Distinct requirements for chromatin assembly in transcriptional repression by thyroid hormone receptor and histone deacetylase

EMBO Journal

Volumn 17, Issue 2, 1998, Pages 520-534

  Wong, Jiemin ^a   Patterton, Danielle ^a   Imhof, Axel ^a   Guschin, Dmitry ^a   Shi, Yun Bo ^a   Wolffe, Alan P ^a  

^a EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH AND HUMAN DEVELOPMENT   (United States)

Author keywords

Chromatin disruption; Histone acetylation; Nuclear receptor; Transcription factor acetylation; Transcriptional control

Indexed keywords

HISTONE DEACETYLASE; MICROCOCCAL NUCLEASE; RETINOIC ACID RECEPTOR; THYROID HORMONE RECEPTOR; TRICHOSTATIN A;

ANIMAL CELL; ARTICLE; CELL NUCLEUS; CHROMATIN STRUCTURE; CONTROLLED STUDY; ENZYME ACTIVE SITE; MICROINJECTION; MINICHROMOSOME; NONHUMAN; NUCLEOSOME; OOCYTE; PRIORITY JOURNAL; PROMOTER REGION; TRANSCRIPTION REGULATION;

AMINO ACID SEQUENCE; ANIMALS; BASE SEQUENCE; CATALYSIS; CHROMATIN; DNA REPLICATION; GENE EXPRESSION REGULATION; HISTONE DEACETYLASES; HYDROXAMIC ACIDS; LIGANDS; MOLECULAR SEQUENCE DATA; NUCLEOSOMES; RECEPTORS, RETINOIC ACID; RECEPTORS, THYROID HORMONE; RETINOID X RECEPTORS; TEMPLATES, GENETIC; THYROID HORMONES; TRANSCRIPTION FACTORS; TRANSCRIPTION, GENETIC; XENOPUS;

AMPHIBIA; ANIMALIA; REPTILIA;

EID: 0032518799     PISSN: 02614189     EISSN: None     Source Type: Journal    
DOI: 10.1093/emboj/17.2.520     Document Type: Article

References (116)

