: Journal    
DOI: 10.1038/6981     Document Type: Article

References (24)

1. Draghia-Akli, R., Li, X. & Schwartz, R.J. Enhanced growth by ectopic expression of growth hormone releasing hormone using an injectable myogenic vector. Nat. Biotechnol. 15, 1285-1289 (1997).
2. Haase, G. et al. Gene therapy of murine motor neuron disease using adenoviral vectors for neurotrophic factors. Nat. Med. 3, 429-436 (1997).
3. Tripathy, S.K. et al. Long-term expression of erythropoietin in the systemic circulation of mice after intramuscular injection of a plasmid DNA vector. Proc. Natl. Acad. Sci. USA 93, 10876-10880 (1996).
4. Wolff, J.A., Ludtke, J.J., Acsadi, G., Williams, P. & Jani, A. Long-term persistence of plasmid DNA and foreign gene expression in mouse muscle. Hum. Mol. Genet. 1, 363-369 (1992).
5. Acsadi, G. et al. Direct gene transfer and expression into rat heart in vivo. New Biologist. 3, 71-81 (1991).
6. Montgomery, D.L., Ulmer, J.B., Donnelly, J.J. & Liu, M.A. 1997. DNA Vaccines Pharmacol. Ther. 74, 195-205 (1991).
7. Lee, T.C., Shi, Y. & Schwartz, R.J. Displacement of BrdUrd-induced YY1 by serum response factor activates skeletal alpha-actin transcription in embryonic myoblasts. Proc. Natl. Acad. Sci. USA 89, 9814-9818 (1992).
8. Bergsma, D.J., Grichnik, J.M., Gossett, L.M. & Schwartz, R.J. Delimitation and characterization of cis-acting DNA sequences required for the regulated expression and transcriptional control of the chicken skeletal alpha-actin gene. Mol. Cell. Biol. 6, 2462-2475 (1986).
9. Chow, K.L. & Schwartz, R.J. A combination of closely associated positive and negative cis-acting promoter elements regulates transcription of the skeletal alpha-actin gene. Mol. Cell. Biol. 10, 528-538 (1990).
10. Minty, A. & Kedes, L. Upstream regions of the human cardiac actin gene that modulate its transcription in muscle cells: presence of an evolutionary conserved repeated motif. Mol. Cell. Biol. 6, 2125-2136 (1986).
11. Gossett, L.A., Kelvin, D.J., Sternberg, E.A. & Olson, E.N. A new myocyte-specific enhancer-binding factor that recognizes a conserved element associated with multiple muscle-specific genes. Mol. Cell. Biol. 9, 5022-5033 (1989).
12. Olson, E.N. et al. Molecular control of myogenesis: antagonism between growth and differentiation. Mol. Cell. Biochem. 104, 7-13 (1991).
13. Weintraub, H., Davis, R., Lockshon, D. & Lassar, A. MyoD binds cooperatively to two sites in a target enhancer sequence: occupancy of two sites is required for activation. Proc. Natl. Acad. Sci. USA 87, 5623-5627 (1990).
14. Lassar, A.B. et al. Functional activity of myogenic HLH proteins requires heterooligomerization with E12/E47-like proteins in vivo. Cell 66, 305-315 (1991).
15. Larkin, S.B., Farrance, I.K. & Ordahl, C.P. Flanking sequences modulate the cell specificity of M-CAT elements. Mol. Cell. Biol. 16, 3742-3755 (1996).
16. Stewart, A.F. et al. Muscle-enriched TEF-1 isoforms bind M-CAT elements from muscle-specific promoters and differentially activate transcription. J. Biol. Chem. 269, 3147-3150 (1994).
17. Schwartz, R.J. & Rothblum, K.N. Gene switching in myogenesis: differential expression of the chicken actin multigene family. Biochemistry 20, 4122-4129 (1981).
18. Lee, T.C., Zhang, Y. & Schwartz, R.J. Bifunctional transcriptional properties of YY1 in regulating muscle actin and c-myc gene expression during myogenesis. Oncogene. 9, 1047-1052 (1994).
19. Chow, K.L., Hogan, M.E. & Schwartz, R.J. Phased cis-acting promoter elements interact at short distances to direct avian skeletal alpha-actin gene transcription. Proc. Natl. Acad. Sci. USA 88, 1301-1305 (1991).
20. Machon, O., Strmen, V., Hejnar, J., Geryk, J. & Svoboda, J. Sp1 binding sites inserted into the Rous sarcoma virus long terminal repeat enhance LTR-driven gene expression. Gene 208, 73-82 (1998).
21. Barnhart, K., Hartikka, J., Manthorpe, M., Norman, J. & Hobart P. Enhancer and promoter chimeras in plasmids designed for intramuscular injection: a comparative in vivo and in vitro study. Hum. Gene Ther. 9, 2545-2553 (1998).
22. Hayward, L.J. & Schwartz, R.J. Sequential expression of chicken actin genes during myogenesis. J. Biol. Chem. 102, 1485-1493 (1986).
23. Hartikka, J. et al An improved plasmid DNA expression vector for direct injection into skeletal muscle. Hum. Gene Ther. 7, 1205-1217 (1996).
24. Skarli, M., Kiri, A., Vrbova, G., Lee, C.A. & Goldspink, G. Myosin regulatory elements as vectors for gene transfer by intramuscular injection. Gene Ther. 5, 514-520 (1998).