In vivo and in vitro expression of human serum albumin genomic sequences in mammary epithelial cells with β-lactoglobulin and when acidic protein promoters

Molecular Reproduction and Development

Volumn 52, Issue 3, 1999, Pages 241-252

  Barash, Itamar ^a   Faerman, Alexander ^a   Richenstein, Moshe ^a   Kari, Rachel ^a   Damary, Golda Meir ^a   Shani, Moshe ^a   Bissell, Mina J ^b  

^a VOLCANI CENTER   (Israel)

^b LAWRENCE BERKELEY NATIONAL LABORATORY   (United States)

Author keywords

lactoglobulin; Mammary epithelial cells; Transgenics; Variegated expression; Whey acidic protein

Indexed keywords

ACID PROTEIN; BETA LACTOGLOBULIN; HUMAN SERUM ALBUMIN; UNCLASSIFIED DRUG; WHEY ACIDIC PROTEIN;

ANIMAL CELL; ANIMAL TISSUE; ARTICLE; BREAST EPITHELIUM; CONTROLLED STUDY; EPITHELIUM CELL; GENE SEQUENCE; MAMMARY GLAND; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN SECRETION; TRANSGENIC MOUSE;

ANIMALS; CELL LINE; EPITHELIAL CELLS; FEMALE; GENE DOSAGE; GENE EXPRESSION; GENETIC VECTORS; HUMANS; LACTATION; LACTOGLOBULINS; MAMMARY GLANDS, ANIMAL; MICE; MICE, TRANSGENIC; MILK; MILK PROTEINS; PROMOTER REGIONS (GENETICS); SERUM ALBUMIN; SHEEP;

ANIMALIA; MUS MUSCULUS; OVIS; OVIS ARIES;

EID: 0032899487     PISSN: 1040452X     EISSN: None     Source Type: Journal    
DOI: 10.1002/(SICI)1098-2795(199903)52:3<241::AID-MRD1>3.0.CO;2-X     Document Type: Article

References (57)

