Repression by Ume6 involves recruitment of a complex containing Sin3 corepressor and Rpd3 histone deacetylase to target promoters

Cell

Volumn 89, Issue 3, 1997, Pages 365-371

  David, Kadosh ^a   Kevin, Struhl ^a  

^a HARVARD MEDICAL SCHOOL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

DNA BINDING PROTEIN; HISTONE DEACETYLASE; TRANSCRIPTION FACTOR;

ARTICLE; CHROMATIN STRUCTURE; CONTROLLED STUDY; DEACETYLATION; GENE EXPRESSION REGULATION; GENE REPRESSION; IMMUNOPRECIPITATION; MEIOSIS; NONHUMAN; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN PROTEIN INTERACTION; TRANSCRIPTION REGULATION;

EID: 0343924289     PISSN: 00928674     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0092-8674(00)80217-2     Document Type: Article

References (37)

1. Ayer, D.E., Lawrence, Q.A., and Eisenman, R.N. (1995). Mad-Max transcriptional repression is mediated by ternary complex formation with mammalian homologs of yeast represser Sin3. Cell 80,767-776.
2. Bannister, A.J., and Kouzarides, T. (1996). The CBP co-activator is a histone acetyltransferase. Nature 384, 641-643.
3. Bowdish, K.S., and Mitchell, A.P. (1993). Bipartite structure of an early meiotic upstream activation sequence from Saccharomyces cerevisiae. Mol. Cell. Biol. 13, 2172-2181.
4. Bowdish, K.S., Yuan, H.E., and Mitchell, A.P. (1995). Positive control of yeast meiotic genes by the negative regulator UME6. Mol. Cell. Biol. 15, 2955-2961.
5. Brownell, J.E., Zhou, J., Ranalli, T., Kobayashi, R., Edmondson, D.G., Roth, S.Y., and Allis, C.D. (1996). Tetrahymena histone acetyltransferase A: a homolog to yeast Gcn5p linking histone acetylation to gene activation. Cell 84, 843-851.
6. De Rubertis, F., Kadosh, D., Henchoz, S., Pauli, D., Reuter, G., Struhl, K., and Spierer, P. (1996). The histone deacetylase RPD3 counteracts genomic silencing in Drosophila and yeast. Nature 384, 589-591.
7. Guarente, L., and Mason, T. (1983). Heme regulates transcription of the cyc1 gene of S. cerevisiae via an upstream activation site. Cell 32, 1279-1286.
8. Hassig, C.A., Fleischer, T.C., Billin, A.N., Schreiber, S.L., and Ayer, D.E. (1997). Histone deacetylase activity is required for full transcriptional repression by mSin3A. Cell, this issue.
9. Jackson, J.C., and Lopes, J.M. (1996). The yeast UME6 gene is required for both negative and positive transcriptional regulation of phospholipid biosynthetic gene expression. Nucleic Acids Res. 24, 1322-1329.
10. Janknecht, R., and Hunter, T. (1996). A growing coactivator network. Nature 383, 22-23.
11. Kamens, J., Richardson, P., Mosialos, G., Brent, R., and Gilmore, T. (1990). Oncogenic transformation by vRel requires an aminoterminal activation domain. Mol. Cell. Biol. 10, 2840-2847.
12. Keleher, C.A., Redd, M.J., Schultz, J., Carlson, M., and Johnson, A.D. (1992). Ssn6-Tup1 is a general represser of transcription in yeast. Cell 68, 709-719.
13. Laherty, C.,Yang, W.-M., Sun, J.-M., Davie, J.R., Seto, E., and Eisenman, R.N. (1997). Histone deacetylases associated with the mSin3 corepressor mediate Mad-Max transcriptional repression. Cell, this issue.
14. McKenzie, E.A., Kent, N.A., Dowell, S.J., Moreno, F., Bird, L.E., and Mellor, J. (1993). The centromere and promoter factor 1, CPF1, of Saccharomyces cerevisiae modulates gene activity through a family of factors including SPT21, RPD1 (SIN3), RPD3 and CCR4. Mol. Gen. Genet. 240, 374-386.
15. ∥250 subunit of TFIID has histone acetyltransferase activity. Cell 87, 1261-1270.
16. Nagy, L., Kao, H.-Y., Chakravarti, D., Lin, R.J., Hassig, C.A., Ayer, D.E., Schreiber, S.L., and Evans, R.M. (1997). Nuclear receptor repression mediated by a complex containing SMRT, mSin3A, and histone deacetylase. Cell, this issue.
