SAP30, a component of the mSin3 corepressor complex involved in N-CoR-mediated repression by specific transcription factors

Molecular Cell

Volumn 2, Issue 1, 1998, Pages 33-42

  Laherty, Carol D ^a   Billin, Andrew N ^b   Lavinsky, Robert M ^c   Yochum, Gregory S ^b   Bush, Angela C ^a   Sun, Jian Min ^e   Mullen, Tina Marie ^c   Davie, James R ^e   Rose, David W ^c   Glass, Christopher K ^d   Rosenfeld, Michael G ^c   Ayer, Donald E ^b   Eisenman, Robert N ^a  

^a USA   (United States)

^b UNIVERSITY OF UTAH   (United States)

^c UNIVERSITY OF CALIFORNIA SAN DIEGO   (United States)

^d UNIVERSITY OF CALIFORNIA   (United States)

^e UNIVERSITY OF MANITOBA   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

DNA BINDING PROTEIN; ESTROGEN RECEPTOR; HISTONE DEACETYLASE; HOMEODOMAIN PROTEIN; MULTIPROTEIN COMPLEX; NUCLEAR PROTEIN; NUCLEAR RECEPTOR CO REPRESSOR 1; NUCLEAR RECEPTOR CO-REPRESSOR 1; PIT1 PROTEIN, MOUSE; POU1F1 PROTEIN, HUMAN; REPRESSOR PROTEIN; RETINOIC ACID RECEPTOR; SACCHAROMYCES CEREVISIAE PROTEIN; SAP30 PROTEIN, HUMAN; SAP30 PROTEIN, MOUSE; SIN3 PROTEIN, S CEREVISIAE; THYROID HORMONE RECEPTOR; TRANSCRIPTION FACTOR; TRANSCRIPTION FACTOR PIT 1;

AMINO ACID SEQUENCE; ANIMAL; ARTICLE; BIOLOGICAL MODEL; CELL LINE; COMPARATIVE STUDY; DRUG ANTAGONISM; GENETIC TRANSCRIPTION; GENETIC TRANSFECTION; GENETICS; HUMAN; KIDNEY; MACROMOLECULE; MOLECULAR GENETICS; MOUSE; PHYSIOLOGY;

AMINO ACID SEQUENCE; ANIMALS; CELL LINE, TRANSFORMED; DNA-BINDING PROTEINS; HISTONE DEACETYLASES; HOMEODOMAIN PROTEINS; HUMANS; KIDNEY; MACROMOLECULAR SUBSTANCES; MICE; MODELS, GENETIC; MOLECULAR SEQUENCE DATA; MULTIPROTEIN COMPLEXES; NUCLEAR PROTEINS; RECEPTORS, ESTROGEN; RECEPTORS, RETINOIC ACID; RECEPTORS, THYROID HORMONE; REPRESSOR PROTEINS; SACCHAROMYCES CEREVISIAE PROTEINS; TRANSCRIPTION FACTOR PIT-1; TRANSCRIPTION FACTORS; TRANSCRIPTION, GENETIC; TRANSFECTION;

EID: 0032110706     PISSN: 10972765     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1097-2765(00)80111-2     Document Type: Article

References (55)