1. Ali S, Clark, J. 1988. Characterization of the gene encoding bovine beta-lactoglobulin. Mol Cell Biol 199:415-426.
2. Archibald AL, McClenaghan M, Hornsey V, Simons JP, Clark AJ. 1990. High-level expression of biologically active human α1-antitrypsin in the milk of transgenic mice. Proc Natl Acad Sci USA 87:5178-5182.
3. Auffray C, Rougeon F. 1980. Purification of mouse immunoglobulin heavy chain messenger RNAs from total myeloma tumor RNA. Eur J Biochem 107:303-314.
4. Barash I, Baruch A, Nathan M, Hurwitz DR, Shani M. 1993. HSA production by mammary explants of virgin transgenic mice: a reliable tool for predicting its level in the milk. Anim Biotech 4:203-215.
5. Barash I, Faerman A, Ratovizky T, Puzis R, Nathan M, Hurwitz, DR, Shani M. 1994. Ectopic expression of β-lactoglobulin/human serum albumin fusion genes in transgenic mice: hormonal regulation and in situ localization. Transgen Res 3:141-151.
6. Barash I, Faerman A, Puzis R, Shani M. 1995. Synthesis and secretion of caseins by the mouse mammary gland: production and characterization of new polyclonal antibodies. Mol Cell Biochem 144:175-180.
7. Barash I, Kari R, Ian N, Baruch A, Hurwitz DR, Shani M. 1996b. Co-integration of β-lactoglobulin/human serum albumin genes with the entire BLG gene or the matrix attachment region element: repression of HSA and BLG expression in the mammary gland and dual regulation of the transgenes. Mol Reprod Dev 45:421-430.
8. Barash I, Nathan M, Ken R, Ilan N, Shani M, Hurwitz DR. 1996a. Elements within the β-lactoglobulin gene inhibit expression of human serum albumin cDNA or minigenes in transfected cells but rescue their expression in the mammary gland of transgenic mice. Nucleic Acids Res 24:602-610.
9. Barcellos-Hoff MH, Aggeler J, Ram TG, Bissell MJ. 1989. Functional differentiation and alveolar morphogenesis of primary mammary cultures on reconstituted basement membrane. Development 105: 223-235.
10. Baruch A, Shani, M, Barash I. 1997. Insulin and prolactin synergize to induce translation of human serum albumin in the mammary gland of transgenic mice. Transgen Res 6 (in press).
11. Baruch A, Shani M, Hurwitz DR, Barash I. 1995. Developmental regulation of the ovine β-lactoglobulin/human serum albumin transgene is distinct from that of the β-lactoglobulin and the endogenous β-casein in the mammary gland of transgenic mice. Dev Genet 16:241-252.
12. Burdon TG, Maitland KA, Clark J Wallace R, and Watson CJ. 1994. Regulation of the sheep β-lactoglobulin gene by lactogenic hormones is mediated by a transcription factor that binds an interferon-β activation (GAS)-related element. Mol Endocrinol 8:1528-1536.
13. Campbell SM, Rosen JM, Hennighausen LG, Strech-Jurk U, Hennighausen L, Sipple AE. 1982. Mouse whey acidic protein is a novel member of the family of "four-disulfide core" proteins. Nucleic Acids Res 10:2677-2684.
14. Carver, AS, Dalrymple MA, Wright G, Cottom DS, Reeves DB, Gibson YH, Keenan JL, Barrass JD, Scott AR, Colman A, Garner I. 1993. Transgenic livestock as bioreactors: stable expression of human alfa-1-antitrypsin by a flock of sheep. Bio/Technol 11:1263-1270.
15. Chen L-H, Bissell MJ. 1989. A novel regulatory mechanism for whey acidic protein gene expression. Cell Regul 1:45-54.
16. Dale TC, Krnacik MJ, Schmidhauser C, Yang CL-Q, Bissell MJ, Rosen J. 1992. High-level expression of the rat whey acidic protein gene is mediated by elements in the promoter and 3′ untranslated region. Mol Cell Biol 12:905-914.
17. Dobie K, Lee M, Fantes JA, Graham E, Clark AJ, Springbell A, Lathe R, McClenaghan M. 1996. Variegated transgene expression in mouse mammary gland is determined by the transgene integration locus. Proc Natal Acad Sci USA 93:6659-6664.
18. Dobie K, Mehtali M, McClenghan M, Lathe R. 1997. Variegated gene expression in mice. TIG 13:127-130.
19. Dorer DR. 1997. Do transgene arrays form heterochromatin in vertebrates? Transgen Res 6:3-10.
20. Dorer DR, Henikoff S. 1994. Expressions of transgene repeats cause heterochromatine formation and gene silencing in Drosophila. Cell 77:993-1002.
21. Drohan W, Zhang DW, Paleyanda R, Chang R, Wroble M, Velander W, Lubon H. 1994. Inefficient processing of human protein C in the mammary gland. Transgen Res 3:355-364.
22. Faerman A, Barash I, Puzis R, Nathan M, Hurwitz DR, Shani M. 1995. Dramatic heterogeneity of transgene expression in the mammary gland of lactating mice: a model system to study the synthetic activity of mammary epithelial cells. J Histochem Cytochem 43:461-470.
23. Farini E, Whitelaw CBA. 1995. Ectopic expression of β-lactoglobulin transgenes. Mol Gen Genet 246:734-738.
24. Festenstein R, Tolaini M, Corbella P, Mamalaki C, Parrington J, Fox M, Miliou A, Jones M, Kioussis D. 1996. Locus control region function and heterochromatin-induced position effect variegation. Science 271:1123-1125.
25. Gunzburg WH, Salmons B, Zimmermann B, Muller M, Erfle V, Brem G. 1991. A mammary-specific promoter directs expression of growth hormone not only to the mammary gland but also to Bregman glia cells in transgenic mice. Mol Endocrinol 5:123-133.
26. Hansson L, Edlund M, Edlund A, Johansson T, Marklund S, Fromm S, Stromqvist M, Tornell J. 1994. Expression and characterization of biologically active human extracellular superoxide dismutase in milk of transgenic mice. J Biol Chem 269:5358-5363.
27. Hennighausen L, Robinson GW, Wagner K-U, Liu, X. 1997. Prolactin signaling in mammary gland development. J Biol Chem 272:7567-7569.
28. Hennighausen L, Sippel AE. 1982. The mouse whey acidic protein is a novel member of the family of four "four disulfide core" proteins. Nucl Acids Res 10:2677-2684.
