A conformational switch in nuclear hormone receptors is involved in coupling hormone binding to corepressor release

Molecular and Cellular Biology

Volumn 17, Issue 10, 1997, Pages 6131-6138

  Lin, Benjamin C ^a   Hong, Suk Hyun ^a   Krig, Sheryl ^a   Yoh, Sunnie M ^a   Privalsky, Martin L ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

GLUTATHIONE TRANSFERASE; HORMONE RECEPTOR; LIOTHYRONINE RECEPTOR; RETINOIC ACID; RETINOID X RECEPTOR; THYROID HORMONE; TRANSCRIPTION FACTOR;

AMINO ACID SUBSTITUTION; ARTICLE; CARBOXY TERMINAL SEQUENCE; CELL NUCLEUS; CONFORMATIONAL TRANSITION; CONTROLLED STUDY; GENE REPRESSION; HORMONE RECEPTOR INTERACTION; HUMAN; NONHUMAN; PRIORITY JOURNAL; PROTEIN DOMAIN; TRANSCRIPTION REGULATION;

EID: 0030771328     PISSN: 02707306     EISSN: None     Source Type: Journal    
DOI: 10.1128/MCB.17.10.6131     Document Type: Article

References (54)

1. Allenby, G., M.-T. Bocquel, M. Saunders, S. Kazmer, J. Speck, M. Rosenberger, A. Lovey, P. Kastner, J. F. Grippo, P. Chambon, and A. A. Levin. 1987. Retinoic acid receptors and retinoid X receptors: interactions with endogenous retinoic acids. Proc. Natl. Acad. Sci. USA 90:30-34.
2. Baniahmad, A., A. C. Kohne, and R. Renkawitz. 1992. A transferable silencing domain is present in the thyroid hormone receptor, in the v-Erb A oncogene product, and in the retinoic acid receptor. EMBO J. 11:1015-1023.
3. Baniahmad, A., X. Leng, T. P. Burris, S. Y. Tsai, M. J. Tsai, and B. W. O'Malley. 1995. The τ4 activation domain of the thyroid hormone receptor is required for release of a putative corepressor(s) necessary for transcriptional silencing. Mol. Cell. Biol. 15:76-86.
4. Beato, M., P. Herrlich, and G. Schutz. 1995. Steroid hormone receptors: many actors in search of a plot. Cell 83:851-858.
5. Beck-Peccoz, P., and V. K. K. Chatterjee. 1994. The variable clinical phenotype in thyroid hormone resistance syndrome. Thyroid 4:225-232.
6. Bigler, J., and R. N. Eisenman. 1988. c-erbA encodes multiple proteins in chicken erythroid cells. Mol. Cell. Biol. 8:4155-4161.
7. Bourguet, W., M. Ruff, P. Chambon, H. Gronemeyer, and D. Moras. 1995. Crystal structure of the ligand-binding domain of the human nuclear hormone receptor RXR alpha. Nature 375:377-382.
8. Casanova, J., E. Helmer, S. Selmi-Ruby, J. S. Qi, M. Au-Flieger, V. DesaiYajnik, N. Koudinova, F. Yarm, B. M. Raaka, and H. H. Samuels. 1994. Functional evidence for ligand-dependent dissociation of thyroid hormone and retinoid acid receptors from an inhibitory cellular factor. Mol. Cell. Biol. 14:5756-5765.
9. Chambon, P. 1994. The retinoid signaling pathway. Semin. Cell Biol. 5:115-125.
10. Chen, H.-W., and M. L. Privalsky. 1993. The erbA oncogene represses the actions of both retinoid X and retinoid A receptors, but does so by distinct mechanisms. Mol. Cell. Biol. 13:5970-5980.
11. Chen, J. D., and R. M. Evans. 1995. A transcriptional co-repressor that interacts with nuclear hormone receptors. Nature 377:454-457.
12. Chen, J. D., K. Umesono, and R. M. Evans. 1996. SMRT isoforms mediate repression and anti-repression of nuclear receptor heterodimers. Proc. Natl. Acad. Sci. USA 93:7567-7571.
13. Collingwood, T. N., M. Adams, Y. Tone, and V. K. K. Chatterjee. 1994. Spectrum of transcriptional, dimerization, and dominant negative properties of twenty different mutant thyroid hormone β receptors in thyroid hormone resistance syndrome. Mol. Endocrinol. 8:1262-1277.
14. Damm, K., C. C. Thompson, and R. M. Evans. 1989. Protein encoded by v-Erb A functions as a thyroid hormone receptor antagonist. Nature 339: 593-597.
15. de The, H., C. Lavau, A. Marchio, C. Chomienne, L. Degos, and A. Dejean. 1991. The PML-RARα fusion mRNA encodes a functionally altered RAR. Cell 66:675-684.
