Analysis of control elements for position-independent expression of human α-lactalbumin YAC

Molecular Reproduction and Development

Volumn 54, Issue 1, 1999, Pages 17-23

  Fujiwara, Yoshihiro ^a   Takahashi, Ri Ichi ^a   Miwa, Masami ^a   Kameda, Midori ^a   Kodaira, Kunihiko ^a   Hirabayashi, Masumi ^a   Suzuki, Takashige ^a   Ueda, Masatsugu ^a  

^a YS New Technology Institute Inc   (Japan)

Author keywords

Bioreactor; LCR; Mammary gland; Microinjection; Transgenic; Vector

Indexed keywords

ALPHA LACTALBUMIN; CASEIN;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; COSMID; FEMALE; GENE EXPRESSION; NONHUMAN; POSITION EFFECT; PRIORITY JOURNAL; RAT; REGULATOR GENE; TRANSGENIC ANIMAL;

ANIMALS; ANIMALS, GENETICALLY MODIFIED; CASEINS; CATTLE; CHROMOSOMES, ARTIFICIAL, YEAST; CLONING, MOLECULAR; COSMIDS; GENE EXPRESSION REGULATION; HUMAN GROWTH HORMONE; HUMANS; LACTALBUMIN; LOCUS CONTROL REGION; MILK PROTEINS; POLYMERASE CHAIN REACTION; PROMOTER REGIONS (GENETICS); RATS; RNA, MESSENGER;

ANIMALIA; BOVINAE;

EID: 0032865046     PISSN: 1040452X     EISSN: None     Source Type: Journal    
DOI: 10.1002/(SICI)1098-2795(199909)54:1<17::AID-MRD3>3.0.CO;2-N     Document Type: Article

References (21)

1. Burke DT, Carle GF, Olson MVH. 1987. Cloning of large segments of exogenous DNA into yeast by means of artificial chromosome vectors. Science 236:806-812.
2. Chomczynski P, Sacchi N. 1987. Single-step method of RNA isolation by acid guanidium thiocyanate-phenol-chloroform extraction. Analyt Biochem 162:156-159.
3. Dracopoli NC, Haines JL, Korf BR, Moir DT, Morton CC, Seidman CE, Seidman JG, Smith DR. 1994. In: Boyle AL, editor. Current protocols in human genetics. New York: John Wiley & Sons, Inc.
4. Ellis J, Tan-Un KC, Harper A, Michalovich D, Yannoutsos N, Philipsen S, Grosveld F. 1996. A dominant chromatin-opening activity in 5′ hypersentisive site 3 of human β-globin locus control region. EMBO J 15:562-568.
5. Frazer P, Grosveld F. 1998. Locus control regions, chromatin activation and transcription. Curr Opin Cell Biol 10:361-365.
6. Fujiwara Y, Miwa M, Takahashi R, Hirabayashi M, Suzuki T, Ueda M. 1997a. Position-independent and high-level expression of human α-lactalbumin in the milk of transgenic rats carrying a 210-kb YAC DNA. Mol Reprod Dev 47:157-163.
7. Fujiwara Y, Miwa M, Takahashi R, Hirabayashi M, Suzuki T, Ueda M. 1997b. Transgenic animals with various YAC constructs: Preparation of 400 kb YAC DNA for microinjection. J Repr Dev 43:81-90.
8. Fujiwara Y, Miwa M, Takahashi R, Kodaira K, Hirabayashi M, Suzuki T, Ueda M. 1999. High-level expressing YAC vector for transgenic animal bioreactor. Mol Reprod Dev 52:414-420.
9. Gietz RD, Woods RA. 1993. High efficiency transformation with lithium acetate. In: Johnston JR. editor. Molecular genetics of yeast. New York: Oxford University Press, p 121-134.
10. Grosveld F, van Assendelft GB, Greaves D, Kollias G. 1987. Position-independent, high-level expression of the human β-globin gene in transgenic mice. Cell 51:975-985.
11. Hall L, Emery DC, Davies MS, Parker D, Craig RK. 1987. Organization and sequence of the human α-lactalbumin gene. Biochem J 242:735-742.
12. Hochi S, Ninomiya T, Waga-Homma M, Sagara J, Yuki A. 1992. Secretion of bovine α-lactalbumin into the milk of transgenic rats. Mol Reprod Dev 33:160-164.
13. Houdebine LM. 1994. Production of pharmaceutical proteins from transgenic animals. J Biotech 34:269-287.
14. Laemmli UK. 1970. Cleavage of structural proteins during the assembly of the head of the bacteriophage T4. Nature 227:680-685.
15. Morag M. 1970. Estimation of milk yield in the rat. Lab Anim 4:259-272.
16. Ninomiya T, Hirabayashi M, Sagara J, Yuki A. 1994. Functions of milk protein gene 5′ flanking regions on human growth hormone gene. Mol Reprod Dev 37:276-283.
17. Palmiter RD, Brinster RL. 1986. Germ-line transformation of mice. Ann Rev Genet 20:465-499.
18. Pavan WJ, Hieter P, Sears D, Burkhoff A, Reeves RH. 1991. High-efficiency yeast artificial chromosome fragmentation vectors. Gene 106:125-127.
19. Sambrook J, Fritsch EF, Maniatis T. 1989. Molecular cloning, 2nd edition. New York: Cold Springs Harbor Laboratory Press.
20. Smith DR, Smyth AP, Moir DT. 1990. Amplification of large artificial chromosomes. Proc Natl Acad Sci USA 87:8242-8246.
21. Soulier S, Vilotte JL, Stinnakre MG, Mercier JC. 1992. Expression analysis of ruminant α-lactoalbumin in transgenic mice: developmental regulation and general location of important cis-regulatory elements. FEBS Lett 297:13-18.