29. Hobbs AA, Richards DA, Kessler DJ, Rosen JM. 1982. Complex hormonal regulation of rat casein gene expression. J Biol Chem 257: 3598-3605.
30. Hurwitz DR, Nathan M, Barash I, Ilan N, Shani M. 1994. Specific combinations of human serum albumin introns direct high level expression of albumin in transfected Cos cells and in the milk of transgenic mice. Transgen Res 3:365-375.
31. Ilan N, Barash I, Faerman A, Shani, M., 1996. Dual regulation of β-lactoglobulin/human serum albumin gene expression by extracellular matrix in mammary cells from transgenic mice. Exp Cell Res 224:28-38.
32. Ilan N, Barash I, Gootwine E, Shani M. 1997. Establishment and initial characterization of the ovine mammary epithelial cell line NISH. In Vitro 34:in press.
33. Kolb AF, Gunzburg WH, Albang R, Brem G, Erfle V, Salmons B. 1994. Negative regulatory element in the mammary specific whey acidic protein promoter. J Cell Biochem 56:245-261.
34. Li S, Rosen JM. 1994. Glucocorticoid regulation of rat whey acidic protein gene expression involves hormone-induced alterations of chromatin structure in the distal promoter region. Mol Endocrinol 8:1328-1335.
35. Li S, Rosen JM. 1995. Nuclear factor I and mammary gland factor (STAT5) play a critical role in regulating rat whey acidic protein gene expression in transgenic mice. Mol Cell Biol 15:2063-2070.
36. Lin CQ, Dempsey PJ, Coffey RJ, Bissell MJ. 1995. Extracellular matrix regulates whey acidic protein gene expression by suppression of TGF-alfa in mouse mammary epithelial cells: studies in culture and in transgenic mice. J Cell Biol 129:1115-1126.
37. Liu X, Robinson GW, Gouilleux F, Hennighausen L. 1995. Cloning and expression of Stat5 and an additional homologue (Stat5b) involved in prolactin signal transduction in mouse mammary gland. Proc Natl Acad Sci USA 92:8831-8835.
38. McGowan R, Campbell R, Peterson A, Sapienza C. 1989. Cellular mosaicism in the methilationand expression of hemizygous loci in the mouse. Genes Dev: 3:1669-1673.
39. McKnight RA, Shamay A, Sankaran L, Wall RJ, Hennighausen L. 1992. Matrix attachment regions can impart position independent regulation of a tissue-specific gene in transgenic mice. Proc Natl Acad Sci USA 89:6943-6947.
40. Mehtali M, LeMeur M, Lathe R. 1990. The methylation-free status of a housekeeping transgene is lost at high copy number. Gene 16:179-184.
41. Molenaar AJ, Davis SR, Wilkins RJ. 1992. Expression of alfa-lactalbumin, alfa-S1-casein, and lactoferrin genes is heterogenous in sheep and cattle mammary tissue. J Histochem 40:611-618.
42. Pervaiz S, Brew K. 1985. Homology of β-lactoglobulin, serum retinol-binding protein and protein HC. Science 228:335-337.
43. Pittius CW, Sankaran L, Topper YJ, Hennighausen L. 1988. Comparison of the regulation of the whey acidic protein gene with that of the hybrid gene containing the whey acidic protein gene promoter in transgenic mice. Mol Endocrinol 2:1027-1032.
44. Prunkard D, Cottingham I, Garner I, Bruce S, Dalrymple MA, Lasser G, Bishop P, Foster D. 1996. High-level expression of recombinant human fibrinogen in the milk of transgenic mice. Nature Biotech 14867-14871.
45. Puissant C, Houdebine LM. 1991. Cortisol induces rapid accumulation of whey acid protein mRNA but not of αSl and β-casein mRNA in rabbit mammary expiants. Cell Biol lnt Rep 15:121-129.
46. Reddy WB, Vitale JA, Wei C, Montaya-Zavala M, Stice SL, Balise J, Robl JM. 1991. Expression of human growth hormone in the milk of transgenic mice. Anim Biotech 2:15-29.
47. Sabl JF, Henikoff S. 1996. Copy number and orientation determine the susceptibility of a gene to silencing by nearby heterochromatin in Drosophila. Genetics 142:447-458.
48. Schmidhauser C, Bissell MJ, Myers CA, Casperson J. 1990. Extracellular matrix and hormones transcriptionally regulate bovine β-casein 5′ sequences in stably transfected mouse mammary cells. Proc Natl Acad Sci USA 87:9118-9122.
49. Shamay A, Solinas S, Pursel VG, McKnight RA, Alexander L, Beattie C, Hennighausen L, Wall RJ. 1991. Production of the mouse whey acidic protein in transgenic pigs during lactation. J Anim Sci 69:4552-4562.
50. Shani M, Barash I, Nathan, M, Ricca G, Searfoss GH, Dekel I, Faerman A, Givol D, Hurwitz DR. 1992. Expression of human serum albumin in the milk of transgenic mice. Transgen Res 1:1950-208.
51. Simons JP, McClenaghan M, Clark AJ. 1987. Alteration of the quality of milk by expression of sheep β-lactoglobulin in transgenic mice. Nature 328:530-532.
52. Takashi N, Masumi H, Sagara J, Yuki A. 1994. Functions of milk protein gene 5′ flanking regions on human growth hormone gene. Mol Reprod Dev 37:276-283.
53. Velander WH, Johnson JL, Page RL, Russell CG, Subramanian A, Wilkins TD, Gwadauskas FC, Pittius C, Drohan WN. 1992. High-level expression of heterologous protein in the milk of transgenic swine using cDNA encoding human protein C. Proc Natl Acad Sci USA 89:12003-12007.
54. Wall RJ, Hyman P, Kerr D, Pintado B, Wells K. 1997. Transgenic animal technology. J Androl 18:236-239.
55. Wall RJ, Pursel VG, Shamay A, McKnight RA, Pittius CW, and Hennighausen L. 1991. High-level expression of a heterologous milk protein in the mammary glands of transgenic swine. Proc Natl Acad Sci USA 88:1696-1700.
56. Wall RJ, Rexroad CE Jr, Powell A, Shamay A, McKnight R, Hennighausen L. 1996. Synthesis and secretion of mouse whey acidic protein in transgenic sheep. Transgen Res 5:67-72.
57. Watson CJ, Gordon KE, Robertson M, Clark AJ. 1991. Interaction of DNA-binding proteins with a milk protein gene promoter in vitro: identification of a mammary gland-specific factor. Nucleic Acids Res 19:6603-6610.