C-terminal maturation fragments of presenilin 1 and 2 control secretion of APPα and Aβ by human cells and are degraded by proteasome

Molecular Medicine

Volumn 5, Issue 3, 1999, Pages 160-168

  Da Costa, Cristine Alves ^a   Ancolio, Karine ^a   Checler, Frédéric ^a  

^a CNRS   (France)

Author keywords

[No Author keywords available]

Indexed keywords

COMPLEMENTARY DNA; LACTACYSTIN; POLYPEPTIDE; PRESENILIN 1; PRESENILIN 2; PROTEASOME; PROTEASOME INHIBITOR;

ALZHEIMER DISEASE; AMINO TERMINAL SEQUENCE; ARTICLE; CARBOXY TERMINAL SEQUENCE; GENETIC TRANSFECTION; HUMAN; HUMAN CELL; KIDNEY CELL; MISSENSE MUTATION; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN EXPRESSION;

EID: 0033054564     PISSN: 10761551     EISSN: None     Source Type: Journal    
DOI: 10.1007/bf03402059     Document Type: Article

References (33)

1. Tanzi RE, St. George-Hyslop P, and Gusella, JF. (1991) Molecular genetics of Alzheimer disease amyloid. J. Biol. Chem. 266: 20579-20582.
2. Sherrington R, Rogaev EI, Liang, Y, et al. (1995) Cloning of a gene bearing missense mutations in early-onset familial Alzheimer's disease. Nature 375: 754-760.
3. Levy-Lahad E, Wasco W, Poorkaj P, et al. (1995) Candidate gene for the chromosome 1 familial Alzheimer's disease locus. Science 269: 973-977.
4. Rogaev EI, Sherrington R, Rogaeva EA, et al. (1995) Familial Alzheimer's disease in kindreds with missense mutations in a gene on chromosome 1 related to the Alzheimer's disease type 3 gene. Nature 376: 775-778.
5. Doan A, Thinakaran, G, Borchelt DR, et al. (1996) Protein topology of presenilin 1. Neuron 17: 1023-1030.
6. Lehmann S, Chiesa R, Harris DA. (1997) Evidence for a six-transmembrane domain structure of presenilin 1. J. Biol. Chem. 272: 12047-12051.
7. Takashima A, Sato M, Mercken M, ct al. (1996) Localization of Alzheimer-associated presenilin 1 in transfected COS-7 cells. Biochem. Biophys. Res. Commun. 227: 423-426.
8. Cook DG, Sung JC, Golde TE, et al. (1996) Expression and analysis of presenilin 1 in a human neuronal system: localization in cell bodies and dendrites. Proc. Natl. Acad. Sci. U.S.A. 93: 9223-9228.
9. Walter J, Capell A, Grünberg J, et al. (1996) The Alzheimer's disease-associated presenilins are differentially phosphorylated proteins located predominantly within the endoplasmic reticulum. Mol. Med. 2: 673-691.
10. Kovacs DM, Fausett HJ, Page KJ, et al. (1996) Alzheimer-associated presenilins 1 and 2: neuronal expression in brain and localization to intracellular membranes in mammalian cells. Nat. Med. 2: 224-229.
11. De Strooper B, Beullens M, Contreras B, et al. (1997) Phosphorylation, subcellular localization, and membrane orientation of the Alzheimer's disease-associated presenilins. J. Biol. Chem. 272: 3590-3598.
12. , Mattson MP, Guo Q, Furukawa K, et al. (1998) Presenilins, the endoplasmic reticulum, and neuronal apoptosis in Alzheimer's disease. J. Neurochem. 70: 1-14.
13. Checler F. (1999) Presenilins. Mol. Neurobiol. (in press).
14. Ward RV, Davis JB, Gray CW, et al. (1996) Presenilin-1 is processed into two major cleavage products in neuronal cell lines. Neurodegeneration 5: 293-298.
15. Thinakaran G, Borchelt DR, Lee MK, et al. (1996) Endoproteolysis of presenilin 1 and accumulation of processed derivatives in vivo. Neuron 17: 181-190.
16. Baumann K, Paganetti PA, Sturchler-Pierrat C., et al. (1997) Distinct processing of endogenous and overexpressed recombinant presenilin 1. Neurobiol. Aging 18: 181-189.
