Cloning of the cDNA encoding rat presenilin-2

Biochimica et Biophysica Acta - Gene Structure and Expression

Volumn 1396, Issue 3, 1998, Pages 259-262

  Tanahashi, Hiroshi ^a   Tabira, Takeshi ^a  

^a NATIONAL INSTITUTE OF NEUROSCIENCE   (Japan)

Author keywords

Alternative splicing; Alzheimer's disease; FAD; Presenilin 2; PS 2; STM2

Indexed keywords

COMPLEMENTARY DNA; PRESENILIN 2;

ALZHEIMER DISEASE; AMINO ACID SEQUENCE; ANIMAL TISSUE; ARTICLE; DNA SEQUENCE; HUMAN; MOLECULAR CLONING; MOUSE; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; RAT; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SEQUENCE HOMOLOGY; SPECIES DIFFERENCE; XENOPUS;

ALTERNATIVE SPLICING; ALZHEIMER DISEASE; AMINO ACID SEQUENCE; ANIMALS; BRAIN; CLONING, MOLECULAR; DNA, COMPLEMENTARY; HUMANS; LEUKOCYTES; MEMBRANE PROTEINS; MICE; MOLECULAR SEQUENCE DATA; PRESENILIN-2; RATS; SEQUENCE ALIGNMENT; SEQUENCE HOMOLOGY, AMINO ACID; XENOPUS;

ANIMALIA; RODENTIA;

EID: 0032513079     PISSN: 01674781     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0167-4781(97)00219-4     Document Type: Article

References (14)

1. Goate A., Chartier-Harlin M.C., Brown J., Crawford F., Fidani L., Giuffra L., Haynes A., Irving N., James L., Mant R., Newton Ph., Rooke K., Roques P., Talbot C., Pericak-Vance M., Roses A., Williamson R., Rossor M., Owen M., Hardy J. Segregation of a missense mutation in amyloid precursor protein gene with familial Alzheimer's disease. Nature. 349:1991;704-706.
2. Sherrington R., Rogaev E.I., Liang Y., Rogaeva E.A., Levesque G., Ikeda M., Chi H., Lin C., Li G., Holman K., Tsuda T., Mar L., Foncin J.F., Bruni A.C., Montesi M.P., Sorbi S., Rainero I., Pinessi L., Nee L., Chumakov I., Pollen D., Brookes A., Sanseau P., Polinski R.J., Wasco W., Da Silva H.A.R., Haines J.L., Pericak-Vance M.A., Tanzi R.E., Roses A.D., Fraser P.E., Rommens J.M., St George-Hyslop P. Cloning of a gene bearing missense mutations in early-onset familial Alzheimer's disease. Nature. 375:1995;754-760.
3. Levy-Lahad E., Wasco W., Poorkaj P., Romano D.M., Oshoma J., Pettingell W.H., Yu C.-E., Jondro P.D., Schmidt S.D., Wang K., Crowley A.C., Fu Y.-H., Guenette S.Y., Galas D., Nemens E., Wijsman E.M., Bird T.D., Schellenberg G.D., Tanzi R.E. Candidate gene for chromosome 1 familial Alzheimer's disease locus. Science. 269:1995;973-977.
4. Rogaev E.I., Sherrington R., Rogaeva E.A., Levesque G., Ikeda M., Liang Y., Chi H., Lin C., Holman K., Tsuda T., Mar L., Sorbi S., Nacmias B., Piacentini S., Amaducci L., Chumakov I., Cohen D., Lannfelt L., Fraser P.E., Rommens J.M., St. George-Hyslop P. Familial Alzheimer's disease in kindreds with missense mutations in a gene on chromosome 1 related to the Alzheimer's disease type 3 gene. Nature. 376:1995;775-778.
5. Corder E.H., Saunders A.M., Strittmatter W.J., Schmechel D.E., Gaskell P.C., Small G.W., Roses A.D., Haines J.L., Pericak-Vance M.A. Gene dose of apolipoprotein E4 type 4 allele and risk of Alzheimer's disease in late onset families. Science. 261:1993;921-923.
6. Tanahashi H., Kawakatsu S., Yamanaka H., Kaneko M., Takahashi K., Takeshi Tabira T. Sequence analysis of presenilin-1 gene mutation in Japanese Alzheimer's disease patients. Neurosci. Lett. 218:1996;139-141.
7. Tanahashi H., Mitsunaga Y., Takahashi K., Tasaki H., Watanabe S., Tabira T. Missense mutation of S182 gene in Japanese familial Alzheimer's disease. Lancet. 346:1995;440.
8. Hardy J. Amyloid, the presenilins and Alzheimer's disease. Trends Neurosci. 20:1997;154-159.
9. Vito P., Wolozin B., Ganjei J.K., Iwasaki K., Lacana E., D'Adamio L. Requirement of the familial Alzheimer's disease gene PS-2 for apoptosis: opposing effect of ALG-3. J. Biol. Chem. 271(1996):1996;31025-31028.
10. Tsujimura A., Yasojima K., Hashimoto-Gotoh T. Cloning of Xenopus presenilin-α and -β cDNAs and their differential expression in oogenesis and embryogenesis. Biochem. Biophys. Res. Commun. 231:1997;392-396.
11. Walter J., Capell A., Grunberg J., Pesold B., Schindzielorz A., Prior R., Podlisny M.B., Fraser P., St. George-Hyslop P., Selkoe D.J., Haass C. The Alzheimer's disease-associated presenilins are differentially phosphorylated proteins located predominantly within the endoplasmic reticulum. Mol. Med. 2:1996;673-691.
12. Levy-Lahad E., Poorkaj P., Wang K., Fu Y.-H., Oshima J., Mulligan J., Schellenberg G.D. Genome structure and expression of STM2, the chromosome 1 familial Alzheimer's disease gene. Genomics. 34:1996;198-204.
13. Prihar G., Fuldner R.A., Perez-Tur J., Lincoln S., Duff K., Crook R., Hardy J., Philips C.A., Venter C., Talbot C., Clark R.F., Goate A., Li J., Potter H., Karran E., Roberts G.W., Hutton M., Adams M.D. Structure and alternative splicing of the presenilin-2 gene. NeuroReport. 7:1996;1680-1684.
14. Rogaev E.I., Sherrington R., Wu C., Levesque G., Liang Y., Rogaeva E.A., Ikeda M., Holman K., Lin C., Lukiw W.J., de Jong P.J., Fraser P.E., Rommens J.M., St. George-Hyslop P. Analysis of the 5′ sequence, genomic structure, and alternative splicing of the presenilin-1 gene (PSEN1) associated with early onset Alzheimer's disease. Genomics. 40:1997;415-424.