1. Alevizopoulos, A., Dusserre, Y., Tsai-Pflulgfelder, M., Von Der Weid, T., Wahli, W. and Mermod, N. (1995) A proline-rich TGF-β-responsive transcriptional activator interacts with histone H3. Genes Dev., 9, 3051-3066.
2. Alland, L., Muhle, R., Hou, H., Jr, Potes, J., Chin, L., Schreiber-Agus, N. and De Pinho, R.A. (1997) Role of NCoR and histone deacetylase in Sin3-mediated transcriptional and oncogenic repression. Nature, 387, 49-55.
3. Almer, A. and Horz, W. (1986) Nuclease hypersensitive regions with adjacent positioned nucleosomes mark the gene boundaries of the PHO5/PHO3 locus in yeast. EMBO J., 5, 2681-2687.
4. Almer, A., Rudolph, H., Hinnen, A. and Horz, W. (1986) Removal of positioned nucleosomes from the yeast PHO5 promoter upon PHO5 induction releases additional activating DNA elements. EMBO J., 5, 2689-2696.
5. Almouzni, G. and Wolffe, A.P. (1993) Replication coupled chromatin assembly is required for the repression of basal transcription in vivo. Genes Dev., 7, 2033-2047.
6. Almouzni, G., Clark, D.J., Méchali, M. and Wolffe, A.P. (1990a) Chromatin assembly on replicating DNA in vitro. Nucleic Acids Res., 18, 5767-5774.
7. Almouzni, G., Méchali, M. and Wolffe, A.P. (1990b) Competition between transcription complex assembly and chromatin assembly on replicating DNA. EMBO J., 9, 573-582.
8. Almouzni, G., Méchali, M. and Wolffe, A.P. (1991) Transcription complex disruption caused by a transition in chromatin structure. Mol. Cell. Biol., 11, 655-665.
9. Almouzni, G., Khochbin, S., Dimitrov, S. and Wolffe, A.P. (1994) Histone acetylation influences both gene expression and development of Xenopus laevis. Dev. Biol., 165, 654-669.
10. Ayer, D., Lawrence, Q.A. and Eisenman, R.N. (1995) Mad-Max transcriptional repression is mediated by ternary complex formation with mammalian homologs of yeast repressor Sin3. Cell. 80, 767-776.
11. Baniahmad, A., Kohne, A.C. and Renkawitz, R. (1992) A transferable silencing domain is present in the thyroid hormone receptor, in the v-erbA oncogene product and in the retinoic acid receptor. EMBO J., 11, 1015-1023.
12. Baniahmad, A., Ha, I., Reinberg, D., Tsai, S.Y., Tsai, M.J. and O'Malley, B.W. (1993) Interaction of a receptor β with transcription factor TFIIB may mediate target gene activation and derepression by thyroid hormone. Proc. Natl Acad. Sci. USA, 90, 8832-8836.
13. Baniahmad, A., Leng, X., Burris, T.P., Tsai, S.Y., Tsai, M.J. and O'Malley, B.W. (1995) The T4 activation domain of the thyroid hormone receptor is required for release of a putative corepressor(s) necessary for transcriptional silencing. Mol. Cell. Biol., 15, 76-86.
14. Barettino, D., Ruiz, M.V. and Stunnenberg, H.G. (1994) Characterization of the ligand dependent transactivation domain of thyroid hormone receptor. EMBO J., 13, 3039-3049.
15. Bartsch, J., Truss, M., Bode, J. and Beato, M. (1996) Moderate increase in histone acetylation activates the mouse mammary tumor virus promoter and remodels its nucleosome structure. Proc. Natl Acad. Sci. USA, 93, 10741-10746.
16. Bauer, W.R., Hayes, J.J., White, J.H. and Wolffe, A.P. (1994) Nucleosome structural changes due to acetylation. J. Mol. Biol., 236, 685-690.
17. Bienz, M. (1984) Xenopus hsp70 genes are constitutively expressed in injected oocytes. EMBO J., 3, 2477-2483.
18. Birkenmeier, E.H., Brown, D.D. and Jordan, E. (1978) A nuclear extract of Xenopus laevis oocytes that accurately transcribes 5S RNA genes. Cell, 15, 1077-1086.
19. Brownell, J.E., Zhou, J., Ranalli, T. Kobayashi, R., Edmondson, D.G., Roth, S.Y. and Allis, C.D. (1996) Tetrahymena histone acetyltransferase A: a homolog to yeast Gcn5p linking histone acetylation to gene activation. Cell, 84, 843-851.