17. Shirotani K, Takahashi K, Ozawa K, et al. (1997) Determination of a cleavage site of presenilin 2 protein in stably transfected SH-SY5Y human neuroblastoma cell lines. Biochem. Biophys. Res. Commun. 240; 728-731.
18. Seeger M, Nordstedt C, Petanceska S, et al. (1997) Evidence for phosphorylation and oligomeric assembly of presenilin 1. Proc. Natl. Acad. Sci. U.S.A. 94:5090-5094.
19. Loetscher H, Deuschle U, Brockhaus M, et al. (1997) Presenilins are processed by caspase-like proteases. J. Biol. Chem. 272: 20655-20659.
20. Kim TW, Pettingell WH, Jung YK, et al. (1997) Alternative cleavage of Alzheimer-associated presenilins during apoptosis by a caspase-3 family protease. Science 277: 373-376.
21. Grünberg J, Walter J, Loetscher H, et al. (1998) Alzheimer's disease associated presenilin-1 holoprotein and its 18-20 kDa C-terminal fragment are death substrates for proteases of the caspase family. Biochemistry 37: 2263-2270.
22. Marambaud P, Lopez-Perez E, Wilk S, et al. (1997) Constitutive and protein kinase C-regulated secretory cleavage of Alzheimer's β amyloid precursor protein: different control of early and late events by the proteasome. J. Neurochem. 69: 2500-2505.
23. Marambaud P, Ancolio K, Lopez-Perez E, et al. (1999) Proteasome inhibitors prevent the degradation of familial Alzheimer's disease-linked presenilin 1 and trigger increased Aβ42 secretion by human cells. Mol. Med. 4: 146-156.
24. Marambaud P, Alves da Costa C, Ancolio K, et al. (1998) Alzheimer's disease-linked mutation of presenilin 2 (N14II-PS2) drastically lowers APPα secretion: control by the proteasome. Biochem. Biophys. Res. Commun. 252: 134-138.
25. Marambaud P, Chevallier N, Ancolio K, et al. (1998) Post-transcriptional contribution of a cAMP-dependent pathway to the formation of α- and β/γ-secretases-derived products of βAPP maturation in human cells expressing wild type and Swedish mutated βAPP. Mol. Med. 4: 715-723.
26. Ancolio K, Marambaud P, Dauch P, et al. (1997) α-secretase-derived product of β-amyloid precursor protein is decreased by presenilin 1 mutations linked to familial Alzheimer's disease. J. Neurochem. 69: 2494-2499.
27. Barelli H, Lebeau A, Vizzavona J, et al. (1997) Characterization of new polyclonal antibodies specific for 40 and 42 aminoacid-long amyloid β peptides: their use to examine the cell biology of presenilins and the immunohistochemistry of sporadic Alzheimer's disease and cerebral amyloid angiopathy cases. Mol. Med. 3: 695-707.
28. Ida N, Johannes H, Pantel J, et al. (1996) Analysis of heterogeneous βA4 peptides in human cerebrospinal fluid and blood by a newly developed sensitive Western blot assay. J. Biol. Chem. 271: 22908-22914.
29. Kim TW, Pettingell WH, Hallmark OG, et al. (1997) Endoproteolytic cleavage and proteasomal degradation of presenilin 2 in transfected cells. J. Biol. Chem. 272: 11006-11010.
30. Fraser PE, Levesque G, Yu G, et al. (1998) Presenilin 1 is actively degraded by the 26S proteasome. Neurobiol. Aging 19: S19-S21.
31. Lee MK, Borchelt DR, Kim G, et al. (1997) Hyperaccumulation of FAD-linked presenilin 1 variants in vivo. Nat. Med. 3: 756-760.
32. Vito P, Ghayur T, and D'Adamio L, (1997) Generation of anti-apoptotic presenilin-2 polypeptides by alternative transcription, proteolysis, and caspase-3 cleavage. J. Biol. Chem. 272: 28315-28320.
33. Tomita T, Tokuhiro S, Hashimoto T, et al. (1998) Molecular dissection of domains in mutant presenilins 2 that mediate overproduction of amyloidogenic forms of amyloid β peptides. Inability of truncated forms of PS2 with familial Alzheimer's disease to increase secretion of Aβ42. J. Biol. Chem. 273: 21153-21160.