Immunohistochemical analysis of presenilin 2 expression in the mouse brain: Distribution pattern and co-localization with presenilin 1 protein

Brain Research

Volumn 758, Issue 1-2, 1997, Pages 209-217

  Blanchard, Véronique ^a   Czech, Christian ^a   Bonici, Bruno ^a   Clavel, Nicole ^a   Gohin, Micheline ^a   Dalet, Karine ^a   Revah, Frédéric ^a   Pradier, Laurent ^a   Imperato, Assunta ^a   Moussaoui, Saliha ^a  

^a SANOFI   (France)

Author keywords

Alzheimer's disease; Beta amyloid protein; Immunohistochemistry; Mouse brain; Presenilin 1; Presenilin 2

Indexed keywords

AMYLOID BETA PROTEIN; EPITOPE; POLYCLONAL ANTIBODY; SYNTHETIC PEPTIDE;

ALZHEIMER DISEASE; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CELL ORGANELLE; CELL STRAIN COS1; CONTROLLED STUDY; ENDOPLASMIC RETICULUM; GENE EXPRESSION; GLIA CELL; GOLGI COMPLEX; IMMUNOHISTOCHEMISTRY; MISSENSE MUTATION; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN LOCALIZATION; PROTEIN PROCESSING; WHITE MATTER;

AMINO ACID SEQUENCE; ANIMALS; BRAIN; GENE EXPRESSION; HUMANS; MALE; MEMBRANE PROTEINS; MICE; MICE, INBRED BALB C; MOLECULAR SEQUENCE DATA; PRECIPITIN TESTS; PRESENILIN-1; PRESENILIN-2;

EID: 0030746669     PISSN: 00068993     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0006-8993(97)00231-X     Document Type: Article

References (29)