20. Chakravarti, D., LaMorte, V.J., Nelson, M.C. Nakajima, T., Juguilon, H., Montminy, M. and Evans, R.M. (1996) Mediation of nuclear receptor signalling by CBP/p300. Nature, 383, 99-103.
21. Chen, J.D. and Evans, R.M. (1995) A transcriptional co-repressor that interacts with nuclear hormone receptor. Nature, 377, 454-457.
22. Chen, J.D., Umesono, K. and Evans, R.M. (1996) SMRT isoforms mediate repression and anti-repression of nuclear receptor heterodimers. Proc. Natl Acad. Sci. USA, 93, 7567-7571.
23. Chiba, H., Muramatsu, M., Nomoto, A. and Kato, H. (1994) Two human homologs of Saccharomyces cerevisiae SWI2/SNF2 and Drosophila brahma are transcriptional coactivators cooperating with the estrogen receptor and the retinoic acid receptor. Nucleic Acids Res., 22, 1815-1820.
24. Clark, D.J. and Wolffe, A.P. (1991) Superhelical stress and nucleosome mediated repression of 5S RNA gene transcription in vitro. EMBO J., 10, 3419-3428.
25. Cook, P.R. (1994) RNA polymerase: structural determinant of the chromatin loop and the chromosome. BioEssays, 16, 425-430.
26. Cooper, J.P., Roth, S.Y. and Simpson, R.T. (1994) The global transcriptional regulators SSN6 and Tup1, play distinct roles in the establishment of a repressive chromatin structure. Genes Dev., 8, 1400-1410.
27. Côté, J., Quinn, J., Workman, J.L. and Peterson, C.L. (1994) Stimulation of GAL4 derivative binding to nucleosomal DNA by the yeast SWI/ SNF complex. Science, 265, 53-60.
28. Damm, K., Beug, H., Graf, T. and Vennstrom, B. (1987) A single point mutation in erbA restores the erythroid transforming potential of a mutant avian erythroblastosis virus (AEV) defective in both erbA and erbB oncogenes. EMBO J., 6, 375-382.
29. Damm, K., Thompson, C.C. and Evans, R.M. (1989) Protein encoded by v-erbA functions as a thyroid hormone receptor antagonist. Nature, 339, 593-597.
30. Dimitrov, S., Almouzni, G., Dasso, M. and Wolffe, A.P. (1993) Chromatin transitions during early Xenopus embryogenesis: changes in histone H4 acetylation and in linker histone type. Dev. Biol., 160, 214-227.
31. Dimitrov, S., Dasso, M.C. and Wolffe, A.P. (1994) Remodeling sperm chromatin in Xenopus laevis egg extracts: the role of core histone phosphorylation and linker histone B4 in chromatin assembly. J. Cell Biol., 126, 591-601.
32. Dingwall, C. and Allan, J. (1984) Accumulation of the isolated carboxy-terminal domain of histone H1 in the Xenopus oocyte nucleus. EMBO J., 3, 1933-1943.
33. Drabik, C.E., Nicita, C.A. and Lutter, L.C. (1997) Measurement of linker number change in transcribing chromatin. J. Mol. Biol., 267, 794-806.
34. Edmondson, D.G., Smith. M.M. and Roth, S.Y. (1996) Repression domain of the yeast global repressor Tup1 interacts directly with histones H3 and H4. Genes Dev., 10, 1247-1259.
35. Fascher, K.D., Smitz, J. and Horz, W. (1993) Structural and functional requirements for the chromatin transition at the PHO5 promoter in Saccharomyces cerevisiae upon PHO5 activation. J. Mol. Biol., 231, 658-667.
36. Fondell, J.D., Roy, A.L. and Roeder, R.G. (1993) Unliganded thyroid hormone receptor inhibits formation of a functional preinitiation complex: implications for active repression. Genes Dev., 7, 1400-1410.
37. Fondell, J.D., Ge, H. and Roeder, R.G. (1996) Ligand induction of a transcriptionally active thyroid hormone receptor coactivator complex. Proc. Natl Acad. Sci. USA, 93, 8329-8333.