17. Nehlin, J.O., Carlberg, M., and Ronne, H. (1992). Yeast SKO1 gene encodes a bZIP protein that binds to the CRE motif and acts as a represser of transcription. Nucleic Acids Res. 20, 5271-5278.
18. Ogryzko, V.V., Schiltz, R.L., Russanova, V., Howard, B.H., and Nakatani, Y. (1996). The transcriptional coactivators p300 and CBP are histone acetyltransferases. Cell 87, 953-959.
19. Park, H.-D., Luche, R.M., and Cooper, T.G. (1992). The yeast UME6 gene product is required for transcriptional repression mediated by the CAR1 URS1 represser binding site. Nucleic Acids Res. 20, 1909-1915.
20. Peterson, C.L. (1996). Multiple switches to turn on chromatin. Curr. Opin. Genet. Dev. 6, 171-175.
21. Roth, S.Y., and Allis, C.D. (1996). Histone acetylation and chromatin assembly: a single escort, multiple dances. Cell 87, 5-8.
22. Rundlett, S.E., Carmen, A.A., Kobayashi, R., Bavykin, S., Turner, B.M., and Grunstein, M. (1996). HDA1 and RPD3 are members of distinct yeast histone deacetylase complexes. Proc. Natl. Acad. Sci. USA 93, 14503-14508.
23. Schreiber-Agus, N., Chin, L., Chen, K., Torres, R., Rao, G., Guida, P., Skoultchi, A.I., and DePinho, R.A. (1995). An amino-terminal domain of Mxi1 mediates anti-Myc oncogenic activity and interacts with a homolog of the yeast transcriptional represser Sin3. Cell 80, 777-786.
24. Slekar, K.H., and Henry, S.A. (1995). SIN3 works through two different promoter elements to regulate INO1 gene expression in yeast. Nucleic Acids Res. 23, 1964-1969.
25. Stillman, D.J., Dorland, S., and Yu, Y. (1994). Epistasis analysis of suppressor mutations that allow HO expression in the absence of the yeast SWI5 transcriptional activator. Genetics 136, 781-788.
26. Strich, R., Surosky, R.T., Steber, C., Dubois, E., Messenguy, F., and Esposito, R.E. (1994). UME6 is a key regulator of nitrogen repression and meiotic development. Genes Dev. 8, 796-810.
27. Struhl, K. (1996). Chromatin structure and RNA polymerase II connection: implications for transcription. Cell 84, 179-182.
28. Taunton, J., Hassig, C.A., and Schreiber, S.L. (1996). A mammalian histone deacetylase related to the yeast transcriptional regulator Rpd3p. Science 272, 408-411.
29. Tzamarias, D., and Struhl, K. (1994). Functional dissection of the yeast Cyc8-Tup1 transcriptional corepressor complex. Nature 369, 758-761.
30. Vidal, M., and Gaber, R.F. (1991). RPD3 encodes a second factor required to achieve maximum positive and negative transcriptional states in Saccharomyces cerevisiae. Mol. Cell. Biol. 11, 6317-6327.
31. Vincent, A.C., and Struhl, K. (1992). ACR1, a yeast ATF/CREB represser. Mol. Cell. Biol. 12, 5394-5405.
32. Wang, H., and Stillman, D.J. (1993). Transcriptional repression in Saccharomyces cerevisiae by a SIN3-Lex A fusion protein. Mol. Cell. Biol. 13, 1805-1814.
33. Wilson, C.J., Chao, D.M., Imbalzano, A.N., Schnitzler, G.R., Kingston, R.E., and Young, R.A. (1996). RNA polymerase II holoenzyme contains SWI/SNF regulators involved in chromatin remodeling. Cell 84, 235-244.
34. Wolffe, A.P., and Pruss, D. (1996). Targeting chromatin disruption: transcription regulators that acetylate histones. Cell 84, 817-819.
35. Yang, W.-M., Inouye, C., Zeng, Y., Bearss, D., and Seto, E. (1996a). Transcriptional repression by YY1 is mediated by interaction with the mammalian homolog of the yeast global regulator RPD3. Proc. Natl. Acad. Sci. USA 93, 12845-12850.
36. Yang, X.-J., Ogryzko, V.V., Nishikawa, J., Howard, B.H., and Nakatani, Y. (1996b). A p300/CBP-associated factor that competes with the adenoviral oncoprotein E1A. Nature 382, 319-324.
37. Zhang, Y., Rabah, I., Erdjument-Bromage, H.,Tempst, P., and Reinberg, D. (1997). Histone deacetylases and SAP18, a novel polypeptide, are components of a human Sin3 complex. Cell, this issue.