Functional expression and germline transmission of a human chromosome fragment in chimaeric mice

Nature Genetics

Volumn 16, Issue 2, 1997, Pages 133-143

  Tomizuka, Kazuma ^a   Yoshida, Hitoshi ^b   Uejima, Hiroshi ^c   Kugoh, Hiroyuki ^a   Sato, Kaoru ^b   Ohguma, Atsuko ^c   Hayasaka, Michiko ^a   Hanaoka, Kazunori ^b   Oshimura, Mitsuo ^c   Ishida, Isao ^a  

^a Central Laboratories for Key Technology   (Japan)

^b TOTTORI UNIVERSITY   (Japan)

^c KITASATO UNIVERSITY   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

ANIMAL CELL; ARTICLE; CHIMERA; CHROMOSOME INSERTION; CONTROLLED STUDY; EMBRYO CELL; FIBROBLAST; IMMUNOGLOBULIN GENE; MOUSE; NONHUMAN; PRIORITY JOURNAL;

ANIMALS; CELL FUSION; CHIMERA; CHROMOSOMES, HUMAN; FEMALE; GENE TRANSFER TECHNIQUES; GENOME, HUMAN; GERM-LINE MUTATION; HUMANS; IMMUNOGLOBULINS; MALE; MICE; RNA, MESSENGER; STEM CELLS;

ANIMALIA;

EID: 0030965015     PISSN: 10614036     EISSN: None     Source Type: Journal    
DOI: 10.1038/ng0697-133     Document Type: Article

References (51)