38. Gaudreau, L., Schmid, A., Blaschke, D., Ptashne, M. and Horz, W. (1997) RNA polymerase II holoenzyme recruitment is sufficient to remodel chromatin at the yeast PHO5 promoter. Cell, 89, 55-62.
39. Ge, H., Martinez, E., Chiang, C.-M. and Roeder, R.G. (1996) Activator-dependent transcription by mammalian RNA polymerase II: in vitro reconstitution with general transcription factors and cofactors. Methods Enzymol., 274, 57-71.
40. Germond, J.E., Hirt, B., Oudet, P., Gross-Bellark, M. and Chambon, P.C. (1975) Folding of the double helix in chromatin like structures from imian virus 40. Proc. Natl Acad. Sci. USA, 72, 1843-1847.
41. Glass, C.K., Lipkin, S.M., Devary, O.V. and Rosenfeld, M.G. (1989) Positive and negative regulation of gene transcription by a retinoic acid-thyroid hormone receptor heterodimer. Cell, 59, 697-708.
42. Gurdon, J.B. and Melton, D.A. (1981) Gene transfer in amphibian eggs and oocytes. Annu. Rev. Genet., 15, 189-218.
43. Hansen, J.C., van Holde, K.E. and Lohr, D. (1991) The mechanism of nucleosome assembly onto oligomers of the sea urchin 5S DNA positioning sequence. J. Biol. Chem., 266, 4276-4282.
44. Hassig, C.A., Fleischer, T.C. Billin, A.N., Schreiber, S.L. and Ayer, D.E. (1997) Histone deacetylase activity is required for full transcriptional repression by mSin 3A. Cell, 89, 341-347.
45. Hecht, A., Laroche, T., Strahl-Bolsinger, S., Gasser, S.M. and Grunstein, M. (1995) Histone H3 and H4 N-termini interact with SIR3 and SIR4 proteins: a molecular model for the formation of heterochromatin in yeast. Cell, 80, 583-592.
46. Heinzel, T. et al. (1997) N-CoR, mSIN3, and histone deacetylase in a complex required for repression by nuclear receptors and Mad. Nature, 387, 43-48.
47. Hirschhorn, J.N., Brown, S.A., Clark, C.D. and Winston, F. (1992) Evidence that SNF2/SWI2 and SNF activate transcription in yeast by altering chromatin structure. Genes Dev., 6. 2288-2298.
48. Horlein, A.J. et al. (1995) Ligand-independent repression by the thyroid hormone receptor mediated by a nuclear receptor co-repressor. Nature, 377, 397-404.
49. Imbalzano, A.M., Kwon, H., Green, H.R. and Kingston, R.E. (1994) Facilitated binding of the TATA-binding protein to nucleosomal DNA. Nature, 370, 481-485.
50. Imhof, A., Yang, X.J., Ogryzko, V.V., Nakatani, Y., Wolffe, A.P. and Ge, H. (1997) Acetylation of general transcription factors by histone acetyltransferases: identification of a major site of acetylation in TFIIEβ. Curr. Biol., 7, 689-692.
51. Kadosh, D. and Struhl, K. (1997) Repression by Ume6 involves recruitment of a complex containing Sin3 corepressor and Rpd3 histone deacetylase to target promoters. Cell. 89, 365-371.
52. Kamei, Y. et al (1996) A CBP integrator complex mediates transcriptional activation and AP-1 inhibition by nuclear receptors. Cell, 85, 403-414.
53. Kass, S.U., Landsberger, N. and Wolffe, A.P. (1997) DNA methylation directs a time-dependent repression of transcription initiation. Curr. Biol., 7, 157-165.
54. La Marca, M.J., Smith, L.D. and Stobel, M.C. (1973) Quantitative and qualitative analysis of RNA synthesis in stage 6 and stage 4 oocytes of Xenopus laevis. Dev. Biol., 34, 106-118.
55. Landsberger, N. and Wolffe, A.P. (1995) The role of chromatin and Xenopus heat shock transcription factor (XHSF1) in the regulation of the Xenopus hsp70 promoter in vivo. Mol. Cell. Biol., 15, 6013-6024.
56. Landsberger, N. and Wolffe, A.P. (1997) Remodeling of regulatory nucleoprotein complexes on the Xenopus hsp70 promoter during meiotic maturation of the Xenopus oocyte. EMBO J., 16, 4361-4373.
57. Landsberger, N., Ranjan, M., Almouzni, G., Stump, D. and Wolffe, A.P. (1995) The heat shock response in Xenopus oocytes, embryos and somatic cells: a regulatory role for chromatin. Dev. Biol., 170, 62-74.
