Transgene expression in mammary glands of newborn rats

Molecular Reproduction and Development

Volumn 43, Issue 2, 1996, Pages 145-149

  Hirabayashi, Masumi ^a,b   Kodaira, Kunihiko ^a   Takahashi, Ri Ichi ^a   Sagara, Junko ^a   Suzuki, Takashige ^a   Ueda, Masatsugu ^a  

^a YS New Technology Institute Inc   (Japan)

^b YS New Technology Institute Inc   (Japan)

Author keywords

Expression; Mammary gland; Neonate; Transgenic animals; Witch's milk

Indexed keywords

GROWTH HORMONE;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; FEMALE; GENE FUSION; GROWTH HORMONE RELEASE; LACTATION; MALE; MESSENGER RNA SYNTHESIS; MILK LEVEL; NONHUMAN; PRIORITY JOURNAL; RAT; RECOMBINANT DNA TECHNOLOGY; TRANSGENIC MOUSE;

ANIMALS; ANIMALS, GENETICALLY MODIFIED; CASEINS; CATTLE; FEMALE; GENE EXPRESSION; GROWTH HORMONE; HUMANS; MALE; MAMMARY GLANDS, ANIMAL; MILK; RATS;

EID: 0030065408     PISSN: 1040452X     EISSN: None     Source Type: Journal    
DOI: 10.1002/(SICI)1098-2795(199602)43:2<145::AID-MRD2>3.0.CO;2-R     Document Type: Article

References (12)

1. Barash I, Baruch A, Nathan M, Shani M, Hurwitz DR (1993): HSA production by mammary explants of virgin transgenic mice: A reliable tool for predicting levels of secretion into milk. Anim Biotechnol 4:203-215.
2. Chomczynski P, Sacchi N (1987): Single-step method of RNA isolation by acid guanidium thiocyanate-phenol-chloroform extraction. Anal Biochem 162:156-159.
3. DeNote FM, Moore DD, Goodman HM (1981): Human growth hormone DNA sequence and mRNA strucuture: Possible aternate splicing. Nucleic Acids Res 9:3719-3730.
4. Ebert KM, DiTullio P, Barry CA, Schindler JE, Ayres SL, Smith TE, Pellerm LJ, Meade HM, Denman J, Roberts B (1994): Induction of human tissue plasminogen activatory in the mammary gland of transgenic goats. Biotechnology 12:699-702.
5. Forbes TR (1950): Witch's milk and witch's marks Yale Biol Med 22:219.
6. Hennighausen L (1990): The mammary gland as a bioreactor: Production of foreign proteins in milk. Protein Expression Purification 1:3-8.
7. Mizuno A, Hoshi M, Hirabayashi M (1987): Cryopreservation of SHR embryos. Proc Jpn Soc Anim Models Hum Dis 3:42-45 (in Japanese).
8. Ninomiya T, Hirabayashi M, Sagara J, Yuki A (1994): Functions of milk protein gene 5′ flanking regions on human growth hormone gene. Mol Reprod Dev 37:276-283.
9. Saiki RK, Gelfand DH, Stoffel S, Scharf SJ, Higuchi R, Horn GT, Mullis KB, Erlich HA (1988): Primer-directed enzymatic amplification of DNA with a thermostable DNA polymerase. Science 239: 487-491.
10. Wall RJ, Hawk HW, Nel N (1992): Making transgenic livestock genetic engineering on a large scale. J Cell Biochem 49:113-120.
11. Wilmut I, Archibald AL, McClenaghan M, Simons JP, Whitelaw CBA, Clark AJ (1991): Production of pharmaceutical proteins in milk. Experientia 47:905-912.
12. Yu-Lee LY, Richter-Mann L, Couch CH, Stewart AF, Mackinlay AG, Rosen JM (1986): Evolution of the casein multigene family: Conserved sequences in the 5′ flanking and exon region. Nucleic Acids Res 14:1883-1902.