RNA interference: Genetic wand and genetic watchdog

Nature Cell Biology

Volumn 2, Issue 2, 2000, Pages

  Bosher, J M ^a   Labouesse, M ^a  

^a INSTITUT DE GÉNÉTIQUE ET DE BIOLOGIE MOLÉCULAIRE ET CELLULAIRE   (France)

Author keywords

[No Author keywords available]

Indexed keywords

DNA; DOUBLE STRANDED RNA; MESSENGER RNA; RNA DIRECTED RNA POLYMERASE;

CAENORHABDITIS ELEGANS; DNA TRANSPOSITION; DROSOPHILA; EMBRYO DEVELOPMENT; GENE MUTATION; GENE REPRESSION; GENE SILENCING; GENETIC TRANSCRIPTION; NONHUMAN; PRIORITY JOURNAL; REVIEW; TRANSGENE;

ANIMAL; CAENORHABDITIS ELEGANS; EUKARYOTIC CELLS; GENE SILENCING; GENETIC ENGINEERING; MODELS, GENETIC; RNA PROCESSING, POST-TRANSCRIPTIONAL; RNA STABILITY; RNA, DOUBLE-STRANDED; SUPPORT, NON-U.S. GOV'T; TRANSGENES;

EID: 0033793081     PISSN: 14657392     EISSN: None     Source Type: Journal    
DOI: 10.1038/35000102     Document Type: Review

References (81)