58. Leblanc, B.P. and Stunnenberg, H.G. (1995) 9-Cis retinoic acid signaling: changing partners causes some excitement. Genes Dev., 9, 1811-1816.
59. Le Douarin, B. et al. (1995) The N-terminal part of TIF1, a putative mediator of the ligand-dependent activation function (AF-2) of nuclear receptors, is fused to B-raf in the oncogenic protein T18. EMBO J., 14, 2020-2033.
60. Lee, D.Y., Hayes, J.J., Pruss, D. and Wolffe, A.P. (1993) A positive role for histone acetylation in transcription factor binding to nucleosomal DNA. Cell, 72, 73-84.
61. Li, C., Schwabe, J.W.R., Banayo, E. and Evans, R.M. (1997) Co-expression of nuclear receptor partners increases their solubility and biological activities. Proc. Natl Acad. Sci. USA, 94, 2278-2283.
62. Lutter, L.C., Judis, L. and Paretti, R.F. (1992) The effects of histone acetylation on chromatin topology in vivo. Mol. Cell. Biol., 12, 5004-5014.
63. Mangelsdorf, D.J. and Evans, R.M. (1995) The RXR heterodimers and orphan receptors. Cell, 83, 841-850.
64. Mizzen, C.A. et al. (1996) The TAF(II)250 subunit of TFIID has histone acetyltransferase activity. Cell, 87, 1261-1270.
65. Nagy, L., Kao, H.Y., Chakravarti, D., Lin, R.J., Hassig, C.A., Ayer, D.E., Schreiber, S.L. and Evans, R.M. (1997) Nuclear receptor repression mediated by a complex containing SMRT, mSin3A, and histone deacetylase. Cell, 89, 373-380.
66. Norton, V.G., Imai, B.S., Yau, P. and Bradbury, E.M. (1989) Histone acetylation reduces nucleosome core particle linking number change. Cell, 57, 449-457.
67. Ogryzko, V.V., Schiltz, R.L., Russanova, V., Howard, B.H. and Nakatani, Y. (1996) The transcriptional coactivators p300 and CBP are histone acetyltransferases. Cell, 87, 953-959.
68. Onate, S.A., Tsai, S.Y., Tsai, M.-J. and O'Malley, B.W. (1995) Sequence and characterization of a coactivator for the steroid hormone receptor superfamily. Science, 270, 1354-1357.
69. Parthun, M.R., Widom, J. and Gottschling, D.E. (1996) The major cytoplasmic histone acetyltransferase in yeast: links to chromatin assembly and histone metabolism. Cell, 87, 85-94.
70. Pederson, D.S. and Morse, R.H. (1990) Effect of transcription of yeast chromatin on DNA topology in vivo. EMBO J., 9, 1873-1881.
71. Peng, H.B. (1991) Solutions and protocols. Methods Cell Biol., 36, 657-662.
72. Pina, B., Bruggemeier, U. and Beato, M. (1990) Nucleosome positioning modulates accessibility of regulatory proteins to the mouse mammary tumor virus promoter. Cell, 60, 719-731.
73. Ranjan, M., Wong, J. and Shi, Y.-B. (1994) Transcriptional repression of Xenopus TRβ gene is mediated by a thyroid hormone response element located near the start site. J. Biol. Chem., 269, 24699-24705.
74. Richard-Foy, H. and Hager, G.L. (1987) Sequence-specific positioning of nucleosomes over the steroid-inducible MMTV promoter. EMBO J., 6, 2321-2328.
75. Roth, S.Y., Dean, A. and Simpson, R.T. (1990) Yeast α2 repressor positions nucleosomes in TRP1/ARS1 chromatin. Mol. Cell. Biol., 10, 2247-2260.
76. Roth, S.Y., Shimizu, M., Johnson, L., Grunstein, M. and Simpson, R.T. (1992) Stable nucleosome positioning and complete repression by the yeast α2 repressor are disrupted by amino-terminal mutation in histone H4. Genes Dev., 6, 411-425.
77. Ruiz-Carillo, A., Wangh, L.J. and Allfrey, V.G. (1975) Processing of newly synthesized histone molecules. Science, 190, 117-128.
78. Rundlett, S.E., Carmen, A.A., Kobayashi, R., Bavykin, S., Turner, B.M. and Grunstein, M. (1996) HDA1 and RPD3 are members of distinct histone deacetylase complexes that regulate silencing and transcription. Proc. Natl Acad. Sci. USA, 93, 14503-14508.