1. Alland, L., Muhle, R., Hou, H., Jr., Potes, J., Chin, L., Schreiber-Agus, N., and DePinho, R.A. (1997). Role for N-CoR and histone deacetylase in Sin3-mediated transcriptional repression. Nature 387, 49-55.
2. Ayer, D.E., Kretzner, L., and Eisenman, R.N. (1993). Mad: a heterodimeric partner for Max that antagonizes Myc transcriptional activity. Cell 72, 211-222.
3. Ayer, D.E., Laherty, C.D., Lawrence, Q.A., Armstrong, A.P., and Eisenman, R.N. (1996). Mad proteins contain a dominant transcription repression domain. Mol. Cell. Biol. 16, 5772-5781.
4. Ayer, D.E., Lawrence, Q.A., and Eisenman, R.N. (1995). Mad-Max transcriptional repression is mediated by ternary complex formation with mammalian homologs of yeast repressor Sin3. Cell 80, 767-776.
5. Bannister, A.J., and Kouzarides, T. (1996). The CBP co-activator is a histone acetyltransferase. Nature 384, 641-643.
6. Bhattacharyya, N., Dey, A., Minucci, S., Zimmer, A., John, S., Hager, G., and Ozato, K. (1997). Retinoid-induced chromatin structure alterations in the retinoic acid receptor β2 promoter. Mol. Cell. Biol. 17, 6481-6490.
7. Brasier, A.R., and Fortin, J.J., eds. (1995). Current Protocols in Molecular Biology, Vol. 3 (New York: John Wiley and Sons, Inc.).
8. Braunstein, M., Rose, A.B., Holmes, S.G., Allis, C.D., and Broach, J.R. (1993). Transcriptional silencing in yeast is associated with reduced nucleosome acetylation. Genes Dev. 7, 592-604.
9. Brehm, A., Miska, E.A., McCance, D.J., Reid, J.L., Bannister, A.J., and Kouzarides, T. (1998). Retinoblastoma protein recruits histone deacetylase to repress transcription. Nature 391, 597-601.
10. Brownell, J.E., Zhou, J., Ranalli, T., Kobayashi, R., Edmondson, D.G., Roth, S.Y., and Allis, C.D. (1996). Tetrahymena histone acetyltransferase A: a homolog to yeast Gcn5p linking histone acetylation to gene activation. Cell 84, 843-851.
11. Chen, H., Lin, R.J., Schiltz, R.L., Chakravarti, D., Nash, A., Nagy, L., Privalsky, M.L., Nakatani, Y., and Evans, R.M. (1997). Nuclear receptor coactivator ACTR is a novel histone acetyltransferase and forms a multimeric activation complex with P/CAF and CBP/p300. Cell 90, 569-580.
12. Chen, J.D., and Evans, R.M. (1995). A transcriptional co-repressor that interacts with nuclear hormone receptors. Nature 377, 454-457.
13. Grunstein, M. (1997). Histone acetylation in chromatin structure and transcription. Nature 389, 349-352.
14. Gu, W., and Roeder, R.G. (1997). Activation of p53 sequence-specific DNA binding by acetylation of the p53 C-terminal domain. Cell 90, 595-606.
15. Hassig, C.A., Fleischer, T.C., Billin, A.N., Schreiber, S.L., and Ayer, D.E. (1997). Histone deacetylase activity is required for full transcriptional repression by mSin3A. Cell 89, 341-347.
16. Heinzel, T., Lavinsky, R.M., Mullen, T.-M., Soderstrom, M., Laherty, C.D., Torchia, J., Yang, W.-M., Brard, G., Ngo, S.D., Davie, J.R., et al. (1997). A complex containing N-CoR, mSin3, and histone deacetylase mediates transcriptional repression. Nature 387, 43-47.
17. Hendzel, M.J., Delcuve, G.P., and Davie, J.R. (1991). Histone deacetylase is a component of the internal nuclear matrix. J. Biol. Chem. 266, 21936-21942.
18. Hollenberg, S.M., Sternglanz, R., Cheng, P.-F., and Weintraub, H. (1996). Identification of a new family of tissue-specific helix-loop-helix proteins with a two-hybrid system. Mol. Cell. Biol. 15, 3813-3822.
19. Horlein, A.J., Naar, A.M., Heinzel, T., Torchia, J., Gloss, B., Kurokawa, R., Ryan, A., Kamei, Y., Soderstrom, M., Glass, C.K., and Rosenfeld, M.G. (1995). Ligand-independent repression by the thyroid hormone receptor mediated by a nuclear receptor co-repressor. Nature 377, 397-454.