1. Flavonoid genes in Petunia: Addition of a limited number of gene copies may lead to a suppression of gene expression
2. Introduction of a chalcone synthase gene into Petunia results in reversible co-suppression of homologous genes in trans
3. Expression of a truncated tomato polygalacturonase gene inhibits expression of the endogenous gene in transgenic plants
4. Quelling: Transient inactivation of geneexpression in Neurospora crassa by transformation with homologous sequences
5. Potent and specific genetic interference by double-stranded RNA in Caenorhabditis elegans
6. par-1, a gene required for establishing polarity in C. elegans embryos, encodes a putative Ser/Thr kinase that is asymmetrically distributed
7. Wnt signaling and an APC-related gene specify endoderm in early C. elegans embryos
8. Use of dsRNA-mediated genetic interference to demonstrate that frizzled and frizzled 2 act in the wingless pathway
9. Targeted disruption of gene function in Drosophila by RNA interference (RNA-i): A role for nautilus in embryonic somatic muscle formation
10. Double-stranded RNA induces mRNA degradation in Trypanosoma brucei
11. Double-stranded RNA specifically disrupts gene expression during planarian regeneration
12. Silencing of developmental genes in Hydra
13. Double-stranded RNA induces specific developmental defects in zebrafish embryos
14. Specific interference with gene function by double-stranded RNA in early mouse development
15. Virus resistance and gene silencing in plants can be induced by simultaneous expression of sense and antisense RNA
16. Distinct patterns of pigment suppression are produced by allelic sense and antisense chalcone synthase transgenes in Petunia flowers
17. Activation of systemic acquired silencing by localised introduction of DNA
18. Systemic spread of sequence-specific transgene RNA degradation in plants is initiated by localized introduction of ectopic promoterless DNA
19. Transgenes and gene suppression: Telling us something new?
20. Post-transcriptional gene silencing in plants
21. Transgene-induced gene silencing in plants
22. RNA makes RNA makes no protein
23. RNA-triggered gene silencing
24. Gene silencing: Repeats that count
25. RNAi and double-strand RNA
26. RNA interference can target pre-mRNA: Consequences for gene expression in a C. elegans operon
27. RNAi in C. elegans: Soaking in the genome sequence
28. Specific interference by ingested dsRNA
29. The rde- 1 gene, RNA interference, and transposon silencing in C. elegans
30. Ultrastructural features of the adult hermaphrodite gonad of Caenorhabditis elegans: Relations between the germ line and soma
31. Heritable and inducible genetic interference by dsRNA
32. RNA as a target of double-stranded RNA-mediated genetic interference in Caenorhabditis elegans
33. RNA as a target and an initiator of post-transcriptional gene silencing in transgenic plants
34. Isolation of quelling-defective (qde) mutants impaired in posttranscriptional transgene-induced gene silencing in Neurospora crassa
35. Induction of a highly specific antiviral state in transgenic plants: Implications for regulation of gene expression and virus expression
36. Gene silencing in Neurospora crassa requires a protein homologous to RNA-dependent RNA polymerase
37. RNA-directed RNA polymerase from tomato leaves. I. Purification and physical properties
38. Isolation o fan RNA-directed RNA polymerase-specific cDNA clone from tomato
39. RNA-directed RNA polymerase from tomato leaves. II. Catalytic in vitro properties
40. Characterization of the RNA-dependent RNA polymerase of tobacco leaves
41. The PINHEAD/ZWILLE gene acts pleiotropically in Arabidopsis development and has overlapping functions with the ARGONAUTE1 gene
42. A novel class of evolutionarily conserved genes defined by piwi are essential for stem cell self-renewal
43. Genetic and molecular characterisation of sting, a gene involved in crystal formation and meiotic drive in the male germ line of Drosophila melanogaster
44. AGO1 defines a novel locus of Arabidopsis controlling leaf development
45. Molecular cloning and characterization of a rabbit eIF2C protein
46. The C. elegans Consortium. Genome sequence of the nematode C. elegans: A platform for investigating biology
47. PKR: A new name and new roles
48. PKR, apoptosis and cancer
49. Activation of a transposable element in the germ line but not the soma of Caenorhabditis elegans
50. mut-7 of C. elegans, required for transposon silencing and RNA interference, is a homolog of Werner syndrome helicase and RNaseD
51. Comparative sequence analysis of ribonucleases HII, III, II PH and D
52. Rrp6p, the yeast homologue of the human PM-Scl 100-kDa autoantigen, is essential for efficient 5.8 S rRNA 3' end formation
53. The yeast exosome and human PM-Scl are related complexes of 3' → 5' exonudeases
54. The exosome: A conserved eukaryotic RNA processing complex containing multiple 3' → 5' exoribonucleases
55. The 3' to 5' degradation of yeast mRNAs is a general mechanism for mRNA turnover that requires the SKI2 DEVH box protein and 3' to 5' exonucleases of the exosome complex
56. mRNA degradation. A tale of poly(A) and multiprotein machines
57. Taming of transposable elements by homology-dependent gene silencing
58. Distinct requirements for somatic and germline expression of a generally expressed Caenorhabditis elegans gene
59. The Polycomb group in Caenorhabditis elegans and maternal control of germline development
60. MES-2, a maternal protein essential for viability of the germline in Caenorhabditis elegans, is homologous to a Drosophila Polycomb group protein
61. Chromatin silencing and the maintenance of a functional germline in Caenorhabditis elegans
62. Cosuppression in Drosophila: Gene silencing of alcohol dehydrogenase by white-Adh transgenes is Polycomb dependent
63. Cosuppression of nonhomologous transgenes in Drosophila involves mutually related endogenous sequences
64. Policing rogue genes
65. RNA surveillance. Unforeseen consequences for gene expression, inherited genetic disorders and cancer
66. Should we kill the messenger? The role of the surveillance complex in translation termination and mRNA turnover
67. A new kind of informational suppression in the nematode Caenorhabditis degans
68. mRNA surveillance by the Caenorhabditis elegans smg genes
69. Arabidopsis mutants impaired in cosuppression
70. Identification of plant genetic loci involved in a posttranscriptional mechanism for meiotically reversible transgene silencing
71. Nucleolar space for RENT
72. Prions and RNA viruses of Saccharomyces cerevisiae
73. The nonmuscle myosin regulatory light chain gene mlc-4 is required for cytokinesis, anterior-posterior polarity, and body morphology during Caenorhabditis elegans embryogenesis
74. Tsix, a gene antisense to Xist at the X-inactivation centre
75. Imprinted expression of the Igf2r gene depends on an intronic CpG island
76. Regulation of the interferon-induced PKR: Can viruses cope?
77. Arabidopsis thaliana DNA methylation mutants
78. Release of epigenetic gene silencing by trans-acting mutations in Arabidopsis
79. Gene silencing and homology-dependent gene silencing in Arabidopsis: Genetic modifiers and DNA methylation
80. Homology-dependent gene silencing in Paramecium
81. Targeted mRNA degradation by double-stranded RNA in vitro