16. Forman, B. M., K. Umesono, J. Chen, and R. M. Evans. 1995. Unique response pathways are established by allosteric interactions among nuclear hormone receptors. Cell 81:541-550.
17. Hall, B. L., Z. Smit-McBride, and M. L. Privalsky. 1993. Reconstitution of retinoid X receptor function and combinatorial regulation of other nuclear hormone receptors in the yeast, Saccharomyces cerevisiae. Proc. Natl. Acad. Sci. USA 90:6929-6933.
18. Hayashi, R. 1977. Carboxypeptidase Y in sequence determination of peptides. Methods Enzymol. 47:84-93.
19. Hong, S.-H., and M. L. Privalsky. Unpublished data.
20. Horlein, A. J., A. M. Naar, T. Heinzel, J. Torchia, B. Gloss, R. Kurokawa, A. Ryan, Y. Kamel, M. Soderstrom, C. K. Glass, and M. G. Rosenfeld. 1995. Ligand-independent repression by the thyroid hormone receptor mediated by a nuclear receptor co-repressor. Nature 377:397-404.
21. Horwitz, K. B., T. A. Jackson, D. L. Bain, J. K. Richer, G. S. Takimoto, and L. Tung. 1996. Nuclear hormone receptor coactivators and corepressors. Mol. Endocrinol. 10:1167-1177.
22. Hughes, M. R., P. J. Malloy, D. G. Kieback, R. A. Kesterson, J. W. Pike, D. Feldman, and B. W. O'Malley. 1993. Point mutations in the vitamin D receptor associated with hypocalcemic rickets. Science 242:1702-1705.
23. Ikeda, M., E. C. Wilcox, and W. W. Chin. 1996. Different DNA elements can modulate the conformation of thyroid hormone receptor heterodimer and its transcriptional activity. J. Biol. Chem. 271:23096-23104.
24. Kakizuka, A., W. H. Miller, K. Umesono, R. P. Warrell, S. R. Frankel, V. V. S. Murty, E. Dmitrovsky, and R. M. Evans. 1991. Chromosomal translocation t(15:17) in human acute promyelocytic leukemia fuses RARα with a novel putative transcription factor. Cell 66:663-674.
25. Kastner, P., M. Mark, and P. Chambon. 1995. Nonsteroidal nuclear receptors: what are genetic studies telling us about their role in real life? Cell 83:859-870.
26. Keidel, S., P. LeMotte, and C. Apfel. 1994. Different agonist- and antagonist-induced conformational changes in retinoic acid receptors analyzed by protease mapping. Mol. Cell. Biol. 14:287-298.
27. Kopp, P., K. Kitajima, and J. L. Jameson. 1996. Syndrome of resistance to thyroid hormone: insights into thyroid hormone action. Proc. Soc. Exp. Biol. Med. 211:49-61.
28. Kurokawa, R., J. DiRenzo, M. Boehm, J. Sugarman, B. Gloss, M. G. Rosenfeld, R. A. Heyman, and C. K. Glass. 1994. Regulation of retinoid signalling by receptor polarity and allosteric control of ligand binding. Nature 371:528-531.
29. Kurokawa, R., M. Soderstrom, A. Horlein, S. Halachmi, M. Brown, M. G. Rosenfeld, and C. K. Glass. 1995. Polarity-specific activities of retinoic acid receptors determined by a co-repressor. Nature 377:451-454.
30. Lazar, M. A. 1993. Thyroid hormone receptors: multiple forms, multiple possibilities. Endocrinol. Rev. 14:184-193.
31. Leng, X., S. Y. Tsai, B. W. O'Malley, and M. J. Tsai. 1993. Ligand-dependent conformational changes in thyroid hormone and retinoic acid receptors are potentially enhanced by heterodimerization with retinoic X receptor. J. Steroid Biochem. Mol. Biol. 46:643-661.
32. Mangelsdorf, D. J., and R. M. Evans. 1995. The RXR heterodimers and orphan receptors. Cell 83:841-850.
33. Mangelsdorf, D. J., C. Thummel, M. Beato, P. Herrlich, G. Schutz, K. Umesono, B. Blumberg, P. Kastner, M. Mark, P. Chambon, and R. M. Evans. 1995. Overview: the nuclear receptor superfamily: the second decade. Cell 83:835-840.
34. McPhaul, M. J., M. Marcelli, S. Zoppi, J. E. Griffin, and J. D. Wilson. 1993. Genetic basis of endocrine disease 4: the spectrum of mutations in the androgen receptor gene that cause androgen resistance. J. Clin. Endocrinol. Metab. 76:17-23.