20. Imhof, A., Yang, X.-J., Ogryzko, V.V., Nakatani, Y., Wolffe, A.P., and Ge, H. (1997). Acetylation of general transcription factors by histone acetyltransferases. Curr. Biol. 7, 689-692.
21. Kadosh, D., and Struhl, K. (1997). Repression by Ume6 involves recruitment of a complex containing Sin3 corepressor and Rpd3 histone deacetylase to target promoters. Cell 89, 365-371.
22. Khyse-Anderson. (1984). Electroblotting of multiple gels: a simple apparatus without buffer tank for rapid transfer of proteins from polyacrylamide to nitrocellulose. J. Biochem. Biophys. Meth. 10, 203-209.
23. Kingston, R.E., Bunker, C.A., and Imbalzano, A.N. (1996). Repression and activation by multiprotein complexes that alter chromatin structure. Genes Dev. 10, 905-920.
24. Laherty, C.D., Yang, E.-M., Sun, J.-M., Davie, J.R., Seto, E., and Eisenman, R.N. (1997). Histone deacetylases associated with the mSin3 corepressor mediate Mad transcriptional repression. Cell 89, 349-356.
25. Lavinsky, R.M., Jepsen, K., Heinzel, T., Torchia, J., Mullen, T.-M., Schiff, R., Del-Rio, A.L., Ricote, M., Ngo, S., Hilsenbeck, S.G., et al. (1998). Diverse signaling pathways modulate nuclear receptor recruitment of N-CoR and SMRT complexes. Proc. Natl. Acad. Sci. USA, in press.
26. Li, H., Leo, C., Schroen, D.J., and Chen, J.D. (1997). Characterization of receptor interaction and transcriptional repression by the corepressor SMRT. Mol. Endocrinol. 11, 2025-2037.
27. Luo, R.X., Postigo, A.A., and Dean, D.C. (1998). Rb interacts with histone deacetylase to repress transcription. Cell 92, 463-473.
28. Magnaghi-Jaulin, L., Groisman, R., Naguibneva, I., Robin, P., Lorain, S., LeVillain, J.P., Troalen, F., Trouche, D., and Harel-Bellan, A. (1998). Retinoblastoma protein represses transcription by recruiting a histone deacetylase. Nature 391, 601-605.
29. Mizzen, C.A., Yang, X.-J., Kokubo, T., Brownell, J.E., Bannister, A.J., Owen-Hughes, T., Workman, J., Berger, S.L., Kouzarides, T., Nakatani, Y., and Allis, C.D. (1996). The TAF250 subunit of TFIID has histone acetyltransferase activity. Cell 87, 1261-1270.
30. Nagy, L., Kao, H.-Y., Chakravarti, D., Lin, R., Hassig, C.A., Ayer, D.E., Schreiber, S.L., and Evans, R.M. (1997). Nuclear receptor repression mediated by a complex containing SMRT, mSin3A and histone deacetylase. Cell 89, 373-380.
31. Ogryzko, V.V., Schiltz, R.L., Russanova, V., Howard, B.H., and Nakatani, Y. (1996). The transcriptional coactivators p300 and CBP are histone acetyltransferases. Cell 87, 953-959.
32. Parthun, M.R., Widom, J., and Gottschling, D.E. (1996). The major cytoplasmic histone acetyltransferase in yeast: links to chromatin replication and histone metabolism. Cell 87, 85-94.
33. Qian, Y.-W., Wang, Y.-C.J., Hollingsworth, R.E. J., Jones, D., Ling, N., and Lee, E.Y.-H.P. (1993). A retinoblastoma-binding protein related to a negative regulator of Ras in yeast. Nature 364, 648-652.
34. Rose, D.W., McCabe, G., Feramisco, J.R., and Adler, M. (1992). Expression of c-fos and AP-1 activity in senescent human fibroblasts is not sufficient for DNA synthesis. J. Cell Biol. 119, 1405-1411.
35. Sande, S., and Privalsky, M.L. (1996). Identification of TRACs, a family of co-factors that associate with and modulate the activity of nuclear hormone receptors. Mol. Endocrinol. 10, 813-825.
36. Schreiber-Agus, N., Chin, L., Chen, K., Torres, R., Rao, G., Guida, P., Skoultchi, A.I., and DePinho, R.A. (1995). An amino-terminal domain of Mxi1 mediates anti-Myc oncogenic activity and interacts with a homolog of the yeast transcriptional repressor SIN3. Cell 80, 777-786.
37. Shiio, Y., Yamamoto, T., and Yamaguchi, N. (1992). Negative regulation of Rb expression by the p53 gene product. Proc. Natl. Acad. Sci. USA 89, 5206-5210.