79. Sambrook, J., Fritsch, E.F. and Maniatis, T. (1989) Molecular Cloning: A Laboratory Manual. Cold Spring Harbor Laboratory Press, Cold Spring Harbor, New York.
80. Sap, J., Munoz, A., Schmit, J., Stunnenberg, H. and Vennstrom, B. (1989) Repression of transcription mediated at a thyroid hormone response element by the v-erb-A oncogene product. Nature, 340, 242-244.
81. Schwarz, P.M. and Hansen, J.C. (1994) Formation and stability of higher order chromatin structures. Contributions of the histone octamer. J. Biol. Chem., 269, 16284-16298.
82. Shi, Y.-B., Yaoita, Y. and Brown, D.D. (1992) Genomic organization and alternative promoter usage of the two thyroid hormone receptor β gene in Xenopus laevis. J. Biol. Chem., 267, 733-788.
83. Shimamura, A. and Worcel, A. (1989) The assembly of regularly spaced nucleosomes in the Xenopus S150 extract is accompanied by deacetylation of histone H4. J. Biol. Chem., 264, 14524-14530.
84. Simpson, R.T., Thoma, F. and Brubaker, J.M. (1985) Chromatin reconstituted from tandemly repeated cloned DNA fragments and core histones: a model system for study of higher order structure. Cell, 42, 799-808.
85. Sobel, R.E., Cook, R.G., Perry, C.A., Annunziato, A.T. and Allis, C.D. (1995) Conservation of deposition-related acetylation sites in newly synthesized histones H3 and H4. Proc. Nad Acad. Sci. USA, 92, 1237-1241.
86. Straka, C. and Horz, W. (1991) A functional role for nucleosomes in the repression of a yeast promoter. EMBO J., 10, 361-368.
87. Svaren, J., Schmitz, J. and Horz, W. (1994) The transactivation domain of Pho4 is required for nucleosome disruption at the PHO5 promoter. EMBO J., 13, 4856-4862.
88. Taunton, J., Hassig, C.A. and Schreiber, S.L. (1996) A mammalian histone deacetylase related to a yeast transcriptional regulator Rpd3. Science, 272, 408-411.
89. Truss, M., Bartsch, J., Schelbert, A., Haché, R.J.G. and Beato, M. (1995) Hormone induces binding of receptors and transcription factors to a rearranged nucleosome on the MMTV promoter in vivo. EMBO J., 14, 1737-1751.
90. Tsukiyama, T., Becker, P.B. and Wu, C. (1994) ATP-dependent nucleosome disruption at a heat-shock promoter mediated by binding of GAGA transcription factor. Nature, 367, 525-532.
91. Ura, K., Kurumizaka, H., Dimitrov, S., Almouzni, G. and Wolffe, A.P. (1997) Histone acetylation: influence on transcription by RNA polymerase, nucleosome mobility and positioning, and linker histone dependent transcriptional repression. EMBO J., 16, 2096-2107.
92. Varga-Weisz, P., Blank, T.A., and Becker, P.B. (1995) Energy-dependent chromatin accessibility and nucleosome mobility in a cell free system. EMBO J., 14, 2209-2216.
93. Verreault, A., Kaufman, P.D., Kobayashi, R. and Stillman, B. (1996) Nucleosome assembly by a complex of CAF-1 and deacetylated histones H3/H4. Cell, 87, 95-104.
94. Vetesse-Dadey, M., Grant, P.A., Hebbes, T.R., Crane-Robinson, C., Allis, C.D. and Workman, J.L. (1996) Acetylation of histone H4 plays a primary role in enhancing transcription factor binding to nucleosomal DNA in vitro. EMBO J., 15, 2508-2518.
95. Vidal, M. and Gaber, R.F. (1991) RPD3 encodes a second factor required to achieve maximum positive and negative transcriptional states in Saccharomyces cerevisiae. Mol. Cell. Biol., 11, 6317-6327.
96. Vidal, M., Strich, R., Esposito, R.E. and Gaber, R.F. (1991) RPD1 (SIN3/ UME4) is required for maximal activation and repression of diverse yeast genes. Mol. Cell. Biol., 11, 6306-6316.
