Loss of transcriptional activity of a transgene is accompanied by DNA methylation and histone deacetylation and is prevented by insulators

Genes and Development

Volumn 12, Issue 18, 1998, Pages 2852-2862

  Pikaart, Michael J ^a   Recillas Targa, Félix ^a   Felsenfeld, Gary ^a  

^a NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES   (United States)

Author keywords

DNA methylation; Histone acetylation; Insulator; Silencing; Transcription

Indexed keywords

BETA GLOBIN; COMPLEMENTARY DNA; DEOXYRIBONUCLEASE I; DNA; HISTONE; INTERLEUKIN 2 RECEPTOR; NUCLEASE;

ANIMAL CELL; ARTICLE; CHROMATIN STRUCTURE; CONTROLLED STUDY; DEACETYLATION; DNA METHYLATION; DNA SEQUENCE; GENETIC TRANSCRIPTION; IMMUNOPRECIPITATION; NONHUMAN; PRIORITY JOURNAL; SOUTHERN BLOTTING; TRANSGENE;

EID: 0032530174     PISSN: 08909369     EISSN: None     Source Type: Journal    
DOI: 10.1101/gad.12.18.2852     Document Type: Article

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