1. Mansour, S.L, Thomas, K.R. &Capecchi, M.R. Disruption of the proto-oncogeneint2 in mouse embryo-derived stem cells: a general strategy for targeting mutations to non-selectable genes. Nature 336, 348-352 (1988).
2. Jakobovits, A. et al. Germ-line transmission and expression of a human-derived yeast artificial chromosome. Nature 362, 255-258 (1993).
3. Strauss, W.M. ef al. Germ line transmission of a yeast artificial chromosome spanning the murine alpha 1 (I) collagen locus. Science 259, 1904-1907 (1993).
4. Ramirez-Solis, R., Liu, P. & Bradley, A. Chromosome engineering in mice. Nature 378, 720-724(1995).
5. Smith. A.J.H. eraJ. A site-directed chromosomal translocation induced in embryonic stem cells by Cre-loxP recombination. Nature Genet 9, 376-385 (1995).
6. Hooper, M.L Isolation of genetic variants and fusion hybrids from embryonal carcinoma cell lines, in Teratocarcinomas and embryonic Stem Cells: a Practical Approach (ed. Robertson, EJ.) 51-70 (IRL press, Oxford, 1987).
7. Benham, FJ., Quintero, M.A. & Goodfellow, P.N. Human-mouse hybrids with an embryonal carcinoma phenotype continue to transcribe HLA-A, B, C. EMBO J. 2. 1963-1968(1983).
8. Illmensee, K., Hoppe, P.C. & Croce, CM. Chimeric mice derived from human-mouse hybrid cells. Proc. Natl. Acad. Sci. USA 75, 1914-1918 (1978).
9. Illmensee, K. & Croce, CM. Xenogenetic gene expression in chimeric mice derived from rat-mouse hybrid cells. Proc. Natl. Acad. Sci. USA 76, 879-883 (1979).
10. Fournier, R.E. & Ruddle, F.H. Microcell-mediated transfer of murine chromosomes into mouse, Chinese hamster, and human somatic cells. Proc. Natl. Acad. Set. USA 74, 319-323(1977).
11. Katoh, K., Takahashi, Y., Hayashi, S. & Kondoh, H. Improved mammalian vectors for high expression of G418 resistance. Cell Struct Funct 12, 575-580 (1987).
12. Honjo, T. & Alt F.W. (eds.) Immunoglobulin Genes. Second edition. (Academic Press, London, 1995).
13. Lengauer. C., Green E. D. & Cremer, T. Fluorescence in situ hybridization of YAC clones after Alu-PCR amplification. Genomics 13, 826-8 (1992).
14. Dorin, J. R., et al. Gene targeting for somatic cell manipulation: rapid analysis of reduced chromosome hybrids by Alu-PCR fingerprinting and chromosome painting. Hum. Mol. Genet 1, 53-59 (1992).
15. Yagi, T. et al. A novel ES cell line, TT2, with high germline-differentiating potency. Anal. Biochem. 214, 70-76 (1993).
16. Uchida, M., Tokunaga, T., Aizawa, S., Niwa, K. & Imai, H. Isolation and nature of mouse embryonic stem cell line efficiently producing female germ-line chimeras. Anim. Sci. TechnoJ. (Jpn.) 66, 361-367 (1995).
17. Koï, M. et al. Tumor cell growth arrest caused by subchromosomal transferable DMA fragments from chromosome 11. Science 260, 361-364(1993).
18. Jonsson, J.J., Williams, S.R. & Mclvor, R.S. Sequence and functional characterization of the human purine nucleoside phosphorylase promoter. Nucl. Acids Kes. 19, 5015-5020(1991).
19. Tomatsu. S. et al. The organization and the complete nucleotide sequence of the human NADH-cytochrome b5 reductase gene. Gene 80, 353-361 (1989).
20. Yamauchi-Takihara, K., Sole. M.J., Liew, I., Ing, D. & Liew, C.C. Characterization of human cardiac myosin heavy chain genes. Proc. WatJ. Acad. Sd. USA 86, 3504-3508 (1989).
21. Berchtold, M.W. & Means, A.R. The Ca2+-binding protein parvalbumin: molecular cloning and developmental regulation of mRNA abundance. Proc. WatJ. Acad. Sci. USA 82, 1414-1418(1985).
22. Devlin, B.H., Wefald, F.C., Kraus, W.E., Bernard, T.S. & Williams R.5. Identification of a muscle-specific enhancer within the S'-flanking region of the human myoglobin gene., J. Blol. Chem. 264, 13896-13901 (1989).
23. Lowe, J.B. et al. Human liver fatty acid binding protein. J. biol. Chem. 260, 3413-3417(1985).
24. Trask. R.V. & Billadello, J.J. Tissue-specific distribution and developmental regulation of M and B creatine kinase mRNAs. Biochim. Biophys. Acta 1049, 182-188(1990).
25. Hatakeyama, M. et al. lnterleukin-2 receptor ßchain gene: generation of three receptor forms by cloned human a and ßchain cDNAs. Science 244, 551-556 (1989).
26. Griffiths, A.D. et al. Isolation of high affinity human antibodies directly from large synthetic repertoires. EMBOJ. 13, 3245-3260 (1994).