1. Alzheimer's Disease Collaborative Group, The structure of the presenilin 1 (S182) gene and identification of six novel mutations in early-onset AD families, Nature Genet., 11 (1995) 219-222.
2. F. Boissière, L. Pradier, P. Delaère, B. Faucheux, F. Revah, A. Brice, Y. Agid, E.C. Hirsch, Regional and cellular presenilin 2 (STM2) gene expression in the human brain, NeuroReport 7 (1996) 2021-2025.
3. O. Bugiani, G. Giaccone, B. Frangione, B. Ghetti, F. Tagliavini, Alzheimer patients preamyloid deposits are more widely distributed than senile plaques throughout the central nervous system, Neurosci. Lett. 103 (1989) 263-268.
4. J.P. Card, R.P. Meade, L.G. Davis, Immunocytochemical localization of the precursor protein for β-amyloid in the rat central nervous system, Neuron 1 (1988) 835-846.
5. D.G. Cook, J.C. Sung, T.E. Golde, K.M. Felsenstein, B.S. Wojczyk, R.E. Tanzi, J.Q. Trojanowski, V.M.-Y. Lee, R.W. Doms, Expression and analysis of presenilin 1 in a human neuronal system: localization in cell bodies and dendrites, Proc. Natl. Acad. Sci. USA 93 (1996) 9223-9228.
6. G.A. Elder, N. Tezapsidis, J. Carter, J. Shioi, C. Bouras, H.-C. Li, J.M. Johnston, S. Efthimiopoulos, V.L. Friedrich Jr., N.K. Robakis, Identification and neuron specific expression of the S182/presenilin I protein in human and rodent brains, J. Neurosci. Res. 45 (1996) 308-320.
7. C. Haass, J. Walter, J. Grünberg, P. St. George-Hyslop, D. Selkoe, B. Pesold and A. Capell, Expression of the presenilin proteins PS-1 and PS-2 in tissue culture cells, Neurobiol. Aging, Suppl. 17 (1996) 150, p. S38.
8. D.M. Kovacs, H.J. Fausett, K.J. Page, T.-W. Kim, R.D. Moir, D.E. Merriam, R.D. Hollister, O.G. Hallmark, R. Mancini, K.M. Felsenstein, B.T. Hyman, R.E. Tanzi, W. Wasco, Alzheimer-associated presenilins 1 and 2: neuronal expression in brain and localization to intracellular membranes in mammalian cells, Nature Med. 2 (1996) 224-229.
9. S.W. L'Hernault, P.M. Arduengo, Mutation of putative sperm membrane protein in Caenorhabditis elegans prevents sperm differentiation but not its associated meiotic divisions, J. Cell. Biol. 119 (1992) 55-69.
10. D. Levitan, I. Greenwald, Facilitation of lin-12-mediated signalling by sel-12, a Caenorhabditis elegans S182 Alzheimer's disease gene, Nature 377 (1995) 351-354.
11. E. Levy-Lahad, W. Wasco, P. Poorkaj, D.M. Romano, J. Oshima, W.H. Pettingell, C.-E. Yu, P.D. Jondro, S.D. Schmidt, K. Wang, A.C. Crowley, Y.-H. Fu, S.Y. Guenette, D. Galas, E. Nemens, E.M. Wijsman, T.D. Bird, G.D. Schellenberg, R.E. Tanzi, Candidate gene for the chromosome 1 familial Alzheimer's disease locus, Science 269 (1995) 973-977.
12. E. Levy-Lahad, P. Poorkaj, K. Wang, Y.H. Fu, J. Oshima, J. Mulligan, G.D. Schellenberg, Genomic structure and expression of STM2, the chromosome 1 familial Alzheimer disease gene, Genomics 34 (1996) 198-204.
13. D.M.A. Mann, T. Iwatsubo, N.J. Cairns, P.L. Lantos, D. Nochlin, S.M. Sumi, T.D. Bird, P. Poorkaj, J. Hardy, M. Hutton, G. Prihar, K. Crook, M.N. Rossor, M. Haltia, Amyloid beta protein (A-beta) deposition in chromosome 14-linked Alzheimer's disease - predominance of A-beta (42(43)), Ann. Neurol. 40 (1996) 149-156.
14. S. Moussaoui, C. Czech, L. Pradier, V. Blanchard, B. Bonici, M. Gohin, A. Imperato, F. Revah, Immunohistochemical analysis of presenilin 1 expression in the mouse brain, FEBS Lett. 383 (1996) 219-222.
15. M. Mullan, F. Crawford, The molecular genetics of Alzheimer's disease, Mol. Neurobiol. 9 (1994) 15-22.
16. C.C. Ouimet, K.D. Baerwarld, S.E. Gandy, P. Greengard, Immunocytochemical localization of amyloid precursor protein in rat brain, J. Comp. Neurol. 384 (1994) 244-260.
17. D. Quarteronet, L. Pradier, C. Czech, L. Delalonde, M.-C. Burgevin, A. Doble, F. Petitet, Localization of presenilin 1 mRNA in the rat brain, NeuroReport 7 (1996) 2587-2591.
18. E.I. Rogaev, R. Sherrington, E.A. Rogaeva, G. Levesque, M. Ikeda, Y. Liang, H. Chi, C. Lin, K. Holman, T. Tsuda, L. Mar, S. Sorbi, B. Nacmias, S. Placentini, L. Amaducci, I. Chumakov, D. Cohen, L. Lannfelt, P.E. Fraser, J.M. Rommens, P.M. St George-Hyslop, Familial Alzheimer's disease in kindreds with missense mutations in a gene on chromosome 1 related to the Alzheimer's disease type 3 gene, Nature 376 (1995) 775-778.
19. N. Sahara, Y.-I. Yahagi, H. Takagi, T. Kondo, M. Okochi, M. Usami, T. Shirasawa, H Mori, Identification and characterization of presenilin I-467, I-463 and I-374, FEBS Lett. 381 (1996) 7-11.
20. G.D. Schellenberg, Genetic dissection of Alzheimer disease, a heterogeneous disorder, Proc. Natl. Acad. Sci. USA 92 (1995) 8552-8559.
21. D. Scheuner, C. Eckman, M. Jensen, X. Song, M. Citron, N. Suzuki, T.D. Bird, J. Hardy, M. Hutton, W. Kukull, E. Larson, E. Levy-Lahad, M. Viitanen, E. Peskind, P. Poorkaj, G. Schellenberg, R. Tanzi, W. Wasco, L. Lannfelt, D. Selkoe, S. Younkin, Secreted amyloid β-amyloid similar to that in the senile plaques of Alzeimer's disease is increased in vivo by the presenilin 1 and 2 and APP mutations linked to familial Alzheimer's disease, Nature Med. 2 (1996) 864-870.
22. R. Sherrington, E.I. Rogaev, Y. Liang, E.A. Rogaeva, G. Levesque, M. Ikeda, H. Chi, C. Lin, G. Li, K. Holman, T. Tsuda, L. Mar, J.-F. Foncin, A.C. Bruni, M.P. Montesi, S. Sorbi, I. Rainero, L. Pinessi, L. Nee, I. Chumakov, D. Pollen, A. Brookes, P. Sanseau, R.J. Polinsky, W. Wasco, H.A.R. Da Silva, J.L. Haines, M.A. pericak-Vance, R.E. Tanzi, A.D. Roses, P.E. Fraser, J.M. Rommens, P.M. St. George-Hyslop, Cloning of a gene bearing missense mutations in early-onset familial Alzheimer's disease, Nature 375 (1995) 754-760.
23. H.H. Slunt, G. Thinakaran, M.K. Lee, S.S. Sisodia, Nucleotide sequence of the chromosome 14-encoded S182 cDNA and revised secondary structure prediction, Int. J. Exp. Clin. Invest. 2 (1995) 188-190.
24. N. Suzuki, T.T. Cheung, X.D. Cai, A. Odaka, L. Otvos Jr., C. Eckman, T.E. Golde, S.G. Younkin, An increased percentage of long amyloid beta protein secreted by familial amyloid beta protein precursor (βAPP 717) mutants, Science 264 (1994) 1336-1340.
25. T. Suzuki, K. Nishiyama, S. Murayama, A. Yamamoto, S. Sato, I. Kanazawa, Y. Sakaki, Regional and cellular presenilin 1 gene expression in human and rat tissues, Biochem. Biophys. Res. Commun. 219 (1996) 708-713.
26. K. Takami, D.G. Walker and P.L. Mc Geer, Expression of presenilin 1 and -2 mRNAs in rat and Alzheimer brains, Neurobiol. Aging, Suppl. 17 (1996) 45, p. S18.
27. R.E. Tanzi, D.M. Kovacs, T.-W. Kim, R.D. Moir, S.Y. Guenette, W. Wasco, The presenilin genes and their role in early-onset familial Alzheimer's disease, Alzheimer's Disease Rev. 1 (1996) 91-98.
28. G. Thinakaran, D.R. Borchelt, M.K. Lee, H.H. Slunt, L. Spitzer, G. Kim, T. Ratovitsky, F. Davenport, C. Nordstedt, M. Seeger, J. Hardy, A.I. Levey, S.E. Gandy, N.A. Jenkins, N.G. Copeland, D.L. Price, S.S. Sisodia, Endoproteolysis of presenilin 1 and accumulation of processed derivates in vivo, Neuron 17 (1996) 181-190.
29. 2+-binding protein ALG-2 and Alzheimer's disease gene ALG-3, Science 271 (1996) 521-525.