38. Soderstrom, M., Vo, A., Heinzel, T., Lavinsky, R.M., Yang, W.-M., Seto, E., Peterson, D.A., Rosenfeld, M.G., and Glass, C.K. (1997). Differential effects of nuclear receptor corepressor (N-CoR) expression levels on retinoic acid receptor-mediated repression support the existence of dynamically regulated corepressor complexes. Mol. Endocrinol. 11, 682-692.
39. Spencer, T.E., Jenster, G., Burcin, M.M., Allis, C.D., Zhou, J., Mizzen, C.A., McKenna, N.J., Onate, S.A., Tsai, S., Tsai, M.-J., and O'Malley, B.W. (1997). Steroid receptor coactivator-1 is a histone acetyltransferase. Nature 389, 194-198.
40. Taunton, J., Hassig, C.A., and Schreiber, S.L. (1996). A mammalian histone deacetylase related to the yeast transcriptional regulator Rpd3p. Science 272, 408-411.
41. Torchia, J., Rose, D.W., Inostroza, J., Kamei, Y., Westin, S., Glass, C.K., and Rosenfeld, M.G. (1997). The transcriptional co-activator p/CIP binds CBP and mediates nuclear-receptor function. Nature 387, 677-684.
42. Turner, B.M. (1993). Decoding the nucleosome. Cell 75, 5-8.
43. Tyler, J.K., Bulger, M., Kamakaka, R.T., Kobayashi, R., and Kadonaga, J.T. (1996). The p55 subunit of Drosophila chromatin assembly factor 1 is homologous to a histone deacetylase-associated protein. Mol. Cell. Biol. 16, 6149-6159.
44. Verreault, A., Kaufman, P.D., Kobayashi, R., and Stillman, B. (1996). Nucleosome assembly by a complex of CAF-1 and acetylated histones H3/H4. Cell 87, 95-104.
45. Vojtek, A.B., Hollenberg, S.M., and Cooper, J.A. (1993). Mammalian Ras interacts directly with the serine/threonine kinase Raf. Cell 74, 205-214.
46. Wang, H., Clark, I., Nicholson, P.R., Herskowitz, I., and Stillman, D.J. (1990). The Saccaromyces cerevisiae SIN3 gene, a negative regulator of HO, contains four paired amphipathic helix motifs. Mol. Cell. Biol. 10, 5927-5936.
47. Wolffe, A.P. (1997). Histone deacetylase: a regulator of transcription. Science 22, 371-372.
48. Wolffe, A.P., Wong, J., and Pruss, D. (1997). Activators and repressors: making use of chromatin to regulate transcription. Genes to Cells 2, 291-302.
49. Xu, L., Lavinsky, R.M., Dasen, J.S., Flynn, S.E., McInerney, E.M, Mullen, T.-M., Heinzel, T., Szeto, D., Korzus, E., Kurokawa, R., et al. (1998). Distinct histone acetyltransferases and CBP domains are required for activation of Pit-1 by different signalling pathways. Nature, in press.
50. Yang, W.-M., Inouye, C., Zeng, Y., Bearss, D., and Seto, E. (1996a). Transcriptional repression by YY1 is mediated by interaction with a mammalian homolog of the yeast global regulator RPD3. Proc. Natl. Acad. Sci. USA 93, 12845-12850.
51. Yang, X.-J., Ogryzko, V.V., Nishikawa, J., Howard, B.H., and Nakatani, Y. (1996b). A p300/CBP-associated factor that competes with the adenoviral oncoprotein E1A. Nature 382, 319-324.
52. Zamir, I., Harding, H.P., Atkins, G.B., Horlein, A., Glass, C.K., Rosenfeld, M.G., and Lazar, M.A. (1996). A nuclear hormone receptor corepressor mediates transcriptional silencing by receptors with distinct repression domains. Mol. Cell. Biol. 16, 5458-5465.
53. Zamir, I., Zhang, J., and Lazar, M.A. (1997).Stoichiometricand steric principles governing repression by nuclear hormone receptors. Genes Dev. 11, 835-846.
54. Zhang, Y., Iratni, R., Erdjument-Bromage, H., Tempst, P., and Reinberg, D. (1997). Histone deacetylases and SAP18, a novel polypeptide, are components of the human Sin3 complex. Cell 89, 357-364.
55. Zhang, Y., Sun, Z.-W., Iratni, R., Erdjument-Bromage, H., Tempst, P., Hampsey, M., and Reinberg, D. (1998). SAP30, a novel protein conserved between human and yeast, is a component of a histone deacetylase complex. Mol. Cell 1, 1021-1031.