97. Voegel, J.J., Heine, M.J.S., Zechel, C., Chambon, P. and Gronemeyer, H. (1996) A 160 kDa transcription mediator for the ligand-dependent activation function AF-2 of nuclear receptors. EMBO J., 15, 3667-3675.
98. Weintraub, H. (1995) Assembly and propagation of repressed and derepressed chromosomal states. Cell, 42, 705-711.
99. Wilson, C.J., Chao, D.M., Imbalzano, A.M., Schnitzer, G.R., Kingston, R. and Young, R.A. (1996) RNA polymerase II holoenzyme contains SWI/SNF regulators involved in chromatin remodeling. Cell, 84, 235-244.
100. Wolffe, A.P. (1997) Sinful repression. Nature, 387, 16-17.
101. Wolffe, A.P. and Hayes, J.J. (1993) The analysis of transcription factor interactions with model nucleosomal templates. Methods Mol. Genet., 2, 314-330.
102. Wolffe, A.P. and Pruss, D. (1996a) Deviant nucleosomes: the functional specialization of chromatin. Trends Genet., 12, 58-62.
103. Wolffe, A.P. and Pruss, D. (1996b) Hanging on to histones. Curr. Biol., 6, 234-237.
104. Wong, J., and Shi, Y.-B. (1995) Coordinated regulation of and transcriptional activation by Xenopus thyroid hormone and retinoid X receptors. J. Biol. Chem., 270, 18479-18483.
105. Wong, J., Shi, Y.-B. and Wolffe, A.P. (1995) A role for nucleosome assembly in both silencing and activation of the Xenopus TRβA gene by the thyroid hormone receptor. Genes Dev., 9, 2696-2711.
106. Wong, J., Shi, Y.-B. and Wolffe, A.P. (1997a) Determinants of chromatin disruption and transcriptional regulation instigated by the thyroid hormone receptor: hormone regulated chromatin disruption is not sufficient for transcriptional activation. EMBO J., 16, 3158-3171.
107. Wong, J., Li, Q., Levi, B.-Z., Shi, Y.-B. and Wolffe, A.P. (1997b) Structural and functional features of a specific nucleosome containing a recognition element for the thyroid hormone receptor. EMBO J., 16, 7130-7145.
108. Yang, W.M., Inouye, C., Zeng, Y., Bearss, D. and Soto, E. (1996) Transcriptional repression by YY1 is mediated by interaction with a mammalian homolog of the yeast global regulator RPD3. Proc. Natl Acad. Sci. USA, 93, 12845-12850.
109. Yang, X.-J., Ogryzko, V.V., Nishikawa, J.-I., Howard, B. and Nakatani, Y. (1996) A p300/CBP-associated factor that competes with the adenoviral E1A oncoprotein. Nature, 382, 319-324.
110. Yao, T.-P. Ku, G., Zhou, N., Scully, R. and Livingston, D.M. (1996) The nuclear hormone receptor coactivator SRC-1 is a specific target of p300. Proc. Natl Acad. Sci. USA, 93, 10626-10631.
111. Yaoita, Y., Shi, Y.-B. and Brown, D.D. (1990) Xenopus laevis α and β thyroid hormone receptors. Proc. Natl Acad. Sci. USA, 87, 7090-7094.
112. Yoshida, M., Kijima, M., Akita, M. and Beppu, T. (1990) Potent and specific inhibition of mammalian histone deacetylase both in vivo and in vitro by Trichostatin A. J. Biol. Chem., 265, 17174-17179.
113. Yoshida, M., Horinouoshi, S. and Beppu, T. (1995) Trichostatin A and trapoxin: novel chemical probes for the role of histone acetylation in chromatin structure and function. BioEssays, 17, 423-430.
114. Yoshinaga, S.K., Peterson, S.L., Herskowitz, I. and Yamamoto, K.R. (1992) Roles of SWI1, SWI2 and SWI3 proteins for transcriptional enhancement by steroid receptors. Science, 258, 1598-1604.
115. Zaret, K.S. and Yamamoto, K.R. (1984) Reversible and persistent changes in chromatin structure accompany activation of a glucocorticoid-dependent enhancer element. Cell, 38, 29-38.
116. Zenke, M., Munoz, A., Sap, J., Vennstrom, B. and Beug, H. (1990) v-erbA oncogene activation entails the loss of hormone-dependent regulator activity of c-erbA. Cell, 61, 1035-1040.