35. Miner, J. N., M. I. Diamond, and K. R. Yamamoto. 1991. Transcriptional factor interactions: selectors of positive or negative regulation from a single DNA element. Cell Growth Differ. 2:525-530.
36. Minucci, S., M. Leid, R. Toyama, J.-P. Saint-Jeannet, V. J. Peterson, V. Horn, J. E. Ishmael, N. Bhattacharyya, A. Dey, I. B. Dawid, and K. Ozato. 1997. Retinoid X receptor (RXR) within the RXR-retinoic acid receptor heterodimer binds its ligand and enhances retinoid-dependent gene expression. Mol. Cell. Biol. 17:644-655.
37. Pazin, M. J., and J. T. Kadonaga. 1997. What's up and down with histone deacetylation and transcription? Cell 89:325-328.
38. Refetoff, S., R. E. Weiss, and S. Usala. 1993. The syndromes of resistance to thyroid hormone. Endocrine Rev. 14:348-399.
39. Renaud, J.-P., N. Rochel, M. Ruff, V. Vivat, P. Chambon, H. Gronemeyer, and D. Moras. 1995. Crystal structure of the RAR-γ ligand-binding domain bound to all-trans retinoic acid. Nature 378:681-689.
40. Ribeiro, R. C., J. W. Apriletti, B. L. West, R. L. Wagner, R. J. Fletterick, F. Schaufele, and J. D. Baxter. 1993. The molecular biology of thyroid hormone action. Ann. N. Y. Acad. Sci. 758:366-389.
41. Saatcioglu, F., P. Bartunek, T. Deng, M. Zenke, and M. Karin. 1993. A conserved C-terminal sequence that is deleted in v-ErbA is essential for the biological activities of c-ErbA (the thyroid hormone receptor). Mol. Cell. Biol. 13:3675-3685.
42. Sande, S., and M. L. Privalsky. 1996. Identification of TRACs (T3 receptor-associating cofactors), a family of cofactors that associate with, and modulate the activity of, nuclear hormone receptors. Mol. Endocrinol. 10:813-825.
43. Sap, J., A. Munoz, H. Schmitt, H. Stunnenberg, and B. Vennstrom. 1989. Repression of transcription mediated by a thyroid hormone response element by the v-Erb A oncogene product. Nature 340:242-244.
44. Schulman, I. G., H. Juguilon, and R. M. Evans. 1996. Activation and repression by nuclear hormone receptors: hormone modulates an equilibrium between active and repressive states. Mol. Cell. Biol. 16:3807-3813.
45. Schulman, I. G., C. Li, J. W. R. Schwabe, and R. M. Evans. 1997. The phantom ligand effect: allosteric control of transcription by the retinoid X receptor. Genes Dev. 11:299-308.
46. Seol, W., H. S. Choi, and D. D. Moore. 1995. Isolation of proteins that interact specifically with the retinoid X receptor: two novel orphan receptors. Mol. Endocrinol. 9:72-85.
47. Seol, W., M. J. Mahon, Y. K. Lee, and D. D. Moore. 1996. Two receptor interacting domains in the nuclear hormone receptor corepressor RIP13/N-CoR. Mol. Endocrinol. 10:1646-1655.
48. Tsai, M. J., and B. W. O'Malley. 1994. Molecular mechanisms of action of steroid/thyroid hormone receptor superfamily members. Annu. Rev. Biochem. 63:451-483.
49. Wagner, R. L., J. W. Apriletti, M. E. McGrath, B. L. West, J. D. Baxter, and R. J. Fletterick. 1995. A structural role for hormone in the thyroid hormone receptor. Nature 378:690-697.
50. Willy, P. J., and D. J. Mangelsdorf. 1997. Unique requirements for retinoid dependent transcriptional activation by the orphan receptor LXR. Genes Dev. 11:289-298.
51. Wolffe, A. P. 1997. Transcriptional control - sinful repression. Nature 387: 16-17.
52. Yoh, S. M., V. K. K. Chatterjee, and M. L. Privalsky. 1997. Thyroid hormone resistance syndrome manifests as an aberrant interaction between mutant T3 receptors and transcriptional corepressors. Mol. Endocrinol. 11:470-480.
53. Zamir, I., H. P. Harding, G. B. Atkins, A. Horlein, C. K. Glass, M. Rosenfeld, and M. A. Lazar. 1996. A nuclear hormone receptor corepressor mediates transcriptional silencing by receptors with distinct repression domains. Mol. Cell. Biol. 16:5458-5465.
54. Zamir, I., J. Zhang, and M. A. Lazar. 1997. Stoichiometric and steric principles governing repression by nuclear hormone receptors. Genes Dev. 11: 835-846.