27. Green LL et al. Antigen-specific human monoclonal antibodies from mice engineered with human Ig heavy and light chain YACs. Nature Genet. 7, 13-21 (1994).
28. Mendez, M.J. et al. Functional transplant of megabase human immunoglobulin loci recapitulates human antibody responses in mice. Nature Genet 15, 146-157 (1997).
29. Gropp, A., Winking, H., Herbst E.W. & Claussen, CP. Murine trisomy: Developmental profiles of the embryo, and isolation of trisomie cellular systems. J. Exp. ZooJ. 228, 253-269 (1983).
30. Epstein, C.J. et al. Production of viable adult trisomy 17 reversible diploid mouse chimeras. Proc. Natl. Acad. Sci. USA 79, 4376-4380 (1982).
31. Dewey, M.J., Martin, D.W., Martin, G.R. & Mintz, B. Mosaic mice with teratocarcinoma-derived mutant cells deficient in hypoxanthine phosphoribosyltransferase. Proc Natl. Acad. Sci. USA, 74, 5564-5568 (1977).
32. Lonberg, N. et al. Antigen-specific human antibodies from mice comprising four distinct genetic modifications. Nature 368, 856-S59 (1994).
33. Wagner, S.D. et al. The diversity of antigen-specific monoclonal antibodies from transgenic mice bearing human immunoglobulin gene miniloci. fur. J. Immunol. r-, 24, 2672-2681(1994).
34. Cook, G.P. et al. A map of the human immunoglobulin VH locus completed by analysis of the telomeric region of chromosome 14q. Nature Genet 7, 162-168 (1994).
35. Hunt, P., LeMaire, R., Embury, P., Sheean. L & Mroz, K. Analysis of chromosome behavior in intact mammalian oocytes: monitoring the segregation of a univalent chromosome during female meiosis. Hum. Mol. Genet 4, 2007-2012(1995).
36. Brown, W., Heller, R., Loupart, M-L, Shen, M-H. & Chand, A. Mammalian artificial chromosomes. Curr. Opin. Genêt Dev. 6, 281-288 (1996).
37. Pritchard, C. & Goodfellow, P.M. Development of new methods in human gene mapping: selection for fragments of the human Y chromosome after chromosome mediated gene transfer. EMBOJ. 5, 979-985 (1986).
38. Farr, C. J. et al. Generation of a human X-derived minichromosome using telomereassociated chromosome fragmentation. EMBOJ. 14, 5444-5454 (1995).
39. Heller, R., Brown, K.E., Burgtorf, C & Brown, W.R.A. Mini-chromosome derived from the human Y chromosome by telomere directed chromosome breakage. Proc. Natl. Acad. Sci. USA 93, 7125-7130 (1996).
40. Dieken, E.S., Epner, E.M., Fiering, S., Fournier, R.E. & Groudine M. Efficient modification of human chromosomal alleles using recombination-proficient chicken/human microcell hybrids. Nature Genet. 12, 174-182 (1996).
41. Koi, M., Shimizu, M., Morita, H., Yamada, H. & Oshimura, M. Construction of mouse A9 clones containing a single human chromosome tagged with neomycinresistance gene via microcell fusion. Jpn. J. Cancer Res. 80, 413-418 (1989).
42. Klein, R., Jaenichen, R. & Zachau, H.G. Expressed human immunoglobulin K genes and their hypermutation. fur. J Immunol. 23.3248-3271 (1993).
43. Hattori, M., Hidaka, S. & Sakaki, Y. Sequence analysis of a Kpn I family member near the 3' end of human beta-globin gene. Natl. Acids Res. 13, 7813-7827 (1985).
44. Siminovitch, K.A., Bakhshi, A., Goldman, P. & Korsmeyer, S.J. A uniform deleting element mediates the loss of K genes in human B cells. Nature 316, 260-262 (1985).
45. Ausubel, P.M. et al. Current Protocols in Molecular Biology. (John Wiley & Sons, Inc., New York, 1994).
46. Dracopoli. N.C. et al. Current Protocols in Human Genetics. (John Wiley & Sons, Inc., New York, 1994).
47. Hanaoka, K., Kato, Y. & Noguchi, T. Comparative study of various teratocarcinomas with different origins on the ability to form chimeric mouse embryos. Dev. Growth Differ. 28, 223-231 (1986).
48. Hedrick. 5.M., Cohen, D.I., Nielsen, E.A. & Davis, M.M. Isolation of cDNA clones encoding T cell-specific membrane-associated proteins. Nature 308, 149-153 (1984).
49. Marks, J.D., Tristem, M., Karpas, A. & Winter, G. Oligonucleotide primers for polymerase chain reaction amplification of human immunoglobulin variable genes and design of family-specific Oligonucleotide probes, fur. J. Immunol. 21, 985-991 (1991).
50. Williams, S.C & Winter, G. Cloning and sequencing of human immunoglobulin VX gene segments, fur. J. Immunol. 23, 1456-1461 (1993).
51. Watanabe, S. et al. Stable production of mutant mice from double gene converted ES cells with puromycin and neomycin. Biochem. Biophys. Res. Commun. 213, 130-137(1995).